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Abstract This article addresses the distance protection challenges associated with the series‐compensated transmission lines and the impact of fault resistance by employing a machine‐learning model. In the proposed model, stacked layers of bidirectional long short‐term memory (Bi‐LSTM) cells are fed by voltage and current signals to distinguish between different fault scenarios. This method takes advantage of only local bus measurements to prevent information leakage in communication channels. Moreover, to make the proposed method harmonics‐robust and improve the correlation interpretation between the features for the Bi‐LSTM model, the 3‐phase raw measurement signals are passed through a discrete Fourier transform (DFT) which extracts their fundamental frequency component magnitudes and angles. Then, an extensive amount of fault scenarios including different compensation levels, fault resistances, and fault locations in normal and power‐swing operational conditions are simulated to train the model. Finally, to validate the performance of the proposed protection method in the series‐compensated transmission lines, distinctive studies are also carried out based on electromagnetic transient simulations. The obtained results confirm the remarkable performance of the proposed method in discriminating fault types, faulty phases, internal or external faults, and normal or power‐swing conditions of the power system.

Abstract The current study aims to introduce a new polymeric composite consisting of epoxy resin as the matrix and gadolinium oxide (Gd2O3) as the neutron adsorption ingredient. The shielding performance of the composite was assessed by neutron attenuation experiments with an Am-Be source and polyethylene moderator. The results of these experiments showed an appreciable agreement with the Monte Carlo simulations. Other characteristics of the composite, including mechanical strength, thermal stability, microtexture, and its chemical compositions, were examined using standard tensile test, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, static light scattering analyses, and Fourier-transform infrared spectroscopy (FTIR). The results indicated that the new composites offer appreciable neutron absorption properties so that samples with 0.5%, 2%, 5%, and 10% Gd2O3 content could reduce the neutron beam intensity by 54%, 63%, 66%, and 70% at a thickness of 4 cm.

Shaped charge liner (SCL) has been extensively applied in oil recovery and defense industries. Achieving superior penetration capability through optimizing SCL structures presents a substantial challenge due to intricate rate-dependent processes involving detonation-driven liner collapse, high-speed jet stretching, and penetration. This study introduces an innovative optimization strategy for SCL structures that employs jet penetration efficiency as the primary objective function. The strategy combines experimentally validated finite element method with machine learning (FEM-ML). We propose a novel jet penetration efficiency index derived from enhanced cutoff velocity and shape characteristics of the jet via machine learning. This index effectively evaluates the jet penetration performance. Furthermore, a multi-model fusion based on a machine learning optimization method, called XGBOOST-MFO, is put forward to optimize SCL structure over a large input space. The strategy's feasibility is demonstrated through the optimization of copper SCL implemented via the FEM-ML strategy. Finally, this strategy is extended to optimize the structure of the recently emerging CrMnFeCoNi high-entropy alloy conical liners and hemispherical copper liners. Therefore, the strategy can provide helpful guidance for the engineering design of SCL.

