Search

In snakes that are known to be ambush predators, tail luring, in which the movement of a snake's tail resembles that of a worm or insect larva and is used to attract prey, has emerged as a complementary hunting strategy. In certain species, some individuals may present a conspicuously bright colour at the tail tip, which eventually disappears with age. Some authors argue that the bright colour enhances the resemblance of the snake's tail with a potential food item, increasing the success of capture. Here, we tested the influence of geographic variation, sex, and environmental factors on the probability that Common Lanceheads Bothrops jararaca (Wied-Neuwied, 1824) from southeastern Brazil were born with this contrasting tail tip and whether snakes retain this trait throughout adulthood. None of the predictors affected the probability of births with a contrasting tail tip. However, a higher proportion of individuals from the coastal populations retained this trait into adulthood. The absence of difference in the probability of being born with this trait indicates that there are other factors influencing tail tip colour, such as phylogenetic correlates, rather than intrinsic or environmental factors. A higher proportion of ectothermic prey in the diet of coastal populations may explain why this population retains tail luring throughout adulthood. [ABSTRACT FROM AUTHOR]

Background: Brazil is one of the countries with the highest rates of caesarean sections (CS), reaching almost 90% of births in the private sector. A quality improvement project called "Adequate Childbirth Project (PPA)" was conceived to reduce CS in the private sector. This project consisted of four primary components: "Governance", "Participation of Women", "Reorganization of Care" and "Monitoring". This paper aims to evaluate: (1) which specific activities of the PPA had the largest effect on the probability of a woman having a vaginal delivery; (2) which primary component of the PPA had the largest effect on the probability of vaginal delivery and (3) which scenarios combining the implementation of different activities planned in the PPA had a higher effect on the probability of vaginal delivery. Methods: A sample of 12 private hospitals participating in the PPA was evaluated. We used a Bayesian Network (BN) to capture both non-linearities and complex cause-effect relations. The BN integrated knowledge from experts and data from women to estimate 26 model parameters. The PPA was evaluated in 2473 women belonging to groups 1–4 of the Robson classification, who were divided into two groups: those participating or not participating in the PPA. Results: The probability of a woman having a vaginal delivery was 37.7% higher in women participating in the PPA. The most important component of the project that led to an increase in the probability of vaginal delivery was "Reorganization of Care", leading to a 73% probability of vaginal delivery among women in labor. The activity that had the greatest effect on the type of delivery was access to best practices during labor, with a 72% probability of vaginal delivery. Considering the 12 scenarios combining the different activities of the PPA, the best scenarios included: a non-scheduled delivery, access to information about best practices, access to at least 4 best practices during labor and respect of the birth plan, with an 80% probability of vaginal delivery in the best combinations. Conclusion: PPA has been shown to be an effective quality improvement program, increasing the likelihood of vaginal delivery in private Brazilian hospitals. Plain English Summary: Introduction: Brazil boasts one of the highest rates of caesarean sections (CS) globally, with nearly 90% of births in private facilities being delivered via CS. In response, the 'Adequate Childbirth Project – PPA' was launched as a quality improvement initiative aimed at curbing CS rates in private healthcare. Its goal is to improve the quality of childbirth and reduce the number of CS in private healthcare. The project has four main parts: 'Governance', 'Participation of Women', 'Reorganization of Care', and 'Monitoring'. Method: an evaluative study was conducted across 12 private hospitals involved in the PPA, involving 2473 women who were categorized into PPA participants and non-participants. They used a method called a cause-effect network to see which parts of the PPA helped more women have vaginal deliveries. Results: They found that women in the PPA were 37.7% more likely to have a vaginal delivery. Giving women access to good practices during labor and birth was really important. Also, 'Reorganization of Care' was the most important part of the project. It led to a 73% chance of vaginal delivery for women in labor. Conclusion: The PPA is effective in helping more women in private hospitals have vaginal deliveries. This means it's a good program for improving childbirth in Brazil's private hospitals. [ABSTRACT FROM AUTHOR]

This study aimed to assess the consumption of ultra‐processed foods (UPF) and identify their association with obesity and abdominal obesity in adult women of reproductive age living in situations of social vulnerability in Maceió, Northeastern Brazil. This was a cross‐sectional study carried out between October 2020 and May 2021. An anthropometric evaluation was carried out to assess obesity and abdominal obesity. A dietary assessment was also conducted using a 24‐h food recall to determine the calorie intake from UPF. To estimate intra‐individual variability in food consumption, the probabilistic Multiple Source Method was used. These data in the form of tertiles were used to analyse the association between the consumption of UPF and obesity and abdominal obesity. Logistic regressions were used to analyse the association. A directed acyclic graph (DAG) was created for this analysis. This study included 1702 women of which 53.7% were 31 years old or older, and 74.2% lived in poverty. It identified that 36.5% and 38.1% of the women had obesity and abdominal obesity, respectively, and that an average of 33.8% of calories consumed came from UPF. In the analysis of association guided by the DAG, it was observed that women with a high‐calorie intake from UPF had a 1.3 times higher probability of being obese. It was also observed that women with a moderate and high‐calorie intake from UPF were 1.4 and 1.3 times more likely, respectively, to have abdominal obesity. Thus, it can be concluded that socially vulnerable women in Brazil have a relatively high consumption of UPF and that this condition increases the probability of obesity in this population group. [ABSTRACT FROM AUTHOR]

Corn is among the main agricultural products produced in Brazil, mainly due to its importance in human and animal food. Corn productivity is mainly related to climatic conditions and nutritional management, especially concerning nitrogen. The study's objective was to evaluate the response of corn hybrids subjected to nitrogen doses in a low-altitude subtropical environment. The experiment was conducted in the agricultural year of 2019/2020 in the municipality of Santa Maria-RS. The experimental design was of completely randomized blocks in a subdivided plot. Four corn hybrids, DKB 240 PRO 3, DKB 290 PRO 3, DKB 345 PRO 3, and Ag 9025 were used as the main plot, and six doses of nitrogen, 0, 50, 100, 150, 200, and 250 kg ha-1 in subplots. We evaluated the number of grain rows (NR) per cob, number of grains per row (NGR), cob length (CL, cm), average grain length (GL, cm), total grain weight per cob (GWC, g), thousand-grain mass (TGM, in g), and grain yield (YIE, in kg ha-1). The data were submitted to the analysis of variance (F test), and the means were compared by the Scott-Knott test at 5% of error probability and submitted to regression analysis. Cultivar Ag 9025 had the highest grain yield, associated with the highest CL, GL, GWC, TGM. The higher GL associated with high TGM compensated for the lower averages of NR and NGR for this cultivar. The maximum technical efficiency for the cultivars was 196.22 kg ha-1 of nitrogen. The mass economic efficiency with commercial values of the 2019/2020 harvest for the cultivars was 185.84 kg ha-1. [ABSTRACT FROM AUTHOR]

Serosurveys are a widely used tool to estimate the cumulative incidence—the fraction of a population that has been infected by a given pathogen. These surveys rely on serological assays that measure the level of pathogen-specific antibodies. Because antibody levels are waning, the fraction of previously infected individuals that have seroreverted increases with time past infection. To avoid underestimating the true cumulative incidence, it is therefore essential to correct for waning antibody levels. We present an empirically supported approach for seroreversion correction in cumulative incidence estimation when sequential serosurveys are conducted in the context of a newly emerging infectious disease. The correction is based on the observed dynamics of antibody titers in seropositive cases and validated using several in silico test scenarios. Furthermore, through this approach we revise a previous cumulative incidence estimate relying on the assumption of an exponentially declining probability of seroreversion over time, of severe acute respiratory syndrome coronavirus 2, of 76% in Manaus, Brazil, by October 2020 to 47.6% (95% confidence region: 43.5–53.5). This estimate has implications, for example, for the proximity to herd immunity in Manaus in late 2020. [ABSTRACT FROM AUTHOR]

Streamflow forecasting plays a crucial role in the operational planning of hydro-dominant power systems, providing valuable insights into future water inflows to reservoirs and hydropower plants. It relies on complex mathematical models, which, despite their sophistication, face various uncertainties affecting their performance. These uncertainties can significantly influence both short-term and long-term operational planning in hydropower systems. To mitigate these effects, this study introduces a novel Bayesian model averaging (BMA) framework to improve the accuracy of streamflow forecasts in real hydro-dominant power systems. Designed to serve as an operational tool, the proposed framework incorporates predictive uncertainty into the forecasting process, enhancing the robustness and reliability of predictions. BMA statistically combines multiple models based on their posterior probability distributions, producing forecasts from the weighted averages of predictions. This approach updates weights periodically using recent historical data of forecasted and measured streamflows. Tested on inflows to 139 reservoirs and hydropower plants in Brazil, the proposed BMA framework proved to be more skillful than individual models, showing improvements in forecasting accuracy, especially in the South and Southeast regions of Brazil. This method offers a more reliable tool for streamflow prediction, enhancing decision making in hydropower system operations. [ABSTRACT FROM AUTHOR]

