Search

Your search keyword '"Molliex, Serge"' showing total 7 results
Start Over Author "Molliex, Serge" Search Limiters Peer Reviewed Publication Year Range This year
7 results on '"Molliex, Serge"'

2. Heparin Dosing Regimen Optimization in Veno-Arterial Extracorporeal Membrane Oxygenation: A Pharmacokinetic Analysis

Author

Lanoiselée, Julien, primary, Mourer, Jérémy, additional, Jungling, Marie, additional, Molliex, Serge, additional, Thellier, Lise, additional, Tabareau, Julien, additional, Jeanpierre, Emmanuelle, additional, Robin, Emmanuel, additional, Susen, Sophie, additional, Tavernier, Benoit, additional, Vincentelli, André, additional, Ollier, Edouard, additional, and Moussa, Mouhamed Djahoum, additional

Published
2024
Full Text
View/download PDF

3. An immune signature of postoperative cognitive decline in elderly patients

Author

Verdonk, Franck, primary, Cambriel, Amélie, additional, Hedou, Julien, additional, Ganio, Ed, additional, Bellan, Grégoire, additional, Gaudilliere, Dyani, additional, Einhaus, Jakob, additional, Sabayev, Maximilian, additional, Stelzer, Ina A., additional, Feyaerts, Dorien, additional, Bonham, Adam T., additional, Ando, Kazuo, additional, Choisy, Benjamin, additional, Drover, David, additional, Heifets, Boris, additional, Chretien, Fabrice, additional, Aghaeepour, Nima, additional, Angst, Martin S., additional, Molliex, Serge, additional, Sharshar, Tarek, additional, Gaillard, Raphael, additional, and Gaudilliere, Brice, additional

Published
2024
Full Text
View/download PDF

4. WITHDRAWN: Démographie médicale en réanimation et unités de soins continus en France en 2018. Quels sont les besoins?

Author

Veber, Benoît, Asehnoune, Karim, Ecoffey, Claude, Gérard, Jean-Louis, Molliex, Serge, Raux, Mathieu, Heyer, Laurent, and Plaud, Benoît

Abstract

Cet article a du être retiré conformément à la ligne de conduite d’Elsevier concernant le retrait d’articles. Vous pouvez consulter le site (http:www.elsevier.com/locate/withdrawalpolicy) pour de plus amples renseignements. L’éditeur vous prie d’accepter ses excuses pour ce désagrément.

Published
2024
Full Text
View/download PDF

5. Regional anaesthesia via parasternal catheters inserted preoperatively and postoperative delirium after cardiac surgery: A prospective unrandomised clinical trial.

Author

Elhadjene N, Grand N, Azarnoush K, Petrosyan A, Raissouni K, Campisi S, Sandri F, Palao JC, Awad S, Magand C, Molliex S, Ollier E, Morel J, and Lanoiselee J

Subjects
Humans, Prospective Studies, Male, Aged, Female, Anesthesia, Conduction methods, Emergence Delirium prevention & control, Emergence Delirium etiology, Emergence Delirium diagnosis, Emergence Delirium epidemiology, Middle Aged, Preoperative Care methods, Postoperative Complications etiology, Postoperative Complications prevention & control, Delirium etiology, Delirium prevention & control, Delirium diagnosis, Cardiac Surgical Procedures adverse effects
Abstract

Visual Abstract: http://links.lww.com/EJA/A927., (Copyright © 2024 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.)

Published
2024
Full Text
View/download PDF

6. Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial.

Author

Verdonk F, Lambert P, Gakuba C, Nelson AC, Lescot T, Garnier F, Constantin JM, Saurel D, Lasocki S, Rineau E, Diemunsch P, Dreyfuss L, Tavernier B, Bezu L, Josserand J, Mebazaa A, Coroir M, Nouette-Gaulain K, Macouillard G, Glasman P, Lemesle D, Minville V, Cuvillon P, Gaudilliere B, Quesnel C, Abdel-Ahad P, Sharshar T, Molliex S, Gaillard R, and Mantz J

Abstract

Background: Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention of postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess the effect of ketamine on this condition., Methods: This is a multicenter, randomized, double-blind, interventional study. Patients ≥60 years undergoing major orthopedic surgery were randomly assigned in a 1:1 ratio to receive preoperative ketamine 0.5 mg/kg as an intravenous bolus (n = 152) or placebo (n = 149) in random blocks stratified according to the study site, preoperative cognitive status and age. The primary outcome was the proportion of objective delayed neurocognitive recovery (dNR) defined as a decline of one or more neuropsychological assessment standard deviations on postoperative day 7. Secondary outcomes included a three-month incidence of objective postoperative neurocognitive disorder (POND), as well as delirium, anxiety, and symptoms of depression seven days and three months after surgery., Results: Among 301 patients included, 292 (97%) completed the trial. Objective dNR occurred in 50 (38.8%) patients in the ketamine group and 54 (40.9%) patients in the placebo group (OR [95% CI] 0.92 [0.56; 1.51], p = 0.73) on postoperative day 7. Incidence of objective POND three months after surgery did not differ significantly between the two groups nor did incidence of delirium, anxiety, apathy, and fatigue. Symptoms of depression were less frequent in the ketamine group three months after surgery (OR [95% CI] 0.34 [0.13-0.86])., Conclusions: A single preoperative bolus of intravenous ketamine does not prevent the occurrence of dNR or POND in elderly patients scheduled for major orthopedic surgery. (Clinicaltrials.gov NCT02892916)., (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)

Published
2024
Full Text
View/download PDF

7. An immune signature of postoperative cognitive decline in elderly patients.

Author

Verdonk F, Cambriel A, Hedou J, Ganio E, Bellan G, Gaudilliere D, Einhaus J, Sabayev M, Stelzer IA, Feyaerts D, Bonham AT, Ando K, Choisy B, Drover D, Heifets B, Chretien F, Aghaeepour N, Angst MS, Molliex S, Sharshar T, Gaillard R, and Gaudilliere B

Abstract

Postoperative cognitive decline (POCD) is the predominant complication affecting elderly patients following major surgery, yet its prediction and prevention remain challenging. Understanding biological processes underlying the pathogenesis of POCD is essential for identifying mechanistic biomarkers to advance diagnostics and therapeutics. This longitudinal study involving 26 elderly patients undergoing orthopedic surgery aimed to characterize the impact of peripheral immune cell responses to surgical trauma on POCD. Trajectory analyses of single-cell mass cytometry data highlighted early JAK/STAT signaling exacerbation and diminished MyD88 signaling post-surgery in patients who developed POCD. Further analyses integrating single-cell and plasma proteomic data collected before surgery with clinical variables yielded a sparse predictive model that accurately identified patients who would develop POCD (AUC = 0.80). The resulting POCD immune signature included one plasma protein and ten immune cell features, offering a concise list of biomarker candidates for developing point-of-care prognostic tests to personalize perioperative management of at-risk patients. The code and the data are documented and available at https://github.com/gregbellan/POCD ., Teaser: Modeling immune cell responses and plasma proteomic data predicts postoperative cognitive decline.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results