Search

Your search keyword '"A De Rosa"' showing total 150 results
Start Over Author "A De Rosa" Publication Year Range This year
150 results on '"A De Rosa"'

1. Achronal localization and representation of the causal logic from conserved current, application to massive scalar boson

Author

Castrigiano, Domenico P. L., De Rosa, Carmine, and Moretti, Valter

Subjects
Mathematical Physics, High Energy Physics - Theory, Quantum Physics
Abstract

Covariant achronal localizations are gained out of covariant conserved currents computing their flux passing through achronal surfaces. This general method applies to the probability density currents with causal kernel regarding the massive scalar boson. Due to the one-to-one correspondence between (covariant) achronal localizations and (covariant) representations of the causal logic thus, apparently for the first time, a covariant representation of the causal logic for an elementary relativistic quantum mechanical system has been achieved. Similarly one derives the covariant family of representations of the causal logic related to the stress energy tensor of the massive scalar boson. While reaching this result the divergence theorem is proven for open sets with almost Lipschitz boundary., Comment: 18 pages, references added

Published
2025

2. Diffraction of Light from Optical Fourier Surfaces

Author

Glauser, Yannik M., Maris, J. J. Erik, Brechbühler, Raphael, Crimmann, Juri G., De Rosa, Valentina G., Petter, Daniel, Nagamine, Gabriel, Lassaline, Nolan, and Norris, David J.

Subjects
Physics - Optics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Diffractive surfaces shape optical wavefronts for applications in spectroscopy, high-speed communication, and imaging. The performance of these structures is primarily determined by how precisely they can be patterned. Fabrication constraints commonly lead to square-shaped, "binary" profiles that contain unwanted spatial frequencies that contaminate the diffraction. Recently, "wavy" surfaces (known as optical Fourier surfaces, OFSs) have been introduced that include only the desired spatial frequencies. However, the optical performance and reliability of these structures have not yet been experimentally tested with respect to models and simulations. Such a quantitative investigation could also provide previously unobtainable information about the diffraction process from the most fundamental diffractive surfaces$\unicode{x2014}$sinusoidally pure profiles. Here, we produce and study two classes of reflective OFSs: (i) single-sinusoidal profiles of varying depth and (ii) double-sinusoidal profiles with varying relative phase. After refining our fabrication procedure to obtain larger and deeper OFSs at higher yields, we find that the measured optical responses from our OFSs agree quantitatively with full electrodynamic simulations. In contrast, our measurements diverge from analytical scalar diffraction models routinely used by researchers to describe diffraction. Overall, our results confirm that OFSs provide a precise and powerful platform for Fourier-spectrum engineering, satisfying the growing demand for intricately patterned interfaces for applications in holography, augmented reality, and optical computing.

Published
2025

3. XMM/HST monitoring of the ultra-soft highly accreting Narrow Line Seyfert 1 RBS 1332

Author

Middei, R., Barnier, S., Saturni, F. G., Ursini, F., Petrucci, P. -O., Bianchi, S., Cappi, M., Clavel, M., De Marco, B., De Rosa, A., Matt, G., Matzeu, G. A., and Perri, M.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Ultra-soft narrow line Seyfert 1 (US-NLSy) are a poorly observed class of active galactic nuclei characterized by significant flux changes and an extreme soft X-ray excess. This peculiar spectral shape represents a golden opportunity to test whether the standard framework commonly adopted for modelling local AGN is still valid. We thus present the results on the joint XMM-Newton and HST monitoring campaign of the highly accreting US-NLSy RBS 1332. The optical-to-UV spectrum of RBS 1332 exhibits evidence of both a stratified narrow-line region and an ionized outflow, that produces absorption troughs over a wide range of velocities (from ~1500 km s-1 to ~1700 km s-1) in several high-ionization transitions (Lyalpha, N V, C IV). From a spectroscopic point of view, the optical/UV/FUV/X-rays emission of this source is due to the superposition of three distinct components which are best modelled in the context of the two-coronae framework in which the radiation of RBS 1332 can be ascribed to a standard outer disk, a warm Comptonization region and a soft coronal continuum. The present dataset is not compatible with a pure relativistic reflection scenario. Finally, the adoption of the novel model reXcor allowed us to determine that the soft X-ray excess in RBS 1332 is dominated by the emission of the optically thick and warm Comptonizing medium, and only marginal contribution is expected from relativistic reflection from a lamppost-like corona., Comment: 13 pages, 9 figures, accepted in A&A

Published
2025

4. The ENUBET monitored neutrino beam and its implementation at CERN

Author

ENUBET collaboration, Halić, L., Acerbi, F., Angelis, I., Bomben, L., Bonesini, M., Bramati, F., Branca, A., Brizzolari, C., Brunetti, G., Calviani, M., Capelli, S., Capitani, M., Carturan, S., Catanesi, M. G., Cecchini, S., Charitonidis, N., Cindolo, F., Cogo, G., Collazuol, G., Corso, F. Dal, Delogu, C., De Rosa, G., Falcone, A., Goddard, B., Gola, A., Guffanti, D., Iacob, F., Jebramcik, M. A., Jollet, C., Kain, V., Kallitsopoulou, A., Kliček, B., Kudenko, Y., Lampoudis, Ch., Laveder, M., Legou, P., Longhin, A., Ludovici, L., Lutsenko, E., Magaletti, L., Mandrioli, G., Marangoni, S., Margotti, A., Mascagna, V., Mauri, N., McElwee, J., Meazza, L., Meregaglia, A., Mezzetto, M., Nessi, M., Paoloni, A., Pari, M., Papaevangelou, T., Parozzi, E. G., Pasqualini, L., Paternoster, G., Patrizii, L., Pozzato, M., Prest, M., Pupilli, F., Radicioni, E., Ruggeri, A. C., Saibene, G., Sampsonidis, D., Scanu, A., Scian, C., Sirri, G., Speziali, R., Stipčević, M., Tenti, M., Terranova, F., Torti, M., Tzamarias, S. E., Vallazza, E., Velotti, F., and Votano, L.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The ENUBET project recently concluded the R&D for a site independent design of a monitored neutrino beam for high precision cross section measurements, in which the neutrino flux is inferred from the measurement of charged leptons in an instrumented decay tunnel. In this phase three fundamental results were obtained and will be discussed here: 1) a beamline not requiring a horn and relying on static focusing elements allows to perform a $\nu_e$ cross section measurement in the DUNE energy range with 1% statistical uncertainty employing $10^{20}$ 400 GeV protons on target (pot) and a neutrino detector of the size of ProtoDUNE; 2) the instrumentation of the decay tunnel, based on a cost effective sampling calorimeter solution, has been tested with a large scale prototype achieving the performance required to identify positrons and muons from kaon decays with high signal-to-noise ratio; 3) the systematics budget on the neutrino flux is constrained at the 1% level by fitting the charged leptons observables measured in the decay tunnel. Based on these successful results ENUBET is now pursuing a study for a site dependent implementation at CERN in the framework of Physics Beyond Colliders. In this context a new beamline, able to enrich the neutrino flux at the energy of HK and to reduce by more than a factor 3 the needed pot, has been designed and is being optimized. The civil engineering and radioprotection studies for the siting of ENUBET in the North Area towards the two ProtoDUNEs are also in the scope of this work, with the goal of proposing a neutrino cross section experiment in 2026. The combined use of both the neutrino detectors and of the improved beamline would allow to perform cross section measurements with unprecedented precision in about 5 years with a proton request compatible with the needs of other users after CERN Long Shutdown 3., Comment: Conference proceedings for the 25th International Workshop on Neutrinos from Accelerators (NuFact 2024)

Published
2025

5. Search for continuous gravitational waves from known pulsars in the first part of the fourth LIGO-Virgo-KAGRA observing run