The analytical treatment of some of the primary environmental controls on landslides has demonstrated that the landslide size distribution in the Paraitinga River basin, southeastern Brazil, are influenced by parameters such as triggering rainfall, lithology, slope gradient, upslope area, and land cover. Through the mapping of the surface of rupture of 1102 landslides triggered during an intense rainfall event in the summer of 2009/2010 and the fitting of a probability density function, we have discovered that the probability of large landslides occurring was significantly disturbed by lithology, slope gradients > 0.56 m/m, and triggering rainfall exceeding 180 mm within 48 h. In contrast, the probability density function for small landslides was affected by slope gradients less than < 0.31 m/m, rainfall less than 120 mm within 48 h, and higher values of upslope area. Moreover, the area of landslides in the probability peaks substantially increased when lithology consisted of schist or quartzite and in forested areas. These findings corroborate previous studies that establish a relationship between landslide size distributions and triggering processes, as well as the mechanics of landslides based on stability models, indicating a variation in triggering processes between the two segments of the curve: rollover (small landslides) and tail (large landslides). [ABSTRACT FROM AUTHOR]

Background: The species M. melini has been observed in both the Pampa and Spinal ecoregions of Argentina. Researchers have underscored that distinguishing M. melini from other species within the same genus relies primarily on craniometric and molecular analyses. Morphological measurements alone do not offer a clear differentiation between M. melini and other members of this genus. This study aims to document the presence of M. melini within the Brazilian ecoregion, focusing on its morphological, morphometric and genetic characteristics. By undertaking a comprehensive examination, we seek to contribute valuable insights into the distribution and differentiation of M. melini in this region. New information: Molossus melini specimens exhibited a forearm length ranging from 39.9 to 40.08 mm. The average intraspecific divergence was 1.2%, with specimens from the Argentine Pampas clustering in the same clade with a 98% bootstrap support and a posterior probability of: Regarding dorsal colouration, the specimens displayed fur with two bands--a Snow White base colour and apex colours ranging from Olive Brown, Broccoli Brown, Wood Brown to Yellowish-Brown. This marks the first record of M. melini in Brazil, expanding its distribution 1,300 km northeastwards into the Curitiba, Paraná, Atlantic Forest Ecoregion. The findings contribute valuable information on the distribution, morphology, morphometrics and genetics of this species. [ABSTRACT FROM AUTHOR]

Brazil's Pantanal wetland is one of the most threatened Brazilian ecosystems from direct anthropogenic pressures and climate change. In this study, the overarching research question is to explore whether compound drought-heat events (CDHEs) have become more recurrent, intense, and widespread over Brazil's Pantanal wetland in recent decades. For this, we purpose and tested two different approaches using validated long-term time series of monthly precipitation, temperature, and the satellite-based Vegetation Health Index (VHI) to characterize the spatiotemporal pattern of CDHEs over Pantanal. Firstly, we assessed global gridded precipitation and temperature data sets against ground measurements to choose an appropriate dataset for this study. Then, we calculated the Standardized Precipitation Index (SPI), Standardized Temperature Index (STI), and Standardized Precipitation Evapotranspiration Index (SPEI) from 1981 to 2021. The results showed that using both approaches (CDHE-M1 and CDHE-M2), the frequency of events is higher considering the moderate category, which is expected since the criteria are less restrictive. In addition, the highest frequency of CDHE events occurs between September and November (the end of the dry season). The results also indicated that CDHE events have been more recurrent and widespread since 2000 in Pantanal. Besides, considering all methods for identifying the CDHEs, the probability density function indicates a shift pattern to warmer and drier conditions in the last 40 years. The Mann–Kendall tests also confirmed the assumption that there is a significantly increasing trend in the compound drought-heat events in the Pantanal. Developing methodologies for monitoring compound climate events is crucial for assessing climate risks in a warming climate. Besides, it is expected that our results contribute to the convincing of the urgent need for environmental protection strategies and disaster risk reduction plans for the Pantanal. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sexually Transmitted Infections (STIs), such as Human Immunodeficiency Virus (HIV) transmitted by biological, socioeconomic and cultural factors that increase the vulnerability of certain population groups such as civil construction workers. OBJECTIVE: To evaluate the knowledge of workers in the construction industry about infection by HIV and associated factors. METHODS: A cross-sectional, analytical study was conducted, including 381 construction workers, in the cities of João Pessoa, Cabedelo, and Santa Rita, in the State of Paraíba, Brazil, performed through interviews, using a data collection instrument with social demographic variables and the HIV Knowledge Questionnaire. Data were analyzed using descriptive measures, and for comparison between the categories the Kruskal-Wallis test was used, with margin of error of 5%. RESULTS: A predominance of male workers was observed (97.4%) among 381 workers; aged 30-39 (34.1%); married (81.4%); with up to eight years of education (66.6%); family income of up to 2x the minimum wage (52.8%) and coming from the country (43.8%). The average of correct responses was 63.3%, with higher indices (70.0%) related to transmission and forms of prevention. There were higher percentages of hits among those who had studied for 12 years or more. Workers from the capital of Paraíba presented a higher number of correct responses (67.44%). CONCLUSIONS: There is a low index of knowledge of construction workers about HIV, highlighting their consequent vulnerability to acquiring this infection. [ABSTRACT FROM AUTHOR]

Anabolic androgenic steroids (AAS) are traditionally used for the treatment/control of various diseases; however, they are being used for non-therapeutic and indiscriminate purposes to enhance sports performance and physical appearance. This study aimed to assess the prevalence and associated factors of AAS use among professional CrossFit® competitors. We conducted an observational cross-sectional survey in which an anonymous questionnaire was applied to professional CrossFit® athletes. The prevalence of AAS usage was 33.3%. Most users were male (74.2%), aged between 30 and 39 years (51.6%), with completed higher education (83.9%), and had been training for more than 5 years (77.4%); the primary motivation for AAS use was performance enhancement (77.4%). Individuals who were older (p < 0.05) and more experienced in competitions (p < 0.01) are more likely to use AAS. Testosterone was the most employed AAS (71.0%); CrossFit® athletes typically used an average of 2 different AAS. The majority of users had notably sought advice from a physician (74.2%), and AAS were acquired from either drugstores (80.6%) or through illicit channels (29.0%). Moreover, 61.3% of AAS users reported experiencing adverse effects. Our results demonstrated a higher prevalence of AAS users among professional competitors in CrossFit® compared to the general population; older age and greater experience in official competitions were decisive factors for a greater inclination toward AAS use. A significant percentage of athletes seek drugs through illegal channels. Despite the majority of users experiencing adverse effects, athletes report satisfaction with use, believing that the benefits still outweigh the drawbacks. [ABSTRACT FROM AUTHOR]

The classical linear regression model allows for a continuous quantitative variable to be modeled simply from other variables. However, this model assumes independence between observations, which, if ignored, can lead to methodological issues. Additionally, not all data follow a normal distribution, prompting the need for alternative modeling methods. In this context, geographically weighted beta regression (GWBR) incorporates spatial dependence into the modeling process and analyzes rates or proportions using the beta distribution. In this study, GWBR was applied to the traffic injury (fatal and non-fatal) crash proportions in Fortaleza, Ceará, Brazil, from 2009 to 2011. The results demonstrated that the local approach using the beta distribution is a viable model for explaining the traffic injury crash proportions, due to its flexibility in handling both symmetric and skewed distributions. Therefore, when analyzing rates or proportions, the use of the GWBR model is recommended. [ABSTRACT FROM AUTHOR]

Governmental research agencies from Germany, Italy, Spain, and UK have suggested the use of specific two- and three-parameter probability density functions (PDFs) for estimating the magnitude and frequency of annual maximum streamflow (AMS). In Brazil, there are no guidelines concerning the use of multiparameter PDFs to model AMS, with most applications relying on two-parameter distributions. Considering the worldwide promising results when using multiparameter PDFs, here we focused on the evaluation of ten PDFs to model AMS over all gauged streams of Brazil. The methodology developed for this study consisted of the: (i) acquisition of streamflow data; (ii) organization of the AMS series; (iii) screening of AMS series considering temporal and statistical criteria; (iv) fit of the following PDFs to the AMS series based on the L-moments method: Gumbel, Gamma, Generalized Logistic, Generalized Normal, Generalized Pareto, three-parameter Log-Normal, Pearson type 3, Generalized Extreme Value, Kappa, and Wakeby; (v) quantile estimation; and (vi) PDF performance assessment according to the Filliben test and the relative absolute error (RAE). Based on the almost 4 thousand AMS series considered on this study, we concluded that: (i) Gumbel and Gamma provided poor performance (more than 17% of non-satisfactory fits); (ii) the multiparameter PDFs (Wakeby and Kappa) outperformed all other PDFs; (iii) Gumbel and Generalized Extreme Value had the highest RAE values for quantile estimate; and (iv) this study contributes to the scientific advances reported in the recent statistical hydrology literature and can provide local decision makers with the necessary technical information for developing national design flood guidelines.. [ABSTRACT FROM AUTHOR]

