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目的 调查缺血性卒中患者服药依从性的影响因素。 方法 前瞻性连续纳入首都医科大学附属北京天坛医院国际部2022年6月—2023年12月的缺血性卒中住院患者。采用问卷调查收集患者的一般情况、服药依从性[采用Morisky服药依从性量表（Morisky medication adherence scale，MMAS）评估]、感知健康能力[采用中文版感知健康能力量表（perceived health competence scale，PHCS）评估]、卒中复发情况等信息。根据MMAS评分将患者分为依从性差（MMAS评分＜６分）组和中高依从性（MMAS评分≥6分）组。比较两组的人口学特点、临床特点和血管危险因素情况，并采用多因素logistic回归分析服药依从性的影响因素。 结果 共纳入缺血性卒中患者212例，平均年龄（59.9±5.9）岁，MMAS评分6（6～7）分，其中服药依从性差组41例（19.34%），中高依从性组171例（80.66%）。多因素logistic回归分析显示，初中及以下学历患者依从性差的风险是大专及以上学历患者的6.290倍（95%CI 1.912～20.689，P=0.002）；无配偶患者依从性差的风险是有配偶患者的4.172倍（95%CI 1.372～12.684，P=0.012）；无业患者依从性差的风险是在职患者的4.115倍（95%CI 1.326～12.773，P=0.014）；PHCS评分低水平的患者服药依从性差的风险是中等水平患者的2.190倍（95%CI 1.098～4.370，P=0.026）。中高依从性组患者出院后1个月（99.42% vs. 92.68%，P=0.004）、3个月（98.83% vs. 80.49%，P＜0.001）和6个月（98.25% vs. 75.61%，P＜0.001）的随访完成率均高于依从性差组；3个月（3.55% vs. 12.12%，P=0.038）、6个月（4.76% vs. 16.13%，P=0.019）的卒中复发率低于依从性差组。 结论 初中及以下学历、无配偶、无业、PHCS评分低的缺血性卒中患者服药依从性差的风险较高。护理人员应综合考虑患者的个体差异，制订并实施个体化的健康教育计划，以提高患者的服药依从性。 Abstract: Objective To investigate the influencing factors of medication adherence in ischemic stroke patients. Methods This prospective study consecutively included the ischemic stroke inpatients at the international department of Beijing Tiantan Hospital, Capital Medical University from June 2022 to December 2023. A questionnaire was used to collect information on patients’ general information, medication adherence [evaluated by the Morisky medication adherence scale (MMAS)], perceived health competence [assessed by the perceived health competence scale (PHCS)], and stroke recurrence. The patients were divided into a poor adherence group (MMAS score

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Copyright of Journal of Distance Education (1672-0008) is the property of Zhejiang Open University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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With the improvement of living standards and the enhancement of environmental awareness, the demand for adhesives grows rapidly. In particular, biomass adhesives have attracted widespread attention, Biomass adhesives are natural adhesives prepared from biomass and its derivatives of animals, plants and microorganisms. Although the biomass adhesives have the advantages of wide source of raw materials, non-toxic, environmental friendliness and degradability, the poor mechanical properties, low water resistance, and easy to be at- tacked by bacteria hinder the practical application of biomass adhesives. By grafting, crosslinking, filling acid treatment and other modifications of these biomass raw materials. their shortcomings can be improved, which enables their application in wood, food, medical treatment, cultural relics restoration and other fields. In this review, the preparation, application and the most recent research status of the adhesives from the biomass of animal and plant proteins, lignin, chitosan, tannin, cellulose and starch are included. The future development trend of biomass adhesives was also reviewed. This review will provide reference for the further development and application of biomass in the field of adhesives. [ABSTRACT FROM AUTHOR]

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Copyright of Research of Soil & Water Conservation is the property of Institute of Soil & Water Conservation, Chinese Academy of Sciences & Ministry of Water Resources and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Test & Measurement Technology is the property of Publishing Center of North University of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective]To explore the biological function of secreted protein AO-492 in the process of chitin induction from nematodetrapping fungus Arthrobotrys oligospora.[Method]The coding region of the main domain of chitinase AO-492 from A. oligospora was cloned and analyzed, and expressed in Pichia pastoris. The recombinant protein ReAO-Z492 was purified by nickel column affinity chromatography. The enzymatic activity of the recombinant protein under different temperature, pH and metal ion conditions was analyzed by NAG assay, and its biological function was analyzed by acting on Caenorhabditis elegans and eggs.[Result]The chitinase AO-492 had a signal peptide, no transmembrane domain, contained two chitin binding domains and a glycoside hydrolase 18 family domain, and the highly conserved substrate binding site of the glycoside hydrolase 18 family chitinase -SVGGWT- and the hydrolase active site -FDGGDLDWE-, as well as a typical TIM barrel molecular structure. Phylogenetic analysis showed that the protein had the closest genetic relationship with chitinase(EPS35099.1). SDS-PAGE and Western Blot analysis showed that the molecular weight of ReAO-Z492 was about 59 kD, which specifically reacted with mouse polyclonal antibody against A. oligospora. The optimal temperature and pH of ReAO-Z492 were 40℃ and 7.0, respectively. Mg2+ promoted the enzyme activity, while Ag+, Cu2+, Fe3+ and Zn2+ inhibited it. ReAO-Z492 had strong degrading activity on the body wall and egg shell of C. elegans.[Conclusion]The chitinase AO-492 of A. oligospora has a strong degradation effect on C. elegans and its eggs. [ABSTRACT FROM AUTHOR]

