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A report from investigators at Peking Union Medical College in Beijing, China compares two urine tests, the Congo-red dot paper test (CRD) and dipstick urinalysis, for screening preeclampsia in pregnant women. The study found that the agreement between the two tests was modest, with the CRD test having higher specificity but lower sensitivity compared to urinalysis. The researchers concluded that urinalysis is a better diagnostic test for preeclampsia, but CRD could aid in the diagnosis and combining the two tests may improve performance. Further research is needed for potential clinical practice. [Extracted from the article]

Researchers from Chaudhary Charan Singh University in India have developed a paper-based analytical device for the early detection of ovarian cancer. The device uses silver nanoparticles coated on paper to detect lysophosphatidic acid (LPA), a biomarker for ovarian cancer, through surface enhanced Raman spectroscopy (SERS). The study found that patients with ovarian cancer had higher levels of LPA compared to those with benign ovarian tumors or healthy individuals. The researchers believe that this point-of-care device could be a simple, effective, and cost-effective tool for early diagnosis of ovarian cancer. [Extracted from the article]

A recent report from Jiangnan University in Jiangsu, China discusses the development of a paper-based mass spectrometric immunoassay platform for the quantification of food allergens. The researchers aimed to address the limitations of current immunoassay kits, which lack sensitivity and accuracy. The new method combines the specificity and accuracy of mass spectrometry with the simplicity of a paper-based immunoassay, allowing for the detection and quantification of peanut allergen in various food matrices. The researchers believe that this method has potential applications in allergen regulation in the food industry and individual allergen differentiation research. [Extracted from the article]

A joint position paper on molecular tumor boards (MTBs) in Taiwan has been published by the Taiwan Oncology Society (TOS) and the Taiwan Society of Pathology (TSP). The paper, formulated by 20 experts from TOS and TSP, aims to raise awareness of MTBs among healthcare professionals, policymakers, and the public. The paper proposes key recommendations for MTB discussions, including the incorporation of diverse molecular analyses, involvement of multidisciplinary participants, prioritization of cases with unique clinical needs, and the use of comprehensive patient data. The primary goal of this initiative is to promote the advancement of precision oncology in Taiwan. [Extracted from the article]

HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

Researchers from the Indian Institute of Technology (IIT) Bhu have developed a simple and affordable microfluidic paper-based device for measuring albumin levels in human blood. The device separates plasma from a small blood sample and uses a colorimetric assay to detect albumin concentration. The researchers have developed a smartphone app called ALB-SENSE to quantify the albumin level. This device has the potential to be used as a point-of-care device in resource-constrained settings where healthcare diagnostic facilities are limited. [Extracted from the article]

A consensus paper from University Hospital in Charleroi, Belgium discusses the role of the cerebellum in human gait and its assessment and therapy. The cerebellum is critical for postural control and mapping sensory information into motor commands. Ataxia of stance/gait is a common symptom in cerebellar disorders and can lead to falls. The understanding of the cerebellar contribution to gait control can improve the management of cerebellar ataxias and potentially use gait parameters as biomarkers in future clinical trials. [Extracted from the article]