Introduction: Fibrolamellar carcinoma (FLC) displays upregulation of several oncogenes, including HER2, and multiple immune-suppressive mechanisms. We investigated the efficacy and safety of the pan-HER tyrosine kinase inhibitor neratinib as monotherapy (SUMMIT phase 2 basket study) or with immune checkpoint and/or mammalian target of rapamycin (mTOR) inhibitors (compassionate-use program) in patients with FLC. Methods: Patients received neratinib 240 mg/day orally in SUMMIT, or as doublet or triplet combinations with pembrolizumab 2 mg/kg intravenously every 3 weeks, nivolumab 240 mg intravenously every 2 weeks, everolimus 7.5 mg/day orally, or sunitinib 37.5 mg/day orally under compassionate use. The primary endpoint in SUMMIT was objective response rate; safety was a secondary endpoint. Results: Fifteen patients with FLC received neratinib monotherapy in SUMMIT. The objective response rate was 5% (95% confidence interval [CI]: 0–21.8) and the disease control rate was 13.3% (95% CI: 1.7–40.5). Upon progression, five had added immune checkpoint inhibitors with or without everolimus or sunitinib. Two additional patients received neratinib-based combinations outside of SUMMIT, for a total of 17 neratinib-treated patients. One patient who received neratinib plus pembrolizumab had a confirmed partial response, one treated with neratinib plus everolimus had stable disease lasting 6 months, and one who received neratinib plus pembrolizumab plus sunitinib had stable disease lasting 16 months. Grade 3/4 adverse events with neratinib monotherapy occurred in 10 (66.7%)/2 (13.3%) patients, respectively. Grade 3 adverse events with neratinib-based combinations were hyperglycemia (n = 1; neratinib plus pembrolizumab), hepatic failure, and anaphylaxis (n = 1 each, neratinib plus pembrolizumab plus everolimus). There were no grade 4 adverse events with combination therapy. Conclusion: In patients with FLC, single-agent neratinib had limited efficacy, but clinical benefit was observed with neratinib in combination with immunotherapy and/or mTOR-targeted agents.

PURPOSEGallbladder cancer (GBC) is a biliary tract malignancy characterized by its high lethality. Although the incidence of GBC is low in most countries, specific areas such as Chile display a high incidence. Our collaborative study sought to compare clinical and molecular features of GBC cohorts from Chile and the United States with a focus on ERBB2 alterations.METHODSPatients were accrued at Memorial Sloan Kettering Cancer Center (MSK) or the Pontificia Universidad Católica de Chile (PUC). Clinical information was retrieved from medical records. Genomic analysis was performed by the next-generation sequencing platform MSK-Integrated Mutation Profiling of Actionable Cancer Targets.RESULTSA total of 260 patients with GBC were included, 237 from MSK and 23 from PUC. There were no significant differences in the clinical characteristics between the patients identified at MSK and at PUC except in terms of lithiasis prevalence which was significantly higher in the PUC cohort (85% v 44%; P = .0003). The prevalence of ERBB2 alterations was comparable between the two cohorts (15% v 9%; P = .42). Overall, ERBB2 alterations were present in 14% of patients (8% with ERBB2 amplification, 4% ERBB2 mutation, 1.5% concurrent amplification and mutation, and 0.4% ERBB2 fusion). Notably, patients with GBC that harbored ERBB2 alterations had better overall survival (OS) versus their ERBB2-wild type counterparts (22.3 months v 11.8 months; P = .024).CONCLUSIONThe prevalence of lithiasis seems to be higher in Chilean versus US patients with GBC. A similar prevalence of ERBB2 alterations of overall 14% and better OS suggests that a proportion of them could benefit from human epidermal growth factor receptor type 2–targeted therapies. The smaller cohort of Chile, where the disease prevalence is higher, is a reminder and invitation for the need of more robust next-generation sequencing analyses globally.

Purpose: Racial and ethnic minorities remain underrepresented in clinical trials . Underrepresentation of racial groups leads to the selection of therapeutic interventions that may not be representative of the population expected to use the medicine. This study evaluates the effectiveness of a set of implementation strategies to increase underrepresented patients in gynecologic cancer clinical trials. Methods: An interrupted time series analysis evaluating implementation strategies (pre-screening and fast-track referral) was conducted from January 2021 to May 2022. Descriptive analysis of gynecologic oncology patient screening and accrual was compared before and after intervention implementation. Results: During the study period (pre- and post-intervention), 26 patients were screened, and 9 patients enrolled in therapeutic gynecologic cancer clinical trials. Prior to the intervention, 7 patients were screened and 2 patients enrolled onto a clinical trial. Following the intervention, 19 patients were screened and 7 patients enrolled in a cancer clinical trial. Black patients comprised 13 of 19 (68.4%) of patients post-intervention compared to 1 of 7 (14.3 %) of patients screened pre-intervention (p