Objectives: This study evaluated the occurrence of Schistosoma mansoni and soil‐transmitted helminths in an endemic area in the Eastern Brazilian Amazon, analysing prevalence and spatial distribution. Methods: The study was conducted in four localities of Primavera Municipality, in Pará state. Data was obtained from the Decit 40/2012 project and the participants were divided into five age range categories for evaluation: children, adolescents, young adults, adults and elderly individuals. For the diagnostic tests, Kato–Katz slides were prepared to detect S. mansoni and soil‐transmitted helminths eggs. The spatial distribution map and the Kernel Density Estimation were performed to assess the presence and location of infections. Results: Stool samples revealed the presence of hookworms, S. mansoni, Ascaris lumbricoides and Trichuris trichiura eggs. Mono‐, bi‐ and poly‐parasitic infections were observed, with a significant prevalence of hookworm monoparasitism. Conclusions: The high frequency of children infected with soil‐transmitted helminths confirms their significance as an ongoing public health problem in the poorest municipalities of Brazil. The Geographic Information System plays a crucial role in environmental surveillance and in the control of epidemics and endemic diseases, enabling accurate assessment and informed decision‐making for their control. [ABSTRACT FROM AUTHOR]

Background: Mortality rate estimation in small areas can be difficult due the low number of events/exposure (i.e. stochastic error). If the death records are not completed, it adds a systematic uncertainty on the mortality estimates. Previous studies in Brazil have combined demographic and statistical methods to partially overcome these issues. We estimated age- and sex-specific mortality rates for all 5,565 Brazilian municipalities in 2010 and forecasted probabilistic mortality rates and life expectancy between 2010 and 2030. Methods: We used a combination of the Tool for Projecting Age-Specific Rates Using Linear Splines (TOPALS), Bayesian Model, Spatial Smoothing Model and an ad-hoc procedure to estimate age- and sex-specific mortality rates for all Brazilian municipalities for 2010. Then we adapted the Lee-Carter model to forecast mortality rates by age and sex in all municipalities between 2010 and 2030. Results: The adjusted sex- and age-specific mortality rates for all Brazilian municipalities in 2010 reveal a distinct regional pattern, showcasing a decrease in life expectancy in less socioeconomically developed municipalities when compared to estimates without adjustments. The forecasted mortality rates indicate varying regional improvements, leading to a convergence in life expectancy at birth among small areas in Brazil. Consequently, a reduction in the variability of age at death across Brazil's municipalities was observed, with a persistent sex differential. Conclusion: Mortality rates at a small-area level were successfully estimated and forecasted, with associated uncertainty estimates also generated for future life tables. Our approach could be applied across countries with data quality issues to improve public policy planning. [ABSTRACT FROM AUTHOR]

Copyright of Ensaio: Avaliação e Políticas Públicas em Educação is the property of Ensaio: Avaliacao e Politicas Publicas em Educacao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Substantial global restoration commitments are occurring alongside a rapid expansion in land-hungry tropical commodities, including to supply increasing demand for wood products. Future commercial tree plantations may deliver high timber yields, shrinking the footprint of production forestry, but there is an as-yet unquantified risk that plantations may expand into priority restoration areas, with marked environmental costs. Focusing on Brazil-a country of exceptional restoration importance and one of the largest tropical timber producers-we use random forest models and information on the economic, social, and spatial drivers of historic commercial tree plantation expansion to estimate and map the probability of future monoculture tree plantation expansion between 2020 and 2030. We then evaluate potential plantation-restoration conflicts and opportunities at national and biome-scales and under different future production and restoration pathways. Our simulations show that of 2.8 Mha of future plantation expansion (equivalent to plantation expansion 2010-2020), ~78,000 ha (3%) is forecast to occur in the top 1% of restoration priority areas for terrestrial vertebrates, with ~547,500 ha (20%) and ~1,300,000 ha (46%) in the top 10% and 30% of priority areas, respectively. Just ~459,000 ha (16%) of expansion is forecast within low-restoration areas (bottom 30% restoration priorities), and the first 1 Mha of plantation expansion is likely to have disproportionate impacts, with potential restoration-plantation overlap starkest in the Atlantic Forest but prominent in the Pampas and Cerrado as well. Our findings suggest that robust, coherent land-use policies must be deployed to ensure that significant trade-offs between restoration and production objectives are navigated, and that commodity expansion does not undermine the most tractable conservation gains under emerging global restoration agendas. They also highlight the potentially significant role an engaged forestry sector could play in improving biodiversity outcomes in restoration projects in Brazil, and presumably elsewhere., (© 2024 The Authors. Global Change Biology published by John Wiley & Sons Ltd.)

This article develops a flexible class of Markov-switching models in which the GDP growth rate is decomposed into a long-run growth trend and evolving regime-dependent means. The models can account for multiple regimes, breaks in the long-run trend, stochastic volatility, and time-varying transition probabilities. They can also handle data outliers that may arise from rare events, such as the COVID-19 crisis. We illustrate our methodology by modelling Brazilian GDP growth, which has exhibited complicated dynamics over the past four decades. Our results suggest two regimes, one long-run trend break, significant time variation in volatility, and the presence of outliers. Moreover, the selected model features time-varying transition probabilities driven by domestic variables (fiscal stance, reserves, and the real interest rate). Significantly, our findings indicate a marked decline in Brazil's long-run growth in recent years. [ABSTRACT FROM AUTHOR]

A series of laboratory tests were carried out focusing on the fracture characteristics of granite under different stress conditions. The macroscopic mechanical characteristics of granite, such as nonlinear stress–strain curve, tension compression bi-modularity, crack initiation, and propagation laws during Brazil splitting, were analyzed with the help of the digital image correlation method. A fine discrete-element model was established based on the laboratory test results and aimed to overcome the shortcomings of traditional simulation. The proposed model reproduced the characteristics of inherent microcrack closure, tension compression bi-modularity, and crack evolution under different stress paths. The detailed calibration method of the microparameters in the model was summarized. The relationship between macro-mechanical properties and micro-attributes of granite was further analyzed using the fine discrete-element model. The stress thresholds in uniaxial compression and crack initiation phenomenon in Brazil splitting were analyzed and explained from the micro-perspective. The microphysical significance of the Hoek–Brown criterion in shear failure was clarified through analyzing numerical test results. Hoek–Brown criterion is found being a statistical rule summary of the overall strength composed of the random distribution of the strength of the two parts in the rock: the cohesion of bonded particles and the friction of nonbonded particles. Highlights: A comprehensive discrete-element model is established that can simultaneously reflect the characteristics of inherent microcrack closure, tension compression bi-modularity and crack evolution under different stress paths. The stress thresholds in uniaxial compression and the crack initiation phenomenon in Brazil splitting are analyzed and explained from the micro-perspective. The microphysical significance of Hoek–Brown criterion is clarified through numerical tests. [ABSTRACT FROM AUTHOR]

Aim: To compare the physical activity pattern before and during the COVID-19 pandemic and verify the association with contextual, behavioral, and health variables related to the pandemic in adults and older adults from southern Brazil. Subject and methods: This is a panel-type, population-based study in Rio Grande-RS and Criciúma-SC, with 4290 individuals. The physical activity pattern (dependent variable) was measured using the International Physical Activity Questionnaire-IPAQ. In addition, contextual, behavioral, and health aspects related to the pandemic (independent variables) were assessed by questionnaires. Fisher's exact test was used for bivariate analyses and Poisson regression with robust variance to calculate crude and adjusted prevalence, with their respective 95% confidence intervals. Results: There was a 72% reduction in commuting physical activity and a 145% increase in physical inactivity when compared before and during the pandemic. Social distancing, excessive search for information about COVID-19, fear of the pandemic, and COVID-19 infection were all factors that contributed to the decline in physical activity during the pandemic. The home office was a protective factor for physical inactivity. Conclusion: The COVID-19 pandemic has negatively affected the pattern of physical activity in the general population, except for those who switched to working from home. [ABSTRACT FROM AUTHOR]

The aim of this study was to analyse the spatial patterns and factors associated with the incidence of tuberculosis-diabetes (TB-DM) in Brazil, from 2001 to 2019. Ecological study. Brazilian municipalities were used as the units of analysis. The local empirical Bayesian rate and the spatial autocorrelation test were calculated. Moran and Getis-Ord Gi∗ were used to identify spatial clusters, and spatially weighted regression was conducted. In total, 75,021 new cases of TB associated with DM were reported in Brazil during the study period. Most Brazilian municipalities had an average TB-DM incidence of 1.0–2.0/100,000 inhabitants. The regression showed that the Gini index (β = 0.85) and family health strategy coverage (β = −0.26) were the two indicators that had the most influence on TB-DM incidence in Brazil. This study identified spatial clusters of TB-DM in Brazil. The results also indicated that social inequalities played a key role in the incidence of TB. [ABSTRACT FROM AUTHOR]

