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3 results on '"Beazley, Debra"'

1. Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Author

Jakobsen, Niels Asger, Turkalj, Sven, Zeng, Andy G.X., Stoilova, Bilyana, Metzner, Marlen, Rahmig, Susann, Nagree, Murtaza S., Shah, Sayyam, Moore, Rachel, Usukhbayar, Batchimeg, Angulo Salazar, Mirian, Gafencu, Grigore-Aristide, Kennedy, Alison, Newman, Simon, Kendrick, Benjamin J.L., Taylor, Adrian H., Afinowi-Luitz, Rasheed, Gundle, Roger, Watkins, Bridget, Wheway, Kim, Beazley, Debra, Murison, Alex, Aguilar-Navarro, Alicia G., Flores-Figueroa, Eugenia, Dakin, Stephanie G., Carr, Andrew J., Nerlov, Claus, Dick, John E., Xie, Stephanie Z., and Vyas, Paresh

Published
2024
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2. A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

Author

Ng, Michael T. H., Borst, Rowie, Gacaferi, Hamez, Davidson, Sarah, Ackerman, Jessica E., Johnson, Peter A., Machado, Caio C., Reekie, Ian, Attar, Moustafa, Windell, Dylan, Kurowska-Stolarska, Mariola, Macdonald, Lucy, Alivernini, Stefano, Garvilles, Micon, Jansen, Kathrin, Bhalla, Ananya, Lee, Angela, Charlesworth, Jame, Chowdhury, Rajat, Klenerman, Paul, Powell, Kate, Hackstein, Carl-Philip, Rangan, Amar, Gwilym, Stephen, Little, Christopher, Titchener, Andrew, Chaudhury, Salma, Holland, Philip, Wheway, Kim, Watkins, Bridget, Beazley, Debra, Vesty-Edwards, Loi, Appleton, Louise, Atkinson, Marc, Kottam, Lucksy, James, Juliet, Clark, Natalie, Furniss, Dominic, Rees, Jonathan, Gilroy, Derek, Coles, Mark, Carr, Andrew J., Sansom, Stephen N., Buckley, Christopher D., Dakin, Stephanie G., Null, Null, Alivernini, Stefano (ORCID:0000-0002-7383-4212), Ng, Michael T. H., Borst, Rowie, Gacaferi, Hamez, Davidson, Sarah, Ackerman, Jessica E., Johnson, Peter A., Machado, Caio C., Reekie, Ian, Attar, Moustafa, Windell, Dylan, Kurowska-Stolarska, Mariola, Macdonald, Lucy, Alivernini, Stefano, Garvilles, Micon, Jansen, Kathrin, Bhalla, Ananya, Lee, Angela, Charlesworth, Jame, Chowdhury, Rajat, Klenerman, Paul, Powell, Kate, Hackstein, Carl-Philip, Rangan, Amar, Gwilym, Stephen, Little, Christopher, Titchener, Andrew, Chaudhury, Salma, Holland, Philip, Wheway, Kim, Watkins, Bridget, Beazley, Debra, Vesty-Edwards, Loi, Appleton, Louise, Atkinson, Marc, Kottam, Lucksy, James, Juliet, Clark, Natalie, Furniss, Dominic, Rees, Jonathan, Gilroy, Derek, Coles, Mark, Carr, Andrew J., Sansom, Stephen N., Buckley, Christopher D., Dakin, Stephanie G., Null, Null, and Alivernini, Stefano (ORCID:0000-0002-7383-4212)

Abstract

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues. Micro-cultures of patient-derived cells identify integrin-mediated cell-matrix interactions between MERTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts, suggesting that matrix remodelling plays a role in frozen shoulder resolution. Cross-tissue analysis reveals a shared gene expression cassette between shoulder capsule MERTK+ macrophages and a respective population enriched in synovial tissues of rheumatoid arthritis patients in disease remission, supporting the concept that MERTK+ macrophages mediate resolution of inflammation and fibrosis. Single-cell transcriptomic profiling and spatial analysis of human foetal shoulder tissues identify MERTK + LYVE1 + MRC1+ macrophages and DKK3+ and POSTN+ fibroblast populations analogous to those in frozen shoulder, suggesting that the template to resolve fibrosis is established during shoulder development. Crosstalk between MerTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts could facilitate resolution of frozen shoulder, providing a basis for potential therapeutic resolution of persistent fibrotic diseases.

Published
2024

3. Resistance to Change or Transformation After Involuntary Unemployment and Underemployment: A Theoretical Model.

Author

Beazley, Debra

Subjects
IDENTITY (Psychology), CHANGE (Psychology), POSITIVE psychology, SPIRITUAL formation, SELF, UNDEREMPLOYMENT
Abstract

Significant changes in workplace strategy or economic instability can lead individuals into emotional and spiritual crises, triggering identity transformations. This paper explores the effects of involuntary unemployment, underemployment, compromised employment, and mandatory retirement, referred to as involuntary second-order employment disruptions, on personal identity. Drawing from theories of quantum personal change and positive psychology, the paper discusses how these changes can lead to emotional and spiritual distress, akin to a "dark night of the soul," potentially resulting in posttraumatic transformation. The transition through this crisis involves stages of resistance and adaptation, ultimately leading to a profound shift in identity and purpose. The process includes disengagement, disidentification, disenchantment, and disorientation, which can create significant psychological challenges, and involuntary opportunities for spiritual growth and self-actualization. The paper proposes that these employment disruptions are catalysts for deep personal transformation, highlighting the importance of managing such transitions effectively to foster resilience and positive outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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