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abac, A. G., Abbott, R., Abouelfettouh, I., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Agarwal, D., Agathos, M., Abchouyeh, M. Aghaei, Aguiar, O. D., Aguilar, I., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Al-Shammari, S., Altin, P. A., Alvarez-Lopez, S., Amato, A., Amez-Droz, L., Amorosi, A., Amra, C., Ananyeva, A., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Anglin, J., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Argianas, L., Aritomi, N., Armato, F., Arnaud, N., Arogeti, M., Aronson, S. M., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Attadio, F., Aubin, F., AultONeal, K., Avallone, G., Babak, S., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bagui, E., Baier, J. G., Baiotti, L., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartoletti, A. M., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bates, D. E., Bawaj, M., Baxi, P., Bayley, J. C., Baylor, A. C., Baynard II, P. A., Bazzan, M., Bedakihale, V. M., Beirnaert, F., Bejger, M., Belardinelli, D., Bell, A. S., Benedetto, V., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bhowmick, S., Bianchi, A., Bilenko, I. A., Billingsley, G., Binetti, A., Bini, S., Birnholtz, O., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blagg, L. A., Blair, C. D., Blair, D. G., Bobba, F., Bode, N., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bolliand, A., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, M. S., Bonino, A., Bonnand, R., Booker, P., Borchers, A., Boschi, V., Bose, S., Bossilkov, V., Boudart, V., Boudon, A., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brandt, J., Braun, I., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brockmueller, E., Brooks, A. F., Brown, B. C., Brown, D. D., Brozzetti, M. L., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cáceres-Barbosa, V., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannon, K. C., Cao, H., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carrillo, G., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakraborty, P., Subrahmanya, S. Chalathadka, Chan, J. C. L., Chan, M., Chandra, K., Chang, R. -J., Chao, S., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chen, A., Chen, A. H. -Y., Chen, D., Chen, H., Chen, H. Y., Chen, J., Chen, K. H., Chen, Y., Chen, Yanbei, Chen, Yitian, Cheng, H. P., Chessa, P., Cheung, H. T., Cheung, S. Y., Chiadini, F., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Chou, C., Choudhary, S., Christensen, N., Chua, S. S. Y., Chugh, P., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciolfi, R., Clara, F., Clark, J. A., Clarke, J., Clarke, T. A., Clearwater, P., Clesse, S., Coccia, E., Codazzo, E., Cohadon, P. -F., Colace, S., Colleoni, M., Collette, C. G., Collins, J., Colloms, S., Colombo, A., Colpi, M., Compton, C. M., Connolly, G., Conti, L., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Costa, C. A., Cottingham, R., Coughlin, M. W., Couineaux, A., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, R., Craig, K., Creed, R., Creighton, J. D. E., Creighton, T. D., Cremonese, P., Criswell, A. W., Crockett-Gray, J. C. G., Crook, S., Crouch, R., Csizmazia, J., Cudell, J. R., Cullen, T. J., Cumming, A., Cuoco, E., Cusinato, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Pra, S. Dal, Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Dartez, L. P., Dasgupta, A., Datta, S., Dattilo, V., Daumas, A., Davari, N., Dave, I., Davenport, A., Davier, M., Davies, T. F., Davis, D., Davis, L., Davis, M. C., Davis, P. J., Dax, M., De Bolle, J., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., De Lillo, F., Dell'Aquila, D., Del Pozzo, W., De Marco, F., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., DePergola, N., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhani, A., Diab, R., Díaz, M. C., Di Cesare, M., Dideron, G., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Michele, A., Ding, J., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Dominguez, D., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Ducoin, J. -G., Dunn, L., Dupletsa, U., D'Urso, D., Duval, H., Duverne, P. -A., Dwyer, S. E., Eassa, C., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Einsle, H., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Eleveld, R. M., Emma, M., Endo, K., Engl, A. J., Enloe, E., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, M., Evstafyeva, T., Ewing, B. E., Ezquiaga, J. M., Fabrizi, F., Faedi, F., Fafone, V., Fairhurst, S., Farah, A. M., Farr, B., Farr, W. M., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Felicetti, R., Fenyvesi, E., Ferguson, D. L., Ferraiuolo, S., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Foley, E. M., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franceschetti, K., Franchini, N., Frasca, S., Frasconi, F., Mascioli, A. Frattale, Frei, Z., Freise, A., Freitas, O., Frey, R., Frischhertz, W., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fuentes-Garcia, M., Fujii, S., Fujimori, T., Fulda, P., Fyffe, M., Gadre, B., Gair, J. R., Galaudage, S., Galdi, V., Gallagher, H., Gallardo, S., Gallego, B., Gamba, R., Gamboa, A., Ganapathy, D., Ganguly, A., Garaventa, B., García-Bellido, J., Núñez, C. García, García-Quirós, C., Gardner, J. W., Gardner, K. A., Gargiulo, J., Garron, A., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., Gennari, V., George, J., George, R., Gerberding, O., Gergely, L., Ghosh, Archisman, Ghosh, Sayantan, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Suprovo, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gibson, D. T., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Glotin, F., Godfrey, J., Godwin, P., Goebbels, N. L., Goetz, E., Golomb, J., Lopez, S. Gomez, Goncharov, B., Gong, Y., González, G., Goodarzi, P., Goode, S., Goodwin-Jones, A. W., Gosselin, M., Göttel, A. S., Gouaty, R., Gould, D. W., Govorkova, K., Goyal, S., Grace, B., Grado, A., Graham, V., Granados, A. E., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, A., Gray, C., Gray, R., Greco, G., Green, A. C., Green, S. M., Green, S. R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grimaud, C., Grote, H., Guerra, D., Guetta, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H., Guo, W., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, Ish, Gupta, N. C., Gupta, P., Gupta, S. K., Gupta, T., Gupte, N., Gurs, J., Gutierrez, N., Guzman, F., H, H. -Y., Haba, D., Haberland, M., Haino, S., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hanselman, A. G., Hansen, H., Hanson, J., Harada, R., Hardison, A. R., Haris, K., Harmark, T., Harms, J., Harry, G. M., Harry, I. W., Hart, J., Haskell, B., Haster, C. -J., Hathaway, J. S., Haughian, K., Hayakawa, H., Hayama, K., Hayes, R., Heffernan, A., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Henderson-Sapir, O., Hendry, M., Heng, I. S., Hennes, E., Henshaw, C., Hertog, T., Heurs, M., Hewitt, A. L., Heyns, J., Higginbotham, S., Hild, S., Hill, S., Himemoto, Y., Hirata, N., Hirose, C., Ho, W. C. G., Hoang, S., Hochheim, S., Hofman, D., Holland, N. A., Holley-Bockelmann, K., Holmes, Z. J., Holz, D. E., Honet, L., Hong, C., Hornung, J., Hoshino, S., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hrishikesh, C. A., Hsieh, H. -F., Hsiung, C., Hsu, H. C., Hsu, W. -F., Hu, P., Hu, Q., Huang, H. Y., Huang, Y. -J., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huxford, R., Huynh-Dinh, T., Iampieri, L., Iandolo, G. A., Ianni, M., Iess, A., Imafuku, H., Inayoshi, K., Inoue, Y., Iorio, G., Iqbal, M. H., Irwin, J., Ishikawa, R., Isi, M., Ismail, M. A., Itoh, Y., Iwanaga, H., Iwaya, M., Iyer, B. R., JaberianHamedan, V., Jacquet, C., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, T., James, A. L., James, P. A., Jamshidi, R., Janquart, J., Janssens, K., Janthalur