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This paper presents the development process and key findings of the first-ever health impact assessment (HIA) conducted on the proposed Alpu coal-fired power plant (ACPP) in Eskisehir, Turkiye. The study followed a systematic HIA methodology, commencing with an extensive literature search on coal-fired power plants and the region's specific characteristics during the screening step. In the subsequent scoping phase, in-depth discussions were conducted with a diverse range of experts and stakeholders to be used as inputs. The study findings highlight that the ACPP's impact on human health will be multifaceted. In addition to the estimated additional 10,000 premature deaths attributed to air pollution during the 35-year, the ACPP is expected to have implications for occupational health, including increased occupational diseases and injuries. Furthermore, it may also affect income, employment, food access, and nutritional quality. The health implications of the ACPP will extend beyond Eskisehir, potentially affecting a region with a current population of approximately 11 million residents throughout its lifetime. [ABSTRACT FROM AUTHOR]