13 results
Search Results
2. Prevalence and factors associated with polydrug use among clients seeking treatment for alcohol misuse.
- Author
-
Lawson S, Bryant J, Freund M, Dizon J, Haber PS, Shakeshaft A, Jefferies M, and Farrell M
- Subjects
- Humans, Male, Female, Adult, Prevalence, Middle Aged, Australia epidemiology, Quality of Life, Young Adult, Risk Factors, Substance Abuse Treatment Centers, Adolescent, Alcoholism epidemiology, Alcoholism therapy, Substance-Related Disorders epidemiology, Substance-Related Disorders therapy
- Abstract
Introduction: The aim of this paper was to examine the client and psychosocial characteristics associated with polydrug use in patients with alcohol misuse as their primary drug of concern (PDC) seeking treatment from substance use treatment centres., Methods: Self-report surveys were undertaken with clients attending 1 of 34 community-based substance use treatment centres across Australia with alcohol as their PDC. Survey items included client's socio-demographic characteristics, level of alcohol dependence, use of other drugs including tobacco, health and wellbeing factors including health-related quality of life. The factors associated with polydrug use (alcohol use concurrent with at least one other drug) were examined., Results: In a sample of 1130 clients seeking treatment primarily for alcohol problems, 71% reported also using another drug. The most frequently used drug was tobacco (50%) followed by cannabis (21%) and benzodiazepines (15%). Excluding tobacco use, 35% of participants reported polydrug use. Factors associated with any polydrug use were younger age, lower education levels, lower levels of mental health related quality of life and housing risk (i.e., risk of eviction or experienced homelessness in past 4 weeks). When tobacco was excluded, factors associated with polydrug use were age, lower physical and mental health-related quality of life, and housing risk., Discussion and Conclusions: Most adults seeking treatment for alcohol misuse as their PDC reported using another drug in addition to alcohol. Treatment services should be designed accordingly to maximise the likelihood of treatment engagement and success., (© 2024 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs.)
- Published
- 2024
- Full Text
- View/download PDF
3. Global, interhemispheric and intrahemispheric functional connection patterns in male adults with alcohol use disorder.
- Author
-
Wei Y, Wang W, Kang Y, Niu X, Zhang Z, Li S, Han S, Cheng J, and Zhang Y
- Subjects
- Humans, Male, Adult, Middle Aged, Prefrontal Cortex physiopathology, Prefrontal Cortex diagnostic imaging, Thalamus diagnostic imaging, Thalamus physiopathology, Case-Control Studies, Gyrus Cinguli physiopathology, Gyrus Cinguli diagnostic imaging, Brain Mapping methods, Young Adult, Alcoholism physiopathology, Alcoholism diagnostic imaging, Magnetic Resonance Imaging, Brain physiopathology, Brain diagnostic imaging
- Abstract
A growing body of evidence indicates the existence of abnormal local and long-range functional connection patterns in patients with alcohol use disorder (AUD). However, it has yet to be established whether AUD is associated with abnormal interhemispheric and intrahemispheric functional connection patterns. In the present study, we analysed resting-state functional magnetic resonance imaging data from 55 individuals with AUD and 32 healthy nonalcohol users. For each subject, whole-brain functional connectivity density (FCD) was decomposed into ipsilateral and contralateral parts. Correlation analysis was performed between abnormal FCD and a range of clinical measurements in the AUD group. Compared with healthy controls, the AUD group exhibited a reduced global FCD in the anterior and middle cingulate gyri, prefrontal cortex and thalamus, along with an enhanced global FCD in the temporal, parietal and occipital cortices. Abnormal interhemispheric and intrahemispheric FCD patterns were also detected in the AUD group. Furthermore, abnormal global, contralateral and ipsilateral FCD data were correlated with the mean amount of pure alcohol and the severity of alcohol addiction in the AUD group. Collectively, our findings indicate that global, interhemispheric and intrahemispheric FCD may represent a robust method to detect abnormal functional connection patterns in AUD; this may help us to identify the neural substrates and therapeutic targets of AUD., (© 2024 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
- Published
- 2024
- Full Text
- View/download PDF
4. Barriers and facilitators to the implementation of the Flinders Chronic Condition Management Program in outpatient drug and alcohol settings in Australia.
