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This paper focusses on the nonlinear fractional Kadomtsev-Petviashvili (FKP) equation in space-time, employing the conformable fractional derivative (CFD) approach. The main objective of this paper is to examine the application of the (G'/G)-expansion method in order to find analytical solutions to the FKP equation. The (G'/G)-expansion method is a powerful tool for constructing traveling wave solutions of nonlinear evolution equations. However, its application to the FKP equation remains relatively unexplored. By employing traveling wave transformation, the FKP equation was transformed into an ordinary differential equation (ODE) to acquire exact wave solutions. A range of exact analytical solutions for the FKP equation is obtained. Graphical illustrations are included to elucidate the physical characteristics of the acquired solutions. To demonstrate the impact of the fractional operator on results, the acquired solutions are exhibited for different values of the fractional order α, with a comparison to their corresponding exact solutions when taking the conventional scenario where α equals 1. The results indicate that the (G'/G)-expansion method serves as an efficient method and dependable in solving the nonlinear FKP equation. [ABSTRACT FROM AUTHOR]

Objective: To determine the utilization of barley and parsley for managing urolithiasis among the Saudi Arabian population. Methods: This is a prospective cross-sectional survey-based study. The survey comprised questions about the use of barley, parsley, and other therapies for managing urolithiasis. A WhatsApp® message with the link to the study survey was sent out to family, friends, patients, and other acquaintances residing in the Kingdom of Saudi Arabia (KSA). Results: A total of 1014 respondents completed the survey, of which 44.8% indicated that they utilized barley, 38.3% stated that they used parsley, and 4.2% indicated that they utilized other non-medical remedies to treat or prevent kidney stones. In contrast, only 29.5% stated that they utilized potassium citrate and/or magnesium citrate, and only 14.4% indicated that they consumed greater amounts of water to treat or prevent kidney stones. Conclusion: Our study findings indicate that among the Saudi Arabian population, non-conventional therapies such as barley and parsley are more commonly utilized for managing urolithiasis rather than established therapies such as increasing water intake and the use of potassium-citrate/magnesium-citrate. There is a need to conduct large-scale clinical studies to evaluate the efficacy and safety of barley, parsley, and other non-conventional therapies for treating urolithiasis. [ABSTRACT FROM AUTHOR]

Objectives: To identify and review the most up‐to‐date guidelines pertaining to bladder trauma in a unifying document as an updated primer in the management of all aspects relating to bladder injury. Methods: In accordance with the PRISMA statement, the most recent guidelines pertaining to bladder injury were identified and subsequently critically appraised. An electronic search of PubMed and Scopus databases was carried out in September 2023. Results: A total of six guidelines were included: European Association of Urology (EAU) guidelines on urological trauma (2023), EAU guidelines on paediatric urology (2022), Urotrauma: American Urological Association (AUA) (2020), Kidney and Uro‐trauma: World Society of Emergency Surgery and the American Association for the Surgery of Trauma (WSES‐AAST) guidelines (2019), Management of blunt force bladder injuries: A practice management guideline from the Eastern Association for the Surgery of Trauma (EAST) (2019), and EAU guidelines on iatrogenic trauma (2012). Recommendations were summarised with the associated supporting level of evidence and strength of recommendation where available. Conclusion: Several widely recognised professional organisations have published guidelines relating to the diagnosis, investigation, classification, management, and follow‐up related to bladder injury. There is consensus amongst all major guidelines in terms of diagnosis and management but there is some discrepancy and lack of recommendation with regards to the follow‐up of bladder injuries, iatrogenic bladder injury, paediatric bladder trauma, and spontaneous bladder rupture. The role of increasing minimally invasive techniques seem to be gaining traction in the select haemodynamically stable patient. Further research is required to better delineate this treatment option. [ABSTRACT FROM AUTHOR]

Mutations in isocitrate dehydrogenase 1 (IDH1) impart a neomorphic reaction that produces D-2-hydroxyglutarate (D2HG), which can inhibit DNA demethylases to drive tumorigenesis. Mutations affect residue R132 and display distinct catalytic profiles for D2HG production. We show that catalytic efficiency of D2HG production is greater in IDH1 R132Q than R132H mutants, and expression of R132Q in cellular and xenograft models leads to higher D2HG concentrations in cells, tumors, and sera compared to R132H. Though expression of IDH1 R132Q leads to hypermethylation in DNA damage pathways, DNA hypomethylation is more notable when compared to R132H expression. Transcriptome analysis shows increased expression of many pro-tumor pathways upon expression of IDH1 R132Q versus R132H, including transcripts of EGFR and PI3K signaling pathways. Thus, IDH1 mutants appear to modulate D2HG levels via altered catalysis, resulting in distinct epigenetic and transcriptomic consequences where higher D2HG levels appear to be associated with more aggressive tumors., Competing Interests: Competing interests The authors declare no competing interests.