Objective: To discuss the regulatory effect of serum and glucocorticoid-induced protein kinase 1 (SGK1) in the early development of fertilized eggs at G1 phase of the mice, and to clarify the related mechanism. Methods: Some female mice aged 4-6 weeks and weighed about 20 g, and several male mice aged over 8 weeks and weighed about 30 g were selected. The female mice were intraperitoneally injected with 10 IU of pregnant mare serum gonadotropin (PMSG), followed by 10 IU of human chorionic gonadotropin (HCG) after 48 h. After HCG injection, the female mice were caged overnight with the male mice at a ratio of 1: 1. The fertilized eggs at G1, S, G2, and M phases were collected at 12-21 h, 21-26 h, 26-28 h, and 28-30 h after injected with HCG, and their cellular morphology at different cell cycles were observed under light microscope. The mouse fertilized eggs at G1 phase after superovulation were collected, the mRNA was synthesized in vitro, and divided into no injection group, Tris-EDTA buffer injection group (TE injection group), and SGK1-mRNA injection group. The SGK1 antibodies were mixed with KSOM culture medium with the concentrations of 1 : 25, 1 : 50, 1 : 100, 1: 200, and 0 to culture the mouse fertilized eggs at G1 phase. Western blotting method was used to detect the expression levels of SGK1 protein in fertilized eggs of the mice in various groups and the dephosphorylation for phosphorylated SGK1-Threonine 256 site tyrosine15 site of cell diusion cyclin 2 (Cdc2) (Cdc2-pTyr15) in the fertilized eggs of the mice in various groups and different concentrations of SGK1 antibody groups and the developmental states of the fertilized eggs in the fertilized eggs of the mice in various groups and different concentrations of SGK1 antibody groups were observed under phase contrast microscope; the expression levels of phosphorylated SGK1-Thr256 (SGK1-pThr256) and Cdc2-pTyr15 proteins in fertilized eggs at different post-HCG injection times were detected by Western blotting method. Results: Compared with no injection and TE injection groups, the expression level of SGK1 protein in the cells in SGK1-mRNA injection group was significantly increased (P<0. 01). 27-28 h after injected with HCG, the phosphorylation signaling of Cdc2-pTyr15 in fertilized eggs of the mice in SGK1-mRNA injection group was gradually disappeared, and there was no phosphorylation signaling 29 h after injected with HCG. At 28-29 h after injected with HCG, the phosphorylation signaling of Cdc2-pTyr15 in fertilized eggs of the mice in no injection and TE injection groups gradually disappeared, completely disappeared at 30 h after injected with HCG. With the increasing of the concentration of SGK1 antibody, the disappearing time of the Cdc2-pTyr15 phosphorylation signaling was increased. At 27 h after injected with HCG, the fertilized eggs of the mice in SGK1-mRNA injection group was initiated cleavage; at 31 h after injected with HCG, nearly all the fertilized eggs turned into G2 phase; at 33 h after injected with HCG, all the fertilized eggs in 0 and 1: 200 SGK1 antibody groups underwent cleavage. However, with the increasing of SGK1 antibody concentration, the cleavage of the fertilized eggs in 1: 25, 1: 50, and 1: 100 SGK1 antibody groups was gradually decreased, particularly at 1: 25 SGK1 antibody group. Compared with no injection and TE injection groups, the death rate of the fertilized eggs of the mice in SGK1-mRNA injection group was significantly decreased at 31 h after injected with HCG (P<0. 05), and the cleavage rate was increased (P<0. 05). With the increasing of the SGK1 antibody concentration, the death rates of the fertilized eggs in different concentrations of SGK1 antibody group were increased (P<0. 05), with the extending of cleavage time was increased, and the cleavage rate of the fertilized eggs was decreased in a dose-dependent manner, and the cleavage rate of fertilized eggs in 1: 25 SGK1 antibody group was the lowest. The expression level of SGK1-pThr256 protein in fertilized eggs of the mice was gradually increased from 27 h after injected with HCG (P<0. 05 or P< 0. 01) in a time-dependent manner; at 28 to 29 h after injected with HCG, the expression levels of Cdc2-Tyr15 protein were gradually decreased (P<0. 05) in a time-dependent manner, and had completely disappeared at 30 h after injected with HCG. Conclusion: Both the over-expression and inhibition of SGK1 can affect the time for the fertilized eggs at G1 phase to entry into M phase, suggesting that SGK1 protein may be one of the regulatory factors in the early development of fertilized eggs at G1 phase of the mice, and it may regulate the development of the fertilized eggs at G1 phase through regulation of Cdc2. [ABSTRACT FROM AUTHOR]

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