- Author
-
Oster C, Hunter S, Schultz T, Harvey G, Lawless M, and Battersby M
- Subjects
- Humans, Reproducibility of Results, Australia, Ethanol, Outpatients, Alcoholism therapy
- Abstract
Introduction: There has been a growing call for drug and/or alcohol dependence to be managed as a chronic condition. The Flinders Chronic Condition Management Program (Flinders Program) was implemented in a drug and alcohol service in Australia in 2019-2022 to explore the feasibility of chronic condition management in outpatient clinics. Implementation involved: adaptation of the Flinders Program; adaptation of clinical procedures; training clinicians and managers; training Flinders Program Accredited Trainers; and system integration. This study aims to explore barriers and enablers to implementation., Methods: A qualitative formative evaluation was undertaken. Data included implementation documents (n = 7), responses to open-ended questions in post-training surveys (n = 27), and focus groups and interviews with implementation staff, clinicians, managers and a trainer (n = 16). Data were analysed using the Consolidated Framework for Implementation Research in a 'coding reliability' approach to thematic analysis., Results: Participants responded positively to the Flinders Program's philosophy, processes, tools and training. However, barriers were identified across three Consolidated Framework for Implementation Research domains: (i) outer setting (client suitability and incompatibility with external policies and incentives); (ii) characteristics of individuals (low self-efficacy); and (iii) inner setting (lack of system and workflow integration)., Discussion and Conclusions: Executive support and systems integration are important for the implementation of the Flinders Program in drug and alcohol services. This needs to be achieved within externally mandated key performance indicators for outpatient services. Further research is needed to fully evaluate the potential of a chronic condition management framework in Australian outpatient drug and alcohol services., (© 2023 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs.)
- Published
- 2024
- Full Text
- View/download PDF
5. Delivery of Interventions for Multiple Lifestyle Factors in Primary Healthcare Settings: A Narrative Review Addressing Strategies for Effective Implementation.
- Author
-
Leese, Callum J., Al‐Zubaidi, Hussain, and Smith, Blair H.
- Subjects
RISK assessment ,SMOKING cessation ,BEHAVIOR modification ,PRIMARY health care ,SMOKING ,SEDENTARY lifestyles ,HEALTH behavior ,SLEEP ,SOCIAL networks ,ALCOHOLISM ,NUTRITION ,PHYSICAL activity ,WELL-being - Abstract
The escalating burden of lifestyle‐related diseases stands as a critical global public health challenge, contributing substantially to the prevalence of chronic conditions and a large portion of premature mortality. Despite this, concise evidence‐based lifestyle interventions targeting physical inactivity, nutrition, alcohol and smoking continue to be underutilised. Although good evidence exists for addressing the four lifestyle‐related risk factors independently, rarely do these present in isolation. Evidence is lacking regarding how to integrate interventions targeting multiple risk factors. Consequently, this paper aims to provide an overview of the evidence for delivering multiple interventions in primary healthcare settings. Different lifestyle factors are inter‐related, with decisions around ordering of the delivery of multiple lifestyle interventions an important consideration. There is evidence supporting the effectiveness of addressing some lifestyle factors simultaneously (e.g., physical activity and nutrition), although smoking cessation may be delivered best in a sequential approach. While the World Health Organisation highlights four key lifestyle factors (nutrition, physical activity, alcohol and smoking), incorporating additional elements such as sleep, mental well‐being and social connectedness offers a holistic framework for promoting well‐being. Despite the presentation of multiple behaviour risk factors being commonplace in healthcare settings, the evidence (outlined in the paper) for how best to deliver interventions to address this is limited, with further research and subsequent clinical guidance required. In order to address the barriers to delivering lifestyle interventions in primary care, innovation will be required. The use of non‐medical personnel, social prescribers and health coaches has the potential to alleviate time constraints, whilst mounting evidence exists for group consultations for addressing lifestyle‐related non‐communicable diseases (NCDs). If the challenges to implementation can be addressed, and if healthcare systems can adapt for the promotion of healthy lifestyles, the impact of NCDs can be mitigated. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action.