In the face of perceived injustice, a huge number of intense anti-World Cup movements took place throughout almost every host city from June 2013 to July 2014 in Brazil. Over a million Brazilians joined anti-World Cup protests in more than 100 cities throughout Brazil in early July 2013, and this civil resistance lasted until the beginning of the World Cup. After the Cup, a number of violent protests in Rio de Janeiro against the 2016 Olympics occurred as well, and these produced far more controversy over the event. This study examines the emergence of social movements against the 2014 World Cup and the 2016 Olympic Games held in Brazil. Despite the importance of the subject, there has been a scarcity of literature addressing networked social movements in Brazil that opposed mega-sporting events and how this relates to theoretical debates about differentiated citizenship and the right to the city. To fill this gap, this article aims to explore the characteristics of protests. Drawing on an analysis of archival sources and interviews conducted during fieldwork in Brazil, this study shows that such demonstrations can be best seen as “networked social movements” that had been struggling for the asymmetric distribution of rights around the neoliberal mega-events. These networked social movements entailed the characteristics of the right-tothe-city movements that intended to subvert the social systems of differentiated citizenship in Brazil. [ABSTRACT FROM AUTHOR]

Boursin is a versatile semisoft cheese that can be made with different types of milk. While widely distributed in the European and North American markets, Boursin is produced to a limited extent in Brazil despite its commercial potential. This scenario encourages consumer‐oriented product development studies by facilitating data collection with less bias and fewer product preconceptions, thus favoring the investigation of technological aspects of commercial interest. This study evaluates Brazilians' perceptions regarding different versions of Boursin cheese, with the aim of gaining a better understanding of the factors related to choosing cheese. Four attributes related to cheese production were evaluated at three different levels using two discrete choice experiments: one with eye tracking (n = 20) and another without (n = 312). These attributes included "type of processing" (evaluating pasteurization, ohmic heating, and preparation with raw milk), "animal origin of milk" (cow, goat, or buffalo milk), "type of product" (traditional, light, and lactose‐free versions), and "price" (10.99, 13.99, and 16.99 BRL). Information regarding processing with ohmic heating did not affect the probability of Boursin being chosen, suggesting that consumers are open to using this emerging technology in Boursin cheese. However, information on being made with goat, buffalo, and raw milk negatively impacted the probability of choice, along with the price of 16.99 BRL. The frequency of cheese consumption and the level of health concerns also affected the probability of choosing the product. Practical Application: Identifying the relationship between extrinsic attributes presented on the Boursin cheese label and the consumer's choice process can aid the communication process with the target audience and reveal how some technological issues of interest to manufacturers are perceived. This study indicates how information regarding the animal origin of the milk (cow, goat, and buffalo), the type of processing (pasteurization, ohmic heating, and raw milk), the version of the product (traditional, light, and lactose‐free), and the price affect the consumer choice process. The results provide insights that can be applied to product processing and designing labels. [ABSTRACT FROM AUTHOR]

Endemic to the Atlantic Forest in Southeastern Brazil, the critically endangered Buffy‐Headed marmoset (Callithrix flaviceps) is lacking the required attention for effective conservation. We modelled its ecological niche with the main objectives of (1) defining suitable habitat and (2) prioritising areas for conservation and/or restoration. The current geographical range of Callithrix flaviceps in the Atlantic Forest of Southeast Brazil. We used Ensemble Species Distribution Modelling to define current habitat suitability considering four climate and two landscape variables. To identify areas to prioritise for conservation and/or restoration, we predicted future habitat suitability considering the intermediate (RCP4.5) and extreme (RCP8.5) climate change scenarios for the years 2050 and 2070. Among the variables included to predict current species distribution, tree canopy cover, precipitation seasonality and temperature seasonality were the most important whereas digital elevation model and precipitation during the wettest month were the least important. Callithrix flaviceps was most likely to occur in areas with tree canopy cover >80%, high precipitation seasonality and temperature seasonality between 21 and 23°C. From the future suitability prediction maps, the Caparaó National Park stands out as a likely key area for the preservation of the species. Furthermore, high climatic suitability but low landscape suitability suggests that habitat restoration in 'Serra das Torres' (South of the current distribution area) might be a useful strategy. However, creating ecological corridors on the west side of Caparaó would be necessary to improve connectivity. More surveys within and beyond the current geographical range are required to define more precisely the distribution of the species. Our results support the notion that seasonality is important for Callithrix flaviceps and that as a montane species, it prefers colder environments and higher altitudes. Within both climate change scenarios, Caparaó National Park was predicted to be highly suitable, with a high probability of presence. [ABSTRACT FROM AUTHOR]

Chromosomal microarray (CMA) is the reference in evaluation of copy number variations (CNVs) in individuals with neurodevelopmental disorders (NDDs), such as intellectual disability (ID) and/or autism spectrum disorder (ASD), which affect around 3–4% of the world's population. Modern platforms for CMA, also include probes for single nucleotide polymorphisms (SNPs) that detect homozygous regions in the genome, such as long contiguous stretches of homozygosity (LCSH). These regions result from complete or segmental chromosomal homozygosis and may be indicative of uniparental disomy (UPD), inbreeding, population characteristics, as well as replicative DNA repair events. In this retrospective study, we analyzed CMA reading files requested by geneticists and neurologists for diagnostic purposes along with available clinical data. Our objectives were interpreting CNVs and assess the frequencies and implications of LCSH detected by Affymetrix CytoScan HD (41%) or 750K (59%) platforms in 1012 patients from the south of Brazil. The patients were mainly children with NDDs and/or congenital anomalies (CAs). A total of 206 CNVs, comprising 132 deletions and 74 duplications, interpreted as pathogenic, were found in 17% of the patients in the cohort and across all chromosomes. Additionally, 12% presented rare variants of uncertain clinical significance, including LPCNVs, as the only clinically relevant CNV. Within the realm of NDDs, ASD carries a particular importance, owing to its escalating prevalence and its growing repercussions for individuals, families, and communities. ASD was one clinical phenotype, if not the main reason for referral to testing, for about one-third of the cohort, and these patients were further analyzed as a sub-cohort. Considering only the patients with ASD, the diagnostic rate was 10%, within the range reported in the literature (8–21%). It was higher (16%) when associated with dysmorphic features and lower (7%) for "isolated" ASD (without ID and without dysmorphic features). In 953 CMAs of the whole cohort, LCSH (≥ 3 Mbp) were analyzed not only for their potential pathogenic significance but were also explored to identify common LCSH in the South Brazilians population. CMA revealed at least one LCSH in 91% of the patients. For about 11.5% of patients, the LCSH suggested consanguinity from the first to the fifth degree, with a greater probability of clinical impact, and in 2.8%, they revealed a putative UPD. LCSH found at a frequency of 5% or more were considered common LCSH in the general population, allowing us to delineate 10 regions as potentially representing ancestral haplotypes of neglectable clinical significance. The main referrals for CMA were developmental delay (56%), ID (33%), ASD (33%) and syndromic features (56%). Some phenotypes in this population may be predictive of a higher probability of indicating a carrier of a pathogenic CNV. Here, we present the largest report of CMA data in a cohort with NDDs and/or CAs from the South of Brazil. We characterize the rare CNVs found along with the main phenotypes presented by each patient and show the importance and usefulness of LCSH interpretation in CMA results that incorporate SNPs, as well as we illustrate the value of CMA to investigate CNV in ASD. [ABSTRACT FROM AUTHOR]

Copyright of Revista Brasileira de Engenharia Agricola e Ambiental - Agriambi is the property of Revista Brasileira de Engenharia Agricola e Ambiental and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Signals recorded by two stations in the Brazilian region: [Fortaleza (3.74°S, 38.57°W) and Inconfidentes (22.31°S, 46.32°W)], receiving L1 transmissions from different geostationary satellites, were used to evaluate the amplitude scintillation index S4 and several characteristics of scintillation events (continuous record with S4 > 0.2) during nighttime hours (18:00 LT–02:00 LT) in the years 2014–2016. The effects from solar activity, season, and local time on the number of scintillation events per night, maximum scintillation, scintillation event duration, and spacing between consecutive events will be discussed. The results indicate that: (a) scintillation occurs from September to March in both links; (b) the most likely numbers of observed scintillation events per night were two or three, particularly during the first 2 years; (c) on average, the first scintillation event usually had larger maximum S4 values when compared to those of the later ones along the night; (d) the first scintillation event had a longer mean duration than the succeeding ones in a given night; (e) the durations of scintillation events, regardless of their numbers per night and the location, decreased with local time; (f) the opposite dependence of spacings between consecutive events on local time was observed; (g) the cumulative distribution functions of the scintillation onset time indicated a strong dependence on the dip latitude of the station; and (h) early occurrences of onset times are directly related to the increased probability of the occurrence of multiple scintillation events. Plain Language Summary: This study used radio signals from geostationary satellites collected from two ground‐based stations in distinct dip latitudes over Brazil to evaluate aspects of amplitude scintillation. The investigation focused on the number of occurrences and in their specific characteristics such as intensity, duration, and spacing between consecutive scintillation events. The early nighttime hours, when scintillation is more likely to affect the signals were considered during the months of September to March over the years of 2014–2016, covering varied seasonal and solar flux conditions. The findings indicate that scintillation events earlier in the night have larger S4 values and longer duration, being more severe for transionospheric signals. The results also show that earlier onset of scintillation events is likely to indicate multiple events over the night. These new findings contribute to the understanding of scintillation phenomenon and provide valuable insights for improving satellite‐based systems in equatorial and low‐latitude regions. Key Points: The first scintillation event has larger maximum S4 values and longer mean duration when compared to the subsequent eventsThe durations of the scintillation events decrease with local time. The spacing between consecutive events shows the opposite trend; andEarlier occurrences of onset times are related to the increased probability of the occurrence of multiple scintillation events [ABSTRACT FROM AUTHOR]

