26 results on '"Benedek B"'
Search Results
2. Connecting CAD-RADS, SYNTAX, And FAI Score For Assessing Perivascular Inflammation And Atheromatous Plaque Vulnerability
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Mátyás, B., primary, Benedek, I., additional, Blindu, E., additional, Benedek, B., additional, Gorea, A., additional, Rodean, I., additional, Rosca, A., additional, Halatiu, B., additional, and Benedek, T., additional
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- 2024
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3. Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes.
- Author
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Groenen AG, Halmos B, van Zeventer IA, Salzbrunn JB, Mayer ML, La Rose ND, Nolte IM, Schuringa JJ, Huls G, and Westerterp M
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- Humans, Male, Female, Middle Aged, Leukocyte Count, Aged, Prospective Studies, Adult, Sex Factors, Diabetes Mellitus, Type 2 blood, Biomarkers blood, Optical Imaging, Prediabetic State blood, Prediabetic State metabolism, Prediabetic State diagnosis, Monocytes metabolism, Glycation End Products, Advanced blood, Glycation End Products, Advanced metabolism, Neutrophils metabolism, Skin metabolism
- Abstract
Background and Aims: Previous studies have shown that skin autofluorescence (SAF), measured with an advanced glycation end product (AGE) reader, estimates the accumulation of AGEs in tissues. SAF is predictive of incident type 2 diabetes, cardiovascular disease (CVD), and CV mortality in the general population. Studies in diabetic mice have shown that activation of the receptor for AGEs in hematopoietic progenitor cells increases blood neutrophils and monocytes, impairing atherosclerosis regression. We asked whether SAF is associated with blood neutrophil and monocyte counts in the general population, and whether this was moderated by prediabetes, diabetes, and sex., Methods: We examined the associations between SAF and blood neutrophil/monocyte counts in participants of the Lifelines cohort (n = 58,923: n = 24,382 men, and n = 34,541 women), a prospective population-based cohort from the North of the Netherlands, employing multivariable regression analyses., Results: SAF positively associated with blood neutrophil and monocyte counts in the whole cohort. The positive association between SAF and monocyte, but not neutrophil, counts was moderated by prediabetes and diabetes. Positive associations between SAF and blood neutrophil and monocyte counts were moderated by male sex. Moreover, three-way interaction analyses revealed that the positive associations between SAF and neutrophil and monocyte counts were moderated by prediabetes, but not diabetes, in male sex., Conclusions: SAF is positively associated with blood neutrophil and monocyte counts in the general population, especially in men with prediabetes. This may contribute to the increased CV risk in men with prediabetes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2024
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4. [Vertebral artery dissection during traumatic injury of the cervical spine, two case reports].
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Oláh ZC, Nagy D, Sas A, Oláh B, Czabajszki M, Tamáska P, and Demeter B
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- Humans, Male, Wounds, Stab complications, Wounds, Stab surgery, Adult, Spinal Injuries complications, Spinal Injuries diagnostic imaging, Spinal Injuries surgery, Middle Aged, Vertebral Artery injuries, Vertebral Artery diagnostic imaging, Vertebral Artery Dissection diagnostic imaging, Vertebral Artery Dissection etiology, Cervical Vertebrae injuries
- Abstract
If severe cervical spinal cord injury or severe cervical vertebral fracture, subluxation or luxation is confirmed, 20-40% of the cases have vertebral artery dissection or occlusion. These can be asymptomatic, but can cause additional neurological damage in addition to cervical myelon and cervical nerve root symptoms. Vertebral artery dissection can be caused by direct injuries, stab wounds or gunshot wounds. Indirect vertebral artery dissection can occur at the same time as subluxation, luxation, or complex fractures of the cervical vertebra. CTA is the examination procedure of choice. In many cases, digital subtaction angiography examination and, if necessary, neurointerventional treatment must precede open neurosurgery. In our report, in the first patient, complete luxation of the C.VI vertebra caused unilateral vertebral artery 2-segment dissection-occlusion, while in our second patient, a stab injury caused direct vertebral artery compression and dissection. The occlusion of the vertebral artery did not cause neurological symptoms in any of the cases. In both of our cases, parent vessel occlusion was performed at the level of the vertebral artery injury before the neurosurgical operation.
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- 2024
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5. Dyotropic Rearrangement of an Iron-Aluminium Complex.
