1. Targeting Adipokines: A Promising Therapeutic Strategy for Epilepsy.
- Author
-
Shaikh I and Bhatt LK
- Subjects
- Humans, Animals, Apelin metabolism, Apelin therapeutic use, Anticonvulsants therapeutic use, Oxidative Stress drug effects, Oxidative Stress physiology, Nicotinamide Phosphoribosyltransferase metabolism, Leptin metabolism, Leptin therapeutic use, Adiponectin metabolism, Adiponectin therapeutic use, Epilepsy drug therapy, Epilepsy metabolism, Adipokines metabolism
- Abstract
Epilepsy affects 65 million people globally and causes neurobehavioral, cognitive, and psychological defects. Although research on the disease is progressing and a wide range of treatments are available, approximately 30% of people have refractory epilepsy that cannot be managed with conventional medications. This underlines the importance of further understanding the condition and exploring cutting-edge targets for treatment. Adipokines are peptides secreted by adipocyte's white adipose tissue, involved in controlling food intake and metabolism. Their regulatory functions in the central nervous system (CNS) are multifaceted and identified in several physiology and pathologies. Adipokines play a role in oxidative stress and neuroinflammation which are associated with brain degeneration and connected neurological diseases. This review aims to highlight the potential impacts of leptin, adiponectin, apelin, vaspin, visfatin, and chimerin in the pathogenesis of epilepsy., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF