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Introduction: Porokeratosis (PK) is an autoinflammatory keratinization disease (AIKD) characterized by circular or annular skin lesions with a hyperkeratotic rim, pathologically shown as the cornoid lamella. Four genes that cause PK are associated with the mevalonate (MV) pathway. In Chinese PK patients, mevalonate diphosphate decarboxylase (MVD) is the most common causative gene. The lack of an animal model has greatly limited research on PK pathogenesis. Materials and Methods: In this research, we constructed K14‐CreERT2‐Mvdfl/fl mice using the Cre‐LoxP system to create a mouse model for in‐depth studies of PK. The Epidermal Mvd gene was knocked out by intraperitoneal injection of Tamoxifen (TAM). Pathology, immunohistochemistry, RNA‐seq, and Western Blot analysis were performed. Results: Skin lesions appeared following Mvd deficiency, and pathological examination revealed the characteristic cornoid lamella, as well as cutaneous inflammation. Furthermore, we observed elevated levels of IL‐17A and IL‐1β, and a decreased Loricrin level in epidermal Mvd‐deficient mice. Compared with the wild‐type (WT) group, Mvd deficiency activated the expression of lipid metabolism‐related proteins. Conclusion: We developed the first mouse model for PK research, enabling further studies on disease development and treatment approaches. [ABSTRACT FROM AUTHOR]

Based on 491 farmers joining in cooperatives microscopic data in Jiangxi Province,the paper uses Ordinary Least Squares to test the influence mechanism of cooperative green production on green performance, and takes environmental regulation as a regulatory variable to explore the relationship between cooperative green production and cooperative green performance. The results have shown that: (1) The green production cooperatives have a significant positive impact on their green performance, and the impact of green production on economic performance, social performance and ecological performance gradually strengthens from weak to strong; (2) Environmental regulations have a positive regulatory effect on the relationship between cooperative green production and cooperative green performance, among which three types of environmental regulations, namely, incentive, restraint and guided, can strengthen the positive relationship between green production and green performance. [ABSTRACT FROM AUTHOR]

Safe and fast charging is important for graphite/lithium iron phosphate (Gr/LFP) batteries in the fast-growing electric vehicle industry. However, conventional carbonate-based electrolytes produce an obstructive solid-electrolyte interface (SEI), which hinders the fast charging of lithium-ion batteries (LIBs). In this study, a unique tri-methylsilyl-2-(fluorosulfonyl)difluoroacetate (TMSFS) additive was introduced to regulate the SEI of Gr/LFP batteries containing a lithium bis(fluorosulfonyl)imide-based electrolyte during fast charging. The addition of TMSFS significantly reduced the charge-transfer resistance of the anode, substantially extending the cycle life of commercial Gr/LFP batteries to over 1000 cycles at 2C rate, which was far superior to that of the baseline electrolyte (< 530 cycles). Further mechanistic studies showed that the inorganic fluorinated and sulfurized species formed on the SEI film stabilized the intermediate lithium carbonate from attack by the side-reaction products. TMSFS acts as a film-forming additive, curbing electrolyte decomposition, and fortifying the structural integrity of the electrode through the formation of a robust and low-impedance SEI film on the anode. These results provide a simple and effective strategy for combining F and S via electrolyte optimization to implement commercially safe fast-charging LIBs. [ABSTRACT FROM AUTHOR]