Background: Hybridization between the local medical systems (LMSs) and biomedicine has been the focus of different studies in ethnobiology, primarily due to the increasing access to biomedicine by indigenous peoples and local communities. Studies on hybridization allow for an understanding of the process of developing and evolving local knowledge systems. In this study, we propose a hybridization score to determine how individuals' socioeconomic characteristics and preference between LMS and biomedicine determine the complementarity of therapeutic options. Methods: We conducted semistructured interviews and applied free listing technique in a rural community in Northeast Brazil to assess the treatments the local population sought and which were preferred. Results: Our analyses showed that the level of schooling was the socioeconomic factor that negatively affected the hybridization process. Individuals with higher levels of schooling tended to prefer LMS strategies less and, consequently, showed a lower probability of hybridizing the two systems. Additionally, older people who preferred LMS strategies showed a greater tendency to adopt hybridization in human health-seeking behavior. Conclusions: Our findings provide further evidence of the complementarity between different medical systems and demonstrate that socioeconomic factors can affect local knowledge and are responsible for differences in individual propensity to hybridize distinct medical systems. [ABSTRACT FROM AUTHOR]

Importance: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in patients with type 2 diabetes, heart failure, and chronic kidney disease, but their effect on outcomes of critically ill patients with organ failure is unknown. Objective: To determine whether the addition of dapagliflozin, an SGLT-2 inhibitor, to standard intensive care unit (ICU) care improves outcomes in a critically ill population with acute organ dysfunction. Design, Setting, and Participants: Multicenter, randomized, open-label, clinical trial conducted at 22 ICUs in Brazil. Participants with unplanned ICU admission and presenting with at least 1 organ dysfunction (respiratory, cardiovascular, or kidney) were enrolled between November 22, 2022, and August 30, 2023, with follow-up through September 27, 2023. Intervention: Participants were randomized to 10 mg of dapagliflozin (intervention, n = 248) plus standard care or to standard care alone (control, n = 259) for up to 14 days or until ICU discharge, whichever occurred first. Main Outcomes and Measures: The primary outcome was a hierarchical composite of hospital mortality, initiation of kidney replacement therapy, and ICU length of stay through 28 days, analyzed using the win ratio method. Secondary outcomes included the individual components of the hierarchical outcome, duration of organ support–free days, ICU, and hospital stay, assessed using bayesian regression models. Results: Among 507 randomized participants (mean age, 63.9 [SD, 15] years; 46.9%, women), 39.6% had an ICU admission due to suspected infection. The median time from ICU admission to randomization was 1 day (IQR, 0-1). The win ratio for dapagliflozin for the primary outcome was 1.01 (95% CI, 0.90 to 1.13; P =.89). Among all secondary outcomes, the highest probability of benefit found was 0.90 for dapagliflozin regarding use of kidney replacement therapy among 27 patients (10.9%) in the dapagliflozin group vs 39 (15.1%) in the control group. Conclusion and Relevance: The addition of dapagliflozin to standard care for critically ill patients and acute organ dysfunction did not improve clinical outcomes; however, confidence intervals were wide and could not exclude relevant benefits or harms for dapagliflozin. Trial Registration: ClinicalTrials.gov Identifier: NCT05558098 Key Points: Question: Does the addition of dapagliflozin to standard of care improve the hierarchical outcome of hospital mortality, initiation of kidney replacement therapy, and the length of stay in the intensive care unit (ICU) among critically ill patients with acute organ dysfunction? Findings: In this multicenter, open-label, randomized clinical trial that included 507 participants with at least 1 acute organ dysfunction (hypotension, kidney injury, or respiratory), the use of 10 mg of dapagliflozin for up to 14 days did not significantly reduce the combined outcome of hospital mortality, initiation of kidney replacement therapy, and ICU length of stay, assessed by the win ratio method (win ratio, 1.01, not significant) through 28 days after randomization. Meaning: The addition of dapagliflozin to standard care for individuals with critical illness and acute organ dysfunction did not improve clinical outcomes. This randomized clinical trial assessed whether adding dapagliflozin to standard care for patients with acute organ dysfunction could reduce the composite outcome of hospital mortality, initiation of kidney replacement therapy, and length of stay compared with standard care alone. [ABSTRACT FROM AUTHOR]

Racial disparity in physical activity in people with diabetes in Brazil remains scarcely investigated. We examined the association between physical activity and diabetes-related complications according to race in the Brazilian population. Cross-sectional. We analyzed data from the 2019 National Health Survey, a population-based survey of Brazilian adults. We used a self-reported questionnaire to assess physical activity during commuting, leisure-time, domestic, and occupational activities. Diabetes-related complications included vision, kidney, and circulatory impairment, foot ulcers, diabetic coma, and all-cause complications. We used robust Poisson regression models with restricted cubic splines to examine the association between physical activity and diabetes-related complications. We included 2529 adults with diabetes (48.9% women; mean age: 53.5 ± 11.9 years). One-third experienced diabetes-related complications. Black adults performed less leisure-time and more occupational and commuting physical activity than White participants. Black participants showed a higher probability of all-cause (1.61; 95%CI: 1.29, 2.02) and vision complications (1.58; 95%CI: 1.23, 2.04) compared to White participants independent of physical activity status. Only leisure-time physical activity was associated with a reduced probability of all-cause complications (PR: 0.78; 0.71, 0.86) whereas commuting and occupational physical activity were not associated with any diabetes-related complications. Physically inactive, Brown adults showed a higher probability of kidney, circulatory, vision, and all-cause complications than active, White adults. However, physical activity attenuated the probability of these complications in Brown participants. The association between physical activity and diabetes-related complications is domain-specific. We revealed a racial disparity in physical activity in people with diabetes in Brazil. [ABSTRACT FROM AUTHOR]

Falls are among the top 10 causes of years lived with disability in people aged 75 and over. Preventive programs like case management (CM) are crucial. Objectives: To evaluate the effects of a multifactorial fall prevention program based on CM on physical performance, the presence of pain, and the risk of falls and fractures in older people who have suffered falls. Methods: This randomized, single-blind clinical trial with parallel groups, Intervention Group (IG) and Control Group (CG), was composed of 55 older people with a history of falling, living in the community. All participants underwent an initial assessment via video call (containing anamnesis, timed up-and-go test, falls risk score, short physical performance battery, and clinical frax). The IG underwent CM, the physical exercise protocol, and the cognitive stimulation protocol. The CG was monitored through telephone calls and received general health and fall guidance. Results: No significant results were found in the physical capacity, the presence of pain, the risk of falls, or the fractures between the Intervention and Control Groups and between assessments. Conclusion: This program was not effective in improving functional performance, but it was important for characterizing pain and the probability of fracture in the next 10 years in this population. [ABSTRACT FROM AUTHOR]

Objectives: To identify the prevalence and associated factors of cognitive dysfunction, 1 year after ICU discharge, among adult patients, and it´s relation with quality of life. Methods: Multicenter, prospective cohort study including ICUs of 10 tertiary hospitals in Brazil, between May 2014 and December 2018. The patients included were 452 adult ICU survivors (median age 60; 47.6% women) with an ICU stay greater than 72 h. Results: At 12 months after ICU discharge, a Montreal Cognitive Assessment (tMOCA) telephone score of less than 12 was defined as cognitive dysfunction. At 12 months, of the 452 ICU survivors who completed the cognitive evaluation 216 (47.8%) had cognitive dysfunction. In multivariable analyses, the factors associated with long-term (1-year) cognitive dysfunction were older age (Prevalence Ratio–PR = 1.44, P < 0.001), absence of higher education (PR = 2.81, P = 0.005), higher comorbidities on admission (PR = 1.089; P = 0.004) and delirium (PR = 1.13, P < 0.001). Health-related Quality of life (HRQoL), assessed by the mental and physical dimensions of the SF-12v2, was significantly better in patients without cognitive dysfunction (Mental SF-12v2 Mean difference = 2.54; CI 95%, − 4.80/− 0.28; p = 0.028 and Physical SF-12v2 Mean difference = − 2.85; CI 95%, − 5.20/− 0.50; P = 0.018). Conclusions: Delirium was found to be the main modifiable predictor of long-term cognitive dysfunction in ICU survivors. Higher education consistently reduced the probability of having long-term cognitive dysfunction. Cognitive dysfunction significantly influenced patients' quality of life, leading us to emphasize the importance of cognitive reserve for long-term prognosis after ICU discharge. [ABSTRACT FROM AUTHOR]