, N. N., Jaraba, S., Jaranowski, P., Jaume, R., Javed, W., Jennings, A., Jia, W., Jiang, J., Jin, H., Kubisz, J., Johanson, C., Johns, G. R., Johnson, N. A., Johnston, M. C., Johnston, R., Johny, N., Jones, D. H., Jones, D. I., Jones, R., Jose, S., Joshi, P., Ju, L., Jung, K., Junker, J., Juste, V., Kajita, T., Kaku, I., Kalaghatgi, C., Kalogera, V., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, T., Katsavounidis, E., Katzman, W., Kaushik, R., Kawabe, K., Kawamoto, R., Kazemi, A., Keitel, D., Kelley-Derzon, J., Kennington, J., Kesharwani, R., Key, J. S., Khadela, R., Khadka, S., Khalili, F. Y., Khan, F., Khan, I., Khanam, T., Khursheed, M., Khusid, N. M., Kiendrebeogo, W., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, M. H., Kim, S., Kim, Y. -M., Kimball, C., Kinley-Hanlon, M., Kinnear, M., Kissel, J. S., Klimenko, S., Knee, A. M., Knust, N., Kobayashi, K., Koch, P., Koehlenbeck, S. M., Koekoek, G., Kohri, K., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kong, A. K. H., Kontos, A., Korobko, M., Kossak, R. V., Kou, X., Koushik, A., Kouvatsos, N., Kovalam, M., Kozak, D. B., Kranzhoff, S. L., Kringel, V., Krishnendu, N. V., Królak, A., Kruska, K., Kuehn, G., Kuijer, P., Kulkarni, S., Ramamohan, A. Kulur, Kumar, A., Kumar, Praveen, Kumar, Prayush, Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuntimaddi, N., Kuroyanagi, S., Kurth, N. J., Kuwahara, S., Kwak, K., Kwan, K., Kwok, J., Lacaille, G., Lagabbe, P., Laghi, D., Lai, S., Laity, A. H., Lakkis, M. H., Lalande, E., Lalleman, M., Lalremruati, P. C., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rana, A., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Lawrence, J., Lawrence, M. N., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Lecoeuche, Y. K., Lee, H. M., Lee, H. W., Lee, K., Lee, R. -K., Lee, R., Lee, S., Lee, Y., Legred, I. N., Lehmann, J., Lehner, L., Jean, M. Le, Lemaître, A., Lenti, M., Leonardi, M., Lequime, M., Leroy, N., Lesovsky, M., Letendre, N., Lethuillier, M., Levin, S. E., Levin, Y., Leyde, K., Li, A. K. Y., Li, K. L., Li, T. G. F., Li, X., Li, Z., Lihos, A., Lin, C-Y., Lin, C. -Y., Lin, E. T., Lin, F., Lin, H., Lin, L. C. -C., Lin, Y. -C., Linde, F., Linker, S. D., Littenberg, T. B., Liu, A., Liu, G. C., Liu, Jian, Villarreal, F. Llamas, Llobera-Querol, J., Lo, R. K. L., Locquet, J. -P., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Lorenzo-Medina, A., Loriette, V., Lormand, M., Losurdo, G., Lott IV, T. P., Lough, J. D., Loughlin, H. A., Lousto, C. O., Lowry, M. J., Lu, N., Lück, H., Lumaca, D., Lundgren, A. P., Lussier, A. W., Ma, L. -T., Ma, S., Ma'arif, M., Macas, R., Macedo, A., MacInnis, M., Maciy, R. R., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Macri, D., Maeda, K., Maenaut, S., Hernandez, I. Magaña, Magare, S. S., Magazzù, C., Magee, R. M., Maggio, E., Maggiore, R., Magnozzi, M., Mahesh, M., Mahesh, S., Maini, M., Majhi, S., Majorana, E., Makarem, C. N., Makelele, E., Malaquias-Reis, J. A., Mali, U., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mannix, B., Mansell, G. L., Mansingh, G., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Pina, D. Marín, Marion, F., Márka, S., Márka, Z., Markosyan, A. S., Markowitz, A., Maros, E., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, B. B., Martinez, M., Martinez, V., Martini, A., Martinovic, K., Martins, J. C., Martynov, D. V., Marx, E. J., Massaro, L., Masserot, A., Masso-Reid, M., Mastrodicasa, M., Mastrogiovanni, S., Matcovich, T., Matiushechkina, M., Matsuyama, M., Mavalvala, N., Maxwell, N., McCarrol, G., McCarthy, R., McClelland, D. E., McCormick, S., McCuller, L., McEachin, S., McElhenny, C., McGhee, G. I., McGinn, J., McGowan, K. B. M., McIver, J., McLeod, A., McRae, T., Meacher, D., Meijer, Q., Melatos, A., Mellaerts, S., Menendez-Vazquez, A., Menoni, C. S., Mera, F., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Mérou, J. R., Merritt, J. D., Merzougui, M., Messenger, C., Messick, C., Metzler, Z., Meyer-Conde, M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Miller, A. L., Miller, S., Millhouse, M., Milotti, E., Milotti, V., Minenkov, Y., Mio, N., Mir, Ll. M., Mirasola, L., Miravet-Tenés, M., Miritescu, C. -A., Mishra, A. K., Mishra, A., Mishra, C., Mishra, T., Mitchell, A. L., Mitchell, J. G., Mitra, S., Mitrofanov, V. P., Mittleman, R., Miyakawa, O., Miyamoto, S., Miyoki, S., Mo, G., Mobilia, L., Mohapatra, S. R. P., Mohite, S. R., Molina-Ruiz, M., Mondal, C., Mondin, M., Montani, M., Moore, C. J., Moraru, D., More, A., More, S., Moreno, G., Morgan, C., Morisaki, S., Moriwaki, Y., Morras, G., Moscatello, A., Mourier, P., Mours, B., Mow-Lowry, C. M., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Samanwaya, Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Mundi, J., Mungioli, C. L., Oberg, W. R. Munn, Murakami, Y., Murakoshi, M., Murray, P. G., Muusse, S., Nabari, D., Nadji, S. L., Nagar, A., Nagarajan, N., Nagler, K. N., Nakagaki, K., Nakamura, K., Nakano, H., Nakano, M., Nandi, D., Napolano, V., Narayan, P., Nardecchia, I., Narikawa, T., Narola, H., Naticchioni, L., Nayak, R. K., Neilson, J., Nelson, A., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, S., Quynh, L. Nguyen, Nichols, S. A., Nielsen, A. B., Nieradka, G., Niko, A., Nishino, Y., Nishizawa, A., Nissanke, S., Nitoglia, E., Niu, W., Nocera, F., Norman, M., North, C., Novak, J., Siles, J. F. Nuño, Nuttall, L. K., Obayashi, K., Oberling, J., O'Dell, J., Oertel, M., Offermans, A., Oganesyan, G., Oh, J. J., Oh, K., O'Hanlon, T., Ohashi, M., Ohkawa, M., Ohme, F., Oliveira, A. S., Oliveri, R., O'Neal, B., Oohara, K., O'Reilly, B., Ormsby, N. D., Orselli, M., O'Shaughnessy, R., O'Shea, S., Oshima, Y., Oshino, S., Ossokine, S., Osthelder, C., Ota, I., Ottaway, D. J., Ouzriat, A., Overmier, H., Owen, B. J., Pace, A. E., Pagano, R., Page, M. A., Pai, A., Pal, A., Pal, S., Palaia, M. A., Pálfi, M., Palma, P. P., Palomba, C., Palud, P., Pan, H., Pan, J., Pan, K. C., Panai, R., Panda, P. K., Pandey, S., Panebianco, L., Pang, P. T. H., Pannarale, F., Pannone, K. A., Pant, B. C., Panther, F. H., Paoletti, F., Paolone, A., Papalexakis, E. E., Papalini, L., Papigkiotis, G., Paquis, A., Parisi, A., Park, B. -J., Park, J., Parker, W., Pascale, G., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passenger, L., Passuello, D., Patane, O., Pathak, D., Pathak, M., Patra, A., Patricelli, B., Patron, A. S., Paul, K., Paul, S., Payne, E., Pearce, T., Pedraza, M., Pegna, R., Pele, A., Arellano, F. E. Peña, Penn, S., Penuliar, M. D., Perego, A., Pereira, Z., Perez, J. J., Périgois, C., Perna, G., Perreca, A., Perret, J., Perriès, S., Perry, J. W., Pesios, D., Petracca, S., Petrillo, C., Pfeiffer, H. P., Pham, H., Pham, K. A., Phukon, K. S., Phurailatpam, H., Piarulli, M., Piccari, L., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierra, G., Pierro, V., Pietrzak, M., Pillas, M., Pilo, F., Pinard, L., Pinto, I. M., Pinto, M., Piotrzkowski, B. J., Pirello, M., Pitkin, M. D., Placidi, A., Placidi, E., Planas, M. L., Plastino, W., Poggiani, R., Polini, E., Pompili, L., Poon, J., Porcelli, E., Porter, E. K., Posnansky, C., Poulton, R., Powell, J., Pracchia, M., Pradhan, B. K., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Prasia, P., Pratten, G., Principe, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Puecher, A., Pullin, J., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Quéméner, G., Quetschke, V., Quigley, C., Quinonez, P. J., Raab, F. J., Raabith, S. S., Raaijmakers, G., Raja, S., Rajan, C., Rajbhandari, B., Ramirez, K. E., Vidal, F. A. Ramis, Ramos-Buades, A., Rana, D., Ranjan, S., Ransom, K., Rapagnani, P., Ratto, B., Rawat, S., Ray, A., Raymond, V., Razzano, M., Read, J., Payo, M. Recaman, Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Relton, P., Renzini, A. I., Rettegno, P