- Author
-
Tap SC
- Subjects
- Animals, Humans, N,N-Dimethyltryptamine, Methoxydimethyltryptamines pharmacology, Methoxydimethyltryptamines therapeutic use, Alcohol Drinking, Hallucinogens pharmacology, Hallucinogens therapeutic use, Alcoholism drug therapy
- Abstract
Alcohol use disorder (AUD) remains one of the most prevalent psychiatric disorders worldwide with high economic costs. Current treatment options show modest efficacy and relapse rates are high. Furthermore, there are increases in the treatment gap and few new medications have been approved in the past 20 years. Recently, psychedelic-assisted therapy with psilocybin and lysergic acid diethylamide has garnered significant attention in the treatment of AUD. Yet, they require significant amounts of therapist input due to prolonged subjective effects (~4-12 h) leading to high costs and impeding implementation. Accordingly, there is an increasing interest in the rapid and short-acting psychedelic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). This paper offers a first look at potential therapeutic mechanisms for AUD by reviewing the current literature on 5-MeO-DMT. Primarily, 5-MeO-DMT is able to induce mystical experiences and ego-dissolution together with increases in psychological flexibility and mindfulness. This could decrease AUD symptoms through the alleviation of psychiatric mood-related comorbidities consistent with the negative reinforcement and self-medication paradigms. In addition, preliminary evidence indicates that 5-MeO-DMT modulates neural oscillations that might subserve ego-dissolution (increases in gamma), psychological flexibility and mindfulness (increases in theta), and the reorganization of executive control networks (increases in coherence across frequencies) that could improve emotion regulation and inhibition. Finally, animal studies show that 5-MeO-DMT is characterized by neuroplasticity, anti-inflammation, 5-HT
2A receptor agonism, and downregulation of metabotropic glutamate receptor 5 with clinical implications for AUD and psychiatric mood-related comorbidities. The paper concludes with several recommendations for future research to establish the purported therapeutic mechanisms of action., (© 2024 The Author. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)- Published
- 2024
- Full Text
- View/download PDF
7. Alcohol use and alcohol use disorders in sub‐Saharan Africa: A systematic review and meta‐analysis.
- Author
-
Belete, Habte, Yimer, Tesfa Mekonen, Dawson, Danielle, Espinosa, Dorothy C., Ambaw, Fentie, Connor, Jason P., Chan, Gary, Hides, Leanne, and Leung, Janni
- Subjects
- *
SUBSTANCE abuse risk factors , *SUBSTANCE abuse , *MEDICAL information storage & retrieval systems , *RISK assessment , *RESEARCH funding , *META-analysis , *DISEASE prevalence , *HEALTH insurance exchanges , *DESCRIPTIVE statistics , *SYSTEMATIC reviews , *MEDLINE , *TEENAGERS' conduct of life , *ALCOHOLISM , *ALCOHOL drinking , *ONLINE information services , *CONFIDENCE intervals , *PSYCHOLOGY information storage & retrieval systems , *LONGEVITY ,DEVELOPED countries - Abstract
Background and aims: Population‐level alcohol use data are available from high‐income countries, but limited research has been conducted in sub‐Saharan Africa. This systematic review and meta‐analysis aimed to summarize population‐level alcohol use in sub‐Saharan Africa. Method: Databases searched included PubMed, EMBASE, PsycINFO and AJOL, without language restrictions. Searches were also conducted in the Global Health Data Exchange (GHDx) and Google Scholar. Search terms encompassed 'substance' or 'substance‐related disorders' and 'prevalence' and 'sub‐Saharan Africa'. We included general population studies on alcohol use (including any use, high‐risk alcohol use and alcohol use disorders) from 2018 onwards. Prevalence data for alcohol use among sub‐Saharan African adolescents (10–17) and adults (18+) were extracted. Analyses included life‐time and past 12‐ and 6‐month alcohol use. Results: We included 141 papers. Among adolescents, the life‐time prevalence of alcohol use was 23.3% [95% confidence interval (CI) = 11.3–37.1%], 36.2% (CI = 18.4–56.1%) in the past year and 11.3% (CI = 4.5–20.4%) in the past 6 months. Among adolescents, 12‐month prevalence of alcohol use