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Stadler B, Gorgas N, Elliott SJ, and Crimmin MR
- Abstract
Ligand exchange processes at metal complexes underpin their reactivity and catalytic applications. While mechanisms of ligand exchange at single site complexes are well established, occurring through textbook associative, dissociative and interchange mechanisms, those involving heterometallic complexes are less well developed. Here we report the reactions of a well-defined Fe-Al hydride complex with exogeneous ligands (CO and CNR, R = Me, tBu, Xyl = 2,6-Me2C6H3). Based on DFT calculations we suggest that these reactions occur through a dyotropic rearrangement, this involves initial coordination of the exogenous ligand at Al followed by migration to Fe, with simultaneous migration of a hydride ligand from Fe to Al. Such processes are rare for heterometallic complexes. We study the bonding and mechanism of the dyotropic rearrangement through in-depth computational analysis (NBO, IBOs, CLMO analysis, QTAIM, NCIplot, IMGH), shedding new light on how the electronic structure of the heterometallic core responds to the migration of ligands between metal sites. The dyotropic rearrangement fundamentally changes the nature of the hydride ligands, exposing new nucleophilic reactivity as evidenced by insertion reactions with CO2, isocyanates, as well as isocyanides., (© 2024 Wiley‐VCH GmbH.)
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- 2024
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6. Advancing Lithium-Ion Batteries' Electrochemical Performance: Ultrathin Alumina Coating on Li(Ni 0.8 Co 0.1 Mn 0.1 )O 2 Cathode Materials.
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Ahangari M, Xia F, Szalai B, Zhou M, and Luo H
- Abstract
Ni-rich Li(Ni
x Coy Mnz )O2 (x ≥ 0.8)-layered oxide materials are highly promising as cathode materials for high-energy-density lithium-ion batteries in electric and hybrid vehicles. However, their tendency to undergo side reactions with electrolytes and their structural instability during cyclic lithiation/delithiation impairs their electrochemical cycling performance, posing challenges for large-scale applications. This paper explores the application of an Al2 O3 coating using an atomic layer deposition (ALD) system on Ni-enriched Li(Ni0.8 Co0.1 Mn0.1 )O2 (NCM811) cathode material. Characterization techniques, including X-ray diffraction, scanning electron microscopy, and transmission electron microscopy, were used to assess the impact of alumina coating on the morphology and crystal structure of NCM811. The results confirmed that an ultrathin Al2 O3 coating was achieved without altering the microstructure and lattice structure of NCM811. The alumina-coated NCM811 exhibited improved cycling stability and capacity retention in the voltage range of 2.8-4.5 V at a 1 C rate. Specifically, the capacity retention of the modified NCM811 was 5%, 9.11%, and 11.28% higher than the pristine material at operating voltages of 4.3, 4.4, and 4.5 V, respectively. This enhanced performance is attributed to reduced electrode-electrolyte interaction, leading to fewer side reactions and improved structural stability. Thus, NCM811@Al2 O3 with this coating process emerges as a highly attractive candidate for high-capacity lithium-ion battery cathode materials.- Published
- 2024
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7. Evaluation of Lateral Radar Positioning for Vital Sign Monitoring: An Empirical Study.
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Hornig L, Szmola B, Pätzold W, Vox JP, and Wolf KI
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- Humans, Monitoring, Physiologic methods, Monitoring, Physiologic instrumentation, Adult, Male, Polysomnography methods, Female, Radar, Vital Signs physiology, Heart Rate physiology, Respiration
- Abstract
Vital sign monitoring is dominated by precise but costly contact-based sensors. Contactless devices such as radars provide a promising alternative. In this article, the effects of lateral radar positions on breathing and heartbeat extraction are evaluated based on a sleep study. A lateral radar position is a radar placement from which multiple human body zones are mapped onto different radar range sections. These body zones can be used to extract breathing and heartbeat motions independently from one another via these different range sections. Radars were positioned above the bed as a conventional approach and on a bedside table as well as at the foot end of the bed as lateral positions. These positions were evaluated based on six nights of sleep collected from healthy volunteers with polysomnography (PSG) as a reference system. For breathing extraction, comparable results were observed for all three radar positions. For heartbeat extraction, a higher level of agreement between the radar foot end position and the PSG was found. An example of the distinction between thoracic and abdominal breathing using a lateral radar position is shown. Lateral radar positions could lead to a more detailed analysis of movements along the body, with the potential for diagnostic applications.
