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3. List of contributors

Author

Abbasi, Milad, primary, Abd El-baky, Mona F., additional, Abdelrazek, Heba M.A., additional, Abdelwahed, B., additional, Alessandro, Bistolfi, additional, Alessandro, Massè, additional, Alsiri, Najla, additional, Amani, Ali Mohammad, additional, Amoabediny, Ghassem, additional, Amoabediny, Zeinab, additional, Animesh, Hazari, additional, Antony, Benny, additional, Anwar, Dilshad, additional, Anwer, Shahnawaz, additional, Arslan, Yunus Ziya, additional, Arulsingh D.R, Watson, additional, Aufa, A.N., additional, Bao, Bin, additional, Barajas-Pedroza, Meztli Amairani, additional, Barati, Aboulfazl, additional, Beheshtizadeh, Nima, additional, Bognar, Gabriella, additional, Broderick, James M., additional, Brown, Ryan, additional, Bukata, Susan, additional, Carlotta, Faccenda, additional, Chakraborty, Kajal, additional, Chang, Eric Y., additional, Chen, Sheng, additional, Chung, Christine B., additional, Darwich, Ayham, additional, Din, Rahman Ud, additional, Du, Jiang, additional, Elango, Jeevithan, additional, El-Hak, Heba Nageh Gad, additional, El-Husseiny, Hussein M., additional, Esmaeili, Javad, additional, Findik, Fehim, additional, Fortunato, Giustra, additional, Francesco, Bosco, additional, García Vicente, Ana, additional, Golchin, Ali, additional, Hamsayeh Abbasi Niasar, Erfan, additional, Hashemi, Sheida, additional, Hassan, Mohamad Zaki, additional, He, Min, additional, Heidary, Seyed Hamidreza, additional, Herger, Simon, additional, Hua, Xijin, additional, Huang, Yizhou, additional, Ismail, Zarini, additional, İyibilgin, Osman, additional, Jang, Hyungseok, additional, Jerban, Saeed, additional, Jiménez Londoño, Germán, additional, Kandakurti, Praveen Kumar, additional, Karabulut, Derya, additional, Khaled, Sherif A., additional, Khedr, Ahmed, additional, Komeili, Amin, additional, Korany, Mohamed, additional, La Barbera, Luigi, additional, Lai, Wilson, additional, Li, Heng, additional, Li, LePing, additional, Liphardt, Anna-Maria, additional, Liu, Shan, additional, Ma, Yajun, additional, Mady, Eman A., additional, Mange, Tyler, additional, Menon, Rajiv G., additional, Mousavi, Mahboubeh Sadat, additional, Mündermann, Annegret, additional, Nazha, Hasan Mohammad, additional, Nemavhola, Fulufhelo, additional, Ngwangwa, Harry, additional, Norazmi, Abu′ Ubaidah Amir, additional, Noriega-Álvarez, Edel, additional, Ó Doinn, Tiarnán, additional, Ogawa, Munehiro, additional, Özacar, Mahmut, additional, Özsoy, Mehmet İskender, additional, Pena Pardo, Francisco, additional, Qin, Shuhao, additional, Rahimnejad, Maedeh, additional, Regatte, Ravinder R., additional, Rezazadeh Nochehdehi, Amirsadegh, additional, Rodríguez-Rodríguez, Rogelio, additional, Sakr, Tamer M., additional, Sha’ban, Munirah, additional, Shu, Liming, additional, Singh, Ambrish, additional, Szabolcs, Szávai, additional, Tanaka, Ryou, additional, Tanaka, Yasuhito, additional, Thomas, Sabu, additional, Türk, Serbülent, additional, Ün, M. Kerem, additional, Ur Rehman, Mohammed Riaz, additional, Vatandoust, Mohammad Hosein, additional, Wang, Dean, additional, Wang, Rui, additional, Wimmer, Markus A., additional, Wong, Arnold Yu Lok, additional, Wu, Guoqiang, additional, Wu, Wenhui, additional, Xie, Huiqi, additional, Yang, Haisheng, additional, Yoshida, Tomohiko, additional, Yu, Jie, additional, Yuh, Catherine, additional, Zahra, T., additional, and Zandieh-Doulabi, Behrouz, additional