Gender-based violence (GBV) poses a significant concern in the construction and natural resources industries, where women, due to lower social status and integration, are at heightened risk. This systematic review aimed to identify the prevalence and experience of GBV in the construction and natural resources industries. A systematic search across databases including PubMed, OVID, Scopus, Web of Science, and CINAHL was conducted. The Risk of Bias Instrument for Cross-sectional Surveys of Attitudes and Practices by McMaster University and the Critical Appraisal of Qualitative Studies by the Center for Evidence Based Medicine at the University of Oxford were used to assess the studies included in the review. Six articles were included after full-text analysis. GBV was reported in the construction, mining, urban forestry, and arboriculture sectors. Workplace GBV was measured differently across the studies, and all studies examined more than one form of GBV. The main forms of GBV discussed in these studies were discrimination, sexual harassment, and sexism. The studies provided some insight for demographic factors that may or may not be associated with GBV, such as age, region of work, and number of years working in the industry. The review also suggests that workplace GBV has a negative impact on mental health and well-being outcomes, such as higher levels of stress and lower job satisfaction. The current research has not established the effectiveness of interventions, tools, or policies in these workplaces. Thus, additional research should include intervention studies that aim to minimize or prevent GBV in male-dominated workplaces. The current study can bring awareness and acknowledgement towards GBV in the workplace and highlight the importance of addressing it as this review outlines the negative consequences of GBV on mental health and well-being in these male-dominated industries.

Introduction and purposeUse of radiological equipment in dentistry is vital for the diagnosis and treatment of oral and dental diseases. However, concerns about the leakage of radiation from these devices and its impact on public health are inevitable. The present study aimed to investigate the extent of radiation leakage in dental clinics in the city of Kashan, Iran, and its results can significantly contribute to the improvement of the safety of these environments. Methods: This cross-sectional descriptive study was conducted in 30 randomly selected dental clinics. Data collection was performed using the Smart Ion Mini_Instruments Ltd (UK) for measuring radiation leakage, along with observations and inquiries to obtain demographic and protective information. The collected data were entered into the SPSS 24 and analyzed using statistical tests. Results: Based on the findings, 6 out of the 30 sampled clinics had radiation leakage values higher than the permissible limit, while 24 clinics were within the safe range. Moreover, in assessing the relationship between variables and radiation leakage, no significant correlation was found between radiation leakage and the demographic information of radiologists, such as gender, specialty, and work experience. Among protective measures, the presence of lead shielding showed the highest significant correlation with radiation leakage. Conclusion: The study showed that 20% of the sampled offices had a high radiation leakage rate and that protective measures, especially the use of lead shields, were very important in reducing the radiation leakage rate in dental offices. The results indicated that the offices that used lead shields had less radiation leakage than other offices. Lack of a significant relationship between the demographic information of radiographers and the amount of radiation leakage indicated that this phenomenon is more related to technical factors and radiation equipment rather than personal factors, such as gender or expertise. These results revealed the necessity of emphasizing education and retraining and the implementation of safety standards and guidelines related to the use of radiology equipment in dental environments, as well as the necessity of periodic visits to dental offices.

