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Your search keyword '"Babusis, Darius"' showing total 4 results
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4 results on '"Babusis, Darius"'

1. The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses

Author

Martinez, David R., primary, Moreira, Fernando R., additional, Catanzaro, Nicholas J., additional, Diefenbacher, Meghan V., additional, Zweigart, Mark R., additional, Gully, Kendra L., additional, De la Cruz, Gabriela, additional, Brown, Ariane J., additional, Adams, Lily E., additional, Yount, Boyd, additional, Baric, Thomas J., additional, Mallory, Michael L., additional, Conrad, Helen, additional, May, Samantha R., additional, Dong, Stephanie, additional, Scobey, D. Trevor, additional, Nguyen, Cameron, additional, Montgomery, Stephanie A., additional, Perry, Jason K., additional, Babusis, Darius, additional, Barrett, Kimberly T., additional, Nguyen, Anh-Hoa, additional, Nguyen, Anh-Quan, additional, Kalla, Rao, additional, Bannister, Roy, additional, Feng, Joy Y., additional, Cihlar, Tomas, additional, Baric, Ralph S., additional, Mackman, Richard L., additional, Bilello, John P., additional, Schäfer, Alexandra, additional, and Sheahan, Timothy P., additional

Published
2024
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3. Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Author

Cross, Robert W., primary, Woolsey, Courtney, additional, Chu, Victor C., additional, Babusis, Darius, additional, Bannister, Roy, additional, Vermillion, Meghan S., additional, Geleziunas, Romas, additional, Barrett, Kimberly T., additional, Bunyan, Elaine, additional, Nguyen, Anh-Quan, additional, Cihlar, Tomas, additional, Porter, Danielle P., additional, Prasad, Abhishek N., additional, Deer, Daniel J., additional, Borisevich, Viktoriya, additional, Agans, Krystle N., additional, Martinez, Jasmine, additional, Harrison, Mack B., additional, Dobias, Natalie S., additional, Fenton, Karla A., additional, Bilello, John P., additional, and Geisbert, Thomas W., additional

Published
2024
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4. A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology.

Author

Lin Y, Khan M, Weynand B, Laporte M, Coenjaerts F, Babusis D, Bilello JP, Mombaerts P, Jochmans D, and Neyts J

Subjects
Animals, Mice, Humans, Virus Replication drug effects, Female, Receptor, Interferon alpha-beta genetics, Receptor, Interferon alpha-beta metabolism, Receptor, Interferon alpha-beta deficiency, Adenosine analogs & derivatives, Adenosine pharmacology, Viral Tropism, Benzamides, Phthalimides, Disease Models, Animal, Lung virology, Lung pathology, Lung drug effects, Parainfluenza Virus 3, Human drug effects, Parainfluenza Virus 3, Human physiology, Antiviral Agents pharmacology, Respirovirus Infections drug therapy, Respirovirus Infections virology, Mice, Knockout
Abstract

Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory tract infections. There are no convenient small-animal infection models. Here, we show viral replication in the upper and lower airways of AG129 mice (double IFNα/β and IFNγ receptor knockout mice) upon intranasal inoculation. By multiplex fluorescence RNAscope and immunohistochemistry followed by confocal microscopy, we demonstrate viral tropism to ciliated cells and club cells of the bronchiolar epithelium. HPIV-3 causes a marked lung pathology. No virus transmission of the virus was observed by cohousing HPIV-3-infected AG129 mice with other mice. Oral treatment with GS-441524, the parent nucleoside of remdesivir, reduced infectious virus titers in the lung, with a relatively normal histology. Intranasal treatment also affords an antiviral effect. Thus, AG129 mice serve as a robust preclinical model for developing therapeutic and prophylactic strategies against HPIV-3. We suggest further investigation of GS-441524 and its prodrug forms to treat HPIV-3 infection in humans., (© 2024. The Author(s).)

Published
2024
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