Published
2024
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5. Gut complement induced by the microbiota combats pathogens and spares commensals

Author

Wu, Meng, Zheng, Wen, Song, Xinyang, Bao, Bin, Wang, Yuanyou, Ramanan, Deepshika, Yang, Daping, Liu, Rui, Macbeth, John C., Do, Elyza A., Andrade, Warrison A., Yang, Tiandi, Cho, Hyoung-Soo, Gazzaniga, Francesca S., Ilves, Marit, Coronado, Daniela, Thompson, Charlotte, Hang, Saiyu, Chiu, Isaac M., Moffitt, Jeffrey R., Hsiao, Ansel, Mekalanos, John J., Benoist, Christophe, and Kasper, Dennis L.

Published
2024
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7. Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma.

Author

Bao, Bin, Yu, Xiaojun, Zheng, Wujun, and Sun, Jiewei

Abstract

Background: Kinesin family member 5A (KIF5A) has been reported to be closely related to cancer progression. The aim of this study was to investigate the effect of KIF5A on lung adenocarcinoma (LUAD) and its potential molecular mechanisms. Methods: Using bioinformatics analysis methods and molecular experiments, the expression of KIF5A in LUAD was analyzed, with its expression in attached and detached tumor cells assessed. Gene set enrichment analysis (GSEA) of KIF5A was carried out. The small molecular drug with the highest affinity for KIF5A was screened out through molecular docking experiments, which was validated through cellular thermal shift assay (CETSA). Quantitative polymerase chain reaction (qPCR) was employed to measure the expression levels of anoikis‐repressing genes (BCL2, CAV1), as well as anoikis‐inducing gene (PDCD4). CCK‐8 assay was applied to examine cell viability. Cell colony formation experiments were utilized to evaluate cell proliferation ability. Results: We observed that KIF5A was highly upregulated in LUAD tissues and cells, with a higher level detected in detached LUAD cells. By resorting to bioinformatics analysis, we discovered that KIF5A was abundant in the anoikis pathway. Knocking down KIF5A reinforced anoikis in LUAD. Further screening identified Ergotamine as the small molecular drug with the highest affinity for KIF5A. The CETSA confirmed the binding relationship between the two. In addition, Ergotamine has a promoting effect on the anoikis of LUAD, while overexpression of KIF5A reversed the effects of Ergotamine on LUAD cells. Conclusion: This project uncovered that the small molecular drug Ergotamine targets and inhibits the expression of KIF5A. Downregulated KIF5A can enhance the anoikis of LUAD. Our results supported the inhibition of KIF5A as an attractive therapeutic strategy for LUAD. This finding provides a new innovative pathway for the treatment of LUAD and offers a strong theoretical basis for the development of therapeutic drugs targeting KIF5A. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Percutaneous Endoscopic Transforaminal Discectomy for the Treatment of Lumbar Disc Herniation with Different Migration Levels: A Retrospective Study

Author

Sun,Jiewei, Yu,Xiaojun, Feng,Kan, Zheng,Wujun, Lu,Yong, Bao,Bin, Sun,Jiewei, Yu,Xiaojun, Feng,Kan, Zheng,Wujun, Lu,Yong, and Bao,Bin

