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A systematic review conducted by the Department of Physiology explores the link between cisplatin-induced nephrotoxicity and the renin-angiotensin system (RAS). The review identifies the involvement of the RAS in the model of nephrotoxicity induced by cisplatin, along with the activation of inflammatory mediators, lipid peroxidation, and changes in markers of kidney tissue damage. The study also highlights gender differences in renal function and response to RAS-related interventions in the presence of cisplatin. These findings provide valuable insights for researchers and clinicians in understanding the physiological and pathological mechanisms of cisplatin-induced nephrotoxicity. [Extracted from the article]