disorder and alcohol dependence were 7.7% (CI = 0.0–27.8%) and 4.1% (CI = 1.4–7.9%), respectively. Among adults, the life‐time prevalence of alcohol use was 34.9% (CI = 17.7–54.1%), 27.1% (CI = 5.0–56.4%) in the past year and 32.2% (CI = 19.8–46.0%) in the past 6 months. Among adults, the 12‐month prevalence of alcohol use disorder and alcohol dependence were 9.5% (CI = 0.0–30.4%) and 4.3% (CI = 0.8–9.8%), respectively. The highest weighted life‐time prevalence of alcohol use, 86.4%, was reported in Tanzania among adults. The highest weighted past 6‐month prevalence of alcohol use, 80.6%, was found in Zambia among adolescents. Conclusion: Alcohol use patterns vary across countries and subregions within sub‐Saharan Africa, and comprehensive population‐level data on alcohol use remain scarce in numerous sub‐Saharan African countries. The prevalence of alcohol use disorder is common among adolescents in sub‐Saharan Africa. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Validation of predicted individual treatment effects in out of sample respondents.
- Author
-
Kuhlemeier, Alena, Jaki, Thomas, Witkiewitz, Katie, Stuart, Elizabeth A., and Van Horn, M. Lee
- Subjects
- *
ALCOHOLISM , *INDIVIDUALIZED medicine - Abstract
Personalized medicine promises the ability to improve patient outcomes by tailoring treatment recommendations to the likelihood that any given patient will respond well to a given treatment. It is important that predictions of treatment response be validated and replicated in independent data to support their use in clinical practice. In this paper, we propose and test an approach for validating predictions of individual treatment effects with continuous outcomes across samples that uses matching in a test (validation) sample to match individuals in the treatment and control arms based on their predicted treatment response and their predicted response under control. To examine the proposed validation approach, we conducted simulations where test data is generated from either an identical, similar, or unrelated process to the training data. We also examined the impact of nuisance variables. To demonstrate the use of this validation procedure in the context of predicting individual treatment effects in the treatment of alcohol use disorder, we apply our validation procedure using data from a clinical trial of combined behavioral and pharmacotherapy treatments. We find that the validation algorithm accurately confirms validation and lack of validation, and also provides insights into cases where test data were generated under similar, but not identical conditions. We also show that the presence of nuisance variables detrimentally impacts algorithm performance, which can be partially reduced though the use of variable selection methods. An advantage of the approach is that it can be widely applied to different predictive methods. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Myelinolysis cases presenting with manic attack after rapid correction of hyponatremia: Two cases.
- Author
-
Boylu, Muhammed Emin and Kırpınar, İsmet
- Subjects
- *
NEUROLOGICAL disorders , *HYPONATREMIA , *DIFFERENTIAL diagnosis , *PSYCHIATRISTS , *ALCOHOLISM - Abstract
Objective: Myelinolysis is a neurological condition that can display diverse psychiatric symptoms, with electrolyte imbalance, alcoholism and malnutrition being the frequent causes. Rapid correction of hyponatremia may trigger pontine and extra‐pontine myelinolysis. Cases: This paper examines two cases: one of hyponatremia after antihypertensive use and the other of myelinolysis due to rapid correction of hyponatremia. Since myelinolysis appeared as a manic episode, the patients sought treatment at the psychiatry outpatient clinic. Further tests were conducted to rule out organic causes and the diagnosis was confirmed prior to referring the patients to the neurology clinic. Conclusion: Psychiatrists should be meticulous in excluding organic causes in first‐episode mania and consider these possibilities in the differential diagnosis for the pertinent patient group. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Trends in substance use among sexual minority adolescents in South Korea.
- Author
-
Joung, Kyoung Hwa, Okoye, Helen, Rana, Monica, and Saewyc, Elizabeth M.
