13 results on '"Ashby, M"'
Search Results
2. Euclid preparation XLVI. The Near-IR Background Dipole Experiment with Euclid
- Author
-
Euclid Collaboration, Kashlinsky, A., Arendt, R. G., Ashby, M. L. N., Atrio-Barandela, F., Scaramella, R., Strauss, M. A., Altieri, B., Amara, A., Andreon, S., Auricchio, N., Baldi, M., Bardelli, S., Bender, R., Bodendorf, C., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castellano, M., Cavuoti, S., Cimatti, A., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dinis, J., Dubath, F., Dupac, X., Dusini, S., Ealet, A., Farina, M., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Galeotta, S., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hook, I., Hormuth, F., Hornstrup, A., Jahnke, K., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kubik, B., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maino, D., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., McCracken, H. J., Medinaceli, E., Mei, S., Mellier, Y., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sapone, D., Sartoris, B., Schirmer, M., Schneider, P., Schrabback, T., Secroun, A., Seidel, G., Seiffert, M., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Surace, C., Tallada-Crespí, P., Taylor, A. N., Teplitz, H. I., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Zamorani, G., Zoubian, J., Zucca, E., Biviano, A., Bozzo, E., Burigana, C., Colodro-Conde, C., Di Ferdinando, D., Fabbian, G., Farinelli, R., Graciá-Carpio, J., Mainetti, G., Martinelli, M., Mauri, N., Neissner, C., Sakr, Z., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Baccigalupi, C., Ballardini, M., Blanchard, A., Borgani, S., Borlaff, A. S., Bruton, S., Cabanac, R., Cappi, A., Carvalho, C. S., Castignani, G., Castro, T., Cañas-Herrera, G., Chambers, K. C., Contarini, S., Coupon, J., De Lucia, G., Desprez, G., Di Domizio, S., Dole, H., Díaz-Sánchez, A., Vigo, J. A. Escartin, Ferrero, I., Finelli, F., Gabarra, L., García-Bellido, J., Gautard, V., Gaztanaga, E., George, K., Giacomini, F., Gozaliasl, G., Gregorio, A., Hall, A., Hildebrandt, H., Kajava, J. J. E., Kansal, V., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Magliocchetti, M., Mannucci, F., Maoli, R., Martins, C. J. A. P., Matthew, S., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Nadathur, S., Walton, Nicholas A., Patrizii, L., Popa, V., Potter, D., Pöntinen, M., Rocci, P. -F., Sahlén, M., Schneider, A., Sefusatti, E., Sereno, M., Steinwagner, J., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valiviita, J., Vergani, D., Verza, G., and Hasinger, G.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology - Abstract
Verifying the fully kinematic nature of the cosmic microwave background (CMB) dipole is of fundamental importance in cosmology. In the standard cosmological model with the Friedman-Lemaitre-Robertson-Walker (FLRW) metric from the inflationary expansion the CMB dipole should be entirely kinematic. Any non-kinematic CMB dipole component would thus reflect the preinflationary structure of spacetime probing the extent of the FLRW applicability. Cosmic backgrounds from galaxies after the matter-radiation decoupling, should have kinematic dipole component identical in velocity with the CMB kinematic dipole. Comparing the two can lead to isolating the CMB non-kinematic dipole. It was recently proposed that such measurement can be done using the near-IR cosmic infrared background (CIB) measured with the currently operating Euclid telescope, and later with Roman. The proposed method reconstructs the resolved CIB, the Integrated Galaxy Light (IGL), from Euclid's Wide Survey and probes its dipole, with a kinematic component amplified over that of the CMB by the Compton-Getting effect. The amplification coupled with the extensive galaxy samples forming the IGL would determine the CIB dipole with an overwhelming signal/noise, isolating its direction to sub-degree accuracy. We develop details of the method for Euclid's Wide Survey in 4 bands spanning 0.6 to 2 mic. We isolate the systematic and other uncertainties and present methodologies to minimize them, after confining the sample to the magnitude range with negligible IGL/CIB dipole from galaxy clustering. These include the required star-galaxy separation, accounting for the extinction correction dipole using the method newly developed here achieving total separation, accounting for the Earth's orbital motion and other systematic effects. (Abridged), Comment: Euclid Key Project paper, A&A, in press
- Published
- 2024
