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Higher education students, formally adults, are nevertheless subject to adultism. The co-authors of this article--the director of the Students as Teachers and Learners (SaLT) program and three undergraduates who have worked in pedagogical partnership with faculty through SaLT--discuss how this program counters adultism on three levels: conceptually, structurally, and personally/interpersonally. We conclude with implications of this work for others interested in creating structures, practices, and relationships that counter adultism in higher education.

There is growing body of scholarship that examines adultism through various methodologies and in a variety of settings, including labor, education, and society. In addition, studies of adultism increasingly recognize how this from of power intersects or is parallel with other forms of oppression. This research is generative for illuminating the various way in which adultism and other forms of power operate or contribute to limiting or exclusionary practices that young people face. However, how can we move away from discourses of liberal inclusivity toward social transformation? Why do the causes, effects, or outcomes of adultism from a critical perspective often fall short? What can decolonial thought offer to understandings of adultism? This essay proposes a de/colonization framework to advance understandings of adultism and center liberation. I argue that adultism and colonization are not separate but birthed in relation to one another. Furthermore, discourses on adultism that fail to seriously engage with de/colonization risk perpetuating the oppression that they attempt to challenge, trouble, or address.

This longitudinal case study from a Complex Dynamic Systems Theory (CDST) perspective touches upon an under-researched issue: L1 development over the lifespan. Levinson (1978) predicts three stages in adulthood: early, mid and late, with a decline in late adulthood. We examine Diane Larsen-Freeman's publications over a period of 50 years (from age 27 to 77) and trace seven complexity measures--three lexical (density, sophistication and diversity) and four syntactic (mean length of sentence, finite verb ratio, dependent clause per T-unit and complex nominals per clause)--to investigate whether early, middle, and late stages in adulthood occur as predicted. After employing common CDST methods to find out if there are significant peaks or interactions among the variables over time, we used a Hidden Markov time-series analysis to locate moments of self-organization, suggesting a new stage of development. The HMM shows a clear phase shift between middle and late adulthood when the writer was 63. Her vocabulary became more diversified, but her sentences were shorter, but not less complex. Therefore, we argue that this shift should not be seen as a decline in complexity but a shift in style as more precise words may lessen the need for more words.

Lesbian, Gay, Bisexual, Transgender, Queer, and other sexual and gender minority (LGBTQ+) youth and young adults (YYAs) have poorer mental health outcomes than their cisgender, heterosexual peers in large part due to multilevel stigmatization and minority stress. This was exacerbated by psychological stressors stemming from the COVID-19 pandemic; these experiences intersected with YYA unique developmental stage. Here we explored LGBTQ+ YYA's pandemic-related experiences, focusing on intersections between stigma and belonging, developmental processes, and their relationship to mental health. We conducted qualitative interviews from August to November 2021 with 34 LGBTQ+ YYA ages 14 to 24; interviews were nested within a quantitative study on YYA experiences during COVID-19. Interviews were transcribed and coded using thematic analysis. YYA described how pandemic impacts like quarantine and isolation directly impacted their mental health; these coalesced around four types of thematic shifts: shifts in (1) time; (2) living situations; (3) community supports; and (4) social and political climate. Multilevel stigmatization also created new mechanisms of norm enforcement for LGBTQ+ YYA. Interviews demonstrated how the pandemic also impacted key developmental processes including identity formation and autonomy seeking. The potential consequences of these pandemic-related shifts largely depended on YYA's experiences of stigma and/or belonging throughout the pandemic. Findings suggested that isolation from the COVID-19 pandemic intersected with existing socio-ecological structures in LGBTQ+ young people's lives. Efforts to investigate longitudinal impacts of the pandemic, as well as to intervene to reduce the stigmatization experienced by LGBTQ+ YYA, remain urgent.

Little research has examined changes in personal identity over different periods of adult development. The aim of the present cross-sectional study was to target these changes through the characterization of the main dimensions in self-defining memories (SDMs; thematic content, specificity, integrative meaning, tension, contamination/redemption, and emotion) and their interactions. Our final sample was composed of 652 healthy French adults aged from 18 to 97 years, divided into four age groups: young adults (n = 163, M = 23.7 years), middle-aged adults (n = 135, M = 44.0 years), young-old adults (n = 178, M = 64.5 years), and old-old adults (n = 176, M = 79.6 years). Participants were asked to recollect three SDMs. A similar pattern of thematic content was observed throughout adulthood, except for relationship narratives were more frequent in the two younger groups. The findings highlighted that specific and integrated SDMs decreased with age and that tension and contaminative sequences were the most frequent in young adults. Redemptive memories did not significantly differ whatever the age of participants. No clear positivity effect was observed with aging. Finally, an analysis of the correlations among the main SDMs' dimensions showed that specificity correlated positively with tension in young adults and integrative meaning with redemption in young and middle-aged participants. We found no significant correlation between specificity and integration in any age group. For the first time, this study sheds new light on lifelong identity adjustments.

The idea of the university has been a matter of intense debate for well over a century. The essential nature, role and purpose of the university have long been questioned. The debate has only intensified as universities have multiplied and expanded across the globe, and the demands made upon them by different stakeholders have grown and diversified. This article focuses on how the research literature on the idea of the university has developed over the last 150 years, using this to assess where the debate might be going. It puts forward three key elements for a contemporary idea of the university: the increased use of educational technology, development beyond the university, and mass undergraduate provision.

Domestic abuse in childhood is seriously impactful, but very little literature uses a critical lens to consider implications for counsellors and psychotherapists working with young adults following domestic abuse in childhood. This article draws on research that explored 10 young women's accounts of transitions to adulthood after domestic abuse in childhood. Interviews with young adult women in England were conducted and a feminist dialogical narrative analysis was used. Findings suggest that socio-cultural structures and ideologies that shape dominant discourses about what growing up after domestic abuse in childhood means, and what "successful" adult femininity looks like, shaped how women made sense of their experiences. This has implications for counsellors and psychotherapists working with this client group. This article concludes that storytelling could be a powerful therapeutic tool, and attention to power, ambiguity and tensions when working with this client group might facilitate and generate important meaning-making and knowledge in therapy.

What is it that develops in adult life? Development through work and family life have been documented and theorised in detail, but much less is known about what is learned beyond these domains, through people's engagements in hobbies or when out of work (e.g., unemployed, retired). We argue that adult development can be addressed in general terms, beyond domain specificity; drawing on our sociocultural psychology framework, and assuming an open-system perspective, we highlight the two processes of progressive differentiation and psychological distancing in diverse domains of activity. To address development over time, we explore 20 years of people's lives through the longitudinal analysis of online diaries. A combination of quantitative and qualitative analysis enables us to identify people's experiences of rupture and transitions, the diversity of their domains of interests, and how these change over time. Based on a case-study, we show that, if the general direction of development does entail progressive differentiation and distanciation, these processes can also be hindered by the cumulation of vulnerabilising events. Finally, we show that some domains, such as the long-standing activity of diary writing, can itself be used as resource for adult development. [ABSTRACT FROM AUTHOR]

If environments stay relatively constant over an individual's lifetime, a juvenile that accurately perceives environmental conditions, like population density, may adjust adult traits to better match their environment, thereby increasing success. While previous studies have explored how adult exposure to population density affects physiological and behavioural plasticity, the influence of juvenile density experience on adult traits is less studied.Using the common house cricket, Acheta domesticus, we explored whether perceived acoustic population density during development affected adult physiology and behaviour. We simulated high‐ and low‐densities using live ambient male song. Upon maturation, we measured metabolic (resting respiration) rate, reproductive investment (testes and accessory gland masses), calling song characteristics and aggressive behaviours from pairwise contests between males from different densities.Male rearing density did not affect resting metabolic rates or reproductive organ masses. However, high‐density males had significantly faster, longer chirps, with more pulses—known to be preferred by females—and higher dominant frequency. Low‐density males won more aggressive contests and sang the aggressive song more. Initiation of aggressive behaviours or song and singing more aggressive song were the only other significant predictors of contest outcome.These results suggest that males may plastically adjust calling song characteristics and aggressive behaviour, but not physiology, based on perceived density during development. We hypothesize that alternative mating tactics—that is, territory guarding versus attractive song production—may underlie these observed patterns.Overall, our study highlights the significant influence of early‐life biotic environments on adult behavioural decisions to enhance success in diverse environments. [ABSTRACT FROM AUTHOR]