- Subjects
- *
SUBSTANCE abuse , *PSYCHOLOGY of gay people , *SECONDARY analysis , *HUMAN sexuality , *MULTIPLE regression analysis , *SEX distribution , *INHALANT abuse , *DESCRIPTIVE statistics , *SEX customs , *ODDS ratio , *HETEROSEXUALS , *SEXUAL intercourse , *BISEXUAL people , *COMPARATIVE studies , *TOBACCO products , *ALCOHOLISM , *DATA analysis software , *PSYCHOSOCIAL factors - Abstract
Purpose: Substance use, that is of cigarettes, alcohol and chemical inhalants, is a major contributor to health‐compromising behaviors and the related consequences among adolescents around the world. The purpose of this paper is to examine trends in this phenomenon in South Korea among sexually active adolescents who reported sexual minority behaviors as compared to their heterosexual (HS) peers. Design and Methods: This study used data from the annual web‐based survey called Korea Youth Risk Behavior Survey in 5‐year intervals: 2006, 2011, and 2016. From 2017, the questions regarding the gender of sex partners were excluded from the survey, thus no data is available for sexual minorities after 2016. Selected data (Unweighted n = 10,029) was used to assess whether substance use increased, decreased, or remained unchanged among adolescents who reported same‐sex (SS) behaviors and bisexual (BS) behaviors compared to their peers reporting HS behaviors. Demographic variables included age and assigned gender. Substances referred to are cigarettes, alcohol, and chemical inhalants. Logistic regression models were sex‐stratified according to assigned gender. Trend analyses were carried out to examine disparities in substance use among sexually active adolescents across the three survey years. Results: Across the three survey years, cigarette use, alcohol use, and problematic drinking declined among all sexually active youths, but there were some differences among the subgroups. In 2016, SS girls were more likely to use cigarettes than HS girls. The prevalence of alcohol use and problematic drinking among BS girls was relatively higher than among girls who exhibited either HS or SS behaviors. Inhalant use was very high among both boys and girls with SS and BS behaviors. Practice Implications: The findings of the study reveal disparities in substance use between sexual minority and heterosexual adolescents in South Korea. This creates an alarm for collecting data separately for sexually diverse youth in future Korean national surveys with a goal of reducing substance use among all adolescents. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Highlights and insights from the 34th AAAP Annual Meeting and Scientific Symposium.
- Author
-
Kosten, Thomas R. and Domingo, Coreen B.
- Subjects
- *
ANNUAL meetings , *ALCOHOLISM , *MENTAL health personnel , *OPIOID abuse , *INVOLUNTARY hospitalization - Abstract
The 34th Annual Meeting and Scientific Symposium of the American Academy of Addiction Psychiatry (AAAP) was a successful event, attended by approximately 650 clinicians from diverse disciplines. The conference focused on evidence-based prevention, treatment, and recovery approaches for individuals with substance use disorders (SUD) and co-occurring psychiatric disorders. The conference included workshops, paper presentations, posters, film workshops, and case conferences on various topics related to addiction psychiatry. The American Journal on Addictions (AJA) has dedicated an issue to sharing select segments of the conference proceedings, including written summaries of presentations and a diverse range of accepted posters. The AJA and AAAP encourage attendance at the 2024 annual meeting, which will offer a wide variety of scientific offerings. CME credits are available for participation in the annual meeting and for serving as a peer reviewer for the AJA. The AJA has seen international recognition, with submissions and readership from countries outside of the United States. The journal's content has focused on opioid use disorder, comorbid SUD, digital therapeutics, and the impact of stigma on SUD. The AJA expresses gratitude to its peer reviewers for their contributions to maintaining the journal's quality. The editors wish readers a successful 2024 and look forward to continued engagement with the AJA and participation in the November 2024 AAAP conference. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
12. Social and structural drivers of HIV vulnerability among a respondent‐driven sample of feminine and non‐feminine presenting transgender women who have sex with men in Zimbabwe.
- Author
-
Parmley, Lauren E., Miller, Sophia S., Chingombe, Innocent, Mapingure, Munyaradzi, Mugurungi, Owen, Rogers, John H., Musuka, Godfrey, Samba, Chesterfield, Hakim, Avi J., and Harris, Tiffany G.