3. TREASUREHUNT: Transients and Variability Discovered with HST in the JWST North Ecliptic Pole Time Domain Field
- Author
-
O'Brien, Rosalia, Jansen, Rolf A., Grogin, Norman A., Cohen, Seth H., Smith, Brent M., Silver, Ross M., Maksym III, W. P., Windhorst, Rogier A., Carleton, Timothy, Koekemoer, Anton M., Hathi, Nimish P., Willmer, Christopher N. A., Frye, Brenda L., Alpaslan, M., Ashby, M. L. N., Ashcraft, T. A., Bonoli, S., Brisken, W., Cappelluti, N., Civano, F., Conselice, C. J., Dhillon, V. S., Driver, S. P., Duncan, K. J., Dupke, R., Elvis, M., Fazio, G. G., Finkelstein, S. L., Gim, H. B., Griffiths, A., Hammel, H. B., Hyun, M., Im, M., Jones, V. R., Kim, D., Ladjelate, B., Larson, R. L., Malhotra, S., Marshall, M. A., Milam, S. N., Pierel, J. D. R., Rhoads, J. E., Rodney, S. A., Röttgering, H. J. A., Rutkowski, M. J., Ryan, Jr., R. E., Ward, M. J., White, C. W., van Weeren, R. J., Zhao, X., Summers, J., D'Silva, J. C. J., Ortiz III, R., Robotham, A. S. G., Coe, D., Nonino, M., Pirzkal, N., Yan, H., and Acharya, T.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
The JWST North Ecliptic Pole (NEP) Time Domain Field (TDF) is a $>$14 arcmin diameter field optimized for multi-wavelength time-domain science with JWST. It has been observed across the electromagnetic spectrum both from the ground and from space, including with the Hubble Space Telescope (HST). As part of HST observations over 3 cycles (the "TREASUREHUNT" program), deep images were obtained with ACS/WFC in F435W and F606W that cover almost the entire JWST NEP TDF. Many of the individual pointings of these programs partially overlap, allowing an initial assessment of the potential of this field for time-domain science with HST and JWST. The cumulative area of overlapping pointings is ~88 arcmin$^2$, with time intervals between individual epochs that range between 1 day and 4$+$ years. To a depth of $m_{AB}$ $\simeq$ 29.5 mag (F606W), we present the discovery of 12 transients and 190 variable candidates. For the variable candidates, we demonstrate that Gaussian statistics are applicable, and estimate that ~80 are false positives. The majority of the transients will be supernovae, although at least two are likely quasars. Most variable candidates are AGN, where we find 0.42% of the general $z$ $<$ 6 field galaxy population to vary at the $~3\sigma$ level. Based on a 5-year timeframe, this translates into a random supernova areal density of up to ~0.07 transients per arcmin$^2$ (~245 deg$^{-2}$) per epoch, and a variable AGN areal density of ~1.25 variables per arcmin$^2$ (~4500 deg$^{-2}$) to these depths., Comment: 32 pages, 11 figures, 5 tables, 1 Appendix
- Published
- 2024
4. TREASUREHUNT: Transients and Variability Discovered with HST in the JWST North Ecliptic Pole Time-domain Field
- Author
-
O’Brien, Rosalia, primary, Jansen, Rolf A., additional, Grogin, Norman A., additional, Cohen, Seth H., additional, Smith, Brent M., additional, Silver, Ross M., additional, Maksym, W. P., additional, Windhorst, Rogier A., additional, Carleton, Timothy, additional, Koekemoer, Anton M., additional, Hathi, Nimish P., additional, Willmer, Christopher N. A., additional, Frye, Brenda L., additional, Alpaslan, M., additional, Ashby, M. L. N., additional, Ashcraft, T. A., additional, Bonoli, S., additional, Brisken, W., additional, Cappelluti, N., additional, Civano, F., additional, Conselice, C. J., additional, Dhillon, V. S., additional, Driver, S. P., additional, Duncan, K. J., additional, Dupke, R., additional, Elvis, M., additional, Fazio, G. G., additional, Finkelstein, S. L., additional, Gim, H. B., additional, Griffiths, A., additional, Hammel, H. B., additional, Hyun, M., additional, Im, M., additional, Jones, V. R., additional, Kim, D., additional, Ladjelate, B., additional, Larson, R. L., additional, Malhotra, S., additional, Marshall, M. A., additional, Milam, S. N., additional, Pierel, J. D. R., additional, Rhoads, J. E., additional, Rodney, S. A., additional, Röttgering, H. J. A., additional, Rutkowski, M. J., additional, Ryan, R. E., additional, Ward, M. J., additional, White, C. W., additional, van Weeren, R. J., additional, Zhao, X., additional, Summers, J., additional, D’Silva, J. C. J., additional, Ortiz, R., additional, Robotham, A. S. G., additional, Coe, D., additional, Nonino, M., additional, Pirzkal, N., additional, Yan, H., additional, and Acharya, T., additional
- Published
- 2024
- Full Text
- View/download PDF
5. Euclid preparation. The Near-IR Background Dipole Experiment with Euclid
- Author
-
