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Your search keyword '"Aurrekoetxea, Igor"' showing total 6 results
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6 results on '"Aurrekoetxea, Igor"'

1. FRI-472-YI Mitochondrial metabolism is disrupted by ciprofloxacin preventing cholangiocarcinoma cell proliferation

Author

de Gauna, Mikel Ruiz, primary, Alfaro-Jiménez, Kendall, additional, Nieva-Zuluaga, Ane, additional, Apodaka-Biguri, Maider, additional, Markaide, Enara, additional, Izquierdo-Sánchez, Laura, additional, Rae, Colin, additional, González-Romero, Francisco, additional, Gomez-Jauregui, Paul, additional, Sainz-Ramírez, Natalia, additional, Santos, Beatriz Gómez, additional, Buque, Xabier, additional, Aurrekoetxea, Igor, additional, Delgado, Igotz, additional, Fernández-Puertas, Idoia, additional, Iglesias, Ainhoa, additional, Rourke, Colm O., additional, Rodrigues, Pedro Miguel, additional, Andersen, Jesper, additional, Calvisi, Diego, additional, Morton, Jennifer, additional, Braconi, Chiara, additional, Zubiaga, Ana, additional, Banales, Jesus Maria, additional, and Aspichueta, Patricia, additional

Published
2024
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2. THU-210 Dysfunctional activation of the DNA damage response is associated with MASLD progression through an E2F2-dependent mechanism

Author

Santos, Beatriz Gómez, primary, Fernández-Puertas, Idoia, additional, Gomez-Jauregui, Paul, additional, Sainz-Ramírez, Natalia, additional, Alfaro-Jiménez, Kendall, additional, Castillero, Estibaliz, additional, Nieva-Zuluaga, Ane, additional, Apodaka-Biguri, Maider, additional, Aurrekoetxea, Igor, additional, Delgado, Igotz, additional, Lopategi, Aritz, additional, Iglesias, Ainhoa, additional, González, Lorena Mosteiro, additional, Olartekoetxea, Gaizka Errazti, additional, Gaztambide, Sonia, additional, González, Luis A. Castaño, additional, Bujanda, Luis, additional, Banales, Jesus Maria, additional, Buque, Xabier, additional, Zubiaga, Ana, additional, and Aspichueta, Patricia, additional

Published
2024
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3. FRI-343-YI APAP induced liver damage is prevented by activation of PPARgamma and PPAR-alpha

Author

Gomez-Jauregui, Paul, primary, Gonzalez-Romero, Francisco, additional, Santos, Beatriz Gómez, additional, Apodaka-Biguri, Maider, additional, Buque, Xabier, additional, Crespo, Maria, additional, Mora, Alfonso, additional, Mesquita, Mariana, additional, Aurrekoetxea, Igor, additional, Delgado, Igotz, additional, Nieva-Zuluaga, Ane, additional, de Gauna, Mikel Ruiz, additional, Fernández-Puertas, Idoia, additional, Sainz-Ramírez, Natalia, additional, Alfaro-Jiménez, Kendall, additional, Irizar, María Esther, additional, Iglesias, Ainhoa, additional, Cubero, Francisco Javier, additional, Sabio, Guadalupe, additional, Zubiaga, Ana, additional, and Aspichueta, Patricia, additional

Published
2024
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4. OS-101-YI Remodelling of hepatocyte cholesterol metabolism mediates colorectal liver metastasis

Author

Nieva-Zuluaga, Ane, primary, Arteta, Beatriz, additional, de Gauna, Mikel Ruiz, additional, Apodaka-Biguri, Maider, additional, Fernández-Puertas, Idoia, additional, González-Romero, Francisco, additional, Gomez-Jauregui, Paul, additional, Sainz-Ramírez, Natalia, additional, Alfaro-Jiménez, Kendall, additional, Santos, Beatriz Gómez, additional, Delgado, Igotz, additional, Valdivieso, Andres, additional, Bustamante, Javier, additional, Bujanda, Luis, additional, Banales, Jesus Maria, additional, Giannou, Anastasios, additional, Huber, Samuel, additional, Aurrekoetxea, Igor, additional, Buque, Xabier, additional, and Aspichueta, Patricia, additional

Published
2024
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5. TOP-229-YI The E2F2 target glycerophosphodiester phosphodiesterase domain containing 3 is involved in MASLD progression to HCC and related dyslipidemias

Author

Apodaka-Biguri, Maider, primary, Muñoz-Llanes, Nerea, additional, Gonzalez-Romero, Francisco, additional, Aurrekoetxea, Igor, additional, Santos, Beatriz Gómez, additional, Delgado, Igotz, additional, Buque, Xabier, additional, Nieva-Zuluaga, Ane, additional, de Gauna, Mikel Ruiz, additional, Fernández-Puertas, Idoia, additional, Gomez-Jauregui, Paul, additional, Sainz-Ramírez, Natalia, additional, Alfaro-Jiménez, Kendall, additional, Castillero, Estibaliz, additional, Congregado, Daniela Mestre, additional, Woodhoo, Ashwin, additional, Varela-Rey, Marta, additional, Lujambio, Amaia, additional, Zubiaga, Ana, additional, and Aspichueta, Patricia, additional

Published
2024
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6. Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway

Author

Gil-Pitarch, Clàudia, Serrano-Maciá, Marina, Simon, Jorge, Mosca, Laura, Conter, Carolina, Rejano-Gordillo, Claudia M., Zapata-Pavas, L. Estefanía, Peña-Sanfélix, Patricia, Azkargorta, Mikel, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofía, Mercado-Gómez, Maria, Delgado, Teresa C., Porcelli, Marina, Aurrekoetxea, Igor, Sutherland, James D., Barrio, Rosa, Xirodimas, Dimitris, Aspichueta, Patricia, Elortza, Felix, Martínez-Cruz, Luis Alfonso, Nogueiras, Rubén, Iruzubieta, Paula, Crespo, Javier, Masson, Steven, McCain, Misti Vanette, Reeves, Helen L., Andrade, Raul J., Lucena, M. Isabel, Mayor, Ugo, Goikoetxea-Usandizaga, Naroa, González-Recio, Irene, and Martínez-Chantar, María L.

Abstract

Drug-induced liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. Acetaminophen (APAP) overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Here, we identified that neddylation, an essential post-translational modification involved in the mitochondria function, was upregulated in liver biopsies from patients with APAP-induced liver injury (AILI) and in mice treated with an APAP overdose. MLN4924, an inhibitor of the neuronal precursor cell-expressed developmentally downregulated protein 8 (NEDD8)-activating enzyme (NAE-1), ameliorated necrosis and boosted liver regeneration in AILI. To understand how neddylation interferes in AILI, whole-body biotinylated NEDD8 (bioNEDD8) and ubiquitin (bioUB) transgenic mice were investigated under APAP overdose with and without MLN4924. The cytidine diphosphate diacylglycerol (CDP-DAG) synthase TAM41, responsible for producing cardiolipin essential for mitochondrial activity, was found modulated under AILI and restored its levels by inhibiting neddylation. Understanding this ubiquitin-like crosstalk in AILI is essential for developing promising targeted inhibitors for DILI treatment.

Published
2024
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