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There have been mixed findings on whether social media use is positively or negatively related to well-being. Using the Midlife in the United States Refresher study ( N = 782, age 25-75), multilevel structural equation modeling examined social support quantity (time giving and receiving) and quality of as mediators at both the within- (intraindividual) and between-person (interindividual) levels. Giving support significantly mediated at within- and between-person levels: more social media use was associated with more time giving support and worse well-being. Receiving support significantly mediated at the between-person level: more social media use was associated with more time receiving support and worse well-being. When examining social support quality as a mediator, findings showed that more social media use to contact family/friends was related to better social support quality and better well-being. Results added to our understanding of the relationship between social media use and well-being by considering the role of social support quantity/quality., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.