Euclid Collaboration, Kashlinsky, A., Arendt, R. G., Ashby, M. L. N., Atrio-Barandela, F., Scaramella, R., Strauss, M. A., Altieri, B., Amara, A., Andreon, S., Auricchio, N., Baldi, M., Bardelli, S., Bender, R., Bodendorf, C., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castellano, M., Cavuoti, S., Cimatti, A., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dinis, J., Dubath, F., Dupac, X., Dusini, S., Ealet, A., Farina, M., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Galeotta, S., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hook, I., Hormuth, F., Hornstrup, A., Jahnke, K., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kubik, B., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maino, D., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., McCracken, H. J., Medinaceli, E., Mei, S., Mellier, Y., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sapone, D., Sartoris, B., Schirmer, M., Schneider, P., Schrabback, T., Secroun, A., Seidel, G., Seiffert, M., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Surace, C., Tallada-Crespí, P., Taylor, A. N., Teplitz, H. I., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Zamorani, G., Zoubian, J., Zucca, E., Biviano, A., Bozzo, E., Burigana, C., Colodro-Conde, C., Di Ferdinando, D., Fabbian, G., Farinelli, R., Graciá-Carpio, J., Mainetti, G., Martinelli, M., Mauri, N., Neissner, C., Sakr, Z., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Baccigalupi, C., Ballardini, M., Blanchard, A., Borgani, S., Borlaff, A. S., Bruton, S., Cabanac, R., Cappi, A., Carvalho, C. S., Castignani, G., Castro, T., {n}as-Herrera, G. Ca\, Chambers, K. C., Contarini, S., Coupon, J., De Lucia, G., Desprez, G., Di Domizio, S., Dole, H., Díaz-Sánchez, A., Vigo, J. A. Escartin, Ferrero, I., Finelli, F., Gabarra, L., García-Bellido, J., Gautard, V., Gaztanaga, E., George, K., Giacomini, F., Gozaliasl, G., Gregorio, A., Hall, A., Hildebrandt, H., Kajava, J. J. E., Kansal, V., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Magliocchetti, M., Mannucci, F., Maoli, R., Martins, C. J. A. P., Matthew, S., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Nadathur, S., Walton, Nicholas A., Patrizii, L., Popa, V., Potter, D., Pöntinen, M., Rocci, P. -F., Sahlén, M., Schneider, A., Sefusatti, E., Sereno, M., Steinwagner, J., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valiviita, J., Vergani, D., Verza, G., Hasinger, G., Euclid Collaboration, Kashlinsky, A., Arendt, R. G., Ashby, M. L. N., Atrio-Barandela, F., Scaramella, R., Strauss, M. A., Altieri, B., Amara, A., Andreon, S., Auricchio, N., Baldi, M., Bardelli, S., Bender, R., Bodendorf, C., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Casas, S., Castellano, M., Cavuoti, S., Cimatti, A., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dinis, J., Dubath, F., Dupac, X., Dusini, S., Ealet, A., Farina, M., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Galeotta, S., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hook, I., Hormuth, F., Hornstrup, A., Jahnke, K., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kubik, B., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maino, D., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Maurogordato, S., McCracken, H. J., Medinaceli, E., Mei, S., Mellier, Y., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Rossetti, E., Saglia, R., Sapone, D., Sartoris, B., Schirmer, M., Schneider, P., Schrabback, T., Secroun, A., Seidel, G., Seiffert, M., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Surace, C., Tallada-Crespí, P., Taylor, A. N., Teplitz, H. I., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Zamorani, G., Zoubian, J., Zucca, E., Biviano, A., Bozzo, E., Burigana, C., Colodro-Conde, C., Di Ferdinando, D., Fabbian, G., Farinelli, R., Graciá-Carpio, J., Mainetti, G., Martinelli, M., Mauri, N., Neissner, C., Sakr, Z., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Baccigalupi, C., Ballardini, M., Blanchard, A., Borgani, S., Borlaff, A. S., Bruton, S., Cabanac, R., Cappi, A., Carvalho, C. S., Castignani, G., Castro, T., {n}as-Herrera, G. Ca\, Chambers, K. C., Contarini, S., Coupon, J., De Lucia, G., Desprez, G., Di Domizio, S., Dole, H., Díaz-Sánchez, A., Vigo, J. A. Escartin, Ferrero, I., Finelli, F., Gabarra, L., García-Bellido, J., Gautard, V., Gaztanaga, E., George, K., Giacomini, F., Gozaliasl, G., Gregorio, A., Hall, A., Hildebrandt, H., Kajava, J. J. E., Kansal, V., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Magliocchetti, M., Mannucci, F., Maoli, R., Martins, C. J. A. P., Matthew, S., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Nadathur, S., Walton, Nicholas A., Patrizii, L., Popa, V., Potter, D., Pöntinen, M., Rocci, P. -F., Sahlén, M., Schneider, A., Sefusatti, E., Sereno, M., Steinwagner, J., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valiviita, J., Vergani, D., Verza, G., and Hasinger, G.