IntroductionMany of the diwans (poetic collections) of ancient poets have been lost for various reasons. This has led to reliance on tazkarehs (biographical works) and jongs (literary anthologies) for compiling the poetic works of the poets without preserved diwans. Although the existence of these tazkarehs and jongs is a great blessing, sometimes the authors' or scribes' errors result in attributing a poem to someone else. However, referring to tazkarehs and jongs is the only way to gather the works of poets without preserved diwans, albeit with caution. The oldest and perhaps the most authoritative tazkareh of Persian poetry is Lobab al-Albab; this tazkareh provides abundant and documented information about poets before the 6th century and serves as a source for other tazkarehs and historical books. Based on the editors' statements in Lobab al-Albab, this tazkareh was edited based on two manuscripts by Elliot and Sprenger, which Browne stated were from the 16th or 17th century AD, approximately the 10th or 11th century AH (See: Aufi, 1982: 7). And elsewhere, he states that: “In fact, none of the manuscript copies used as the basis possesses significant antiquity or scholarly precision” (ibid: 19). However, this lateness of the manuscripts of Lobab cannot be a reason for major alterations in the poems, and on this basis, it can be considered one of the most authentic sources for poems before the 6th century, as it was of interest to the authors of tazkarehs, and many later tazkarehs, literary works, and historical books have cited it. After Lobab, various tazkarehs and jongs such as Rawzat al-Nazir, Arafat al-Ashiqin, Atishkadeh, Aftab-e Alamtab, Ruz-e Rushan, Majales al-Nafais, and similar tazkarehs were compiled. Although the main benefit of these tazkarehs is the collecting poems and biographies of earlier poets, especially those without preserved diwans, they sometimes contain attribution errors. In such cases, the most logical approach is referring to the earliest of these tazkarehs and jongs and their consensus on a subject and presenting rational evidence to minimize errors. Literature ReviewThere are various articles and editions regarding Mahseti Ganjavi and the quatrains attributed to him. One of the oldest articles related to Mahseti is “Mahseti Nayshaburi” by Ali Akbar Qawim al-Dowleh, in which he mentions Mahseti Nayshaburi through a narration from Sultan Sanjar (Qawim al-Dowleh, 1960: 161-168). Among the most important articles about Mahseti is “Mahseti-shenasi” by Maryam Mosharraf, which discusses Mahseti's life and introduces two books about him (Mosharraf, 2005: 85-101). There is also an article titled “Stylistic Analysis of Mahseti Ganjavi's Quatrains” by Mohammad Reza Najjarian, which lists his stylistic characteristics (Najjarian, 2016: 241-268). There are more articles about Mahseti, but they are beyond the scope of this research. However, none of the aforementioned studies mention the attribution of the ghazal in question to Mahseti Ganjavi. Furthermore, this ghazal is not present in any of the editions of Mahseti's quatrains. Additionally, the authors of this research did not find any studies on the works and potential poems of Rafi' Marvazi. There has also been no research regarding the attribution of this ghazal to Saadi. MethodsThe method of data collection in the present research is library-based and note-taking. In this study, a descriptive-analytical approach is used to examine a ghazal attributed to three poets. Several manuscripts and printed copies have also been studied to reach the most accurate conclusion. DiscussionOne of the current problems regarding the poems of past poets is the wandering of some of these poems in different jongs and tazkarehs. A famous ghazal attributed to Saadi, and also included as a “mukhammas” (five-line poem based on another poem) on Saadi's ghazal in Helali Joghatayi's diwan, is recorded with Saadi's pen name. However, after examining Saadi's Kolliyat (complete works) and scrutinizing several manuscripts, we did not find this ghazal in Saadi's diwan. This ghazal, present in Helali's “tazmin” (incorporation), also has Saadi's pen name. It is attributed to Mahseti in the tazkareh Biyaz by Taj al-Din Ahmad Wazir and the jong Rawzat al-Nazir wa Nuzhat al-Khatir by Abdulaziz Kashi. A critical point that casts doubt on these attributions is the inclusion of this ghazal in Lobab al-Albab under the name of Rafi' Marvazi. Considering that Lobab precedes all of these works, the attribution of the ghazal to Mahseti and Saadi becomes questionable. Furthermore, in three instances in Jawame’ al-Hekayat, Tarikh-e Jahangushay-e Juvayni, and Makaram al-Akhlaq, a line or lines from this ghazal are mentioned; and given the historical periods of these books, its attribution to Saadi is impossible. Moreover, the attribution of the ghazal to Rafi' takes precedence over Mahseti, as the ghazal in question is attributed to Rafi' Marvazi in Lobab, which is earlier than the other manuscripts. ConclusionGiven that the ghazal in question is attributed to Rafi' Marvazi in Lobab al-Albab by Aufi, and since Rafi' Marvazi was a poet of the Seljughi era, while Saadi is later than him and even the author of Lobab, it can be said with certainty that this ghazal is not by Saadi. The inclusion of two lines from this poem without mentioning the author's name in Jawame’ al-Hekayat, Tarikh-e Jahangushay, and Makaram al-Akhlaq is Another reason to reject its attribution to Saadi. The attribution of this ghazal to Mahseti should also be doubted, as the oldest tazkareh closest to Mahseti's time has attributed it to Rafi' Marvazi. Additionally, this ghazal differs from Mahseti's poems in terms of stylistic and poetic form. Therefore, considering the refutation of its attribution to Saadi and the doubt in its attribution to Mahseti, it is logical and more accurate to trust Lobab and attribute it to Rafi' Marvazi.