., Revenu, B., Reyes, R., Rezaei, A. S., Ricci, F., Ricci, M., Ricciardone, A., Richardson, J. W., Richardson, M., Rijal, A., Riles, K., Riley, H. K., Rinaldi, S., Rittmeyer, J., Robertson, C., Robinet, F., Robinson, M., Rocchi, A., Rolland, L., Rollins, J. G., Romano, A. E., Romano, R., Romero, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Roocke, T. J., Rosa, L., Rosauer, T. J., Rose, C. A., Rosińska, D., Ross, M. P., Rossello, M., Rowan, S., Roy, S. K., Roy, S., Rozza, D., Ruggi, P., Ruhama, N., Morales, E. Ruiz, Ruiz-Rocha, K., Sachdev, S., Sadecki, T., Sadiq, J., Saffarieh, P., Sah, M. R., Saha, S. S., Saha, S., Sainrat, T., Menon, S. Sajith, Sakai, K., Sakellariadou, M., Sakon, S., Salafia, O. S., Salces-Carcoba, F., Salconi, L., Saleem, M., Salemi, F., Sallé, M., Salvador, S., Sanchez, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sänger, E. M., Santoliquido, F., Saravanan, T. R., Sarin, N., Sasaoka, S., Sasli, A., Sassi, P., Sassolas, B., Satari, H., Sato, R., Sato, Y., Sauter, O., Savage, R. L., Sawada, T., Sawant, H. L., Sayah, S., Scacco, V., Schaetzl, D., Scheel, M., Schiebelbein, A., Schiworski, M. G., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schouteden, K., Schulte, B. W., Schutz, B. F., Schwartz, E., Scialpi, M., Scott, J., Scott, S. M., Seetharamu, T. C., Seglar-Arroyo, M., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Seo, J. W., Sequino, V., Serra, M., Servignat, G., Sevrin, A., Shaffer, T., Shah, U. S., Shaikh, M. A., Shao, L., Sharma, A. K., Sharma, P., Sharma-Chaudhary, S., Shaw, M. R., Shawhan, P., Shcheblanov, N. S., Sheridan, E., Shikano, Y., Shikauchi, M., Shimode, K., Shinkai, H., Shiota, J., Shoemaker, D. H., Shoemaker, D. M., Short, R. W., ShyamSundar, S., Sider, A., Siegel, H., Sieniawska, M., Sigg, D., Silenzi, L., Simmonds, M., Singer, L. P., Singh, A., Singh, D., Singh, M. K., Singh, S., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, L., Smith, R. J. E., Smith, W. J., Soldateschi, J., Somiya, K., Song, I., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Southgate, A., Spagnuolo, V., Spencer, A. P., Spera, M., Spinicelli, P., Spoon, J. B., Sprague, C. A., Srivastava, A. K., Stachurski, F., Steer, D. A., Steinlechner, J., Steinlechner, S., Stergioulas, N., Stevens, P., StPierre, M., Stratta, G., Strong, M. D., Strunk, A., Sturani, R., Stuver, A. L., Suchenek, M., Sudhagar, S., Sueltmann, N., Suleiman, L., Sullivan, K. D., Sun, L., Sunil, S., Suresh, J., Sutton, P. J., Suzuki, T., Suzuki, Y., Swinkels, B. L., Syx, A., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takase, T., Takatani, K., Takeda, H., Takeshita, K., Talbot, C., Tamaki, M., Tamanini, N., Tanabe, D., Tanaka, K., Tanaka, S. J., Tanaka, T., Tang, D., Tanioka, S., Tanner, D. B., Tao, L., Tapia, R. D., Martín, E. N. Tapia San, Tarafder, R., Taranto, C., Taruya, A., Tasson, J. D., Teloi, M., Tenorio, R., Themann, H., Theodoropoulos, A., Thirugnanasambandam, M. P., Thomas, L. M., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tissino, J., Tiwari, A., Tiwari, P., Tiwari, S., Tiwari, V., Todd, M. R., Toivonen, A. M., Toland, K., Tolley, A. E., Tomaru, T., Tomita, K., Tomura, T., Tong-Yu, C., Toriyama, A., Toropov, N., Torres-Forné, A., Torrie, C. I., Toscani, M., Melo, I. Tosta e, Tournefier, E., Trapananti, A., Travasso, F., Traylor, G., Trevor, M., Tringali, M. C., Tripathee, A., Troian, G., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsang, T. T. L., Tso, R., Tsuchida, S., Tsukada, L., Tsutsui, T., Turbang, K., Turconi, M., Turski, C., Ubach, H., Uchiyama, T., Udall, R. P., Uehara, T., Uematsu, M., Ueno, K., Ueno, S., Undheim, V., Ushiba, T., Vacatello, M., Vahlbruch, H., Vaidya, N., Vajente, G., Vajpeyi, A., Valdes, G., Valencia, J., Valentini, M., Vallejo-Peña, S. A., Vallero, S., Valsan, V., van Bakel, N., van Beuzekom, M., van Dael, M., Brand, J. F. J. van den, Broeck, C. Van Den, Vander-Hyde, D. C., van der Sluys, M., Van de Walle, A., van Dongen, J., Vandra, K., van Haevermaet, H., van Heijningen, J. V., Van Hove, P., VanKeuren, M., Vanosky, J., van Putten, M. H. P. M., van Ranst, Z., van Remortel, N., Vardaro, M., Vargas, A. F., Varghese, J. J., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venikoudis, S., Venneberg, J., Verdier, P., Verkindt, D., Verma, B., Verma, P., Verma, Y., Vermeulen, S. M., Vetrano, F., Veutro, A., Vibhute, A. M., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Vilkha, A., Villa-Ortega, V., Vincent, E. T., Vinet, J. -Y., Viret, S., Virtuoso, A., Vitale, S., Vives, A., Vocca, H., Voigt, D., von Reis, E. R. G., von Wrangel, J. S. A., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Wajid, A., Walker, M., Wallace, G. S., Wallace, L., Wang, H., Wang, J. Z., Wang, W. H., Wang, Z., Waratkar, G., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watarai, D., Wayt, K. E., Weaver, B. R., Weaver, B., Weaving, C. R., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wildberger, J. B., Wilk, O. S., Wilken, D., Wilkin, A. T., Willadsen, D. J., Willetts, K., Williams, D., Williams, M. J., Williams, N. S., Willis, J. L., Willke, B., Wils, M., Winterflood, J., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wolfe, N. E., Wong, H. T., Wong, H. W. Y., Wong, I. C. F., Wright, J. L., Wright, M., Wu, C., Wu, D. S., Wu, H., Wuchner, E., Wysocki, D. M., Xu, V. A., Xu, Y., Yadav, N., Yamamoto, H., Yamamoto, K., Yamamoto, T. S., Yamamoto, T., Yamamura, S., Yamazaki, R., Yan, S., Yan, T., Yang, F. W., Yang, F., Yang, K. Z., Yang, Y., Yarbrough, Z., Yasui, H., Yeh, S. -W., Yelikar, A. B., Yin, X., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, H., Yuan, S., Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeeshan, M., Zelenova, T., Zendri, J. -P., Zeoli, M., Zerrad, M., Zevin, M., Zhang, A. C., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhou, R., Zhu, X. -J., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Furlan, S. B. Araujo, Arzoumanian, Z., Basu, A., Cassity, A., Cognard, I., Crowter, K., del Palacio, S., Espinoza, C. M., Fonseca, E., Flynn, C. M. L., Gancio, G., Garcia, F., Gendreau, K. C., Good, D. C., Guillemot, L., Guillot, S., Keith, M. J., Kuiper, L., Lower, M. E., Lyne, A. G., McKee, J. W., Meyers, B. W., Palfreyman, J. L., Pearlman, A. B., Romero, G. E., Shannon, R. M., Shaw, B., Stairs, I. H., Stappers, B. W., Tan, C. M., Theureau, G., Thompson, M., Weltevrede, P., and Zubieta, E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Continuous gravitational waves (CWs) emission from neutron stars carries information about their internal structure and equation of state, and it can provide tests of General Relativity. We present a search for CWs from a set of 45 known pulsars in the first part of the fourth LIGO--Virgo--KAGRA observing run, known as O4a. We conducted a targeted search for each pulsar using three independent analysis methods considering the single-harmonic and the dual-harmonic emission models. We find no evidence of a CW signal in O4a data for both models and set upper limits on the signal amplitude and on the ellipticity, which quantifies the asymmetry in the neutron star mass distribution. For the single-harmonic emission model, 29 targets have the upper limit on the amplitude below the theoretical spin-down limit. The lowest upper limit on the amplitude is $6.4\!\times\!10^{-27}$ for the young energetic pulsar J0537-6910, while the lowest constraint on the ellipticity is $8.8\!\times\!10^{-9}$ for the bright nearby millisecond pulsar J0437-4715. Additionally, for a subset of 16 targets we performed a narrowband search that is more robust regarding the emission model, with no evidence of a signal. We also found no evidence of non-standard polarizations as predicted by the Brans-Dicke theory., Comment: main paper: 12 pages, 6 figures, 4 tables