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- 2024
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8. [A race against time: POEMS syndrome].
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Rónaszéki B, Sandi D, Ónodi Á, Szabó N, Dézsi L, Tajti J, and Piukovics K
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- Humans, Middle Aged, Male, Female, Delayed Diagnosis, POEMS Syndrome diagnosis, POEMS Syndrome therapy
- Abstract
Background - POEMS syndrome is a potentially well manageable disease with an ascendant therapeutic arsenal nowadays. The early recognition of the syndrome is key to prevent serious multiorgan damage, and that is still a big challenge for physicians. With the following two case reports the authors aimed to highlight the consequences of late recognition of the disease and summarize the potential therapeutic options for POEMS syndrome.
Results - We have presented two patients’ cases with a long history of examination and treatment because of uncleared polyneuropathy. Through these cases we could see how serious could be the consequences of late diagnosis and despite multiorgan impairment there are still therapeutic options which could improve the patient’s condition. Although the diagnosis of POEMS syndrome is not easy, it must raise our mind the thought and be prudent when we start a treatment in polyneuropathy.
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- 2024
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9. [Az arteria meningea media embolisatio szerepe a krónikus subduralis haematoma kezelési algoritmusában, legújabb evidenciák és saját tapasztalataink].
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Oláh ZC, Papp GJ, Sas A, Oláh B, Czabajszki M, and Demeter B
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- Humans, Aged, Treatment Outcome, Embolization, Therapeutic methods, Hematoma, Subdural, Chronic surgery, Hematoma, Subdural, Chronic diagnostic imaging, Hematoma, Subdural, Chronic therapy, Meningeal Arteries
- Abstract
Chronic subdural hematoma is one of the most common diseases requiring a neurosurgical operation that affect elderly and fragile patients. In addition to standard neurosurgical operations (trepanation and craniotomy), embolization of the meningeal artery media is an alternative solution. Several review aerticles have confirmed the very high rate of success and safety of the endovascular treatment. We present the technical details and results of our 10 consecutive selective media meningeal artery embolization procedures for residual chronic subdural hematomas. Our interventions were performed without complications and all resulted in complete recovery.
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- 2024
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10. Effects of Gamma Irradiation on Polyethylene Terephthalate and Detection of Microplastic Particles Down to 1 μm.
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Mikac L, Csáki A, Zentai B, Tolić A, Ivanda M, and Veres M
- Abstract
In response to increasing concern about the impact of plastic degradation on the environment, this study investigates the degradation of virgin and recycled polyethylene terephthalate (PET) under γ-irradiation in aqueous solutions, with particular focus on the resulting formation of microplastic particles (MP). By exposing both virgin and recycled PET samples to different doses of γ-irradiation (10, 50, and 100 kGy), a comprehensive analysis using UV-vis spectroscopy, dynamic light scattering (DLS) and micro-Raman spectroscopy is presented. The results, highlighted by micro-Raman spectroscopy, show that γ-irradiation produces micrometer-sized plastic particles, with the recycled PET having a significantly higher MP content than its original counterpart. Careful examination reveals the presence of a stabilizer in samples of recycled PET juice bottles. This study not only contributes to our understanding of the effects of γ-irradiation on PET but also highlights the need for further research into the environmental impact of such processes. The insights gained shed light on the behavior of PET under γ-irradiation and the resulting impact on microplastic pollution and make an important contribution to our understanding of the broader environmental context.
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- 2024
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11. Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer.
