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After adopting the Paris Agreement, many countries (including developing countries) have started to develop targets aimed at achieving net-zero emissions to realize a "decarbonized society" in response to the 1.5 °C target. Effective plans and actions need to be urgently developed on how to achieve the ambitious targets associated with these targets, but not many countries have developed long-term strategies to achieve net zero emissions. The Asia–Pacific Integrated Model (AIM) team has been working with researchers and policymakers in Japan and other Asian countries to develop a long-term strategy toward a decarbonized society. Asia is a region with diverse countries, and there are many different pathways to achieve decarbonized societies. This paper presents the process of developing a long-term strategy for several Asian countries based on our experiences to date and discusses challenges and solutions, including how to use the AIM models in the policy-making process. [ABSTRACT FROM AUTHOR]

Background: As chromatographic techniques have advanced, many articles that analyze the constituting compounds of medicinal materials have been published in relation to Northeast Asian traditional medicine, including traditional Chinese medicine (TCM). TM-MC was launched in 2015, providing information about the chemical compounds in medicinal materials from chromatographic articles in PubMed. Since 2015, through continuous curation efforts, we have now released TM-MC 2.0 with significant improvements to the quantity and quality of the data (https://tm-mc.kr). Description: TM-MC 2.0 contains 635 medicinal materials, 34,107 chemical compounds (21,306 identified and de-duplicated), 13,992 targets, 27,997 diseases, and 5,075 prescriptions (2,393 de-duplicated by name). The database provides the largest number of identified compounds for medicinal materials listed in the pharmacopoeia compared to all TCM databases. In particular, marker compounds of medicinal materials and many newly discovered compounds were added through the manual curation of recent chromatographic articles. Conclusion: TM-MC 2.0 provides the largest collection of information about the chemical compounds of the medicinal materials listed in the Korean, Chinese, and Japanese pharmacopoeias. Our database can be utilized for network pharmacology in traditional medicine and for the compound screening of medicinal materials for modern drug discovery. [ABSTRACT FROM AUTHOR]