Rice leaffolder, Cnaphalocrocis medinalis (Lepidoptera: Plutellidae) is an important migratory pest in Asia. While many lepidopteran species are known to enhance adult life history by obtaining supplementary nutrition, little is known about the effects of adult diet on C. medinalis. We first examined the effects of offering five dilutions of honey solution (0%, 5%, 10%, 15% and 20%) on the longevity, fecundity and ovary development of adult C. medinalis. We then compared the effects of 10% honey solution to 25% glucose solution, which was previously reported to be the best adult diet for C. medinalis. We found that adult male and female C. medinalis fed 5%–20% honey solution lived significantly longer than those fed just water. Importantly, a honey–based diet accelerated and increased ovary development and prolonged the oviposition period, leading to higher fecundity. More specifically, females fed 5%–15% honey solution had the highest fecundity, followed by 20% honey solution, and the lowest when fed only water. In addition, the oviposition rate was 100% in females fed 10% and 15% honey solution. When we compared 10% honey solution to 25% glucose solution, those fed honey solution had significantly higher estimated female performance, which is a composite measure consisting of fecundity, percentage of egg‐laying females and percentage of eggs that hatched. Overall, our findings indicate that adult diet quality significantly impacts C. medinalis performance and that using a 10%–15% honey solution is optimal for mass‐rearing under laboratory conditions. [ABSTRACT FROM AUTHOR]

Fleas (Siphonaptera) are holometabolous insects with larval and adult stages that exhibit vastly different ecologies from each other. Adult fleas are parasitic and feed exclusively on the blood of a vertebrate host, whereas flea larvae do not live on hosts and consume dried faecal blood from adult fleas. Because flea larvae rely on adult flea faeces for food, excrement and eggs must fall in the same location; thus, larval density is likely high in these restricted habitats. However, the influence of larval density on the subsequent adult stage has not been examined. In the present study, we utilized egg density to investigate density‐dependent effects on larval development and adult body size in the cat flea (Ctenocephalides felis Bouché) (Siphonaptera: Pulicidae). Specifically, eggs were collected to create three different larval densities (n = 50, 100 and 150 per 56.7 cm2), and hatched larvae from all groups were fed an excess amount of adult faecal pellets. Larval development was measured by recording the proportion of eggs that developed to the pupal stage and the proportion of eggs that reached adulthood (eclosion). The body size of eclosed adults was quantified for both sexes using head length and length of the total body. We found that the number of eggs had no effect on the proportion of larvae that pupated or the proportion of larvae that eclosed; however, higher egg densities resulted in larger body sizes for both sexes. Overall, these data yield significant insight into how the ecology of larval fleas impacts the biology of the resultant adults. [ABSTRACT FROM AUTHOR]

Scholars have identified reflexivity, the ability to question what one might be taking for granted, as a critical meta-cognitive skill that management schools should cultivate amongst students. Reflexive learning though is a complex and idiosyncratic process. Little is known about how students experience this process, what they learn, or how a range of students representing different degrees of potential for reflexivity experience such a process differently. This article reports on a study using Kegan's Constructive Developmental Theory to assess how masters students at a professional school studying leadership and representing different developmental stages experience the same teaching methods for cultivating reflexivity. This work illuminates how students at different stages of development experience the same teaching method for cultivating reflexivity quite differently. Results indicate that for students with limited potential for reflexivity, there is profound developmental growth. Other students who began the course with existing reflexive capacity did not initially demonstrate skills of reflexivity. However, this group of students learned to practice reflexivity without actually interrogating their own assumptions in a way that represents developmental growth. I share details of the study and conclude with implications for teaching reflexivity across a diverse range of experience. [ABSTRACT FROM AUTHOR]

Background Methods Key results Conclusions and Inferences Cyclic vomiting syndrome is a chronic disorder of gut‐brain interaction that is present in both adults and children. It is characterized by severe nausea, vomiting, abdominal pain, and several non‐GI symptoms. It is also associated with several comorbid conditions such as anxiety and depression, which affect overall health care outcomes.This article delineates treatment principles, encompassing both abortive interventions and prophylactic regimens currently recommended for CVS. However, it underscores a critical concern: the absence of FDA‐approved medications for CVS treatment, with existing therapies relying on retrospective and open‐labeled trials.This article emphasizes the pressing need for the development of CVS‐specific outcome assessment tools to facilitate more accurate evaluation and robust data collection for the future studies. In exploring this deficiency, the manuscript also presents the up‐to‐date data and development that enhances our comprehension of patient‐centric concepts, and the challenges faced in creating CVS‐specific tools, and presents a roadmap for their development. Addressing this gap is crucial for advancing our understanding of CVS and optimizing patient care.This elucidates the current state of CVS management but also advocates for a future where tailored tools enhance our ability to measure and improve the outcomes for individuals with this debilitating disorder. [ABSTRACT FROM AUTHOR]

A gap often exists between adult leadership learning and development practice. This gap seems particularly pronounced when considering training through a collective, practice, and constructionist theoretical lens. Leadership developers need to address this gap in their teaching methods if they are to support learning capable of responding to Complex Adaptive System (CAS) challenges. Drawing from a case-in-point (CIP) train-the-trainer experience hosted by the Kansas Leadership Center (KLC) this study will help trainers understand how primary and keying frames can be used to analyze how facilitators train trainers to use collective sensemaking for adult leadership learning. The case-in-point leadership development method is capable of moving adult leadership learners to make more systemic interpretations of leadership challenges and collectively interrogate cultural assumptions and identity. [ABSTRACT FROM AUTHOR]

Solid organ transplantation (SOT) is the gold standard of therapy for individuals with end‐organ dysfunction. Improved survival outcomes after SOT can help adolescent and young adult (AYA) recipients lead long and healthy life. However, successful SOT during adolescence and young adulthood is often complicated by the innate developmental challenges of this age group. The psychosocial tasks of adolescence include identity development, autonomous decision‐making, establishing social networks, educational and vocational preparation, and navigating romantic relationships. These goals may be amplified or delayed for pediatric SOT recipients. Adolescence is also marked by rapid physical changes in linear growth and the development of secondary sexual characteristics. Yet AYA may experience physical and pubertal delays related to transplantation, as well as exaggerated body image dissatisfaction due to medication side effects. Strict adherence to medication and post‐transplant regimens may interfere with adolescents' desire for normalcy and fitting in with peers. Healthcare providers should be aware that AYA value education and self‐empowerment in transplant care. Transplant success needs to be defined by both medical and psychosocial outcomes, particularly when it relates to the vulnerable AYA population. Fortunately, investment from the patient, family, and care team can aid in transplant recovery and success. This article will identify the developmental challenges faced by AYA undergoing solid organ transplantation as well as strategies to engage positive outcomes. [ABSTRACT FROM AUTHOR]

