1. Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study.
- Author
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Gao L, Song Y, Sun X, Zhang J, Liu Y, Chen Y, Wu Z, Jian Y, Liu X, Lv L, Chen S, Wang YS, Chen N, Ke X, and Zhang F
- Subjects
- Humans, Male, Female, Middle Aged, Treatment Outcome, Double-Blind Method, Fluorescein Angiography, Follow-Up Studies, Prospective Studies, Aged, Angiogenesis Inhibitors administration & dosage, Angiogenesis Inhibitors adverse effects, Vascular Endothelial Growth Factor A antagonists & inhibitors, Adult, Dose-Response Relationship, Drug, Intravitreal Injections, Choroidal Neovascularization drug therapy, Choroidal Neovascularization etiology, Choroidal Neovascularization diagnosis, Choroidal Neovascularization physiopathology, Myopia, Degenerative complications, Myopia, Degenerative diagnosis, Myopia, Degenerative physiopathology, Recombinant Fusion Proteins administration & dosage, Recombinant Fusion Proteins adverse effects, Visual Acuity physiology, Tomography, Optical Coherence
- Abstract
Purpose: To evaluate the safety and efficacy of intravitreal injections of 0.5 mg conbercept in patients with choroidal neovascularization secondary to pathological myopia (pmCNV)., Methods: The 177 pmCNV patients were randomly assigned in a 3:1 ratio to receive conbercept or sham injection, respectively. The conbercept group receive conbercept intravitreal injections administered on a pro re nata (PRN) basis after 3 monthly loading doses. The sham group received three consecutive monthly sham injections and then one conbercept injection followed by PRN conbercept intravitreal injections., Results: At month 3, the mean BCVA for the two groups were improved by 12.0 letters (conbercept group, from 54.05 letters to 66.05 letters) and 0.6 letters (sham group, from 49.77 letters to 50.33 letters), respectively (p < 0.001). The mean central retinal thickness (CRT) at month 3 in the two groups decreased 62.0 μm (conbercept group, from 348.90 μm to 286.18 μm) and 4.4 μm (sham group, from 347.86 μm to 343.47 μm) (p < 0.001). At month 9, the mean BCVA improved by 13.3 letters in the conbercept group and 11.3 letters in the sham group. The mean CRT decreased 73.6 μm in the conbercept group and 55.9 μm in the sham group (p < 0.001). The most common ocular adverse events were associated with intravitreal injections, such as conjunctival haemorrhage and increased intraocular pressure., Conclusion: Intravitreal injections of 0.5 mg conbercept provided improvement in visual and anatomical outcomes in pmCNV patients with low rates of ocular and nonocular safety events., (© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
- Published
- 2024
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