1. Long-term use of mepolizumab in a case of chronic eosinophilic pneumonia: extending interval dosing.
- Author
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Prieto-García A, Peligros MI, Pérez Tamayo I, Zubeldia JM, Álvarez-Sala L, and Lavilla C
- Subjects
- Humans, Quality of Life, Chronic Disease, Adrenal Cortex Hormones therapeutic use, Recurrence, Pulmonary Eosinophilia drug therapy, Asthma drug therapy, Anti-Asthmatic Agents therapeutic use
- Abstract
Introduction: Mepolizumab, a humanized anti IL-5 monoclonal antibody, has been used off-label for chronic eosinophilic pneumonia (CEP), inducing disease remission and saving systemic corticosteroids., Case Study: We present a case of CEP, requiring long-term corticosteroids therapy due to relapse upon withdrawal. Mepolizumab was started and maintained for 2 years and 6 months., Results: Corticosteroids could be withdrawn and mepolizumab dose interval was spared up to 10 wk with no disease relapse., Conclusion: Mepolizumab is shown to be useful for chronic eosinophilic pneumonia, allowing corticosteroid withdrawal. Dose interval may be individualized under close monitoring, for a more efficient treatment, reducing medical costs while improving patients' quality of life.
- Published
- 2024
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