The city of Gotvand in Iran is located in a hot and semi-arid region, where it can be challenging to grow crops. Abiotic stresses such as drought and heat can affect crop productivity during both vegetative and reproductive growth. Melatonin plays a vital role in regulating various mechanisms in plants and acts as a primary defense against environmental stresses. However, its interaction with zinc is not well understood. In the experiment, a randomized complete block design with three repetitions was used. A field experiment was conducted to investigate the interaction effects of zinc fertilizer (ZnSO4) - no application, 1 mg/L, and 2 mg/L and different concentrations of melatonin (0, 25, 50, 100, 200 mg/L. Mung bean plants treated with melatonin and higher levels of zinc fertilizer showed increased vegetative growth and improved yield attributes. The specific combination of 200 mg/L of melatonin and 2 mg/L of zinc fertilizer emerges as a promising strategy to maximize yield components, including pod number, seed number per pod, and seed weight. Notably, this combination proved to be the most effective treatment for enhancing mung bean yield formation which resulted in the highest average seed yield to 1764 kg/ha. It is concluded that melatonin and zinc combination is an effective approach to alleviate environmental challenges such as high temperatures during fluorescence and reproductive growth.

Variation in short-circuit levels (SCLs) caused by the occasional operation of on-load tap-changers (OLTCs) presents a significant challenge in maintaining protection coordination in distribution networks (DNs), especially where the integration of distributed energy resources (DERs) increases complexities. To tackle this complex issue, this paper first develops an AI-assisted protection scheme utilizing smart relays (SRs) in conjunction with conventional overcurrent relays (CRs). In the proposed scheme, the SR logic is trained by deployment of a multilayer perceptron (MLP) model which enables the detection and classification of faults across diverse locations, accounting for a wide range of fault resistances, DERs outages, capacitor bank switching conditions, and on/off grid states, while also considering various OLTC tap levels. To maintain security and functionality in case of SR operation failures and to reduce model errors, the scheme designates SRs as the primary protection mechanism while CRs serving as a backup. Next, a techno-economic model employing a fuzzy decision-making approach is introduced to optimize the placement of SRs, minimizing relay replacement costs while ensuring technical coordination among SRs and CRs. The conventional and proposed protection frameworks are implemented and extensively evaluated on the IEEE 14-bus and PG&E 69-bus test systems. The obtained results demonstrate a 99.5% fault detection accuracy by SRs and an impressive 74.2% reduction in overall relay operation time. Moreover, complete miscoordination rectification is achieved by 25% replacement rate of SRs which confirm the technical superiority and economic optimality of the proposed framework.

This paper shows that since high penetration level of distributed generations (DGs) makes the protection coordination complicated in active electrical grids, selectivity task among relays pairs can be easily affected by on-load tap changer (OLTC) tap position. Therefore, mitigating the side effect of OLTC tap position on relays coordination in active distribution networks is of crucial importance which should be considered in relaying process. To tackle this challenging issue, this paper presents a protection scheme based on deployment of numerical relays and low bandwidth communication links besides considering OLTC tap position. The proposed approach provides a selective scheme with individual settings for relays which are set independent from OLTC tap positions. The relays settings are obtained through the optimization process to minimize the relays tripping times. In this regard, a new logarithmic objective function (OF) is also presented to steer the relays setting toward optimal solutions with fast convergence. The feasibility and the effectiveness of the proposed formulation is tested on the IEEE 14-bus test system.