Published
2025

6. Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients

Author

Panuccio, Giuseppe, Correale, Pierpaolo, d’Apolito, Maria, Mutti, Luciano, Giannicola, Rocco, Pirtoli, Luigi, Giordano, Antonio, Labate, Demetrio, Macheda, Sebastiano, Carabetta, Nicole, Abdelwahed, Youssef S., Landmesser, Ulf, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, De Rosa, Salvatore, and Torella, Daniele

Published
2025
Full Text
View/download PDF

7. Can nCD64 and mCD169 biomarkers improve the diagnosis of viral and bacterial respiratory syndromes in the emergency department? A prospective cohort pilot study

Author

Venturini, Sergio, Crapis, Massimo, Zanus-Fortes, Agnese, Orso, Daniele, Cugini, Francesco, Fabro, Giovanni Del, Bramuzzo, Igor, Callegari, Astrid, Pellis, Tommaso, Sagnelli, Vincenzo, Marangone, Anna, Pontoni, Elisa, Arcidiacono, Domenico, De Santi, Laura, Ziraldo, Barbra, Valentini, Giada, Santin, Veronica, Reffo, Ingrid, Doretto, Paolo, Pratesi, Chiara, Pivetta, Eliana, Vattamattahil, Kathreena, De Rosa, Rita, Avolio, Manuela, Tedeschi, Rosamaria, Basaglia, Giancarlo, Bove, Tiziana, and Tascini, Carlo

Published
2025
Full Text
View/download PDF

10. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts

Author

Mariarosaria De Rosa, Ryan P. Barnes, Ariana C. Detwiler, Prasanth R. Nyalapatla, Peter Wipf, and Patricia L. Opresko

Subjects
Science
Abstract

Abstract Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine (8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases initiate base excision repair (BER) to remove 8oxoG or prevent mutation. Here, we show OGG1 loss or inhibition, or MUTYH loss, partially rescues telomeric 8oxoG-induced premature senescence and associated proinflammatory responses, while loss of both glycosylases causes a near complete rescue in human fibroblasts. Glycosylase deficiency also suppresses 8oxoG-induced telomere fragility and dysfunction, indicating that downstream single-stranded break (SSB) repair intermediates impair telomere replication. Preventing BER initiation suppresses PARylation and confers resistance to the synergistic effects of PARP inhibitors on 8oxoG-induced senescence. However, OGG1 activity is essential for preserving cell growth after chronic telomeric 8oxoG formation, whereas MUTYH promotes senescence to prevent chromosomal instability from unrepaired damage. Our studies reveal that inefficient completion of 8oxoG BER at telomeres triggers cellular senescence via SSB intermediates which disrupt telomere function.

Published
2025
Full Text
View/download PDF

11. Influence of ESBL colonization status on gut microbiota composition during allogenic hematopoietic stem cell transplantation

Author

Silvia Corcione, Ilario Ferrocino, Tommaso Lupia, Alessandro Busca, Gabriele Bianco, Chiara Dellacasa, Luisa Giaccone, Lucia Brunello, Sara Butera, Cristina Costa, Benedetto Bruno, and Francesco Giuseppe De Rosa

Subjects
Microbiome, Allo-HSCT, MDR, ESBL, Medicine, Science
Abstract

Abstract After allogeneic HSCT (allo-HSCT), the diversity of the intestinal microbiota significantly decreases. The changes can be rapid and are thought to be caused by chemotherapy, antibiotics, or intestinal inflammation. Most patients are exposed to prophylactic and therapeutic antibiotics during neutropenia and several patients are colonized by ESBL bacteria. We investigated the changes in gut microbiota composition in allo-HSCT, aiming at investigating if the acquisition of ESBL colonization may affect gut microbiome diversity during allo-HSCT. This was a single-center prospective pilot study. All patients consecutively admitted to the Haematological Unit of the City of Health and Science, Molinette Hospital in Turin, Italy, and undergoing allo-HSCT between August 2017 to August 2020 were enrolled in the study. Microbiome analysis on fecal samples were collected every 7 days from hospital admission to discharge and until 1 year after HSCT. 48 patients were enrolled in the study. At baseline 14 patients (29.16%) were colonized by MDR bacteria, mostly extended-spectrum beta-lactamase (ESBL)-producing gram negatives (N = 11; 78.57%). During allo-HSCT, one patient had a positive rectal swab for a carbapenemase-producing Klebsiella pneumoniae and eight patients lost the colonization during the hospital stay. Microbiota composition was compared between patients colonized by ESBL at baseline and non-colonized patients. Patients colonized by ESBL had a greater abundances of Bifidobacterium, Blautia, Clostridium, Coprococcus, L-Ruminococcus Mogibacteriaceae, Peptostreptococceae and Oscillospira, while non-colonized ESBL patients had a greater abundance of Actinomycetales, Staphylococcus and Sutterella. Moreover, microbiota composition of colonized by ESBL that retained colonization after HSCT showed an increased in abundances of Akkermansia, Dialister, Erysipelotrichaceae and Methanobrevibacter when compared with patients that become negative at rectal swabs. From a clinical perspective, the evolution of this prospective pilot study will be to investigate markers of gut barrier functions, SCFA productions and to correlate the predictivity of these parameters with risk of invasive infections and clinical outcomes in allo-HSCT population.

Published
2025
Full Text
View/download PDF

14. The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.

Author

Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, and Diego Rayes

Subjects
Biology (General), QH301-705.5
Abstract

The DAF-2/insulin/insulin-like growth factor signaling (IIS) pathway plays an evolutionarily conserved role in regulating reproductive development, life span, and stress resistance. In Caenorhabditis elegans, DAF-2/IIS signaling is modulated by an extensive array of insulin-like peptides (ILPs) with diverse spatial and temporal expression patterns. However, the release dynamics and specific functions of these ILPs in adapting to different environmental conditions remain poorly understood. Here, we show that the ILP, insulin-3 (INS-3), plays a crucial role in modulating the response to various environmental stressors in C. elegans. ins-3 mutants display increased resistance to heat, oxidative stress, and starvation; however, this advantage is countered by slower reproductive development under favorable conditions. We find that ins-3 expression is downregulated in response to environmental stressors, whereas, the neurohormone tyramine, which is released during the acute flight response, increases ins-3 expression. We show that tyramine induces intestinal calcium (Ca2+) transients through the activation of the TYRA-3 receptor. Our data support a model in which tyramine negatively impacts environmental stress resistance by stimulating the release of INS-3 from the intestine via the activation of a TYRA-3-Gαq-IP3 pathway. The release of INS-3 systemically activates the DAF-2 pathway, resulting in the inhibition of cytoprotective mechanisms mediated by DAF-16/FOXO. These studies offer mechanistic insights into a brain-gut communication pathway that weighs adaptive strategies to respond to acute and long-term stressors.

Published
2025
Full Text
View/download PDF

15. Characterization of a WAS splice-site variant in a patient with Wiskott-Aldrich syndrome

Author

Elisabetta Toriello, Rosa Maritato, Antonio De Rosa, Maria Valeria Esposito, Carla Damiano, Carmen Rosano, Emilia Cirillo, Antonietta Tarallo, Cosimo Abagnale, Francesca Cillo, Roberta Romano, Laura Grilli, Marika Comegna, Giancarlo Blasio, Giancarlo Parenti, Enrico Maria Surace, Giuseppe Castaldo, Claudio Pignata, and Giuliana Giardino

Subjects
Wiskott-Aldrich, WASP, splice-site mutation, next-generation sequencing (NGS), gene panel, Immunologic diseases. Allergy, RC581-607
Abstract

Wiskott-Aldrich syndrome (WAS) (MIM #301000) is a rare X-linked primary immunodeficiency due to mutations in the WAS gene, characterized by thrombocytopenia with small platelets, eczema, recurrent infections, and an increased incidence of autoimmunity and malignancies. A wide spectrum of mutations has been identified in the WAS gene responsible for a broad variety of clinical phenotypes. By using targeted next-generation sequencing (t-NGS), we identified in a 2-month-old boy with thrombocytopenia and immunological alterations a 4-nucleotide deletion from position +3 to +6 of intron 8 (c.777 + 3_777 + 6delGAGT) of WAS, currently classified on ClinVar as a variant of uncertain significance. The in-vitro characterization of the variant revealed the complete retention of intron 8 in the mature transcript, suggesting a splicing defect due to the loss of a splice donor site at the 5′-end of intron 8. By sequencing the polymerase chain reaction product, we identified a premature stop at codon 269; thus, consequently, no Wiskott-Aldrich syndrome protein (WASp) was detectable in peripheral blood mononuclear cells from the patient. Due to the total absence of a full-length WASp, it is expected that the patient will develop the severe form of the disease, although further monitoring is needed to better define his phenotype.