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Dankó B, Hess J, Unger K, Samaga D, Walz C, Walch A, Sun N, Baumeister P, Zeng PYF, Walter F, Marschner S, Späth R, Gires O, Herkommer T, Dazeh R, Matos T, Kreutzer L, Matschke J, Eul K, Klauschen F, Pflugradt U, Canis M, Ganswindt U, Mymryk JS, Wollenberg B, Nichols AC, Belka C, Zitzelsberger H, Lauber K, and Selmansberger M
- Abstract
Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous malignancy that remains a significant challenge in clinical management due to frequent treatment failures and pronounced therapy resistance. While metabolic dysregulation appears to be a critical factor in this scenario, comprehensive analyses of the metabolic HNSCC landscape and its impact on clinical outcomes are lacking. This study utilized transcriptomic data from four independent clinical cohorts to investigate metabolic heterogeneity in HNSCC and define metabolic pathway-based subtypes (MPS). In HPV-negative HNSCCs, MPS1 and MPS2 were identified, while MPS3 was enriched in HPV-positive cases. MPS classification was associated with clinical outcome post adjuvant radio(chemo)therapy, with MPS1 consistently exhibiting the highest risk of therapeutic failure. MPS1 was uniquely characterized by upregulation of glycan (particularly chondroitin/dermatan sulfate) metabolism genes. Immunohistochemistry and pilot mass spectrometry imaging analyses confirmed this at metabolite level. The histological context and single-cell RNA sequencing data identified the malignant cells as key contributors. Globally, MPS1 was distinguished by a unique transcriptomic landscape associated with increased disease aggressiveness, featuring motifs related to epithelial-mesenchymal transition, immune signaling, cancer stemness, tumor microenvironment assembly, and oncogenic signaling. This translated into a distinct histological appearance marked by extensive extracellular matrix remodeling, abundant spindle-shaped cancer-associated fibroblasts, and intimately intertwined populations of malignant and stromal cells. Proof-of-concept data from orthotopic xenotransplants replicated the MPS phenotypes on the histological and transcriptome levels. In summary, this study introduces a metabolic pathway-based classification of HNSCC, pinpointing glycan metabolism-enriched MPS1 as the most challenging subgroup that necessitates alternative therapeutic strategies., (© 2024. The Author(s).)
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- 2024
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12. Softly empowering a prosocial expert in the family: lasting effects of a counter-misinformation intervention in an informational autocracy.
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Orosz G, Faragó L, Paskuj B, Rakovics Z, Sam-Mine D, Audemard G, Modeliar MS, and Krekó P
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- Humans, Male, Female, Adult, Young Adult, Hungary, Mass Media, Empowerment, Deception, Family psychology, Adolescent, Communication
- Abstract
The present work is the first to comprehensively analyze the gravity of the misinformation problem in Hungary, where misinformation appears regularly in the pro-governmental, populist, and socially conservative mainstream media. In line with international data, using a Hungarian representative sample (Study 1, N = 991), we found that voters of the reigning populist, conservative party could hardly distinguish fake from real news. In Study 2, we demonstrated that a prosocial intervention of ~ 10 min (N = 801) helped young adult participants discern misinformation four weeks later compared to the control group without implementing any boosters. This effect was the most salient regarding pro-governmental conservative fake news content, leaving real news evaluations intact. Although the hypotheses of the present work were not preregistered, it appears that prosocial misinformation interventions might be promising attempts to counter misinformation in an informational autocracy in which the media is highly centralized. Despite using social motivations, it does not mean that long-term cognitive changes cannot occur. Future studies might explore exactly how these interventions can have an impact on the long-term cognitive processing of news content as well as their underlying neural structures., (© 2024. The Author(s).)
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- 2024
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13. Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data.
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Middleton L, Melas I, Vasavda C, Raies A, Rozemberczki B, Dhindsa RS, Dhindsa JS, Weido B, Wang Q, Harper AR, Edwards G, Petrovski S, and Vitsios D
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- Humans, Algorithms, Computational Biology methods, Databases, Genetic, Genetic Predisposition to Disease, Genome-Wide Association Study methods, Genomics methods, Phenomics methods, Phenotype, UK Biobank, United Kingdom, Neural Networks, Computer
- Abstract
The ongoing expansion of human genomic datasets propels therapeutic target identification; however, extracting gene-disease associations from gene annotations remains challenging. Here, we introduce Mantis-ML 2.0, a framework integrating AstraZeneca's Biological Insights Knowledge Graph and numerous tabular datasets, to assess gene-disease probabilities throughout the phenome. We use graph neural networks, capturing the graph's holistic structure, and train them on hundreds of balanced datasets via a robust semi-supervised learning framework to provide gene-disease probabilities across the human exome. Mantis-ML 2.0 incorporates natural language processing to automate disease-relevant feature selection for thousands of diseases. The enhanced models demonstrate a 6.9% average classification power boost, achieving a median receiver operating characteristic (ROC) area under curve (AUC) score of 0.90 across 5220 diseases from Human Phenotype Ontology, OpenTargets, and Genomics England. Notably, Mantis-ML 2.0 prioritizes associations from an independent UK Biobank phenome-wide association study (PheWAS), providing a stronger form of triaging and mitigating against underpowered PheWAS associations. Results are exposed through an interactive web resource.