- Abstract
Verifying the fully kinematic nature of the cosmic microwave background (CMB) dipole is of fundamental importance in cosmology. In the standard cosmological model with the Friedman-Lemaitre-Robertson-Walker (FLRW) metric from the inflationary expansion the CMB dipole should be entirely kinematic. Any non-kinematic CMB dipole component would thus reflect the preinflationary structure of spacetime probing the extent of the FLRW applicability. Cosmic backgrounds from galaxies after the matter-radiation decoupling, should have kinematic dipole component identical in velocity with the CMB kinematic dipole. Comparing the two can lead to isolating the CMB non-kinematic dipole. It was recently proposed that such measurement can be done using the near-IR cosmic infrared background (CIB) measured with the currently operating Euclid telescope, and later with Roman. The proposed method reconstructs the resolved CIB, the Integrated Galaxy Light (IGL), from Euclid's Wide Survey and probes its dipole, with a kinematic component amplified over that of the CMB by the Compton-Getting effect. The amplification coupled with the extensive galaxy samples forming the IGL would determine the CIB dipole with an overwhelming signal/noise, isolating its direction to sub-degree accuracy. We develop details of the method for Euclid's Wide Survey in 4 bands spanning 0.6 to 2 mic. We isolate the systematic and other uncertainties and present methodologies to minimize them, after confining the sample to the magnitude range with negligible IGL/CIB dipole from galaxy clustering. These include the required star-galaxy separation, accounting for the extinction correction dipole using the method newly developed here achieving total separation, accounting for the Earth's orbital motion and other systematic effects. (Abridged), Comment: Euclid Key Project paper, A&A submitted
- Published
- 2024
6. SPT-SZ MCMF: an extension of the SPT-SZ catalogue over the DES region.
- Author
-
Klein, M, Mohr, J J, Bocquet, S, Aguena, M, Allen, S W, Alves, O, Ansarinejad, B, Ashby, M L N, Bacon, D, Bayliss, M, Benson, B A, Bleem, L E, Brodwin, M, Brooks, D, Bulbul, E, Burke, D L, Canning, R E A, Carlstrom, J E, Rosell, A Carnero, and Carretero, J
- Subjects
SUNYAEV-Zel'dovich effect ,MATCHED filters ,CATALOGS ,RANDOM noise theory ,GALAXY clusters ,DARK energy ,REDSHIFT - Abstract
We present an extension to a Sunyaev–Zel'dovich Effect (SZE) selected cluster catalogue based on observations from the South Pole Telescope (SPT); this catalogue extends to lower signal to noise than the previous SPT–SZ catalogue and therefore includes lower mass clusters. Optically derived redshifts, centres, richnesses, and morphological parameters together with catalogue contamination and completeness statistics are extracted using the multicomponent matched filter (MCMF) algorithm applied to the S/N > 4 SPT–SZ candidate list and the Dark Energy Survey (DES) photometric galaxy catalogue. The main catalogue contains 811 sources above S/N = 4, has 91 per cent purity, and is 95 per cent complete with respect to the original SZE selection. It contains in total 50 per cent more clusters and twice as many clusters above z = 0.8 in comparison to the original SPT-SZ sample. The MCMF algorithm allows us to define subsamples of the desired purity with traceable impact on catalogue completeness. As an example, we provide two subsamples with S/N > 4.25 and S/N > 4.5 for which the sample contamination and cleaning-induced incompleteness are both as low as the expected Poisson noise for samples of their size. The subsample with S/N > 4.5 has 98 per cent purity and 96 per cent completeness and is part of our new combined SPT cluster and DES weak-lensing cosmological analysis. We measure the number of false detections in the SPT-SZ candidate list as function of S/N, finding that it follows that expected from assuming Gaussian noise, but with a lower amplitude compared to previous estimates from simulations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Targeting Molecular Measurable Residual Disease and Low-Blast Relapse in AML With Venetoclax and Low-Dose Cytarabine: A Prospective Phase II Study (VALDAC).
