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Key Clinical Message: Prurigo nodularis is frequently difficult to manage with conventional therapy. Given the pathogenesis and refractory nature, we demonstrate a case in which inhibition of JAK–STAT signaling may significantly improve prurigo nodularis. Based on the results, we would like to draw a conclusion that abrocitinib as an inhibitor of Jak is a promising choice for the treatment of prurigo nodularis. [ABSTRACT FROM AUTHOR]

• Janus electrospun fibers were designed based on all-natural materials. • Multifunctional Janus electrospun fibers were prepared by electrospinning. • Janus electrospun fibers prevent liquid penetration for 17 days. • Multibody dissipative particle dynamics elucidated liquid infiltration mechanism. The liquid barrier is a central component of functional liquid packaging materials and is crucial for encapsulating liquid food. To develop high-performance liquid packaging materials for the long-term storage of liquid food, a strong and stable liquid barrier and the simultaneous integration of diverse functionalities must be realized. In this study, inspired by mussel adhesion proteins, nanoparticles are synthesized through oxidative self-polymerization. Furthermore, electrostatic spinning is used for creating multifunctional electrospun fibers for liquid food packaging, which is inspired by the superhydrophobicity of lotus leaf surface and structures of red blood cells. A unique Janus structure with a thin hydrophilic layer and a thick hydrophobic layer prevents liquid food penetration for 12 (EHN/KN electrospun fibers) and 17 days (KN/EHN electrospun fibers). The liquid infiltration mechanism of Janus electrospun fibers is elucidated using the multibody dissipative particle dynamics method, emphasizing their efficacy in avoiding liquid penetration. Moreover, multifunctional KN/EHN electrospun fibers exhibit remarkable characteristics such as water resistance (water contact angle > 150°), UV-blocking (∼100 %), degradability (70 days in soil), biosafety (∼100 %), antioxidation (> 90 %), antimicrobial (∼100 %), grapes and meat freshness retention properties. Thus, this study provides insights into sustainable, high-performance liquid food packaging for enhanced preservation. [ABSTRACT FROM AUTHOR]

This study investigates and compares large-scale moisture and heat budgets over the eastern rainy sea area around Dongsha, the western rainless sea area around Xisha, and the northern coastland of the South China Sea. Ten-year (2011–20) surface, balloon-sounding, satellite measurements, and ERA5 reanalysis are merged into the physically consistent data to study annual and vertical variations of the budgets. It shows that the surface and column-integrated heat and moisture budgets have the smallest annual evolution over the coastland. The latent heat as a key heat contributor in summer is mainly offset by total cold advection and partially offset by net radiative cooling. The horizontal moisture advection below 700 hPa presents moistening over the sea whereas drying over the coastland during rainy months, in which the vertical moisture advection presents moistening up to 250 hPa for all three subregions. The horizontal temperature advection is weak throughout the year over the sea but displays strong top warming and bottom cooling in summer and nearly the opposite in winter over the coastland. The diabatic cooling with a peak at ∼700 hPa in winter is largely due to the enhanced radiative cooling and latent cooling. While the diabatic heating with a peak at ∼500 hPa in summer is largely due to the enhanced latent heating. The earliest atmospheric heating and moistening occur in spring over the coastland, inducing the earliest precipitation increase. The enhanced heating and moistening over Xisha have a 1-month lag relative to Dongsha, resulting in lagging precipitation. [ABSTRACT FROM AUTHOR]