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- 2024
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14. Responsible data sharing: Identifying and remedying possible re-identification of human participants.
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Morehouse KN, Kurdi B, and Nosek BA
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Open data collected from research participants creates a tension between scholarly values of transparency and sharing, on the one hand, and privacy and security, on the other hand. A common solution is to make data sets anonymous by removing personally identifying information (e.g., names or worker IDs) before sharing. However, ostensibly anonymized data sets may be at risk of re-identification if they include demographic information. In the present article, we provide researchers with broadly applicable guidance and tangible tools so that they can engage in open science practices without jeopardizing participants' privacy. Specifically, we (a) review current privacy standards, (b) describe computer science data protection frameworks and their adaptability to the social sciences, (c) provide practical guidance for assessing and addressing re-identification risk, (d) introduce two open-source algorithms developed for psychological scientists-MinBlur and MinBlurLite-to increase privacy while maintaining the integrity of open data, and (e) highlight aspects of ethical data sharing that require further attention. Ultimately, the risk of re-identification should not dissuade engagement with open science practices. Instead, technical innovations should be developed and harnessed so that science can be as open as possible to promote transparency and sharing and as closed as necessary to maintain privacy and security. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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15. A digital distance on the kisrhombille tiling.
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Kablan F, Vizvári B, and Nagy B
- Abstract
The kisrhombille tiling is the dual tessellation of one of the semi-regular tessellations. It consists of right-angled triangle tiles with 12 different orientations. An adequate coordinate system for the tiles of the grid has been defined that allows a formal description of the grid. In this paper, two tiles are considered to be neighbors if they share at least one point in their boundary. Paths are sequences of tiles such that any two consecutive tiles are neighbors. The digital distance is defined as the minimum number of steps in a path between the tiles, and the distance formula is proven through constructing minimum paths. In fact, the distance between triangles is almost twice the hexagonal distance of their embedding hexagons.
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- 2024
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16. High-throughput quantum photonic devices emitting indistinguishable photons in the telecom C-band.
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Holewa P, Vajner DA, Zięba-Ostój E, Wasiluk M, Gaál B, Sakanas A, Burakowski M, Mrowiński P, Krajnik B, Xiong M, Yvind K, Gregersen N, Musiał A, Huck A, Heindel T, Syperek M, and Semenova E
- Abstract
Single indistinguishable photons at telecom C-band wavelengths are essential for quantum networks and the future quantum internet. However, high-throughput technology for single-photon generation at 1550 nm remained a missing building block to overcome present limitations in quantum communication and information technologies. Here, we demonstrate the high-throughput fabrication of quantum-photonic integrated devices operating at C-band wavelengths based on epitaxial semiconductor quantum dots. Our technique enables the deterministic integration of single pre-selected quantum emitters into microcavities based on circular Bragg gratings. Respective devices feature the triggered generation of single photons with ultra-high purity and record-high photon indistinguishability. Further improvements in yield and coherence properties will pave the way for implementing single-photon non-linear devices and advanced quantum networks at telecom wavelengths., (© 2024. The Author(s).)
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- 2024
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17. Testing the automaticity features of the affect misattribution procedure: The roles of awareness and intentionality.
- Author
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Kurdi B, Melnikoff DE, Hannay JW, Korkmaz A, Lee KM, Ritchie E, Surdel N, Vuletich HA, Yang X, Payne BK, and Ferguson MJ
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- Humans, Female, Male, Young Adult, Adult, Affect physiology, Reaction Time physiology, Adolescent, Awareness physiology, Intention
- Abstract
The affect misattribution procedure (AMP) is a measure of implicit evaluations, designed to index the automatic retrieval of evaluative knowledge. The AMP effect consists in participants evaluating neutral target stimuli positively when preceded by positive primes and negatively when preceded by negative primes. After multiple prior tests of intentionality, Hughes et al. (Behav Res Methods 55(4):1558-1586, 2023) examined the role of awareness in the AMP and found that AMP effects were larger when participants indicated that their response was influenced by the prime than when they did not. Here we report seven experiments (six preregistered; N = 2350) in which we vary the methodological features of the AMP to better understand this awareness effect. In Experiments 1-4, we establish variability in the magnitude of the awareness effect in response to variations in the AMP procedure. By introducing further modifications to the AMP procedure, Experiments 5-7 suggest an alternative explanation of the awareness effect, namely that awareness can be the outcome, rather than the cause, of evaluative congruency between primes and responses: Awareness effects emerged even when awareness could not have contributed to AMP effects, including when participants judged influence awareness for third parties or primes were presented post hoc. Finally, increasing the evaluative strength of the primes increased participants' tendency to misattribute AMP effects to the influence of target stimuli. Together, the present findings suggest that AMP effects can create awareness effects rather than vice versa and support the AMP's construct validity as a measure of unintentional evaluations of which participants are also potentially unaware., (© 2023. The Psychonomic Society, Inc.)