Background: Primary Health Care (PHC) is essential for effective, efficient, and more equitable health systems for all people, including those living with HIV/AIDS. This study evaluated the impact of the exposure to one of the largest community-based PHC programs in the world, the Brazilian Family Health Strategy (FHS), on AIDS incidence and mortality. Methods and findings: A retrospective cohort study carried out in Brazil from January 1, 2007 to December 31, 2015. We conducted an impact evaluation using a cohort of 3,435,068 ≥13 years low-income individuals who were members of the 100 Million Brazilians Cohort, linked to AIDS diagnoses and deaths registries. We evaluated the impact of FHS on AIDS incidence and mortality and compared outcomes between residents of municipalities with low or no FHS coverage (unexposed) with those in municipalities with 100% FHS coverage (exposed). We used multivariable Poisson regressions adjusted for all relevant municipal and individual-level demographic, socioeconomic, and contextual variables, and weighted with inverse probability of treatment weighting (IPTW). We also estimated the FHS impact by sex and age and performed a wide range of sensitivity and triangulation analyses; 100% FHS coverage was associated with lower AIDS incidence (rate ratio [RR]: 0.76, 95% CI: 0.68 to 0.84) and mortality (RR: 0.68, 95%CI: 0.56 to 0.82). FHS impact was similar between men and women, but was larger in people aged ≥35 years old both for incidence (RR: 0.62, 95% CI: 0.53 to 0.72) and mortality (RR: 0.56, 95% CI: 0.43 to 0.72). The absence of important confounding variables (e.g., sexual behavior) is a key limitation of this study. Conclusions: AIDS should be an avoidable outcome for most people living with HIV today and our study shows that FHS coverage could significantly reduce AIDS incidence and mortality among low-income populations in Brazil. Universal access to comprehensive healthcare through community-based PHC programs should be promoted to achieve the Sustainable Development Goals of ending AIDS by 2030. Priscila Pinto and colleagues assess the impact of a community-based primary health program—the Brazilian Family Health Strategy—on HIV/AIDS incidence and HIV-related mortality in Brazil. Author summary: Why was this study done?: The Family Health Strategy (FHS), the main model for Primary Health Care (PHC) in Brazil, has been associated with improved healthcare access and quality as well as better health outcomes. Although PHC is identified as a key element to achieve the goal of ending AIDS by 2030, the impact of FHS on HIV/AIDS outcomes has not been studied. What did the researchers do and find?: Using a large cohort of 3.4 million low-income Brazilians, we evaluate the impact of FHS on AIDS incidence and mortality. We found lower AIDS incidence and mortality among individuals exposed to FHS throughout the study period. What do these findings mean?: FHS is a robust community-based PHC model associated with improved population health outcomes including for people living with HIV/AIDS. While promising, these findings must be interpreted cautiously considering that some confounders, such as sexual behavior, were unavailable. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the feasibility of using the pulp volume (Pv) to total volume (Tv) ratio (Pv:Tv), obtained from cone beam computed tomography (CBCT) scans of single-rooted teeth, for age estimation in a Brazilian population sample. Methods: After obtaining approval from the ethics committee, the study commenced by applying inclusion criteria to screen CBCT scans, resulting in a probability-based sample of participants aged 18 years and older (ranging from 18 to 82 years, with a mean age of 46.44 years). A total of 517 single-rooted teeth, including maxillary central incisors (CI), mandibular canines (C), and mandibular first premolars (FP), were chosen based on excellent agreement values (> 0.9). Pv and Tv measurements were conducted using semi-automatic segmentation with ITK-SNAP 3.8 software. Statistical analysis was performed using Jamovi software, with a significance level set at 5% (α = 0.05). Results: A strong negative correlation (r > −0.7) was observed between chronological age and the Pv:Tv ratio across all examined teeth. However, when conducting regression analysis with Pv:Tv data and chronological age as the independent variable, only the mandibular FP teeth exhibited a normal distribution. The resulting linear model demonstrated moderate predictive value (approximately 64%) in explaining the variance in chronological age, but caution should be exercised when interpreting these findings. Conclusions: The method of measuring individual tooth volume using CBCT to estimate chronological age via Pv:Tv has been demonstrated as effective and reproducible within the Brazilian population sample. [ABSTRACT FROM AUTHOR]

Introduction: Currently, 21 million people live with the disease, mostly in low to middle-income countries. We aimed to assess the survival of patients with schizophrenia using clozapine compared with non-clozapine atypical antipsychotics provided by the Brazilian National Health System using realworld data. Materials and methods: This is an open retrospective cohort study of patients diagnosed with schizophrenia to whom atypical antipsychotics were dispensed by the Brazilian National Health System between 2000 and 2015, based on deterministic-probabilistic pairing of administrative data records. The Kaplan-Meier method was used to estimate the cumulative probability of survival and the Cox proportional hazards model was adjusted to assess the risk factors for survival via the hazard ratio (HR). Result: Participants were 375,352 adults with schizophrenia, with an overall survival rate of 76.0% (95%CI 75.0-76.0) at the end of the cohort. Multivariate analysis indicated a greater risk of death for men (HR=1.30; 95%CI 1.27-1.32), older adults (HR=17.05; 95%CI 16.52-17.60), and in the Southeast region of Brazil (HR=1.20; 95%CI 1.17-1.23). Patients who used non-clozapine atypical antipsychotics had a 21% greater risk of death when compared to those taking clozapine (HR=1.21; 95%CI 1.14-1.29). Additionally, a history of hospitalization for pneumonia (HR=2.17; 95%CI 2.11-2.23) was the main clinical variable associated with increased risk of death, followed by hospitalization for lung cancer (HR=1.82; 95%CI 1.58-2.08), cardiovascular diseases (HR=1.44; 95%CI 1.40-1.49) and any type of neoplasia (HR=1.29; 95%CI 1.19-1.40). Discussion: This is the first published Brazilian cohort study that evaluated survival in people with schizophrenia, highlighting the impact of atypical antipsychotics. In this real-world analysis, the use of clozapine had a protective effect on survival when compared to olanzapine, risperidone, quetiapine, and ziprasidone. [ABSTRACT FROM AUTHOR]

Studies on the interaction sites of peptide toxins and ion channels typically involve site-directed mutations in toxins. However, natural mutant toxins exist among them, offering insights into how the evolutionary process has conserved crucial sequences for activities and molecular target selection. In this study, we present a comparative investigation using electrophysiological approaches and computational analysis between two alpha toxins from evolutionarily close scorpion species of the genus Tityus, namely, Tst3 and Ts3 from T. stigmurus and T. serrulatus, respectively. These toxins exhibit three natural substitutions near the C-terminal region, which is directly involved in the interaction between alpha toxins and Nav channels. Additionally, we characterized the activity of the Tst3 toxin on Nav1.1-Nav1.7 channels. The three natural changes between the toxins did not alter sensitivity to Nav1.4, maintaining similar intensities regarding their ability to alter opening probabilities, delay fast inactivation, and induce persistent currents. Computational analysis demonstrated a preference for the down conformation of VSD4 and a shift in the conformational equilibrium towards this state. This illustrates that the sequence of these toxins retained the necessary information, even with alterations in the interaction site region. Through electrophysiological and computational analyses, screening of the Tst3 toxin on sodium isoform revealed its classification as a classic α-NaTx with a broad spectrum of activity. It effectively delays fast inactivation across all tested isoforms. Structural analysis of molecular energetics at the interface of the VSD4-Tst3 complex further confirmed this effect. [ABSTRACT FROM AUTHOR]