- Author
-
Tiong IS, Hiwase DK, Abro E, Bajel A, Palfreyman E, Beligaswatte A, Reynolds J, Anstee N, Nguyen T, Loo S, Chua CC, Ashby M, Wiltshire KM, Fleming S, Fong CY, Teh TC, Blombery P, Dillon R, Ivey A, and Wei AH
- Subjects
- Humans, Aged, Middle Aged, Adult, Female, Male, Aged, 80 and over, Prospective Studies, Young Adult, Adolescent, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute mortality, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute pathology, Neoplasm, Residual, Cytarabine administration & dosage, Sulfonamides administration & dosage, Sulfonamides adverse effects, Bridged Bicyclo Compounds, Heterocyclic administration & dosage, Bridged Bicyclo Compounds, Heterocyclic adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Nucleophosmin
- Abstract
Purpose: A prospective phase II study examined the safety and efficacy of venetoclax combined with low-dose cytarabine (LDAC) in AML at first measurable residual disease (MRD) or oligoblastic relapse., Methods: Patients with either MRD (≥1 log
10 rise) or oligoblastic relapse (blasts 5%-15%) received venetoclax 600 mg once daily D1-28 plus LDAC once daily D1-10 in 28-day cycles. The primary objective was MRD response in the MRD relapse cohort or complete remission (CR/CRh/CRi) in the oligoblastic relapse cohort., Results: Forty-eight adults with either MRD (n = 26) or oligoblastic (n = 22) relapse were enrolled. Median age was 67 years (range, 18-80) and 94% had received previous intensive chemotherapy. Patients received a median of four cycles of therapy; 17% completed ≥12 cycles. Patients with oligoblastic relapse had more grade ≥3 anemia (32% v 4%; P = .02) and infections (36% v 8%; P = .03), whereas grade 4 neutropenia (32 v 23%) or thrombocytopenia (27 v 15%) were comparable with the MRD relapse cohort. Markers of molecular MRD relapse included mutant NPM1 (77%), CBFB::MYH11 (4%), RUNX1::RUNX1T1 (4%), or KMT2A::MLLT3 (4%). Three patients with a log10 rise in IDH1 / 2 (12%) were included. By cycle 2 in the MRD relapse cohort, a log10 reduction in MRD was observed in 69%; 46% achieved MRD negative remission. In the oligoblastic relapse cohort, 73% achieved CR/CRh/CRi. Overall, 21 (44%) underwent hematopoietic cell transplantation. Median overall survival (OS) was not reached in either cohort. Estimated 2-year OS rate was 67% (95% CI, 50 to 89) in the MRD and 53% (95% CI, 34 to 84) in the oligoblastic relapse cohorts., Conclusion: For AML in first remission and either MRD or oligoblastic relapse, venetoclax plus LDAC is well tolerated and highly effective.- Published