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- 2024
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18. Apolipoprotein(a) production and clearance are associated with plasma IL-6 and IL-18 levels, dependent on ethnicity.
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Groenen AG, Matveyenko A, Matienzo N, Halmos B, Zhang H, Westerterp M, and Reyes-Soffer G
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- Humans, Apoprotein(a), Ethnicity, Interleukin-18, Kinetics, Apolipoproteins A, Lipoprotein(a), Protein Isoforms metabolism, Interleukin-6, Atherosclerosis
- Abstract
Background and Aims: High plasma lipoprotein (a) [Lp(a)] levels are associated with increased atherosclerotic cardiovascular disease (ASCVD), in part attributed to elevated inflammation. High plasma Lp(a) levels inversely correlate with apolipoprotein (a) [(APO(a)] isoform size. APO(a) isoform size is negatively associated with APO(a) production rate (PR) and positively associated with APO(a) fractional catabolic rate (FCR). We asked whether APO(a) PR and FCR (kinetics) are associated with plasma levels of interleukin (IL)-6 and IL-18, pro-inflammatory interleukins that promote ASCVD., Methods: We used samples from existing data of APO(a) kinetic studies from an ethnically diverse cohort (n = 25: 10 Black, 9 Hispanic, and 6 White subjects) and assessed IL-6 and IL-18 plasma levels. We performed multivariate linear regression analyses to examine the relationships between predictors APO(a) PR or APO(a) FCR, and outcome variables IL-6 or IL-18. In these analyses, we adjusted for parameters known to affect Lp(a) levels and APO(a) PR and FCR, including race/ethnicity and APO(a) isoform size., Results: APO(a) PR and FCR were positively associated with plasma IL-6, independent of isoform size, and dependent on race/ethnicity. APO(a) PR was positively associated with plasma IL-18, independent of isoform size and race/ethnicity. APO(a) FCR was not associated with plasma IL-18., Conclusions: Our studies demonstrate a relationship between APO(a) PR and FCR and plasma IL-6 or IL-18, interleukins that promote ASCVD. These studies provide new insights into Lp(a) pro-inflammatory properties and are especially relevant in view of therapies targeting APO(a) to decrease cardiovascular risk., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2024
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19. (when) do counterattitudinal exemplars shift implicit racial evaluations? Replications and extensions of Dasgupta and Greenwald (2001).
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Kurdi B, Sanchez A, Dasgupta N, and Banaji MR
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- Humans, Male, Female, Adult, Young Adult, Social Perception, Adolescent, Middle Aged, White People, Racism
- Abstract
Dasgupta and Greenwald (2001) demonstrated that exposure to positive Black exemplars (e.g., Colin Powell) and negative White exemplars (e.g., Jeffrey Dahmer) can reduce implicit pro-White/anti-Black evaluations, as measured by an Implicit Association Test. Here, we report seven preregistered online experiments conducted with volunteer U.S. participants ( N = 6,953) that sought to replicate and probe the boundary conditions of this finding. Contrary to expectations, we found no shift in implicit racial evaluations in two close replication attempts (Experiments 1-2). Experiments 3-4 ruled out the possibility of insufficiently strong exemplar valence and subtyping as explanations for the failures to replicate. In Experiment 5, implicit racial evaluations did exhibit malleability in response to two different procedures relying on repeated evaluative pairings and evaluative statements, suggesting that they are capable of change. With insight from these studies, Experiments 6-7 were mounted with modifications to the Dasgupta and Greenwald (2001) procedure. Significant reductions in implicit pro-White/anti-Black evaluations were now observed when race, valence, and the contingency between the two were highlighted. In addition, across all experiments, the magnitude of shift in implicit racial evaluations was significantly predicted by participants' ability to recall the Black-positive and White-negative contingencies experienced during the exemplar exposure task. Together, these data suggest that exposure to counterattitudinal exemplars can shift implicit racial evaluations toward neutrality, but such malleability strongly depends on contingency awareness. We discuss implications for social cognitive theory, theoretically informed debiasing interventions, and different paths toward resolving initial replication failures. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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20. [Middle meningeal artery embolization to treat acute epidural haematoma, case report and literature review].
