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Objective To investigate the impact of combining triamcinolone acetonide injections with negative pressure suction therapy on plaque size, pain, and outcomes in patients with penile induration (PD). Methods A retrospective analysis was conducted on the clinical data of 60 PD patients admitted to Suixi County Hospital from January 2018 to January 2023. They were divided into the control group (27 cases) and the study group (33 cases) by different treatment methods. The control group was treated with verapamil injection, and the study group was treated with triamcinolone acetonide injection combined with negative pressure suction therapy. The clinical efficacy, penile curvature, length, volume, plaque area, pain level, erectile function, adverse reactions, and recurrence rate of two groups of patients were compared. Results In comparision with the control group, the total effective rate of treatment in the study group was higher, with a statistically significant difference (P＜0.05). After treatment, the penile curvature in both groups was smaller than before treatment, and the length and volume were greater, in comparision with the control group, the penile curvature of the study group was smaller, and the length and volume were greater, with a statistically significant difference (P＜0.05). After treatment, the plaque area in both groups were smaller than before treatment, and the visual analogue scale (VAS) score was lower, in comparision with the control group, the plaque area of the study group was smaller, and the VAS score was lower, with a statistically significant difference (P＜0.05). The International Erectile Function Index Score-5 (IIEF-5) scores in both groups after treatment were higher than those before treatment, in comparision with the control group, the IIEF-5 scores of the study group after treatment were higher, with a statistically significant difference (P＜0.05). Conclusion The utilization of triamcinolone acetonide injection therapy in conjunction with negative pressure suction in the treatment of PD has been shown to enhance clinical effectiveness, reduce penile curvature, increase length and volume, decrease plaque area, alleviate pain, improve erectile function, and prevent adverse reactions or disease recurrence. [ABSTRACT FROM AUTHOR]