- Subjects
TRANS women ,PRE-exposure prophylaxis ,HIV ,GENDER identity ,ALCOHOLISM ,FISHER exact test - Abstract
Introduction: We sought to characterize social and structural drivers of HIV vulnerability for transgender women (TGW) in Zimbabwe, where TGW are not legally recognized, and explore differences in vulnerability by feminine presentation. Methods: A secondary analysis was conducted with a sub‐sample of participants recruited from a 2019 respondent‐driven sampling survey that comprised men who have sex with men, TGW and genderqueer individuals assigned male sex at birth, from two cities in Zimbabwe. Survey questionnaires captured information related to socio‐demographics, sexual and substance use behaviours, and social and structural barriers to HIV services. Secondary analyses were restricted to participants who identified as female, transfemale or transwomen (236/1538) and were unweighted. Descriptive statistics were used to calculate sample estimates and chi‐square and Fisher's exact tests were used to assess differences in vulnerability by feminine presentation. Results: Among 236 TGW, almost half (45.3%) presented as feminine in the 6 months preceding the survey and 8.5% had ever used hormones to affirm their gender identities. Median age among TGW was 23 years (interquartile range: 20–26). Feminine presenting TGW in our sample had higher prevalence of arrest (15.9% vs. 3.9%), rejection by family/friends (38.3% vs. 14.0%), employment termination (11.2% vs. 3.9%), employment refusal (14.0% vs. 3.9%), denial of healthcare (16.8% vs. 2.3%), physical, sexual or verbal harassment or abuse (59.8% vs. 34.1%), alcohol dependence (32.7% vs. 12.4%), recent transactional sex with a male or TGW partner (30.8% vs. 13.3%) and recent non‐injection drug use (38.3% vs. 20.2%) than non‐feminine presenting TGW (all p‐value <0.05). Conclusions: Findings suggest that TGW, particularly feminine presenting TGW, experience social and structural inequities which may contribute to HIV vulnerability. Interventions aimed at addressing inequities, including trans competency training for providers and gender‐affirming, psychosocial and legal support services for TGW, might mitigate risk. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes.
- Author
-
Chvilicek, Maggie M., Seguin, Alexandra, Lathen, Daniel R., Titos, Iris, Cummins‐Beebee, Pearl N., Pabon, Miguel A., Miščević, Maša, Nickel, Emily, Merrill, Collin B., Rodan, Aylin R., and Rothenfluh, Adrian
- Subjects
INVERSE relationships (Mathematics) ,ALCOHOLISM ,PHENOTYPES ,DROSOPHILA melanogaster ,LINEAR equations ,ETHANOL - Abstract
Tolerance occurs when, following an initial experience with a substance, more of the substance is required subsequently to induce identical behavioral effects. Tolerance is not well‐understood, and numerous researchers have turned to model organisms, particularly Drosophila melanogaster, to unravel its mechanisms. Flies have high translational relevance for human alcohol responses, and there is substantial overlap in disease‐causing genes between flies and humans, including those associated with Alcohol Use Disorder. Numerous Drosophila tolerance mutants have been described; however, approaches used to identify and characterize these mutants have varied across time and labs and have mostly disregarded any impact of initial resistance/sensitivity to ethanol on subsequent tolerance development. Here, we analyzed our own, as well as data published by other labs to uncover an inverse correlation between initial ethanol resistance and tolerance phenotypes. This inverse correlation suggests that initial resistance phenotypes can explain many 'perceived' tolerance phenotypes, thus classifying such mutants as 'secondary' tolerance mutants. Additionally, we show that tolerance should be measured as a relative increase in time to sedation between an initial and second exposure rather than an absolute change in time to sedation. Finally, based on our analysis, we provide a method for using a linear regression equation to assess the residuals of potential tolerance mutants. These residuals provide predictive insight into the likelihood of a mutant being a 'primary' tolerance mutant, where a tolerance phenotype is not solely a consequence of initial resistance, and we offer a framework for understanding the relationship between initial resistance and tolerance. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.