• Observational cohort study including 5115 participants over 30 years. • Current cannabis was associated with lower BMI, probably due to residual confounding. • Cannabis cessation or cumulative cannabis exposure were not associated with BMI. With increasing use of cannabis, we need to know if cannabis use and Body Mass Index (BMI) are associated. The Coronary Artery Risk Development in Young Adults Study followed Black and White adults over 30 years with assessments every 2 to 5 years in four centers in the USA. We assessed self-reported current and computed cumulative cannabis exposure at every visit, and studied associations with BMI, adjusted for relevant covariables in mixed longitudinal models. We also applied marginal structural models (MSM) accounting for the probability of having stopped cannabis over the last 5 years. At the Year 30 visit, 1,912 (58 %) identified as women and 1,600 (48 %) as Black, mean age was 56 (SD 2) years. While 2,849 (85 %) had ever used cannabis, 479 (14 %) currently used cannabis. Overall, participants contributed to 35,882 individual visits over 30 years. In multivariable adjusted models, mean BMI was significantly lower in daily cannabis users (26.6 kg/m2, 95 %CI 26.3 to 27.0) than in participants without current use (27.7 kg/m2, 95 %CI 27.5 to 27.9, p < 0.001). Cumulative cannabis use was not associated with BMI. The MSM showed no change in BMI when stopping cannabis use over a 5-year period (β=0.2 kg/m2 total, 95 %CI -0.2 to 0.6). Current cannabis use was associated with lower BMI, but cumulative cannabis use and cessation were not. This suggests that recreational cannabis use may not lead to clinically relevant changes in BMI and that the association between current cannabis use and lower BMI is likely due to residual confounding. [ABSTRACT FROM AUTHOR]

The marginalisation of children globally is frequently justified by appeal to medical, developmental science. While childhood has increasingly become recognised as a social construct, this research has focused largely on education and legal structures, leaving this medicalisation unexamined. This essay closes that gap by examining the medicalisation of childhood and the contribution of the medical system to adult power. These are approached in separate sections. The first portion of this essay addresses the theoretical and rhetorical manner in which children are medicalised, using Piaget's theories as examples of a trend to over‐state the universality of childhood deficiencies and assume adult competences. Latour's work on the scientific black‐box is combined with Halliday's assessment of scientific language to examine how these theories are transformed from specific psychological findings, into assumed objective truths, carrying disenfranchising assumptions about children into public discourse. The essay's second part examines the practical role of the medical system in mobilising adultist discourses and disempowering children, through the operation of scientific management. This is built up from discussions of childbirth and adolescence to wider issues of medical power as it permeates educational, legislative and media spaces through Samuel's concept of biocertification. Finally, these two parts meet in highlighting the role of medicalisation in maintaining the hegemony of adult power through its veil of objectivity and expansive reach. I contend anthropological works referenced throughout the essay show that medicalised narratives of childhood are insufficient but culturally contingent and thus open to revision. [ABSTRACT FROM AUTHOR]

The Wnt/β-catenin signaling pathway is crucial for embryonic development and adult tissue homeostasis. Dysregulation of Wnt signaling is linked to various developmental anomalies and diseases, notably cancer. Although numerous regulators of the Wnt signaling pathway have been identified, their precise function during mouse embryo development remains unclear. Here, we revealed that TMEM132A is a crucial regulator of canonical Wnt/β-catenin signaling in mouse development. Mouse embryos lacking Tmem132a displayed a range of malformations, including open spina bifida, caudal truncation, syndactyly, and renal defects, similar to the phenotypes of Wnt/β-catenin mutants. Tmem132a knockdown in cultured cells suppressed canonical Wnt/β-catenin signaling. In developing mice, loss of Tmem132a also led to diminished Wnt/β-catenin signaling. Mechanistically, we showed that TMEM132A interacts with the Wnt co-receptor LRP6, thereby stabilizing it and preventing its lysosomal degradation. These findings shed light on a novel role for TMEM132A in regulating LRP6 stability and canonical Wnt/β-catenin signaling during mouse embryo development. This study provides valuable insights into the molecular intricacies of the Wnt signaling pathway. Further research may deepen our understanding of Wnt pathway regulation and offer its potential therapeutic applications. [ABSTRACT FROM AUTHOR]

The fall armyworm, Spodopterafrugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a highly polyphagous, migratory pest native to the tropical and subtropical region of Americas. Grass crops particularly corn have been most heavily impacted since S. frugiperda invaded Australia in 2020. In northern Western Australia, S. frugiperda is primarily a problem in dry season (May to October) crops when there are abundant host plants available in monocultures. During the wet season (November to April) it is not known what host plants may support larval growth and development. Accordingly, this present study undertook a no-choice feeding bioassay to assess larval and pupal development on several grasses and legumes that are present over the wet season in northern Western Australia to evaluate their potential as suitable host plants for S. frugiperda. Maize (control) and sorghum were the most suitable hosts for S. frugiperda development as they supported greater larval and pupal survival, heavier larvae and pupae, and shorter development period. Following maize and sorghum, pastoral grasses, particularly blue grass, and a weedy grass, barnyard grass, had comparable effects on larval and pupal development. Legume pastures (Cavalcade, butterfly pea, and siratro) were unsuitable hosts in this bioassay as very few larvae completed their development to adults. This study demonstrates the potential for rangeland pasture grasses and weedy grasses as wet season host plants for S. frugiperda. They provide the necessary green bridge for S. frugiperda populations to survive. It is recommended that pastoralists monitor their grass forage for S. frugiperda and consider management if significant reductions in biomass are detected. [ABSTRACT FROM AUTHOR]

Human T cell leukaemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes lifelong infection in ~5–10 million individuals globally. It is endemic to certain First Nations populations of Northern and Central Australia, Japan, South and Central America, Africa, and the Caribbean region. HTLV-1 preferentially infects CD4+ T cells and remains in a state of reduced transcription, often being asymptomatic in the beginning of infection, with symptoms developing later in life. HTLV-1 infection is implicated in the development of adult T cell leukaemia/lymphoma (ATL) and HTLV-1-associated myelopathies (HAM), amongst other immune-related disorders. With no preventive or curative interventions, infected individuals have limited treatment options, most of which manage symptoms. The clinical burden and lack of treatment options directs the need for alternative treatment strategies for HTLV-1 infection. Recent advances have been made in the development of RNA-based antiviral therapeutics for Human Immunodeficiency Virus Type-1 (HIV-1), an analogous retrovirus that shares modes of transmission with HTLV-1. This review highlights past and ongoing efforts in the development of HTLV-1 therapeutics and vaccines, with a focus on the potential for gene therapy as a new treatment modality in light of its successes in HIV-1, as well as animal models that may help the advancement of novel antiviral and anticancer interventions. [ABSTRACT FROM AUTHOR]

Aims. To identify the difference between adult patients with septal defects and paroxysmal atrial fibrillation (AF) and patients without a history of arrhythmia using the left atrial (LA) volume and function parameters, to reveal the parameters associated with AF development. Methods and results. In this prospective study, 81 patients with septal defects and left-to-right shunts were enrolled between 2021 and 2023 and divided into two groups: with paroxysmal AF and without AF. Left atrial function was analyzed based on the indexed left atrial volumes (LAVI and preA-LAVI), ejection fraction (LAEF), expansion index (LAEI), reservoir (LAS-r), conduit (LAS-cd) and contractile (LAS-ct) strain, and stiffness index (LASI) using a Philips CVx3D ultrasound system (Philips, Amsterdam, The Netherlands) and corresponding software. In total, 26 patients with paroxysmal atrial fibrillation (mean age: 59.6 ± 11.7 years, female: 80.8%) and 55 patients with septal defects without any history of arrhythmias (mean age: 44.8 ± 11.6 years, female: 81.8%) were included. All patients were in the NYHA class I or II at baseline. Our findings demonstrated a significant difference between all LA function parameters in the two groups. Upon univariable analysis, the LAVI, preA-LAVI, LASI, LAEF, LAEI, LAS-r, LAS-c, LAS-ct, age, cardiac index, E/A, and RV pressure were found to be associated with AF. The multivariate analysis identified LAVI (OR 1.236, 95% CI 1.022–1.494, p = 0.03), LAS-r (OR 0.723, 95% CI 0.556–0.940, p = 0.02), and LAS-ct (OR 1.518, 95% CI 1.225–1.880, p < 0.001) as independent predictors of AF development. The proposed model demonstrated high sensitivity and specificity with an adjusted classification threshold of 0.38 (AUC: 0.97, 95% CI 0.93–1.00, sensitivity 92% and specificity 92%, p < 0.001). Conclusions. The assessment of LA function using speckle-tracking echocardiography demonstrated significantly different values in the AF group among patients with congenital septal defects. This technique can therefore be implemented in routine clinical management. The key message. Atrial fibrillation development in adult patients with congenital septal defects and a left-to-right shunt is associated with the changes in left atrial function under conditions of an increased preload. [ABSTRACT FROM AUTHOR]