- 2024
- Full Text
- View/download PDF
8. Feasibility of Endovascular Deep Brain Stimulation of Anterior Nucleus of the Thalamus for Refractory Epilepsy.
- Author
-
Kashyap V, Ashby M, Stanslaski S, Nguyen K, Hageman K, Chang YC, and Khalessi AA
- Abstract
Background and Objectives: Deep brain stimulation (DBS) has developed into an effective therapy for several disease states including treatment-resistant Parkinson disease and medically intractable essential tremor, as well as segmental, generalized and cervical dystonia, and obsessive-compulsive disorder (OCD). Dystonia and OCD are approved with Humanitarian Device Exemption. In addition, DBS is also approved for the treatment of epilepsy in the anterior nucleus of the thalamus. Although overall considered an effective treatment for Parkinson disease and epilepsy, a number of specific factors determine the treatment success for DBS including careful patient selection, effective postoperative programming of DBS devices and accurate electrode placement. Furthermore, invasiveness of the procedure is a rate limiter for patient adoption. It is desired to explore a less invasive way to deliver DBS therapy., Methods: Here, we report for the first time the direct comparison of endovascular and parenchymal DBS in a triplicate ovine model using the anterior nucleus of the thalamus as the parenchymal target for refractory epilepsy., Results: Triplicate ovine studies show comparable sensing resolution and stimulation performance of endovascular DBS with parenchymal DBS., Conclusion: The results from this feasibility study opens up a new frontier for minimally invasive DBS therapy., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc on behalf of Congress of Neurological Surgeons.)
- Published
- 2024
- Full Text
- View/download PDF
9. Designing a Multiplex PCR-xMAP Assay for the Detection and Differentiation of African Horse Sickness Virus, Serotypes 1-9.
- Author
-
Ashby M, Moore R, King S, Newbrook K, Flannery J, and Batten C
- Abstract
African horse sickness is a severe and often fatal disease affecting all species of equids. The aetiological agent, African horse sickness virus (AHSV), can be differentiated into nine serotypes. The identification of AHSV serotypes is vital for disease management, as this can influence vaccine selection and help trace disease incursion routes. In this study, we report the development and optimisation of a novel, molecular-based assay that utilises multiplex PCR and microsphere-based technology to expedite detection and differentiation of multiple AHSV serotypes in one assay. We demonstrated the ability of this assay to identify all nine AHSV serotypes, with detection limits ranging from 1 to 277 genome copies/µL depending on the AHSV serotype. An evaluation of diagnostic sensitivity and specificity revealed a sensitivity of 88% and specificity of 100%. This method can serotype up to 42 samples per run and can be completed in approximately 4-6 h. It provides a powerful tool to enhance the rapidity and efficiency of AHSV serotype detection, thereby facilitating the generation of epidemiological data that can help understand and control the incidence of AHSV worldwide.
- Published
- 2024
- Full Text
- View/download PDF
10. Arsenic-induced neurotoxicity in patients with acute promyelocytic leukaemia.
- Author
-
Loh Z, Ashby M, Van Veldhuizen E, Li W, Chee A, Aung W, Lavrukhina Y, Mason G, Pelly T, Nedumannil R, Kosciejew S, Mokoonlall M, Lim J, Calov G, Butler L, Hillebrand P, Beekman A, Rathnasekara GK, Raj S, Zhang C, Yao Y, Iland H, and Grigg A
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Retrospective Studies, Aged, Obesity complications, Australia epidemiology, Arsenic adverse effects, Arsenic toxicity, Young Adult, Adolescent, Aged, 80 and over, Leukemia, Promyelocytic, Acute drug therapy, Arsenic Trioxide adverse effects, Arsenic Trioxide administration & dosage, Arsenic Trioxide therapeutic use, Neurotoxicity Syndromes etiology, Neurotoxicity Syndromes epidemiology
- Abstract
Arsenic trioxide is an essential component of therapy for acute promyelocytic leukaemia (APL) and is currently dosed on actual body weight with no upper limit. Arsenic-induced neurotoxicity is a well-recognised complication; however, there is uncertainty about its relationship to arsenic dose and obesity. We conducted a large multicentre retrospective study of 487 patients with APL treated with arsenic-based therapy across 23 sites in Australia from 2008 to 2023. The primary outcome was incidence of neurotoxicity, and secondary outcomes included relationship of neurotoxicity to obesity and cumulative arsenic dose. Any-grade neurotoxicity occurred in 113 (23%) patients, predominantly peripheral neuropathy (91%). Most events were grade 1-2 severity (85%), with grade 3 events in 12% and grade 4-5 in 3%. The incidence of neurotoxicity increased with BMI (non-obese: 16%, obesity class I: 25%, obesity class II-III: 41%; p < 0.001). On univariable analysis, obesity class I (OR 1.81, p = 0.036), obesity class II-III (OR 3.93, p < 0.001), weight >100 kg (OR 2.72, p < 0.001), daily arsenic trioxide dose >15 mg (OR 5.05, p < 0.001) and cumulative induction dose >500 mg (OR 3.95, p < 0.001) were all significantly associated with neurotoxicity. Obesity class II-III and induction dose >500 mg remained significant on multivariable analysis. Our study highlights the strong association between BMI, arsenic trioxide dose and neurotoxicity. Pre-emptive dose reductions should be considered for obese patients receiving high doses of arsenic., (© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
11. Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus.