Published
2025
Full Text
View/download PDF

20. Self-assembling nanoparticles for delivery of miR-603 and miR-221 in glioblastoma as a new strategy to overcome resistance to temozolomide

Author

Abate, Marianna, Porru, Manuela, Campani, Virginia, Leonetti, Carlo, Nele, Valeria, Di Paola, Rossella, De Martino, Marco, Russo, Margherita, Tathode, Madhura, Cossu, Alessia Maria, Bocchetti, Marco, Angelillo, Alessia, Ianniello, Monica, Petrillo, Nadia, Savarese, Giovanni, Monica, Rosa Della, Chiariotti, Lorenzo, Addeo, Raffaele, Caraglia, Michele, De Rosa, Giuseppe, and Zappavigna, Silvia

Published
2025
Full Text
View/download PDF

21. Effect of timing of casirivimab and imdevimab administration relative to mRNA-1273 COVID-19 vaccination on vaccine-induced SARS-CoV-2 neutralising antibody responses: a prospective, open-label, phase 2, randomised controlled trial

Author

Turner, Kenneth C, Kim, Yunji, Konis, George, Rosenthal, Mark J, Trbovic, Caryn F, Kowal, Bari, DiCioccio, A Thomas, Dakin, Paula, Isa, Flonza, Gonzalez Ortiz, Ana M, Meyer, Jonathan, Hamilton, Jennifer D, Olenchock, Benjamin A, Brackin, Taylor, Ganguly, Samit, Forleo-Neto, Eduardo, Faria, Lori, Heirman, Ingeborg, Marovich, Mary, Hutter, Julia, Polakowski, Laura, Irvin, Susan C, Thakur, Mazhar, Hooper, Andrea T, Baum, Alina, Petro, Christopher D, Fakih, Faisal A, McElrath, M Juliana, De Rosa, Stephen C, Cohen, Kristen W, Williams, LaTonya D, Hellman, Caleb A, Odeh, Ahmad J, Patel, Aloki H, Tomaras, Georgia D, Geba, Gregory P, Kyratsous, Christos A, Musser, Bret, Yancopoulos, George D, and Herman, Gary A

Published
2025
Full Text
View/download PDF

24. The Effects of Urban Pollution on the 'Gesù Nuovo' Façade (Naples, Italy): A Diagnostic Overview

Author

Alessandro De Rosa, Paola Cennamo, Chiara Saltarelli, Giorgio Trojsi, Juri Rimauro, Maria Rosaria Vigorito, and Elena Chianese

Subjects
black crusts, air pollution, stone’s degradation, biodeteriogens, historical building, Meteorology. Climatology, QC851-999
Abstract

The deterioration of stone heritage in urban environments is mainly the product of sources of air pollution like vehicular traffic and domestic heating. The results of these phenomena usually manifest as acid rain and particulate patinas, acting on the surface of stone monuments to form the so-called “black crusts”, a typical stone degradation product, mainly composed of gypsum. The aims of this study were to investigate the extent of these phenomena on the decorative apparatus of the frontal façade of Gesù Nuovo Church, in the historical centre of Naples (Italy). Preliminary diagnostics consisted of XRD and FTIR to analyse the composition of stone materials and inquire about previous restorations. The chemical characterization of black crusts was performed, using a diverse array of techniques, to highlight how different compounds are distributed along a vertical gradient and considering the proximity of specific sources of pollution (vehicle engine ignition, incense combustion, domestic heating products). Finally, molecular biology techniques were employed to identify the organisms which typically dwell in this formation and speculate about their contribution to the degradation of stone.

Published
2025
Full Text
View/download PDF

25. Identification method of cyclic top defects in track geometry measurements in its early stage.

Author

De Rosa, Anna, Luber, Bernd, and Fuchs, Josef

Abstract

Track irregularities in the long wavelengths are often overlooked in the development of new track identification and detection techniques, yet they can have serious implications for the safety of freight wagons and the comfort of passengers. This study is aimed to extend the current published literature, by proposing a methodology for the identification and classification of evolving cyclic top (CT) irregularities in the mid and long wavelength range between 25 and 70 m. The methodology required a dataset of historical vertical track geometry measurements to identify and classify CT irregularities, by analysing the growing wavelength contents. The classification of detected CT into early and advanced stage of evolution allows maintenance interventions to be timely planned, improving transportation efficiency. This study contributes to enhancing monitoring methodologies for track geometry and highlights the importance of considering mid and long wavelength irregularities. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

26. Diagnostic and prognostic value of time to positivity in blood cultures. An opinion paper.

Author

Maffezzoli, Paola, Kestler, Martha, Burillo, Almudena, Corcione, Silvia, Giuseppe De Rosa, Francesco, Muñoz, Patricia, and Bouza, Emilio

Subjects
MICROBIAL cultures, CATHETER-related infections, FUNGAL growth, BLOOD volume, PROGNOSIS
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
Full Text
View/download PDF

28. Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients.

Author

De Rosa, Silvia, Sella, Nicolò, Bellani, Giacomo, Foti, Giuseppe, Cortegiani, Andrea, Lorenzoni, Giulia, Gregori, Dario, Boscolo, Annalisa, Cattin, Lucia, Elhadi, Muhammed, Fullin, Giorgio, Garofalo, Eugenio, Gottin, Leonardo, Grassetto, Alberto, Maggiore, Salvatore Maurizio, Momesso, Elena, Peta, Mario, Poole, Daniele, Rona, Roberto, and Tiberio, Ivo

Subjects
*OXYGEN saturation, *PEARSON correlation (Statistics), *PATIENTS, *LYING down position, *FISHER exact test, *LOGISTIC regression analysis, *TREATMENT duration, *HOSPITAL mortality, *DESCRIPTIVE statistics, *CHI-squared test, *MANN Whitney U Test, *REACTIVE oxygen species, *OXYGEN in the body, *ODDS ratio, *INTENSIVE care units, *ARTIFICIAL respiration, *CONFIDENCE intervals, *SURVIVAL analysis (Biometry), *DATA analysis software, *COVID-19, *MECHANICAL ventilators, *EVALUATION
Abstract

Background: Prone position has been diffusely applied in mechanically ventilated COVID-19 patients. Our aim is ascertaining the association between the physiologic response and the length of the first cycle of prone position and intensive care unit (ICU) mortality. Methods: International registry including COVID-19 adult patients who underwent prone positioning. We measured the difference for arterial partial pressure of oxygen to inspired fraction of oxygen ratio (PaO2/FiO2), ventilatory ratio, and respiratory system compliance (Crs) between baseline supine position and at either the end of the first cycle of prone position (Delta-PP) or re-supination (Delta-PostPP). Results: We enrolled 1816 patients from 53 centers. Delta-PP and Delta-PostPP for PaO2/FiO2 were both associated with ICU mortality [OR (95% CI) 0.48 (0.38, 0.59), and OR (95% CI) 0.60 (0.52, 0.68), respectively]. Ventilatory ratio had a non-linear relationship with ICU mortality for Delta-PP (p = 0.022) and Delta-PostPP (p = 0.004). Delta-PP, while not Delta-PostPP, for Crs was associated with ICU mortality [OR (95% CI) 0.80 (0.65, 0.98)]. The length of the first cycle of prone position showed an inverse relationship with ICU mortality [OR (95% CI) 0.82 (0.73, 0.91)]. At the multivariable analysis, the duration of the first cycle of prone position, Delta-PP and Delta-PostPP for PaO2/FiO2, and Delta-PostPP for ventilatory ratio were independently associated with ICU mortality. Conclusion: In COVID-19 patients with acute respiratory failure receiving invasive mechanical ventilation and prone positioning, the physiological response to prone position is associated with ICU mortality. Prolonging the duration of the first cycle of prone position is associated with improved survival. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

29. The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.

Author

Veuthey, Tania, Florman, Jeremy T., Giunti, Sebastián, Romussi, Stefano, De Rosa, María José, Alkema, Mark J., and Rayes, Diego

Subjects
CAENORHABDITIS elegans, TYRAMINE, PEPTIDES, LIFE spans, INTESTINES
Abstract

The DAF-2/insulin/insulin-like growth factor signaling (IIS) pathway plays an evolutionarily conserved role in regulating reproductive development, life span, and stress resistance. In Caenorhabditis elegans, DAF-2/IIS signaling is modulated by an extensive array of insulin-like peptides (ILPs) with diverse spatial and temporal expression patterns. However, the release dynamics and specific functions of these ILPs in adapting to different environmental conditions remain poorly understood. Here, we show that the ILP, insulin-3 (INS-3), plays a crucial role in modulating the response to various environmental stressors in C. elegans. ins-3 mutants display increased resistance to heat, oxidative stress, and starvation; however, this advantage is countered by slower reproductive development under favorable conditions. We find that ins-3 expression is downregulated in response to environmental stressors, whereas, the neurohormone tyramine, which is released during the acute flight response, increases ins-3 expression. We show that tyramine induces intestinal calcium (Ca2+) transients through the activation of the TYRA-3 receptor. Our data support a model in which tyramine negatively impacts environmental stress resistance by stimulating the release of INS-3 from the intestine via the activation of a TYRA-3-Gαq-IP3 pathway. The release of INS-3 systemically activates the DAF-2 pathway, resulting in the inhibition of cytoprotective mechanisms mediated by DAF-16/FOXO. These studies offer mechanistic insights into a brain–gut communication pathway that weighs adaptive strategies to respond to acute and long-term stressors. The flight response in worms induces changes in insulin signaling that promote short-term metabolic benefits at the cost of decreased cytoprotective mechanisms. Here, the authors define a brain-gut pathway mediating this adaptive tradeoff, wherein TYRA-3 stimulates INS-3 expression in the intestine, leading to the systemic activation of insulin signaling and reduced stress resistance. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

30. Impact of Multidrug-Resistant Bacteria in a Cohort of COVID-19 Critically Ill Patients: Data from a Prospective Observational Study Conducted in a High-Antimicrobial-Resistance-Prevalence Center.

