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Loan frauds in India have gotten more difficult by exploiting financial system vulnerabilities. Online purchasing has exacerbated these frauds. Identity fraud, phoney paperwork, and unclear loan conditions are common. This article looks at how blockchain and IoT could make loans safer, more open, and more efficient, reducing loan fraud. On an independent blockchain network, the proposed IoTBlockFin system records all loan events. This opens up the system and prevents dishonest alterations. IoT devices verify borrower identities and property, reducing false claims. An online loan application and smartphone app allow remote loan status checks. This speeds up and simplifies client service. Blockchain's digital safety measures protect sensitive user and transaction data from unauthorised parties. This prevents data breaches and illegal access. This comprehensive approach reduces loan frauds and improves financial transactions. IoTBlockFin seeks to solve today's lending process, which will transform India's banking business. [ABSTRACT FROM AUTHOR]

Clonal hematopoiesis is highly prevalent in elderly patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), and around 20% of BPDCN patients have an associated myeloid malignancy. We present a patient with localized BPDCN and concomitant myelodysplastic syndrome (MDS), previously followed for several years due to clonal cytopenia of unknown significance. Compared targeted next-generation sequencing (NGS) of the skin tumor and sequential bone marrow samples showed shared variants in ASXL1 and TET2 with a de novo NRAS variant in both BPDCN and MDS compared to preceding bone marrow samples. These findings illustrate a shared clonal origin of BPDCN and MDS resulting from progressive clonal hematopoiesis., (© 2024 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.)