Parvovirus infection affects several animal species, especially young animals. In birds, parvovirus infection has been described in Muscovy ducks, turkeys, and chickens, all of which had enteric diseases characterized by diarrhea. Chicken parvovirus (ChPV) has been detected in poultry around the world in animals affected by enteric problems, showing dwarfism, cloacal pasting, and diarrhea. In Brazil, ChPV was detected in chickens affected by diarrhea fifteen years ago. However, the genetic characteristics of ChPV circulating in chicken flocks were not determined. Therefore, the aim of the present investigation was to determine the genetic characteristics of the VP1 gene from ChPV detected in chickens affected by enteric diseases in Brazil. For this purpose, a molecular approach was used. Specific primers were designed to flank the complete VP1 gene of ChPV and amplify it using PCR. The amplified products from samples of chickens with enteric diseases were sequenced, and 22 complete CDs of the VP1 gene were obtained. These samples, compared to the ABU-P1 sequence, showed 17 sequences with high nucleotide (NT) similarity of 92.7–97.4% and amino acid (AA) similarity of 94.8–99.5% associated with Runting and Stunting syndrome (RSS); there were also five samples associated with hens with diarrhea with unusual jejunal dilatation (JD) that had less similarity than the RSS sequences (NT of 86.5% and AA of 93–93.1%). The phylogenetic analysis determined four groups. Group I had sequences from Korea. The second group included sequences from Korea, China, and Brazil (not included in this work). The third group had studied RSS sequences grouped with the ABU-P1 strain and sequences from China and the United States. Finally, the sequences from JD were clustered in a separate group with a bootstrap of 100%, a group that was denoted as group IV, and included sequences from China. RDP4 and SimPlot analysis showed one point of recombination with the sequences of group III ChPV in the JD sequences. Herein, we show that circulating strains of ChPV exhibit genetic differences in the VP1 gene in Brazilian chicken flocks. Nevertheless, more studies are needed to determine the probability of a new genetic group of ChPV based on the analysis of the complete genome. [ABSTRACT FROM AUTHOR]

• The perception that COVID-19 vaccine is safe is positively affected by age group and negatively by religion; • The older the person, the greater the probability of considering the vaccine safe and, consequently, of getting vaccinated; • The religion variable showed great importance in the causal model. • The religion variable has a simultaneous causal effect on political preferences and the perception of vaccine safety; • The probability of a person accepting the vaccination against COVID-19 is reduced given the fact that they believe fake news related to the vaccine. This article presents a causal inference analysis of vaccine hesitancy for Coronavirus disease 2019 (COVID-19) vaccines based on socio-demographic data obtained via questionnaires applied to a sample of the Brazilian population. This data includes the respondents' political preferences, age group, education, salary range, country region, sex, believing fake news, vaccine confidence, and intention to get the COVID-19 vaccine. The research created a causal graph using these variables, seeking to answer questions about the probability of people getting vaccinated. The results of this research corroborate findings observed in the literature, also presenting unique findings: (i) The perception that the vaccine is safe is positively affected by age group and negatively by religion; (ii) The older the person, the greater the probability of considering the vaccine safe and, consequently, of getting vaccinated; (iii) The religion variable showed great importance in the model since it has a simultaneous causal effect on political preferences and the perception of vaccine safety; (iv) The data reveal that the probability of a person accepting the vaccination against COVID-19 is reduced given the fact that they believe fake news related to the vaccine. The methodology applied in this research can be replicated for populations from other countries so that it is possible to generate customized models. General causal models can be helpful for agencies dealing with vaccine hesitancy to decide which variables should be addressed to reduce this phenomenon. [ABSTRACT FROM AUTHOR]

Front-of-package food labelling (FOPL) is a mechanism to inform consumers on food nutrients content and risks for health. Each country, within its own institutional framework, defines methods and protocols to formulate rules capable of influencing organizations and the behavior of agents. The paper aims at evaluating the role of some meso-institutions in shaping arenas for policymaking on FOPL based on an exploratory study in Brazil, Chile, and Mexico. A documental analysis and literature review were employed, followed by in-depth interviews. The relevant aspects of FOPL assessed were thresholds for sugar, fats, and sodium; marketing restrictions, and timeframe given for compliance with the new rules. The contribution of this article is to illuminate the way in which meso-institutions operate in a specific context, namely the development of food labelling standards. The focus is to find the rules that allowed the participation of stakeholders in the process of defining normative acts intended to regulate food labelling. The discussion of mandatory FOPL can be interpreted as a struggle to define proper rights for the food industry and the consumer. Meso-institutions, as translators of general normative principles in specific contexts, can encourage or restrict stakeholder participation in policymaking. Besides political arena, the participation can be done in other arenas, such as legislature, regulatory agencies, scientific community, media and public opinion. Institutions that encourage stakeholder participation increase the probability of obtaining widely accepted specific rules. [ABSTRACT FROM AUTHOR]

Urban locations with high centrality are associated with locational advantages, making them more desirable and expensive. There is not a consensus yet on how centrality affects real estate prices for different markets and income groups. In Brazil, this theme is relatively unexplored. This article uses an approach based on urban spatial networks, going beyond simple centrality descriptions considering the distance to the Central Business District (CBD). The objective is to analyse how apartment prices relate to two location attributes: accessibility (relative distance) and centrality (relative importance). Weighted network models are applied at two scales: city-wide and neighbourhoods. The database includes a sample of 400 offers for the sale of used apartments in 2022 and 2023 in Porto Alegre, analysed collectively and segmented into three price classes. Configurational indicators were calculated using the Graph Analysis Urban Networks (GAUS) plugin. Both configurational measures and prices were normalized using the Kernel Density Estimation (KDE) technique and correlated in a GIS environment. Results indicate that the most accessible areas of Porto Alegre have higher unit price (per square meter) apartments. Conversely, areas with higher centrality have cheaper properties, likely due to the availability of services and transportation. The more expensive apartments tend to avoid locations with higher centrality values, both globally and at the neighbourhood level. [ABSTRACT FROM AUTHOR]

Copyright of Investigacion & Educacion en Enfermeria is the property of Universidad de Antioquia, Facultad de Enfermeria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aims to comprehensively examine the determinants of household poverty in Brazil, placing a specific emphasis on the heads of households as the primary unit of analysis. Household poverty is a critical and multifaceted issue in developing countries, a reality that holds true for Brazil as well. Understanding the intricate web of factors that contribute to household poverty is of paramount importance to policymakers, researchers, and advocates dedicated to poverty alleviation and socioeconomic development. Household poverty remains a persistent challenge in Brazil, with far-reaching social and economic consequences. To address this issue effectively, it is essential to identify the factors that contribute to poverty among households, particularly those led by individuals who are the primary income earners. These households often face unique economic and social challenges that demand targeted interventions. To analyze household poverty determinants, this study utilizes data from the "Pesquisa Nacional por Amostras de Domicílios Contínua" (Continuous National Household Sample Survey) (PNADC). The dataset provides comprehensive information on the individual characteristics of the household head and household-level attributes, offering a nuanced view of the factors at play. A probit model is employed to estimate the probability of a household head experiencing poverty, allowing for a examination of various factors. The research findings reveal several significant determinants of household poverty in Brazil. Firstly, households led by men are found to be less likely to be in a situation of poverty, shedding light on gender-related disparities in income and opportunities. Secondly, households with heads who have attained higher levels of education exhibit a lower probability of being in poverty, underscoring the importance of education as a pathway out of poverty. Moreover, urban households are found to be less prone to poverty compared to their rural counterparts, since households led by individuals who work in agricultural-related activities are more likely to experience poverty. This emphasizes the need for targeted rural development strategies. Additionally, households located in the North and Northeast regions of Brazil face a higher likelihood of poverty, possibly due to regional economic disparities that require specific policy attention. These findings have important policy implications for poverty alleviation efforts in Brazil. Policymakers should consider targeted interventions that focus on improving access to education, particularly in regions with higher poverty rates, as education is a powerful tool for poverty reduction. Efforts to promote gender equality and enhance economic opportunities in rural areas are also essential to address the diverse causes of poverty. Additionally, regional disparities in poverty should be addressed through comprehensive regional development initiatives that take into account the unique challenges faced by different areas of the country. Our results also highlight the importance of community-specific social programs, including conditional-cash transfers and incentives for childhood education, which can play a pivotal role in breaking the cycle of poverty in Brazil's diverse communities. [ABSTRACT FROM AUTHOR]

Understanding the mechanisms by which tropical forest fragmentation can affect the persistence of species and populations is of scientific and practical interest. However, nest survival has been one the least addressed of the potentially harmful effects associated with habitat fragmentation, and studies involving nest predator's identification are still underdeveloped. The Pernambuco Endemism Center (PEC) is the part of the Atlantic Forest located north of the São Francisco River, in northeastern Brazil, where large forest tracts no longer exist and a wave of bird extinctions has occurred recently. Here, we investigated the nest survival of forest understory birds from three PEC fragments (690, 979, and 1036 ha), and we used infra-red camera traps for predators' identification. Overall, the apparent nest survival was 15.5%, and nest-day-based survival probability for the four more representative species (including two endemic and threatened taxa) were 2.6, 4.4, 6.9, and 18.9%, being 2.7 to 8.5 times smaller than populations or related taxa from the Atlantic Forest of southeastern Brazil. Predators were marmosets (25%), opossums (25%), tegu (19.4%), coati (16.7%), snakes (8.3%), and hawks (5.5%). Jackknife2 model-predicted nest predator's richness was 20.7 (SD = 1.6). We reinforce the evidence that nest predation associated with fragmentation can affect negatively the bird populations from tropical forests. [ABSTRACT FROM AUTHOR]