Author

Montrucchio, Giorgia, Grillo, Francesca, Balzani, Eleonora, Gavanna, Giulia, Sales, Gabriele, Bonetto, Chiara, Simonetti, Umberto, Zanierato, Marinella, Fanelli, Vito, Filippini, Claudia, Corcione, Silvia, De Rosa, Francesco Giuseppe, Curtoni, Antonio, Costa, Cristina, and Brazzi, Luca

Subjects
EXTRACORPOREAL membrane oxygenation, VIRUS diseases, CARBAPENEM-resistant bacteria, ACINETOBACTER baumannii, PATIENT positioning
Abstract

Background: Bacterial superinfections are common complications during viral infections, but the impact of multidrug-resistant (MDR) pathogens in critically ill patients affected by coronavirus disease 2019 (COVID-19) is still debated. Methods: This is an observational, monocentric, and prospective study designed to investigate the incidence, risk factors, and outcomes of MDR bacterial superinfections in COVID-19 patients admitted to the intensive care unit (ICU). Results: A high incidence of superinfections (66%, 159/241) was observed: ventilator-associated pneumonia (VAP) (65%, 104/159) and bloodstream infection (BSI, 32%, 51/159) were the most common. Superinfections, Extra-Corporeal Membrane Oxygenation (ECMO) support, and prone positioning increased the risk of death five, four, and more-than-two times, respectively (OR = 5.431, IC 95%: 1.637–18.014; 4.462, IC 95%: 1.616–12.324 and 2.346, IC 95%: 1.127–4.883). MDR bacteria were identified in 61% of patients with superinfection, with a cumulative incidence of 37.2% at day 14. Carbapenem-resistant Acinetobacter baumannii (CR-AB) and CR-Klebsiella pneumoniae (CR-KP) were the most common causative agents (24.3% and 13.7%). CR-AB was found to significantly increase both ICU and in-hospital mortality (76.4% and 78.2%), whereas CR-KP had no direct impact on mortality. Prior rectal colonization (p < 0.0001), mechanical ventilation (p = 0.0017), a prolonged ICU stay (p < 0.0001), the use of iNO (p = 0.0082), vasopressors (p = 0.0025), curarization (p = 0.0004), and prone positioning (p = 0.0084) were found to be risk factors for CR-AB. Conclusions: Critically ill COVID-19 patients are at high risk of developing MDR superinfection. While CR-KP had no direct impact on mortality, CR-AB appeared to increase ICU and in-hospital mortality. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

31. Archival Research, Underwater Optical Surveys, and 3D Modelling: Three Stages for Shaping the Wreck of the Steamship Bengala (Isola di Capo Rizzuto, Crotone, Italy).

Author

Medaglia, Salvatore, Bruno, Fabio, Castelli, Ana, Collina, Matteo, Davidde Petriaggi, Barbara, De Rosa, Luca, Frere, Julieta, Fuoco, Fabrizio, Gutiérrez, Guillermo, Lagudi, Antonio, Megna, Francesco, and Peluso, Raffaele

Subjects
UNDERWATER exploration, MARITIME shipping, ARCHIVAL resources, MARITIME history, PUBLIC history, UNDERWATER archaeology
Abstract

Bengala, a steamer that sank in 1889 near Capo Rizzuto, Italy, was a relatively new vessel for its time, with an unusually short 18-year service life, given that steamers of the period typically operated for 30 to 40 years. Despite its brief history, SS Bengala played a significant role in the development of Italy's young merchant navy, undergoing multiple ownership changes and serving various Italian shipping companies. Employed mainly along the route to Southeast Asia, it transported Italian migrants overseas and also participated in troop raids during the Italian military expedition to Eritrea in 1887. Despite its historical significance, no iconographic material has yet been found to depict SS Bengala, and archival research conducted in Italy and England has not uncovered any naval plans, photographs, or drawings of the ship. To overcome this gap, the authors employed new technologies and historical information to create a virtual reconstruction. This research combined archival sources with underwater surveys, including a detailed 3D survey by divers and archaeologists. Archival research, including consultation of official documents, provided critical information on the ship's dimensions, superstructure, rigging, materials, and construction methods. The 3D modelling of the ship's external hull, based on precise geometric data from the wreck site, offers a first step towards virtual reconstruction. The modelling is grounded in photogrammetric surveying techniques, ensuring high accuracy in the reconstruction process. The model can be used in augmented reality (AR) applications to enhance underwater exploration, allowing divers to visualise the reconstructed ship in its original environment. Additionally, it supports museum exhibits, interactive visualisations, and educational games, making it a valuable resource for engaging the public with maritime history and archaeology. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

32. The Effects of Urban Pollution on the "Gesù Nuovo" Façade (Naples, Italy): A Diagnostic Overview.

Author

De Rosa, Alessandro, Cennamo, Paola, Saltarelli, Chiara, Trojsi, Giorgio, Rimauro, Juri, Vigorito, Maria Rosaria, and Chianese, Elena

Subjects
BUILDING stones, URBAN pollution, STONE, AIR pollution, HISTORIC buildings
Abstract

The deterioration of stone heritage in urban environments is mainly the product of sources of air pollution like vehicular traffic and domestic heating. The results of these phenomena usually manifest as acid rain and particulate patinas, acting on the surface of stone monuments to form the so-called "black crusts", a typical stone degradation product, mainly composed of gypsum. The aims of this study were to investigate the extent of these phenomena on the decorative apparatus of the frontal façade of Gesù Nuovo Church, in the historical centre of Naples (Italy). Preliminary diagnostics consisted of XRD and FTIR to analyse the composition of stone materials and inquire about previous restorations. The chemical characterization of black crusts was performed, using a diverse array of techniques, to highlight how different compounds are distributed along a vertical gradient and considering the proximity of specific sources of pollution (vehicle engine ignition, incense combustion, domestic heating products). Finally, molecular biology techniques were employed to identify the organisms which typically dwell in this formation and speculate about their contribution to the degradation of stone. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

33. Three Unrelated Patients of Roma Ethnicity from a Single Center Carrying the Same Deletion in MYD88 Gene: A Founder Effect?

Author

Romano, Roberta, Cillo, Francesca, Grilli, Laura, Ciaccio, Alessio, Bufalo, Lorenzo, Toriello, Elisabetta, De Rosa, Antonio, Rosano, Carmen, Cirillo, Emilia, Blasio, Giancarlo, Comegna, Marika, Di Domenico, Carmela, Castaldo, Giuseppe, Pignata, Claudio, and Giardino, Giuliana

Subjects
NUCLEOTIDE sequencing, IMMUNOGLOBULIN E, MYELOID differentiation factor 88, HEALTH services accessibility, DISEASE relapse
Abstract

MyD88 deficiency is a rare inborn error of immunity (IEI) characterized by susceptibility to pyogenic infections without overt signs of inflammation. Half of the reported patients belong to Roma descent, an itinerant ethnic group living mostly in Europe, with an increased risk of childhood mortality due to limited access to healthcare services. We describe three unrelated patients from the Campania region in Italy with MyD88 deficiency, all belonging to Roma descent and displaying severe or recurrent infections in early infancy. They underwent a comprehensive immunological work-up including targeted next-generation sequencing for IEIs that identified a homozygous pathogenic in-frame deletion c.157_159del p.(Glu53del) in MYD88 gene, already described in this ethnic group, suggesting a founder effect. A high level of alert should be kept in patients of Roma ethnicity with early onset severe infections. Moreover, being associated with increased Immunoglobulin E (IgE) levels, this condition should be included in the differential diagnosis of Hyper-IgE syndromes. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

34. Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer.

