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Objective: This systematic review explores the intricate relationship between body composition, with a specific focus on skeletal muscle mass, and vascular health indices, including measures of arterial stiffness-pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI)-as well as arterial structure, specifically carotid artery intima-media thickness (cIMT)., Methods: An extensive literature search, encompassing PubMed, Scopus, EMBASE, Web of Science, and Google Scholar, was conducted until January 2024. Inclusion criteria involved original observational studies, with cross-sectional or longitudinal designs, reporting body composition parameters and vascular health measures. The Newcastle-Ottawa Scale (NOS) assessed study quality. Statistical analyses utilized Stata 17.0, employing random-effects meta-analysis, sensitivity analysis, and evaluation of publication bias., Results: Fifteen observational studies (n = 21,215) met the inclusion criteria. Pooled analyses revealed a positive association between fat-free mass (FFM) and carotid intima-media thickness (IMT) (effect size [ES]: 1.79, 95% CI 1.68-1.91), highlighting a relationship with arterial structure. Similarly, body fat percentage (BFP) was positively associated with PWV (ES: 1.45, 95% CI 1.15-1.82), and FFM showed a positive association with CAVI (ES: 1.46, 95% CI 0.78-2.71), both measures of arterial stiffness. Subgroup analyses revealed a non-significant association between appendicular skeletal muscle (ASM) and IMT (ES: 1.01, 95% CI 0.76-1.35)., Conclusion: This meta-analysis highlights the complex relationship between body composition and vascular health. Subgroup analyses suggest the need for further research into specific body composition indices and their clinical implications., Level of Evidence: III evidence obtained from well-designed cohort and cross-sectional studies., Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors have given consent for the paper to be published by the corresponding author. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

Objective: To evaluate the Neuropathy Score-Reporting and Data System (NS-RADS) MRI grading system in conjunction with electrodiagnostic (EDx) testing for radial neuropathy at the elbow., Materials and Methods: Patients presenting between 2010 and 2023 with suspected radial neuropathy who underwent both EDx testing in the form of electromyography and nerve conduction studies and MRI within a 12-month period were evaluated. Three blinded radiologists used the NS-RADS grading system to evaluate nerve entrapment (E grades), muscle denervation (M grades) proximally within the supinator/extensor carpi radialis brevis (ECRB), and more distally within the forearm extensor muscles. These grades and the presence of lateral epicondylitis were then correlated with EDx abnormalities., Results: Forty-nine participants were included. Inter-reader reliability for M grades in the forearm extensor muscles was good (ICC = 0.90 [95% CI = 0.83 - 0.94], p < 0.001), as was reliability for the supinator/ECRB muscles (ICC = 0.91 [95% CI = 0.86-0.95], p < 0.001). Inter-reader reliability for E grades was moderate (ICC = 0.83 [95% CI = 0.69-0.90], p < 0.001). Patients with positive EDx studies had a significantly different distribution of M grades for the forearm extensors and supinator/ECRB than those with negative studies (all p values < 0.001). However, overall consensus reads showed no significant difference in the distribution of E grades between patients with positive and negative EDx studies., Conclusion: Muscle grading strongly correlated with EDx positivity, with a high level of inter-reader agreement for muscle denervation-related alterations. Nerve grading, however, did not show a statistical correlation., Competing Interests: Declarations. Ethical approval: All procedures performed in studies involving human subjects were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the IRB. Conflict of interest: The authors declare no competing interests., (© 2025. The Author(s), under exclusive licence to International Skeletal Society (ISS).)