Objectives: Cortical bone geometry is commonly used to investigate biomechanical properties of primate mandibles. However, the ontogeny of these properties is less understood. Here we investigate changes in cortical bone cross‐sectional properties throughout capuchin ontogeny and compare captive versus wild, semi‐provisioned groups. Tufted capuchins (Sapajus spp.) are known to consume relatively hard/tough foods, while untufted capuchins (Cebus spp.) exploit less mechanically challenging foods. Previous research indicates dietary differences are present early in development and adult Sapajus mandibles can resist higher bending/shear/torsional loads. Materials and methods: This study utilized microCT scans of 22 Cebus and 45 Sapajus from early infancy to adulthood from three sample populations: one captive Cebus, one captive Sapajus, and one semi‐provisioned, free‐ranging Sapajus. Mandibular cross‐sectional properties were calculated at the symphysis, P3, and M1. If the tooth had not erupted, its position within the crypt was used. A series of one‐way ANOVAs were performed to assess differences between and within the sample populations. Results: Mandible robusticity increases across ontogeny for all three sample populations. Sapajus were better able to withstand bending and torsional loading even early in ontogeny, but no difference in shear resistance was found. Semi‐provisioned, free‐ranging Sapajus tend to show increased abilities to resist bending and torsional loading but not shear loading compared to captive Sapajus. Discussion: This study helps advance our understanding of the primate masticatory system development and opens the door for further studies into adaptive plasticity in shaping the masticatory apparatus of capuchins and differences in captive versus free‐ranging sample populations. [ABSTRACT FROM AUTHOR]

Whilst there is concern about the role of social media use in adolescent and emerging adult development, there is a gathering consensus that how individuals spend their time on social media may be more important than how much time they spend on it, with potential benefits and risks of engagement. In addition, there is growing interest in a broader range of outcomes, including wellbeing, mental health and educational attainment. Building on this research, the present study offers a new, theory-driven investigation of complex cross-sectional associations between users' motivations for social media use and wellbeing, as well as users' motivations and academic outcomes. Specifically, self-perceived stress and Grade Point Average scores were regressed on self-reported social media motivations, using data collected from nearly 6000 Chinese undergraduate students. In line with our predictions and a transdiagnostic cognitive behavioral conceptualization of social media use, social enhancement/approach motivations ("to make new friends") and escapist motivations ("to kill time") were associated with lower and higher levels of self-reported stress, respectively. In addition, academic motivations for social media use (i.e., "for academic purposes") were associated with higher educational attainment. These effects persisted after controlling for a number of potential confounders, including key demographic and socioeconomic variables. Whilst the cross-sectional design precludes inferences about underlying directions of causality, these findings suggest that inter-individual differences in motivations for engagement may be crucial in understanding the role that social media plays in adolescent and emerging adult life and generate predictions for future longitudinal and cross-sectional studies. [ABSTRACT FROM AUTHOR]

AbstractThe aim of this study was to examine the development of purpose among college students, especially in relation to experiences typical of a liberal arts education. We surveyed 1,019 students in 11 U.S. colleges and universities at two-time points over three years. At Time 1, 546 of the students were in their first year of college and 473 were in their second year or above. The survey assessed three dimensions of purpose, as well as learning experiences, advising experiences, and course types. Repeated measures mixed-effects model analyses were conducted to investigate the associations between purpose and college experiences and changes in purpose from Time 1 to Time 2. Results indicate some college experiences predict modest changes in purpose during college. However, these limited effects suggest that colleges could do more to promote students’ purpose development during college and to sustain students’ purpose after graduation. [ABSTRACT FROM AUTHOR]

The ability of a 1-time measurement of non–high-density lipoprotein cholesterol (non–HDL-C) or low-density lipoprotein cholesterol (LDL-C) to predict the cumulative exposure to these lipids during early adulthood (age 18-40 years) and the associated atherosclerotic cardiovascular disease (ASCVD) risk after age 40 years is not clear. The objectives of this study were to evaluate whether a 1-time measurement of non-HDL-C or LDL-C in a young adult can predict cumulative exposure to these lipids during early adulthood, and to quantify the association between cumulative exposure to non-HDL-C or LDL-C during early adulthood and the risk of ASCVD after age 40 years. We included CARDIA (Coronary Artery Risk Development in Young Adults Study) participants who were free of cardiovascular disease before age 40 years, were not taking lipid-lowering medications, and had ≥3 measurements of LDL-C and non–HDL-C before age 40 years. First, we assessed the ability of a 1-time measurement of LDL-C or non–HDL-C obtained between age 18 and 30 years to predict the quartile of cumulative lipid exposure from ages 18 to 40 years. Second, we assessed the associations between quartiles of cumulative lipid exposure from ages 18 to 40 years with ASCVD events (fatal and nonfatal myocardial infarction and stroke) after age 40 years. Of 4,104 CARDIA participants who had multiple lipid measurements before and after age 30 years, 3,995 participants met our inclusion criteria and were in the final analysis set. A 1-time measure of non–HDL-C and LDL-C had excellent discrimination for predicting membership in the top or bottom quartiles of cumulative exposure (AUC: 0.93 for the 4 models). The absolute values of non–HDL-C and LDL-C that predicted membership in the top quartiles with the highest simultaneous sensitivity and specificity (highest Youden's Index) were >135 mg/dL for non–HDL-C and >118 mg/dL for LDL-C; the values that predicted membership in the bottom quartiles were <107 mg/dL for non–HDL-C and <96 mg/dL for LDL-C. Individuals in the top quartile of non–HDL-C and LDL-C exposure had demographic-adjusted HRs of 4.6 (95% CI: 2.84-7.29) and 4.0 (95% CI: 2.50-6.33) for ASCVD events after age 40 years, respectively, when compared with each bottom quartile. Single measures of non–HDL-C and LDL-C obtained between ages 18 and 30 years are highly predictive of cumulative exposure before age 40 years, which in turn strongly predicts later-life ASCVD events. [ABSTRACT FROM AUTHOR]

Little research has examined how prior learning experiences influence adult learning attitudes and lifelong learning engagement. We adopted a person‐centric approach to examine past work‐related learning experiences and assessed the effects of recalled challenges on current learning attitudes, intentions, and behavior in the same domain. Surveying alumni from an online master's degree program, we found that recollected challenges from past learning entail multifaceted challenge foci (e.g., curriculum‐related vs. social obstacles). Learners reporting more challenges in curriculum and social dimensions reported less positive attitudes toward lifelong learning, supporting the notion that negative learning experiences may hinder the development of self‐identity as a lifelong learner. Limited support was obtained for predictions about relationships between past challenges and post‐graduation learning intentions and behavior. The person‐centric approach also permits the analysis of past learning experiences that are not well captured by standard assessments of "successful" adult learning. [ABSTRACT FROM AUTHOR]