Author

Tomassi, Stefano, Natale, Benito, Roggia, Michele, Amato, Luisa, De Rosa, Caterina, Della Corte, Carminia Maria, Baglini, Emma, Amendola, Giorgio, Messere, Anna, Di Maro, Salvatore, Barresi, Elisabetta, Da Settimo, Federico, Trincavelli, Maria Letizia, Ciardiello, Fortunato, Taliani, Sabrina, Morgillo, Floriana, and Cosconati, Sandro

Published
2025
Full Text
View/download PDF

35. Editorial: Inborn Errors of Immunity (IEI) breaking immune homeostasis and tolerance: a key role for T regulatory cells.

Author

De Rosa, Veronica, Sogkas, Georgios, and Bacchetta, Rosa

Subjects
REGULATORY T cells, REGULATORY B cells, IMMUNOLOGIC memory, IMMUNITY, TRANSCRIPTION factors
Abstract

The editorial in Frontiers in Immunology discusses Inborn Errors of Immunity (IEI) and their impact on immune homeostasis and tolerance, with a focus on T regulatory cells. IEI are caused by mutations in genes regulating immune processes, leading to susceptibility to infections and immune-related complications. The article highlights the classification of IEI into 9 groups and introduces the concept of Primary Immune Regulatory Disorders (PIRDs) and Tregopathies. It also explores the role of Tregs in various immune disorders and potential therapeutic approaches for IEI. [Extracted from the article]

Published
2025
Full Text
View/download PDF

36. Clinical trial eligibility in PSP: Population representativeness and potential criteria adjustment based on PSP-NET findings

Author

D'Amico, Lorenza, Tepedino, Maria Francesca, De Rosa, Anna, Riccio, Gabriele, Panetta, Salvatore, Gualtieri, Vittorio, Scheveger, Francesco, Umbertini, Elisa, Belvisi, Daniele, Ceravolo, Maria Gabriella, Capecci, Marianna, Benevento, Elena, Mascioli, Davide, Nicoletti, Alessandra, Cicero, Edoardo, Failla, Gaetano, Cincotta, Massimo, Piccininni, Maristella, Lucidi, Giulia, Olivola, Enrica, Modugno, Nicola, Tessitore, Alessandro, De Micco, Rosa, Magistrelli, Luca, Contaldi, Elena, Stocchi, Fabrizio, Vacca, Laura, Altavista, Maria Concetta, Moschella, Vincenzo, Di Giacopo, Raffaella, Lopiano, Leonardo, Zibetti, Maurizio, De Togni, Laura, Abate, Filomena, Di Biasio, Francesca, Marchese, Roberta, Markushi, Tiziana Benzi, Ciammola, Andrea, Ticozzi, Nicola, Calandra-Buonaura, Giovanna, Cani, Ilaria, Sambati, Luisa, Fabbrini, Giovanni, Costanzo, Matteo, Soricelli, Andrea, Frosini, Daniela, Del Prete, Eleonora, Schirinzi, Tommaso, Stefani, Alessandro, Borroni, Barbara, Padovani, Alessandro, Barone, Paolo, Picillo, Marina, and Pilotto, Andrea

Published
2025
Full Text
View/download PDF

37. IFT140-related ADPKD

Author

Catania, Martina, Mancassola, Giulia, De Rosa, Liliana Italia, Kola, Kristiana, Pepe, Gino, Manunta, Paolo, Vezzoli, Giuseppe, Carrera, Paola, and Sciarrone Alibrandi, Maria Teresa

Published
2025
Full Text
View/download PDF

40. Sisters in Peace: The Women's International League for Peace and Freedom in Australia, 1915–2015: By Kate Laing. Canberra: ANU Press, 2023. Pp. 348. $49.95 paper. Open access pdf.

Author

Crozier-De Rosa, Sharon

Subjects
*WOMEN'S rights, *INTERNATIONAL conflict, *WORLD War I, *RADICAL feminism, *AUSTRALIANS
Abstract

"Sisters in Peace: The Women's International League for Peace and Freedom in Australia, 1915–2015" by Kate Laing is a comprehensive history of the WILPF in Australia, spanning a century of activism. Laing's research draws from various archival sources to create a cohesive narrative of Australian women's peace advocacy efforts, highlighting their struggles and achievements. The book explores the organization's evolution amidst international conflicts, feminist movements, and societal changes, shedding light on its enduring impact on Australian women's political activism. [Extracted from the article]

Published
2025
Full Text
View/download PDF

41. Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma

Author

Paolino, Giovanni, Podo Brunetti, Antonio, De Rosa, Carolina, Cantisani, Carmen, Rongioletti, Franco, Carugno, Andrea, Zerbinati, Nicola, Valenti, Mario, Mascagni, Domenico, Tosti, Giulio, Mercuri, Santo Raffaele, and Pampena, Riccardo

Abstract

Anorectal melanoma (ARM) is a rare malignancy often associated with a poor prognosis due to its late diagnosis and aggressive biological behavior. This review aims to comprehensively investigate ARM’s diagnosis, management, and treatment, emphasizing its clinical characteristics, laboratory findings, and implications for patient prognosis. A systematic literature search was conducted in PubMed, Embase, and Cochrane CENTRAL databases from inception to 1 July 2024. This review synthesizes existing literature to provide a comprehensive understanding of this rare primary malignancy. A total of 110 articles reporting on 166 patients were included. Gender data were available for 131 cases, comprising 67 females (51.1%) and 64 males (48.9%). The median age was 66 years. The overall median time to diagnosis was 4 months for anal melanoma, 3 months for rectal melanoma, and 4 months for anorectal junction melanoma. The clinical presentation was nodular in 98.2% of cases. Pre-diagnosis symptoms included bleeding in 84.9% of cases, mucous elimination (6%), pain (68.7%), tenesmus (16.9%), and changes in bowel movements (28.5%). Overall survival (OS) was reported in 82 cases, with a median OS of 11 months: 11 months for anal melanoma, 7 months for rectal melanoma, and 12 months for anorectal junction melanoma. ARM is a rare and aggressive melanoma subtype often diagnosed at an advanced stage, leading to a poor prognosis. A female predominance was observed, consistent with other mucosal melanomas. Anal melanoma exhibited better progression-free survival, and OS compared to rectal and anorectal junction melanoma.

Published
2025
Full Text
View/download PDF

42. Spectroscopic Time-Resolving Observatory for Broadband Energy X-ray high-energy modular array

Author

Hutcheson, Anthony L., Feroci, Marco, Argan, Andrea, Antonelli, Matias, Barbera, Marco, Bayer, Jorg, Bellutti, Pierluigi, Bertuccio, Giuseppe, Bonvicini, Valter, Cadoux, Franck, Campana, Riccardo, Vignali, Matteo Centis, Ceraudo, Francesco, Christophersen, Marc, Cirrincione, Daniela, D’Anca, Fabio, De Angelis, Nicolas, De Rosa, Alessandra, Casa, Giovanni Della, Monte, Ettore Del, Dilillo, Giuseppe, Evangelista, Yuri, Favre, Yannick, Ficorella, Francesco, Fiorini, Mauro, Ford, Jeremy J., Heddermann, Paul, Grassi, Marco, Grove, J. Eric, Guzman, Alejandro, Kole, Merlin R., Cicero, Ugo Lo, Lombardi, Giovanni, Malcovati, Piero, Michalska, Malgorzata, Meuris, Aline, Minervini, Gabriele, Nowosielski, Witold, Nuti, Alessio, Pacciani, Luigi, Pepponi, Giancarlo, Persyn, Steven C., Picciotto, Antonino, Pliego, Samuel, Rachevski, Alexander, Rashevskaya, Irina, Ray, Paul S., Samusenko, Alina, Santangelo, Andrea, Schanne, Stephane, Schwendeman, Carl L., Sleator, Clio, Smith, Jacob R., Sveda, Libor, Svoboda, Jiri, Tenzer, Christoph, Todaro, Michela, Trois, Alessio, Vacchi, Andrea, Xiong, Hao, Wang, Xianqi, Wu, Xin, Wulf, Eric A., Zampa, Gianluigi, Zampa, Nicola, Zdziarski, Andrzej, and Zorzi, Nicola

Published
2025
Full Text
View/download PDF

43. Leucoencefalopatía multifocal progresiva: recursos diagnósticos y evolución en una serie de casos

Author

Mosconi, Sandra Valeria, De Rosa, Lisi, Talamonti, Maximiliano, Menichini, María Laura, and Reinoso, Catalino

Abstract

La leucoencefalopatía multifocal progresiva (LMP) es una enfermedad desmielinizante producto de la reactivación del virus John Cunningham (JC) en el sistema nervioso central (SNC) en pacientes que presentan diversos grados de inmunocompromiso. Sus manifestaciones clínicas e imagenológicas están bien descriptas, pero es necesaria una alta sospecha de la enfermedad para arribar al diagnóstico.

Published
2025
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results