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Oláh B and Oláh ZC
- Subjects
- Humans, Meningeal Arteries diagnostic imaging, Meningeal Arteries surgery, Tomography, X-Ray Computed, Hematoma, Epidural, Cranial diagnostic imaging, Hematoma, Epidural, Cranial therapy, Hematoma, Epidural, Cranial etiology, Embolization, Therapeutic adverse effects
- Abstract
The treatment of acute epidural haematoma is surgery as soon as possible, elimination of the source of bleeding and evacuation of the haematoma. In case of small epidural haematoma, strict neurological and radiological follow-up is necessary. In a significant percentage of cases, open surgery must also be performed within a few days. In case of small epidural haematomas, embolization of the middle meningeal artery is considered as an alternative solution. We review the literature on middle meningeal artery embolization and present our first treatment. Our case report is the first European report about an acute epidural haematoma which was treated by embolization of middle meningeal artery. Our case study is the first report in which a patient was treated with both open surgery and endovascular treatment for acute epidural haematoma within a year.
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- 2024
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21. Vinylic C-H Activation of Styrenes by an Iron-Aluminum Complex.
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Gorgas N, Stadler B, White AJP, and Crimmin MR
- Abstract
The oxidative addition of sp
2 C-H bonds of alkenes to single-site transition-metal complexes is complicated by the competing π-coordination of the C═C double bond, limiting the examples of this type of reactivity and onward applications. Here, we report the C-H activation of styrenes by a well-defined bimetallic Fe-Al complex. These reactions are highly selective, resulting in the ( E )-β-metalation of the alkene. For this bimetallic system, alkene binding appears to be essential for the reaction to occur. Experimental and computational insights suggest an unusual reaction pathway in which a (2 + 2) cycloaddition intermediate is directly converted into the hydrido vinyl product via an intramolecular sp2 C-H bond activation across the two metals. The key C-H cleavage step proceeds through a highly asynchronous transition state near the boundary between a concerted and a stepwise mechanism influenced by the resonance stabilization ability of the aryl substituent. The metalated alkenes can be further functionalized, which has been demonstrated by the ( E )-selective phosphination of the employed styrenes.- Published
- 2024
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22. Advancements and Challenges in High-Capacity Ni-Rich Cathode Materials for Lithium-Ion Batteries.
- Author
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Ahangari M, Szalai B, Lujan J, Zhou M, and Luo H
- Abstract
Nowadays, lithium-ion batteries are undoubtedly known as the most promising rechargeable batteries. However, these batteries face some big challenges, like not having enough energy and not lasting long enough, that should be addressed. Ternary Ni-rich Li[Ni
x Coy Mnz ]O2 and Li[Nix Coy Alz ]O2 cathode materials stand as the ideal candidate for a cathode active material to achieve high capacity and energy density, low manufacturing cost, and high operating voltage. However, capacity gain from Ni enrichment is nullified by the concurrent fast capacity fading because of issues such as gas evolution, microcracks propagation and pulverization, phase transition, electrolyte decomposition, cation mixing, and dissolution of transition metals at high operating voltage, which hinders their commercialization. In order to tackle these problems, researchers conducted many strategies, including elemental doping, surface coating, and particle engineering. This review paper mainly talks about origins of problems and their mechanisms leading to electrochemical performance deterioration for Ni-rich cathode materials and modification approaches to address the problems.- Published
- 2024
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23. UV Irradiation of Polyethylene Terephthalate and Polypropylene and Detection of Formed Microplastic Particles Down to 1 μm.