Lysophosphatidic acid (LPA) is a bioactive phospholipid that participates in critical processes in neural development and adult brain function and is implicated in various pathophysiological conditions. Along with its six well‐characterized receptors, atypical regulators of LPA signaling have also been suggested, including phospholipid phosphatase‐related proteins (PLPPRs). PLPPRs have been mostly studied in the developing brain where they control LPA‐dependent axon guidance, cortical network hyperexcitability, and glutamatergic neurotransmission. PLPPR4 and PLPPR3 represent two closely related proteins reported to localize predominantly in dendrites and axons, respectively, and differ in their developmental expression patterns. Herein, we have revised the expression patterns of PLPPRs in the cerebellum, dorsal and ventral hippocampus, prefrontal cortex (PFC), nucleus accumbens, and striatum during development and in the adult using quantitative PCR. Expression patterns of Plppr2,4 and 5 were consistent with previous studies, whereas Plppr3 and Plppr1 exhibited a unique expression profile in nucleus accumbens (NAc) and striatum in later developmental and adult stages, which we verified at the protein level for PLPPR3. To investigate neuron type‐specific expression at the single cell level, we developed a bioinformatic tool to analyze recent single‐cell RNA‐sequencing data in the cerebral cortex and hippocampus of adult mice. Our analysis revealed a widespread but also selective adult neuron‐type expression with higher expression levels of Plppr3, Plppr1, and Plppr5 in GABAergic and Plppr4 and Plppr2 in glutamatergic neurons. PLPPR4 has been identified as a post‐synaptic modulator of LPA levels in glutamatergic synapses operating via an uptake mechanism, to control LPA‐dependent cortical network hyperexcitability. Using subcellular fractionation experiments, we found that both PLPPR4 and PLPPR3 are co‐expressed in adult synaptosomal membranes. Furthermore, flow cytometry experiments in HEK293 cells showed comparable LPA uptake by PLPPR4 and PLPPR3, whereas PLPRR3, but not PLPPR4, induced also uptake of monoacylglycerol, the dephosphorylation product of LPA. We propose that synaptic LPA may be subject to both pre‐synaptic and post‐synaptic mechanisms of regulation by PLPPRs in addition to LPARs in developing and adult synapses. [ABSTRACT FROM AUTHOR]

The lymphatic system is formed during embryonic development by the commitment of specialized lymphatic endothelial cells (LECs) and their subsequent assembly in primary lymphatic vessels. Although lymphatic cells are in continuous contact with mesenchymal cells during development and in adult tissues, the role of mesenchymal cells in lymphatic vasculature development remains poorly characterized. Here, we show that a subpopulation of mesenchymal cells expressing the transcription factor Osr1 are in close association with migrating LECs and established lymphatic vessels in mice. Lineage tracing experiments revealed that Osr1+ cells precede LEC arrival during lymphatic vasculature assembly in the back of the embryo. Using Osr1- deficient embryos and functional in vitro assays, we show that Osr1 acts in a non-cell-autonomous manner controlling proliferation and early migration of LECs to peripheral tissues. Thereby, mesenchymal Osr1+ cells control, in a bimodal manner, the production of extracellular matrix scaffold components and signal ligands crucial for lymphatic vessel formation. [ABSTRACT FROM AUTHOR]

Ethnic identity is a major area of study across many disciplines including psychology, sociology, anthropology, and political science. Yet, little is known about changes in ethnic identity across the adult lifespan, and whether such changes are driven by normal aging processes (aging effects), unique societal influences linked with one's formative years (cohort effects), or social changes during a specific time frame (period effects). We address these key oversights by utilizing 13 annual waves of longitudinal panel data from a nationwide random sample of both ethnic majority (N = 49,660) and Indigenous ethnic minority (N = 8,325) group members in New Zealand to examine changes in ethnic identity centrality using cohort-sequential latent growth modeling. This approach helps to identify changes in mean levels of ethnic identity centrality over time and whether such changes are driven by aging, cohort, and/or period effects. Our data reveal that, among both ethnic majority and ethnic minority individuals, changes in ethnic identity centrality were informed by a combination of normative aging processes, societal circumstances that reflected the unique historical context in which people grew to maturity, and societal changes during the 13 annual assessments of our study. Collectively, these results demonstrate for the first time that ethnic identity centrality in adulthood is subject to lifelong changes. [ABSTRACT FROM AUTHOR]

Hydrocephalus, a major complication in tuberculous meningitis (TBM) patients, often necessitates treatment via ventriculoperitoneal shunt (VPS). However, post-VPS, some patients develop a complication called contralateral isolated lateral ventricle (CILV), leading to persistent hydrocephalus symptoms. This study aims to evaluate cerebrospinal fluid (CSF) parameters in predicting CILV occurrence post-VPS in adult TBM patients. A retrospective analysis was conducted, focusing on the relationship between preoperative CSF parameters and the development of CILV in 40 adult TBM patients who underwent VPS. The study compared CSF parameters from lumbar puncture after admission with those from ventricular CSF post-external ventricular drainage tube insertion. CILV was observed in 6 of the 40 patients following VPS. Statistical analysis showed no significant difference between the CSF parameters obtained via lumbar and ventricular punctures. Notably, the mean CSF glucose level in patients with CILV was significantly lower (1.92 mmol/L) compared to the non-CILV group (3.03 mmol/L). Conversely, the median adenosine deaminase (ADA) level in the CILV group was higher (5.69 U/L) compared to the non-CILV group (3.18 U/L). The optimal cutoff values for CSF glucose and ADA levels were 1.90 mmol/L and 4.80 U/L, respectively, with a sensitivity of 66.67% and 83.33% and a specificity of 88.24% and 79.41%. The study identified elevated ADA levels and decreased glucose levels in CSF as potential risk factors for CILV development in adult TBM patients post-VPS. These findings suggest the necessity for more tailored surgical approaches, in patients with altered CSF parameters to mitigate the risk of CILV. [ABSTRACT FROM AUTHOR]

Generativity is a main adulthood developmental task, centred on the concern to contribute for the wellbeing of younger generations, and has been associated with improved health and wellbeing. Generativity, nevertheless, has not been explored in persons with rare late-onset neurological diseases, such as transthyretin-related familial amyloid polyneuropathy (TTR-FAP). This study aims at examining generativity in older individuals with TTR-FAP and consider its association with satisfaction with life and self-rated health. The method is descriptive-comparative, using a sample of persons without family history of a hereditary disease. A total of 69 adults were recruited: 31 with TTR-FAP (through the national patient's association); 38 non-TTR-FAP (through researchers' social networks). Participants completed self-administered questionnaires, assessing quantitative measures of generativity (Loyola Generative Scale, LGS, Portuguese version), satisfaction with life (Satisfaction with Life Scale, SWLS, Portuguese version), self-rated health (single item of self-perceived health), and social and demographic data. Main findings indicated that (i) no significant differences were found on generativity, satisfaction with life and self-rated health between older persons with and without TTR-FAP; (ii) generativity was positively correlated with satisfaction with life and satisfaction with life was positively correlated with self-rated health in older TTR-FAP adults, but not in the non-TTR-FAP group; (iii) from linear regression models, satisfaction with life was predicted by "hereditary disease (TTR-PAF)", "formal education (University degree)", "professional Status (retired)", and "age"; self-rated health was only predicted by related to "professional Status (retired)". Results contribute to building a body of work on the development and aging psychosocial experiences in individuals from families with severe hereditary diseases. Also, they are relevant for the provision of care to people living with hereditary conditions and their families. Generative members will be better positioned and may be involved in promoting healthier behaviors in their family members. [ABSTRACT FROM AUTHOR]

