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Following a period of slow progress, the completion of genome sequencing and the paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led to a new perspective on the biology and therapeutic solutions for this deadly cancer. Experimental models were revisited to address old questions, and improved tools were generated. Additional pathways emerging as drivers of ovarian tumorigenesis and key dependencies for therapeutic targeting, in particular, VEGF-driven angiogenesis and homologous recombination deficiency, were discovered. Molecular profiling of histological subtypes of ovarian cancer defined distinct genetic events for each entity, enabling the first attempts toward personalized treatment. Armed with this knowledge, HGSOC treatment was revised to include new agents. Among them, PARP inhibitors (PARPis) were shown to induce unprecedented improvement in clinical benefit for selected subsets of patients. Research on mechanisms of resistance to PARPis is beginning to discover vulnerabilities and point to new treatment possibilities. This Review highlights these advances, the remaining challenges, and unsolved problems in the field. [ABSTRACT FROM AUTHOR]

"The Real World of College: What Higher Education Is and What It Can Be" by Wendy Fischman and Howard Gardner is a book that examines the state of higher education in the United States. The authors conducted 2,000 interviews over five years at ten colleges to gain insight into current expectations and experiences of higher education. The book explores different justifications for engaging in higher education, such as inertia, transaction, exploration, and transformation. While the book defends traditional humanist scholarship, it could have made a stronger case for the liberal arts. However, it lacks awareness of sociological problems associated with the university and does not consider the broader issues affecting higher education. Overall, the book provides a harmless addition to the library of defenses of liberal education. [Extracted from the article]

As a legal aid union president in New Haven, laboring within shouting distance of a different large research university, I recall how our membership rolled our eyes when Professors Greiner, Pattanayak, and Hennesy of Harvard published their study providing evidence, through a randomized control trial, that law clinic housing work made no difference for clients.1 Representing, as I was, "lawyers, secretaries, and paralegals who have dedicated their careers to serving poor clients in crisis,"2 the authors' conclusion generated first shock, then denial, and then an anxious realization that somebody's job was to research and disseminate such conclusions. In a 2013 United States where there was one legal aid lawyer for every 8,893 people who qualified,3 where federal Legal Services Corporation funding had dropped 40% over ten years in real dollars,4 and in an America that spends as much on Halloween costumes for its pets as it does legal aid for the poor,5 the inquiry felt like a pile-on. It made no more sense to us than asking if a teacher is "good for students," a nurse "good for the sick," or a chef "good for the hungry."6 [ABSTRACT FROM AUTHOR]

The book "Art, Science, and the Politics of Knowledge" by Hannah Star Rogers explores the intersection of art, science, and technology studies (ASTS). The author examines specific episodes in the history of science where science has generated aesthetic objects and instances where artists have attempted to insert themselves into scientific endeavors. However, the reviewer criticizes the book for its narrow focus and lack of historical depth, suggesting that it offers a frivolous perspective on the distinction between art and science. The reviewer finds the book's use of lofty language and references to be wearisome and lacking in substance. [Extracted from the article]

A binary preference relation on a real vector space satisfying four (natural) axioms is shown to induce a utility function composed of a linear function to the reals and a weakly monotonic function. The key axiom is decomposition, and the utility function can be taken to be linear if and only if this axiom’s converse is also satisfied. Important consequences follow for risk-sensitive discounted Markov decision processes, decision trees, and the discounted utility model in economics. Since the four axioms imply that preferences correspond to discounting, the four axioms without the converse imply that preferences are consistent with discounting without risk neutrality. [ABSTRACT FROM AUTHOR]

• Analyzing the impacts of FDA Breakthrough Therapy Designation. • This study unveils intriguing economic and developmental outcomes for biotechnology and small pharmaceutical companies. • There is the potential for significant short-term share price jumps and improved approval rates. • Cautionary insights into long-term market performance are discussed. Biotechnology and small pharma companies must recognize the opportunity presented by FDA Breakthrough Therapy Designation (BTD) to expedite drug development for serious conditions. This paper evaluates BTD economic and developmental impacts on such companies. Analysis of 29 BTD events from 2017 to 2022 revealed immediate share price boosts and improved drug approval rates, alongside faster development times. Yet, long-term share prices underperformed relative to the broader market, underscoring the persistent risks in pharma investments. Although offering new insights, the limited sample size calls for further investigation. [ABSTRACT FROM AUTHOR]

A correction to the article "Introduction: Medical-Legal Partnerships: Equity, Evolution, and Evaluation" that was published in the March 13, 2024 issue is presented.