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Mikac L, Csáki A, Zentai B, Rigó I, Veres M, Tolić A, Gotić M, and Ivanda M
- Abstract
The degradation of plastics upon UVC irradiation in aqueous solution and the formation of microplastic (MP) particles were investigated. Polypropylene (PP) and recycled and virgin polyethylene terephthalate (PET) were irradiated with a UV lamp emitting light at 254 nm. Irradiation was performed for 15 and 30 min, respectively, at an intensity of about 0.3 W cm
-2 . The formation of MP was studied by Raman spectroscopy. The results showed that MP particles were formed after irradiation and that their number was significantly higher in the recycled PET than in the virgin material. The number of PP MP formed was lower compared to PET and was not significantly different after 15 and 30 min. In addition, ethanol was used as an alternative solvent to investigate how its chemical properties and interactions with UVC irradiation affect the degradation of PET and PP plastics. The use of ethanol and recycled PET resulted in a lower number of MP particles at both irradiation times. When ethanol was used after 30 min of irradiation, significantly more PP MP formed. The different chemical structures of PET and PP combined with the different solvent properties of water and ethanol contribute to the differences in their susceptibility to UVC degradation., (© 2023 Wiley-VCH GmbH.)- Published
- 2024
- Full Text
- View/download PDF
24. [An enormous epidural abscess secondary to cranial metastasis of a lung tumor].
- Author
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Oláh CZ, Oláh B, Demeter B, and Papp A
- Subjects
- Humans, Magnetic Resonance Imaging, Epidural Abscess etiology, Epidural Abscess complications, Osteomyelitis, Lung Neoplasms complications
- Published
- 2024
- Full Text
- View/download PDF
25. Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics.
- Author
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Valdeolivas A, Amberg B, Giroud N, Richardson M, Gálvez EJC, Badillo S, Julien-Laferrière A, Túrós D, Voith von Voithenberg L, Wells I, Pesti B, Lo AA, Yángüez E, Das Thakur M, Bscheider M, Sultan M, Kumpesa N, Jacobsen B, Bergauer T, Saez-Rodriguez J, Rottenberg S, Schwalie PC, and Hahn K
- Abstract
The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-used gene expression-based classification and has contributed to a better understanding of disease heterogeneity and prognosis. Nevertheless, CMS intratumoral heterogeneity restricts its clinical application, stressing the necessity of further characterizing the composition and architecture of CRC. Here, we used Spatial Transcriptomics (ST) in combination with single-cell RNA sequencing (scRNA-seq) to decipher the spatially resolved cellular and molecular composition of CRC. In addition to mapping the intratumoral heterogeneity of CMS and their microenvironment, we identified cell communication events in the tumor-stroma interface of CMS2 carcinomas. This includes tumor growth-inhibiting as well as -activating signals, such as the potential regulation of the ETV4 transcriptional activity by DCN or the PLAU-PLAUR ligand-receptor interaction. Our study illustrates the potential of ST to resolve CRC molecular heterogeneity and thereby help advance personalized therapy., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
26. Impact of information technology supported serious leisure gardening on the wellbeing of older adults: The Turntable project.
- Author
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Vassányi I, Szakonyi B, Loi D, Mantur-Vierendeel A, Quintas J, Solinas A, Blažica B, Raffo L, Guicciardi M, Manca A, Gaál B, and Rárosi F
- Subjects
- Humans, Aged, Gardening, Leisure Activities, Italy, Quality of Life, Information Technology
- Abstract
Objective: The study presented in this paper aimed to assess the effect of an Information Technology enabled community gardening program for older adults, developed by an international consortium., Methods: We have executed a quantitative, pre- and post-test field trial with older adult volunteers to test the proposed programme in two European countries, Italy and Belgium (n=98). We used standardized and ad hoc questionnaires to measure changes in the volunteers' mental and psychological state during the trial. The statistical data analysis sought for differences in the pre- and post-test values of the key scores related to the perceived quality of life and benefits of gardening via paired-samples t-tests, and also tried to identify the important factors of significant changes via logistic regression., Results: We found significant improvements in the perceived benefits of gardening and also in the scores computed from the WHO Quality of Life instruments, especially in the social sub-domains. The improvements were associated with the country, age, marital state and education of the volunteers. Higher age or being widow, divorced or single increased the odds of a significant improvement in the scores in more than one sub-domains., Conclusion: Though the two trial settings were different in some aspects, the observed significant improvements generally confirmed the positive effects of gardening concerning the perceived quality of life and benefits of gardening., Competing Interests: Declaration of Competing Interest None declared., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
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