Juvenile diet can profoundly affect subsequent adult development, morphology and reproductive investment. Yet, little is known about how juvenile diet affects adult investment into chemical‐based sexual signalling, perhaps due to the historical assumption that pheromone production is not costly. We explored how juvenile diet influenced the reproductive investment of adults in the gumleaf skeletonizer moth, Uraba lugens. Juveniles were reared on different host plant species (Eucalyptus camaldulensis and Eucalyptus moorei) and on E. moorei host plants with different fertilizer treatments (fertilized and non‐fertilized). These juvenile diets differ in foliage carbon and nitrogen content. Several adult life history traits were influenced by juvenile diet, including body size in females, and longevity in males. However, we found no evidence from Y‐maze olfactometer assays that diet affected the attractiveness of female pheromones to males. Finally, host plant species affected male pre‐copulatory investment: males reared on E. moorei had longer antennae, but less dense sensilla. Combined, our experiments suggest that the effects of juvenile diet on investment in reproductive traits, including those associated with signalling, differ between males and females. Females allocate nutrients to adult body size, which determines fecundity. In contrast, males allocate nutrients to adult longevity and antennae size, both of which improve mate search and mating success. [ABSTRACT FROM AUTHOR]

Providing older people with quality long-term care (LTC) contributes to the Sustainable Development Goal (SDG) 3—Good Health and Well-being. Person-Centered Care (PCC) is the optimal approach that enhances the quality of life for older adults residing in LTC facilities. This study develops the Long-Term Care Unit Environment Assessment Tool (LTCU-EAT) to assess how LTC environments support PCC goals. The study was conducted in five steps. (1) Reviewing and revising assessment items based on existing literature; (2) Preliminary assessment and protocolling with expert opinions; (3) On-site assessments conducted by two raters among 21 LTC units across 13 facilities; (4) Reliability test of assessment items; (5) Scoring and reliability test of LTC unit samples. The LTCU-EAT, comprising 89 items distributed across 12 subscales within four themes, was developed based on a summary of 14 PCC goals. A total of 83 items (93.26%) demonstrated strong inter-rater reliability. The assessments of all LTC unit samples displayed good criterion-related validity. The LTCU-EAT is a valuable tool for conducting post-occupancy evaluation (POE) of LTC facilities, systematically evaluating the level of environment support for PCC, and providing empirical evidence for future research, policy and practice. [ABSTRACT FROM AUTHOR]

Rationale: Chronic obstructive pulmonary disease (COPD) has its origin in early life, and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposes a predisease state termed "pre-COPD." Objectives: We tested the hypothesis that susceptible young adults identified with chronic bronchitis and subtle lung function impairment will develop COPD later in life. Methods: We followed random individuals without COPD ages 20–50 years from two population-based cohorts from different smoking eras—the Copenhagen General Population Study from 2003 (N = 5,497) and the Copenhagen City Heart Study from 1976–1978 (N = 2,609)—for 10 and 25 years, for the development of COPD (FEV1/FVC <0.70) and COPD GOLD Stages 2–4 (additionally, FEV1 <80% predicted). Measurements and Main Results: After 10 years, 28% developed COPD and 13% developed COPD GOLD Stages 2–4 in individuals susceptible to COPD, compared with 8% and 1% in those without any susceptibility to COPD. Correspondingly, after 25 years, 22% versus 13% developed COPD and 20% versus 8% developed COPD GOLD Stages 2–4. More than half of incident COPD cases developed from a susceptible state. Compared with those without susceptibility to COPD, multivariable-adjusted odds ratios in those susceptible to COPD were 3.42 (95% confidence interval: 2.78–4.21) for COPD and 10.1 (6.77–15.2) for COPD GOLD Stages 2–4 after 10 years and were 1.54 (1.23–1.93) and 2.12 (1.64–2.73) after 25 years. The ability of a COPD risk score—consisting of the state of susceptibility to COPD with smoking and asthma as risk factors—to predict COPD later in life was high. Conclusions: Our study suggests the existence of a predisease state of COPD, which can be used for early identification of susceptible individuals at risk for COPD later in life. [ABSTRACT FROM AUTHOR]

Health researchers are encouraged by governments, funders, and journals to conduct research in partnership with people with lived experience. However, conducting research with authentic engagement and partnership with those who are experts by experience, but may not have research methods training, requires resources and specialized skills. The McMaster Collaborative for Health and Aging developed a fellowship program for trainees that builds their capacity to conduct research in partnership with older adults with relevant lived experience. We share this case example, with its successes and challenges, to encourage creative reformation of traditional research training. The Collaborative used an iterative design process, involving researchers, trainees and older adult and caregiver partners, who, together, developed a fellowship program for trainees that provides support and mentorship to plan and conduct health research in partnership with people with lived experience. Since 2022, the Partnership in Research Fellowship has been offered biannually. The application process was purposefully designed to be both constructive and supportive. Opportunities for one-on-one consultations; key resources, including a guide for developing a plan to involve people with relevant lived experience; and feedback from older adult and researcher reviewers are provided to all applicants. Successful trainees engage with older adult and caregiver partners from the Collaborative to advance and enhance a range of skills from facilitating partner meetings to forming advisory committees. Trainees are awarded $1500 CAD to foster reciprocal partnerships. Ten graduate students from various disciplines have participated. Trainees reported positive impacts on their knowledge, comfort, and approach to partnered research. However, the time required for undertaking partnered research activities and involving diverse partners remain obstacles to meaningful engagement. Partnering with people with lived experience in the design of educational programs embeds the principles of partnership and can increase the value and reward for all involved. We share the Partnership in Research Fellowship as a case example to inspire new and transformative approaches in research training and mentorship that will move the field forward from engagement theory to meaningful enactment. Plain English summary: Health researchers are encouraged by governments, funders, and journals to conduct research in partnership with individuals with relevant health conditions or experience. However, conducting research with individuals who are experts by experience, but may not have research training, requires resources and specialized skills. The McMaster Collaborative for Health and Aging developed a fellowship program to support and mentor trainees to conduct their research in partnership with people with lived experience and turn engagement theory into action. The Collaborative involved researchers, trainees, and older adults in the development of the fellowship program. Since 2022, the Partnership in Research Fellowship has been offered twice a year. The application process was designed to be both supportive and informative. Opportunities for one-on-one consultations; key resources, including guiding questions to consider when planning to involve people with relevant lived experience; and feedback from older adults and researchers, are provided to all applicants. Each trainee receives $1500 CAD to support building strong, two-way partnerships. Since the fellowship's launch, 10 graduate students from different fields have participated. Trainees reported improvements in their knowledge and comfort to partner with people with lived experience in research. However, challenges, such as the extra time needed for conducting partnered research as well as locating and involving those from diverse backgrounds, were identified. Involving people with lived experience in the design of research training incorporates partnership principles and may enhance the benefits and satisfaction for everyone involved. We share the Partnership in Research Fellowship, as an example, to inspire new approaches in research training and mentorship. [ABSTRACT FROM AUTHOR]

This study compared the perception of English semivowels /j/ and /w/ and their corresponding vowels /i/ and /u/ by two groups of Japanese-speaking learners of English: foreign language (FL) learners in Japan and second language learners who were initially FL learners (FL-L2). The phonological targets were /i/ and /u/ with and without preceding /j/ and /w/, respectively (/ji/-/i/ and /wu/-/u/). Discrimination and identification results showed that both groups performed comparably for /i/ with and without /j/, indicating their reliance on native phonological sensitivity to /i/ and /j/, which closely resemble Japanese /i/ and /j/. However, important differences emerged for /u/ with and without /w/, possibly due to articulatory differences in lip rounding for /u/ and /w/ between the two languages. Notably, while FL-L2 learners were equally competent in both the /u/-/wu/ and the /i/-/ji/ discriminations, FL learners were much less capable of the /u/-/wu/ discrimination than of the /i/-/ji/ discrimination. Moreover, FL-L2 learners were better at identifying /u/ than their FL peers, suggesting that L2 exposure may have facilitated their acquisition of the articulatory details associated with /u/. Overall, the study showed that engaging in L2 immersion following FL learning is beneficial for non-native phonological development among adult learners. [ABSTRACT FROM AUTHOR]

