1. Clinical Evaluation of the Adult with Eosinophilic Esophagitis.
- Author
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Biedermann L and Straumann A
- Subjects
- Adult, Humans, Eosinophils, Inflammation pathology, Eosinophilic Esophagitis diagnosis, Eosinophilic Esophagitis epidemiology, Eosinophilic Esophagitis therapy, Deglutition Disorders diagnosis, Deglutition Disorders etiology, Deglutition Disorders pathology, Enteritis, Eosinophilia, Gastritis
- Abstract
Adult patients with eosinophilic esophagitis (EoE) typically present with a history of dysphagia for solids, sometimes with additional reflux-like pain and a history of prior food impactions. In contrast to these alarming symptoms, the general appearance and physical examination of adult patients with EoE is in line with apparently healthy individuals. Therefore, the diagnosis is based on a history of solid-food dysphagia and eosinophilic tissue infiltration. Importantly, the increasing prevalence of EoE variants, that is, typical EoE symptoms in the absence of a relevant eosinophilia, and several studies with eosinophil-targeting drugs, call the pathogenic role of eosinophils into question., Competing Interests: Disclosure L. Biedermann has consulting contracts with Abbvie, BMS, MSD, Vifor, Falk, Esocap, Calypso, Ferring, Pfizer, Takeda, Janssen, Sanofi. A. Straumann has consulting contracts with Astra-Zeneca, BMS, Calypso, EsoCap, Falk Pharma, GSK and Sanofi., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2024
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