Abstract

Jiewei Sun, Xiaojun Yu, Kan Feng, Wujun Zheng, Yong Lu, Bin Bao Department of Cardiothoracic Surgery, Fuyang First People’s Hospital, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Xiaojun Yu, Department of Cardiothoracic Surgery, Fuyang First People’s Hospital, No. 429, Beihuan Road, Fuyang District, Hangzhou, Zhejiang Province, People’s Republic of China, Tel +8613858020606, Email yuxj1977@163.comObjective: To investigate the surgical method and efficacy of percutaneous endoscopic transforaminal discectomy (PETD) for the treatment of lumbar disc herniation (LDH) with different migration levels by introducing the strategy of foramenoplasty with the “distal nucleus pulposus as the core”.Methods: Clinical data of LDH patients who underwent single-segment PETD surgery were retrospectively analyzed. Three groups were categorized according to the degree of nucleus pulposus migration in the sagittal position: no migration group, mild migration group, and high migration group. Different sites of foramenoplasty were used for LDH with different degrees of migration. All patients were followed up for at least 12 months. The clinical and follow-up data of the three groups were compared.Results: A total of 102 patients were included, of which 46 (45.1%) were in the no migration group, 36 (35.3%) in the mild migration group, and 20 (19.6%) in the high migration group. Encouraging treatment results were obtained in all three groups.Conclusion: PETD is effective in the treatment of LDH with different degrees of migration, and the foramenoplasty concept of “distal nucleus pulposus as the core” can effectively guide the molding site of foramenoplasty and facilitate the accurate placement of the working trocar.Keywords: PETD, nuclear migration, superior articular process, foraminoplasty, 3D slicer

Published
2024

10. BACTERIAL SPHINGOLIPIDS EXACERBATE COLITIS BY INHIBITING ILC3-DERIVED IL-22 PRODUCTION

Author

Bao, Bin, primary, Wang, Youyuan, additional, Boudreau, Pavl, additional, Song, Xinyang, additional, Wu, Meng, additional, Chen, Xi, additional, Patik, Izabel, additional, Tang, Ying, additional, Ouahed, Jodie, additional, Wu, Chuan, additional, Balskus, Emily, additional, Thiagarajah, Jay, additional, Liu, Jian, additional, Wessels, Michael, additional, Lencer, Wayne, additional, Kasper, Dennis, additional, An, Dingding, additional, Horwitz, Bruce, additional, and Snapper, Scott, additional

Published
2024
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12. Magnetic Structure-Dependent Spin Texture Lattice in Hexagonal MnFeCoGe Magnets

Author

Xu, Jiawang, Xi, Lei, Xing, Shouyuan, Sheng, Junchao, Li, Shihao, Wang, Liming, Kan, Xucai, Ma, Tianping, Zang, Yipeng, Bao, Bin, Zhou, Zhonghao, Yang, Mengmeng, Gao, Yawei, Wang, Dingsong, Wang, Guyue, Zheng, Xinqi, Zhang, Jingyan, Du, Haifeng, Xu, Juping, Yin, Wen, Zhang, Ying, Zhou, Shiming, Shen, Baogen, and Wang, Shouguo

Abstract

Topological spin textures are of great significance in magnetic information storage and spintronics due to their high storage density and low drive current. In this work, the transformation of magnetic configuration from chaotic labyrinth domains to uniform stripe domains was observed in MnFe1–xCoxGe magnets. This change occurs due to the noncollinear magnetic structure switching to a uniaxial ferromagnetic structure with increasing Co content, as identified by neutron diffraction results and Lorentz transmission electron microscopy (L-TEM). Of utmost importance, a hexagonal lattice of high-density robust type-II magnetic bubble lattice was established for x= 0.8 through out-of-plane magnetic field stimulation and field-cooling. The dimensions of the type-II magnetic bubbles were found to be tuned by the sample thickness. Therefore, the stabilization of complex magnetic spin textures, associated with enhanced uniaxial ferromagnetic interaction and magnetic dipole–dipole interaction in MnFe1–xCoxGe through magnetic structure manipulation, as further confirmed by the micromagnetic simulations, will provide a convenient and efficient strategy for designing topological spin textures with potential applications in spintronic devices.

Published
2024
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