The brain of adult honeybee (Apis mellifera) workers is larger than that of queens, facilitating behavioural differentiation between the castes. This brain diphenism develops during the pharate‐adult stage and is driven by a caste‐specific gene expression cascade in response to unique hormonal milieus. Previous molecular screening identified minibrain (mnb; DYRK1A) as a potential regulator in this process. Here, we used RNAi approach to reduce mnb transcript levels and test its role on brain diphenism development in honeybees. White‐eyed unpigmented cuticle worker pupae were injected with dsRNA for mnb (Mnb‐i) or gfp, and their phenotypes were assessed two and 8 days later using classic histological and transcriptomic analyses. After 2 days of the injections, Mnb‐i bees showed 98% of downregulation of mnb transcripts. After 8 days, the brain of Mnb‐i bees showed reduction in total volume and in the volume of the mushroom bodies (MB), antennal, and optic lobes. Additionally, signs of apoptosis were observed in the Kenyon cells region of the MB, and the cohesion of the brain tissues was affected. Our transcriptomic analyses revealed that 226 genes were affected by the knockdown of mnb transcripts, most of which allowing axonal fasciculation. These results suggest the evolutionary conserved mnb gene has been co‐opted for promoting hormone‐mediated developmental brain morphological plasticity generating caste diphenism in honeybees. [ABSTRACT FROM AUTHOR]

Loss of function (LoF) mutations affecting the histone methyl transferase SETD1A are implicated in the aetiology of a range of neurodevelopmental disorders including schizophrenia. We examined indices of development and adult behaviour in a mouse model of Setd1a haploinsufficiency, revealing a complex pattern of sex-related differences spanning the pre- and post-natal period. Specifically, male Setd1a+/- mice had smaller placentae at E11.5 and females at E18.5 without any apparent changes in foetal size. In contrast, young male Setd1a+/- mice had lower body weight and showed enhanced growth, leading to equivalent weights by adulthood. Embryonic whole brain RNA-seq analysis revealed expression changes that were significantly enriched for mitochondria-related genes in Setd1a+/ samples. In adulthood, we found enhanced acoustic startle responding in male Setd1a+/- mice which was insentitive to the effects of risperidone, but not haloperidol, both commonly used antipsychotic drugs. We also observed reduced pre-pulse inhibition of acoustic startle, a schizophrenia-relevant phenotype, in both male and female Setd1a+/- mice which could not be rescued by either drug. In the open field and elevated plus maze tests of anxiety, Setd1a haplosufficiency led to more anxiogenic behaviour in both sexes, whereas there were no differences in general motoric ability and memory. Thus, we find evidence for changes in a number of phenotypes which strengthen the support for the use of Setd1a haploinsufficient mice as a model for the biological basis of schizophrenia. Furthermore, our data point towards possible underpinning neural and developmental mechanisms that may be subtly different between the sexes. [ABSTRACT FROM AUTHOR]

Background: Silver nanotechnology is widely applied in industry and medicine, with an increased likelihood of environmental and food contamination. Aim: This study aimed to explore the adverse effects of orally administering silver nanoparticles (AgNPs) to pregnant or lactating female rats on adults and the development of their offspring. Methods: Forty female albino rats were used to assess the immediate impacts of AgNPs in two separate experiments. The experimental group received 1 ml of AgNPs, dissolved in deionized water, at doses of 0, 50, and 100 mg/kg of body weight from the 6th to the 15th day of gestation in pregnant albino rats. After a 20-day gestation period, euthanasia was performed on the female rats, followed by a gross examination post-dissection. Results: The feti were preserved in ethyl alcohol and Poin’s solution for the identification of skeletal and visceral malformations. It was noticed that feti of dams that received AgNPs showed teratogenicities such as delayed ossification and deletion of bones or ribs. Notably, dams showed necrosis and satellitosis with evidence of behavioral alteration. While rats’ pups showed only brain edema and no behavioral changes. Conclusion: AgNPs at a dose of 50 or 100 mg/kg induced teratogenic effect in terms of delayed ossification, abnormal limb formation, and brain edema in rat pups, however, induced necrosis and satellitosis in dam rats. Hence, greater emphasis should be placed on preventing exposure to Ag-NPs, especially among pregnant females. [ABSTRACT FROM AUTHOR]

Aim: To investigate metabolic risk factors (RFs) that accumulated over 20 years related to left ventricular mass index (LVMI), relative wall thickness (RWT) and LV remodelling patterns in participants with versus without early‐onset type 2 diabetes (T2D) or prediabetes (pre‐D). Methods: A total of 287 early‐onset T2D/pre‐D individuals versus 565 sociodemographic‐matched euglycaemic individuals were selected from the Coronary Artery Risk Development in Young Adults (CARDIA) study, years 0‐25. We used the area under the growth curve (AUC) derived from quadratic random‐effects models of four or more repeated measures of RFs (fasting glucose [FG], insulin, triglycerides [TG], low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol (HDL‐c), total cholesterol (total‐c), blood pressure and body mass index) to estimate the cumulative burden, and their associations with LV outcomes. Results: One standard deviation greater AUC of log (TG) (per 0.48) and HDL‐c (per 13.5 mg/dL) were associated with RWT (β 0.21 and −0.2) in the early‐onset T2D/pre‐D group, but not in the euglycaemia group (β 0.01 and 0.05, P interactions.02 and.03). In both the early‐onset T2D/pre‐D and euglycaemia groups, greater AUCs of log (FG) (per 0.17) and log (insulin) (per 0.43) were associated with higher RWT (β ranges 0.12‐0.24). Greater AUCs of systolic blood pressure (per 10 mmHg) and diastolic blood pressure (per 7.3 mmHg) were associated with higher RWT and LVMI, irrespective of glycaemic status (β ranges 0.17‐0.28). Cumulative TG (odds ratio 3.4, 95% confidence interval: 1.8‐6.3), HDL‐c (0.23, 0.09‐0.59), total‐c (1.9, 1.1‐3.1) and FG (2.2, 1.25‐3.9) were statistically associated with concentric hypertrophy in the T2D/pre‐D group only. Conclusions: Sustained hyperglycaemia and hyperinsulinaemia are associated with RWT, and those individuals with early T2D/pre‐D are potentially at greater risk because of their higher levels of glucose and insulin. Dyslipidaemia was associated with LV structural abnormalities in those individuals with early‐onset T2D/pre‐D. [ABSTRACT FROM AUTHOR]

[Display omitted] • Cross-fostering induced social deficit involved in the vagal gut-to-brain axis in the adulthood of mice. • Gut-innervating sensory neurons connect with PVN oxytocin neurons across multiple synapses. • Sex-specific alteration in gut microbiota and its metabolites may be involved in social impairments and immune imbalances brought by cross-fostering via the gut-brain axis. • Cross-fostering social cognitive impairment may result from a combination of PVN oxytocinergic neurons, gut microbiota, and metabolites. The gut microbiota and neurological development of neonatal mice are susceptible to environmental factors that may lead to altered behavior into adulthood. However, the role that changed gut microbiota and neurodevelopment early in life play in this needs to be clarified. In this study, by modeling early-life environmental changes by cross-fostering BALB/c mice, we revealed the effects of the environment during the critical period of postnatal development on adult social behavior and their relationship with the gut microbiota and the nervous system. The neural projections exist between the ascending colon and oxytocin neurons in the paraventricular nuclei (PVN), peripheral oxytocin levels and PVN neuron numbers decreased after cross-fostering, and sex-specific alteration in gut microbiota and its metabolites may be involved in social impairments and immune imbalances brought by cross-fostering via the gut-brain axis. Our findings also suggest that social cognitive impairment may result from a combination of PVN oxytocinergic neurons, gut microbiota, and metabolites. [ABSTRACT FROM AUTHOR]