This field study explores construction workers’ perceptions of using a passive shoulder exoskeleton to better understand how to improve its adoption in construction. We provided forty-one construction workers with an exoskeleton to perform their regular work activities for two days. Workers’ feedback of the tool was collected at the end of each day. Two-thirds indicated they would likely or very likely use an exoskeleton if their employer provided it. Participants felt exoskeletons were helpful for specific overhead tasks, such as installing upper tracks, framing and drywalling bulkheads, taping and mudding ceilings, and installing light fixtures. To improve their adoption within the construction industry, exoskeletons should be designed to be compatible with harnesses and toolbelts, be close-fitting to allow working in tight spaces, be easily adjustable (for fit and level of support), be rugged and easy to clean, and should not encumber workers in performing their tasks.

Background: We aimed to evaluate the differential expression of nanos and ago genes in the protoscoleces, germinal layer, the neck, and the sucker regions of adult Echinococcus granulosus. Methods: The study was conducted in 2018 at the Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran. In the present study E. granulosus protoscoleces were cultured in a di-phasic medium to obtain strobilated worms. The strobilated worms were harvested and using a sterile razor blade, the neck region was separated. In the molecular study the neck sections were compared with the tissues derived from the suckers from the same worm. The primers were specifically designed for RT-qPCR on nanos and ago. The germinative cells were isolated from the cyst germinal layer and cultured in DMEM for further molecular studies. The Immunohistochemical profile was designed to explore the nature of nanos protein in the strobilated worms. Differences between and within groups were statistically assessed relative to the protoscoleces. Results: An increasing nanos gene expressions were found in sucker, neck, cells and germinal layer in comparison to the protoscoleces. The expression of ago gene was decreased in sucker, cell and germinal layer, and increased in the neck region in comparison to the protoscoleces. The results showed that both genes were expressed in all developmental stages of E. granulosus. Conclusion: nanos and ago genes were differentially expressed at different developmental stages of E. granulosus and may contribute to differentiation of the parasite.

Recruiting and retaining research participants is challenging because it often requires overcoming structural barriers and addressing how histories of mistrust and individuals’ lived experiences affect their research engagement. We describe a pilot workshop designed to educate clinical research professionals on using empathy skills to recognize and mitigate bias to improve recruitment and retention. In a post-workshop survey (22/31 participants completed), 94% agreed the workshop helped them practice perspective-taking, recognize implicit bias, and identify opportunities for empathy. Participants reported increased confidence in key recruitment and retention skills (p < 0.05). Future studies will evaluate whether this translates into improved recruitment.