Understanding how physical climate-related hazards affect food production requires transforming climate data into relevant information for regional risk assessment. Data-driven methods can bridge this gap; however, more development must be done to create interpretable models, emphasizing regions lacking data availability. The main objective of this article was to evaluate the impact of climate risks on food security. We adopted the climatic impact-driver (CID) approach proposed by Working Group I (WGI) in the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC). In this work, we used the CID framework to select the most relevant indices that drive crop yield losses and identify important thresholds for the indices. When these thresholds are exceeded, the impact probability increases. We then examine the impact of two CID types (heat and cold, and wet and dry) represented by indices of climate extremes considering the impact on different crop yield datasets, focusing on maize and soybeans in the central agro-producing municipalities in Brazil. We used the random forest model in a bootstrapping experiment to select the most relevant climate indices. Then, we applied the Shapley Additive Explanations (SHAP) with the XGBoost model explanatory analysis to identify the indices thresholds that caused impacts. We found that the mean precipitation is a highly relevant CID. However, there is a window in which crops are more vulnerable to precipitation deficit. For soybeans, in many regions of Brazil, precipitation below 80 mm/month in December, January, and February represents an increasing risk of crop yield losses. This is the end of the growing season for those regions. In the case of maize, there is a similar pattern with precipitation below 100 mm/month in April and May. Indices of extremes are relevant to represent crop yield variability. Nevertheless, including climate means remains highly relevant and recommended for studying the impact of climate risk on agriculture. Our findings contribute to a growing body of knowledge critical for informed decision-making, policy development, and adaptive strategies in response to climate change and its impact on agriculture. [ABSTRACT FROM AUTHOR]

Urban landscape can support a many wild species, especially within green areas like remnants of native forests. Thus, conserving such remnants of native habitat patches is crucial for maintaining urban biodiversity. However, because limited resources and conflicting interests preclude the conservation of all patches, it is necessary to prioritize the most relevant ones, including the ones that facilitate organisms' dispersal across landscapes, maintaining the landscape functional connectivity. Here we present a framework for prioritizing patches based on their functional connectivity role in the urban landscape, using Rio de Janeiro, Brazil, as a model city. Functional connectivity was assessed through the Probability of the Connectivity Index of the entire landscape, using two model species that represent low- and high-dispersal scenarios. We then prioritized patches based on their individual contribution to the connectivity of the landscape (dPC values). Our results showed that Rio de Janeiro has very low functional connectivity, with only 20 priority forest fragments out of the ca. 1,400 available in the landscape. We propose four main strategies to ensure that prioritized patches can fulfil their functional connectivity role in urban landscapes: i) incorporate unprotected patches into the landscape's Protected Areas network; ii) use other effective area-based conservation measures for patches unlikely to become PAs; iii) resolve legal uncertainties about the land ownership situation; and iv) effectively manage already protected patches. Our proposed methodological framework and recommendations apply to any urban landscapes that contain remnants of native habitat patches. It requires easily obtainable data and provides a step toward the implementation of more science-based conservation strategies for urban areas. [ABSTRACT FROM AUTHOR]

Objectives: To identify the strategies used by Brazilian adults for coping with the COVID-19 pandemic and to verify the effect of these strategies on subjective distress. Methods: This was a cross-sectional observational study with online data collection in May/June 2020, November/December 2020, and May/June 2021. The BriefCOPE Inventory and the Impact of Event Scale (IES-R) were used. The prevalence of strategies used at different time points was estimated with a 95% confidence interval and compared with a z-test. A multiple logistic regression model was constructed and the odds ratio (OR, 95%CI) was calculated to verify the probability of subjective distress according to the coping strategy used. Results: Younger individuals had a lower prevalence of adaptive strategies, which increased significantly with age. Participants with higher income levels had a higher prevalence of adaptive strategies, as did those who were never diagnosed with a mental health disorder. The prevalence of using only maladaptive strategies ranged from 6.1% to 5.4% (p > 0.05). The use of problem-centered strategies (Active Coping and Planning), venting of emotions, and substance use increased with time, while acceptance and behavioral disengagement decreased. In general, the population used problem-centered strategies, but the high prevalence of problem avoidance was striking. Positive reinterpretation and acceptance were protective factors for subjective distress, whereas maladaptive strategies increased the chance of distress. The presence of a negative valence component (problem- or emotion-centered) increased the chance of subjective distress, whereas strategies based on Problem Solving acted as a protective factor. Conclusion: Coping strategies were significantly associated to subjective distress and have changed since the beginning of the pandemic. Strategies focused on emotion regulation may be relevant to minimize distress. [ABSTRACT FROM AUTHOR]

Background: Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium vivax radical cure but has not investigated the associated costs. This study evaluated the cost-effectiveness of P. vivax treatment with tafenoquine after G6PD testing using a transmission model. Methods and findings: We explored the cost-effectiveness of using tafenoquine after G6PD screening as compared to usual practice (7-day low-dose primaquine (0.5 mg/kg/day) without G6PD screening) in Brazil using a 10-year time horizon with 5% discounting considering 4 scenarios: (1) tafenoquine for adults only assuming 66.7% primaquine treatment adherence; (2) tafenoquine for adults and children aged >2 years assuming 66.7% primaquine adherence; (3) tafenoquine for adults only assuming 90% primaquine adherence; and (4) tafenoquine for adults only assuming 30% primaquine adherence. The incremental cost-effectiveness ratios (ICERs) were estimated by dividing the incremental costs by the disability-adjusted life years (DALYs) averted. These were compared to a willingness to pay (WTP) threshold of US$7,800 for Brazil, and one-way and probabilistic sensitivity analyses were performed. All 4 scenarios were cost-effective in the base case analysis using this WTP threshold with ICERs ranging from US$154 to US$1,836. One-way sensitivity analyses showed that the results were most sensitive to severity and mortality due to vivax malaria, the lifetime and number of semiquantitative G6PD analysers needed, cost per malaria episode and per G6PD test strips, and life expectancy. All scenarios had a 100% likelihood of being cost-effective at the WTP threshold. The main limitations of this study are due to parameter uncertainty around our cost estimates for low transmission settings, the costs of G6PD screening, and the severity of vivax malaria Conclusions: In our modelling study that incorporated impact on transmission, tafenoquine prescribed after a semiquantitative G6PD testing was highly likely to be cost-effective in Brazil. These results demonstrate the potential health and economic importance of ensuring safe and effective radical cure. Author summary: Why was this study done?: Radical cure with primaquine or recently approved tafenoquine is required to clear the dormant liver parasites of vivax malaria. While single-dose tafenoquine overcomes the barrier of patient adherence to the current 7-day primaquine treatment, it costs more and requires screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency. While the impact of changing policies to tafenoquine after G6PD screening on transmission has been evaluated, the associated costs and cost-effectiveness will be important considerations for policymakers. What did the researchers find?: Using an economic evaluation model coupled with a transmission model, we found that prescribing tafenoquine to vivax malaria patients without G6PD deficiency would be highly likely to be cost-effective in Brazil. Tafenoquine will be particularly cost-effective in settings where patient adherence to the current 7-day treatment is low and when paediatric tafenoquine is available to treat children as well as adults. What do these findings mean?: To our knowledge, this is the first study that has looked at the cost-effectiveness of tafenoquine when including the impact on disease transmission. The high probability of cost-effectiveness across a wide range of scenarios and municipalities should reassure decision-makers in Brazil, where tafenoquine has recently been adopted into national policy, and aid other countries considering the implementation of tafenoquine after G6PD screening. [ABSTRACT FROM AUTHOR]

Purpose: This paper constitutes the first academic study to be made of Google Discover as applied to online journalism. Design/methodology/approach: This paper constitutes the first academic study to be made of Google Discover as applied to online journalism. The study involved conducting 61 semi-structured interviews with experts that are representative of a range of different professional profiles within the fields of journalism and search engine positioning (SEO) in Brazil, Spain and Greece. Based on the data collected, the authors created five semantic categories and compared the experts' perceptions in order to detect common response patterns. Findings: This study results confirm the existence of different degrees of convergence and divergence in the opinions expressed in these three countries regarding the main dimensions of Google Discover, including specific strategies using the feed, its impact on web traffic, its impact on both quality and sensationalist content and on the degree of responsibility shown by the digital media in its use. The authors are also able to propose a set of best practices that journalists and digital media in-house web visibility teams should take into account to increase their probability of appearing in Google Discover. To this end, the authors consider strategies in the following areas of application: topics, different aspects of publication, elements of user experience, strategic analysis and diffusion and marketing. Originality/value: Although research exists on the application of SEO to different areas, there have not, to date, been any studies examining Google Discover. Peer review: The peer-review history for this article is available at: https://publons.com/publon/10.1108/OIR-10-2022-0574 [ABSTRACT FROM AUTHOR]