Polycyclic aromatic hydrocarbons (PAHs) are widespread globally, primarily due to long-term anthropogenic pollution sources. Since PAHs tend to accumulate in soil sediments, liverwort plants, such as Lunularia cruciata, are susceptible to their adverse effects, making them good models for bioindicators. The aim of this study was to probe the impact of anthracene, a three-ring linear PAH, on the growth parameters of L. cruciata and the relationship established with the internalization of the pollutant throughout the phenology of the plant. Intrinsic plant responses, isolated from external factors, were assessed in vitro. L. cruciata absorbed anthracene from the culture medium, and its bioaccumulation was monitored throughout the entire process, from the gemma germination stage to the development of the adult plant, over a total period of 60 days. Consequently, plants exposed to concentrations higher than 50 μM anthracene, decreased the growth area of the thallus, the biomass and number of tips. Moreover, anthracene also impinged on plant symmetry. This concentration represented the maximum limit of bioaccumulation in the tissues. This study provides the first evidence that architectural variables in liverwort plants are suitable parameters for their use as bioindicators of PAHs. [ABSTRACT FROM AUTHOR]

The leaf-mining microlepidopteran, Macrosaccus morrisella (Fitch) (Lepidoptera: Gracillariidae), has emerged as a new pest of soybean, Glycine max (L.) Merrill (Fabales: Fabaceae), in Canada and the United States, but little is known about its life history traits. Thus, this study was conducted to assess the immature developmental rate of M. morrisella , from egg to adult emergence, on soybean at different temperatures, and the longevity of adults supplied with water and/or honey at different temperatures. The time to 50% emergence of adults was 71.90, 36.33, 24.62, and 17.83 days at 15, 20, 25, and 30 °C, respectively. The lower developmental threshold of M. morrisella was estimated at 8.96 °C, with 425.04 degree-days required for egg-to-adult development. For adult longevity, time to 50% mortality at 25 °C was 15.00, 4.00, and 2.00 days when adults were provided with 25% (v/v) honey–water solution, water, or nothing, respectively. In a follow-up experiment, time to 50% mortality at 25 °C was 24.00, 6.00, 3.00, and 3.00 days when adults were provided with honey and water (offered separately), honey, water, or nothing, respectively, with a synergistic effect when honey and water were offered simultaneously as opposed to honey or water alone. Finally, when fed 25% (v/v) honey–water solution and maintained at 20, 25, and 30 °C, time to 50% mortality of adults was 26.50, 15.00, and 15.00 days. These results inform the understanding of the basic biology of M. morrisella and will help inform the future development of management programs for this insect in soybean. [ABSTRACT FROM AUTHOR]

The egg parasitoid Mesocomys trabalae Yao, Yang, and Zhao is used as a biocontrol agent against the emerging defoliator pest Caligula japonica Moore in East Asia. It has been proven that the eggs of Antheraea pernyi Guérin-Méneville can be used as a factitious host for the mass production of M. trabalae. We examined the parasitic behavior and morphological characteristics of the developmental stages of M. trabalae reared on A. pernyi eggs. The parasitic behavior of M. trabalae encompasses 10 steps, involving searching, antennation, locating the oviposition site, drilling, probing, detecting, oviposition, host feeding, grooming, and resting, with the oviposition step further divided into 3 stages. We determined that the parasitoid released an egg during the second stage of the oviposition step, while her body remained in a relatively static state. Among all the steps in parasitic behavior, probing occupied the longest time, accounting for 26.33% of the entire parasitism process. It was followed by oviposition (15.88%), drilling (15.10%), antennation (13.09%), detecting (10.79%), host feeding (10.02%), and the remaining steps, each occupying less than 5.00% of the total time in steps. The pre-emergence of adult M. trabalae comprised of 4 stages: egg (0–1 day), larva (2–6 days), prepupa (7–11 days), pupa (12–20 days), followed by the development into an adult, and it usually took 20–22 days to develop from an egg into an adult at 25°C. This study advances our understanding of the biology of Mesocomys parasitoids and their mass-rearing for use in augmentation programs. [ABSTRACT FROM AUTHOR]

Background: Hematopoiesis in mammal is a complex and highly regulated process in which hematopoietic stem cells (HSCs) give rise to all types of differentiated blood cells. Previous studies have shown that hairy and enhancer of split (HES) repressors are essential regulators of adult HSC development downstream of Notch signaling. Methods: In this study, we investigated the role of HES1, a member of HES family, in fetal hematopoiesis using an embryonic hematopoietic specific Hes1 conditional knockout mouse model by using phenotypic flow cytometry, histopathology analysis, and functional in vitro colony forming unit (CFU) assay and in vivo bone marrow transplant (BMT) assay. Results: We found that loss of Hes1 in early embryonic stage leads to smaller embryos and fetal livers, decreases hematopoietic stem progenitor cell (HSPC) pool, results in defective multi-lineage differentiation. Functionally, fetal hematopoietic cells deficient for Hes1 exhibit reduced in vitro progenitor activity and compromised in vivo repopulation capacity in the transplanted recipients. Further analysis shows that fetal hematopoiesis defects in Hes1fl/flFlt3Cre embryos are resulted from decreased proliferation and elevated apoptosis, associated with de-repressed HES1 targets, p27 and PTEN in Hes1-KO fetal HSPCs. Finally, pharmacological inhibition of p27 or PTEN improves fetal HSPCs function both in vitro and in vivo. Conclusion: Together, our findings reveal a previously unappreciated role for HES1 in regulating fetal hematopoiesis, and provide new insight into the differences between fetal and adult HSC maintenance. [ABSTRACT FROM AUTHOR]

Introduction: Obesity is a silent pandemic affecting all ages and is a component of metabolic syndrome. Its treatment is conducted by lifestyle and behavioral changes, pharmacological therapy, and when correctly indicated, bariatric surgery. In recent years, the procedures for weight loss have been investigated due to their relationship with the development of many types of cancer. Although many studies have shown that bariatric surgery decreases cancer risk, other researchers observed an increase in this association. Carcinogenesis is affected by many factors, such as age, sex, type of cancer, and the bariatric surgery performed on each patient. This systematic review and meta-analysis protocol aims to clarify the association between the different modalities of bariatric surgery and the risk of cancer development in adult patients with metabolic syndrome. Method and analysis: The proposed systematic review and meta-analysis will be reported conforming to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-P) guidelines. This research will include observational studies (case-control and cohort studies) about patients who undergo bariatric surgery due to metabolic syndrome. Will be accepted in any language and any year. Publications without peer review will be excluded from this review. Data will be entered into the Review Manager software (RevMan5.2.3). We extracted or calculated the OR and 95% CI for dichotomous outcomes for each study. In case of heterogeneity (I2>50%), the random-effects model will combine the studies to calculate the OR and 95% CI. Ethics and dissemination: This study will review the published data; Thus, obtaining ethical approval is unnecessary. The findings of this systematic review will be published in a peer-reviewed journal. Prospero registration number: CRD42023432079. [ABSTRACT FROM AUTHOR]

T cell development in the thymus is dependent on the thymic microenvironment, in which thymic epithelial cells (TECs) are the major component. However, TECs undergo both a qualitative and quantitative loss during aging, which is believed to be the major factor responsible for age-dependent thymic atrophy. FOXN1 plays a critical role in TEC development and adult TECs maintenance. We have previously reported that intrathymic injection of a recombinant (r) protein containing murine FOXN1 and a protein transduction domain increases the number of TECs in mice, leading to enhanced thymopoiesis. However, intrathymic injection may not be an ideal choice for clinical applications. In this study, we produced a rFOXN1 fusion protein containing the N-terminal of CCR9, human FOXN1 and a protein transduction domain. When injected intravenously into 14-month-old mice, the rFOXN1 fusion protein enters the thymus and TECs, and enhances thymopoiesis, resulting in increased T cell generation in the thymus and increased number of T cells in peripheral lymphoid organ. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in older adults. [ABSTRACT FROM AUTHOR]