Sofosbuvir is one of the crucial drugs used in the treatment of chronic hepatitis C virus (HCV) in adults and children with compensated liver disease, including cirrhosis. It may be used alone or with other drugs. Ribavirin is an antiviral medication used to treat HCV infection. It is not effective when used alone and must be used in combination with other medications, such as sofosbuvir. This study pertains to a comprehensive assessment of the deleterious effects of sofosbuvir (an antiviral drug against chronic HCV) or sofosbuvir combined with ribavirin (an antiviral drug against RNA and DNA viruses) on several biological activities of the body, including hematological, hormonal, biochemical, histological, and immunohistochemical examinations during a long-standing period on male healthy rats. In addition, fertility assessments were performed, including sperm collections and semen parameter investigations. This study was conducted on 21 male rats divided into three equal groups. Group I (control group) received distilled water; group II (sofosbuvir group) received sofosbuvir (4 mg/kg); and group III (sofosbuvir + ribavirin) received sofosbuvir (4 mg/kg) plus ribavirin (30 ml/kg). All groups received the specific drug for six months. Blood and tissue samples were collected for hematological, hormonal, biochemical, histological, and immunohistochemical examinations. In addition, sperm collection and assessments of semen parameters were performed. Results revealed that sofosbuvir causes a highly significant decrease in the mean of most hematological, immunological, hormonal, and biochemical parameters, except for a few numbers of parameters such as neutrophils, monocytes, basophils, cortisol, GOT, and lipase, which exhibit a significant increase. The same occurred in the sofosbuvir + ribavirin group, but at much higher levels, as most hematological, immunological, hormonal, and biochemical parameters exhibit a highly significant decrease except for monocytes, triglyceride, and lipase, which exhibit a significant increase. When compared to the sofosbuvir group alone, the sofosbuvir + ribavirin group demonstrated a highly significant decline in the mean of most hematological, immunological, hormonal, and biochemical parameters except lymphocytes and triglycerides, which exhibit a substantial increase. For the reproductive parameters, both groups exhibit a significant decrease in the total sperm motility percentage. Finally, it can be concluded that sofosbuvir causes acute pancreatitis and combined immunodeficiency. Ribavirin is associated with hormonal deficiency, which indicates the occurrence of hypopituitarism. Moreover, sofosbuvir and ribavirin synergistically affect myelosuppression and cause iron-deficiency anemia. However, sofosbuvir, or its combination with ribavirin, is associated with a reduced risk of hepatocellular carcinoma. Besides, adding ribavirin to be combined with sofosbuvir improved the immunodeficiency caused by sofosbuvir; this confirms that using ribavirin with sofosbuvir reduces the side effects of both alone., (© 2024. The Author(s).)

Heavy metals are one of the most toxic chemical pollutants of the environment. Their hazards not restricted to human but extend to animal productivity and reproductively. The present study aimed to assess the impact of grazing around industrial areas on the levels of copper (Cu) and aluminum (Al) residues in milk samples collected from dromedary she-camels and studying their effects on some ovarian hormones. In addition, the study aimed to investigate methods of removal of the toxic concentrations of these heavy metals in milk by applying different technological processes. Blood and milk samples were collected from 30 dromedary she-camels, 15 grazing in non-industrial areas (group A) and 15 grazing in industrial areas (group B). Detection of the levels of these heavy metals in milk was done. Ovarian hormones investigation on the blood was performed. Different technological processes such as boiling, skimming and fermentation were applied to all contaminated samples to reduce the toxic concentrations of these heavy metals. Results revealed that all examined milk samples in both groups contained Cu, while 40% of group A and 100 % of group B contained Al residues with different concentrations. The levels of Cu and Al residues in samples of group A not exceeded the maximum residual limit (MRL) set by World Health Organization (WHO) while 60% and 100% of milk samples in group B contained Cu and Al residues exceeded MRL, respectively. Technological processes induce variant changes in the levels of these metals in milk. Heat treatment of milk in Al vats leads to leaching of Al from containers to the milk causing significant increase in Al load, while Cu level was not significantly affected. Boiling in stainless-steel containers decreased the levels of Al and Cu but in non-significant levels. Regarding skimming process, small amount of Cu and Al escaped into the skimmed milk while greater amount were recovered in the cream. Fermentation by probiotic bacteria showed that milk fermentation has non-significant effect on Cu and Al levels. Investigation of ovarian hormones (estrogen and progesterone) revealed presence of a signification reduction in the levels of these hormones in group B compared to group A. In addition, a negative correlation was found between these heavy metals and ovarian hormones concentrations in the blood. It is concluded that grazing of dromedary camels around industrial areas induce heavy metals toxicity represented by excretion of these metals in milk and significant reduction on ovarian function showed by reduction of estrogen and progesterone levels. Technological processes such as skimming decreased the levels of Al and Cu residues in milk., (© 2024. The Author(s).)