- Author
-
Newbrook K, Khan N, Fisher A, Chong K, Gubbins S, Davies WC, Sanders C, Busquets MG, Cooke L, Corla A, Ashby M, Flannery J, Batten C, Stokes JE, Sanz-Bernardo B, Carpenter S, Moffat K, and Darpel KE
- Subjects
- Sheep, Animals, Livestock, Viremia, CD8-Positive T-Lymphocytes, Ruminants, T-Lymphocyte Subsets, Arboviruses, Bluetongue virus, Bluetongue prevention & control, Ceratopogonidae physiology
- Abstract
Introduction: Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by immunosuppression and substantial lymphopenia at peak viraemia in the host., Methods: In this study, the role of cell-mediated immunity and specific T-cell subsets in BTV pathogenesis, clinical outcome, viral dynamics, immune protection, and onwards transmission to a susceptible Culicoides vector is defined in unprecedented detail for the first time, using an in vivo arboviral infection model system that closely mirrors natural infection and transmission of BTV. Individual circulating CD4
+ , CD8+ , or WC1+ γδ T-cell subsets in sheep were depleted through the administration of specific monoclonal antibodies., Results: The absence of cytotoxic CD8+ T cells was consistently associated with less severe clinical signs of BT, whilst the absence of CD4+ and WC1+ γδ T cells both resulted in an increased clinical severity. The absence of CD4+ T cells also impaired both a timely protective neutralising antibody response and the production of IgG antibodies targeting BTV non-structural protein, NS2, highlighting that the CD4+ T-cell subset is important for a timely protective immune response. T cells did not influence viral replication characteristics, including onset/dynamics of viraemia, shedding, or onwards transmission of BTV to Culicoides . We also highlight differences in T-cell dependency for the generation of immunoglobulin subclasses targeting BTV NS2 and the structural protein, VP7., Discussion: This study identifies a diverse repertoire of T-cell functions during BTV infection in sheep, particularly in inducing specific anti-viral immune responses and disease manifestation, and will support more effective vaccination strategies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Newbrook, Khan, Fisher, Chong, Gubbins, Davies, Sanders, Busquets, Cooke, Corla, Ashby, Flannery, Batten, Stokes, Sanz-Bernardo, Carpenter, Moffat and Darpel.)- Published
- 2024
- Full Text
- View/download PDF
12. Real-Time RT-PCR for the Diagnosis of Epizootic Hemorrhagic Disease Virus.
- Author
-
Ashby M
- Subjects
- Animals, RNA, Viral genetics, Hemorrhagic Disease Virus, Epizootic genetics, Hemorrhagic Disease Virus, Epizootic isolation & purification, Real-Time Polymerase Chain Reaction methods, Reoviridae Infections diagnosis, Reoviridae Infections veterinary, Reoviridae Infections virology, Reverse Transcriptase Polymerase Chain Reaction methods
- Abstract
Real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) has become an essential tool in rapid and reliable detection of animal diseases such as epizootic hemorrhagic disease (EHD). Here we provide a protocol for the detection of epizootic hemorrhagic disease virus (EHDV) genetic material in blood and tissue samples, using a real-time RT-PCR that targets a conserved region in segment 9 of the EHDV genome. This protocol can be used to detect up to approximately 90 samples in a single run and can be completed in less than 4 h., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
13. Low-intensity venetoclax-based salvage as a bridge to allogeneic stem cell transplant in patients with acute myeloid leukemia failing conventional intensive chemotherapy.
- Author
-
Ashby M, Fleming S, Teh TC, Tiong IS, Inam S, Curtis DJ, Patil S, Vassili C, and Chua CC
- Subjects
- Humans, Bridged Bicyclo Compounds, Heterocyclic therapeutic use, Stem Cell Transplantation, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Leukemia, Myeloid, Acute drug therapy, Hematopoietic Stem Cell Transplantation, Sulfonamides
- Abstract
Competing Interests: Declaration of Competing Interest We declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.