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Objective: The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the potential causal link between HZ and ischaemic stroke, including its subtypes. Methods: For our MR analysis, we identified genetic instrumental variables related to both HZ and stroke by screening two prominent publicly accessible genome-wide association study databases. The primary approach involved using the inverse variance weighting method. To supplement this, we also employed methods such as MR-Egger regression, the weighted median approach, simple and weighted models. Lastly, to ascertain the stability and reliability of the results, we conducted tests for heterogeneity detection, horizontal pleiotropy assessment, and a leave-one-out analysis; Results: The genetically predicted HZ did not indicate an association with stroke risk ([OR] 1.041; 95% [CI] 0.958–1.131;p = 0.336). This lack of association also held true for different subtypes of stroke: ischaemic stroke (OR = 1.047, 95% CI = 0.955–1.148, p = 0.323), large vessel stroke (OR = 1.13, 95% CI = 0.90–1.41, p = 0.272), cardioembolic stroke (OR = 1.020, 95% CI = 0.859–1.211, p = 0.816), small vessel stroke (OR = 1.14, 95% CI = 0.93–1.40, p = 0.195), and lacunar stroke (OR = 1.195, 95% CI = 0.967–1.476, p = 0.097). Conclusion: This MR study showed that not uncover a causal link between herpes zoster and ischaemic stroke. Additional research will be necessary in the future to shed light on the fundamental mechanisms involved. [ABSTRACT FROM AUTHOR]

To promote the transformation of remote sensing (RS) data into geoscience knowledge, it is necessary to provide better data discovery capabilities, especially when large amounts of RS data have been accumulated. Spatio-temporal range query is one of them to enable data discovery on RS images by the spatio-temporal range. Although existing RS image indexing methods are suitable for data discovery based on spatio-temporal range queries, they do not fully consider the problem of low data retrieval efficiency when the temporal and spatial range scales are unbalanced. To address this problem, we propose a multi-scale spatio-temporal grid index model (MSTGI). First, we divide the time dimension into three levels according to the granularity of year, month and day, and build an independent grid index structure for the object at different levels. Second, we design an adaptive hierarchical indexing strategy to perform parallel retrieval in an appropriate combination of partitions. MSTGI linearizes the grid obtained after global geospatial subdivision using Hilbert curves. Our experimental results, obtained on the Landsat series satellite dataset, reveal that the proposed method improves query efficiency levels by approximately 12.582% and 87.754% compared with GeoSOT-ST and AGMC at various spatial scales, respectively, and reaches 100% recall. [ABSTRACT FROM AUTHOR]

AbstractThe high hydrophilicity of titanium dioxide (TiO2) caused by surface hydroxyl groups limited their application in Pickering emulsions. Inspired by the structure and function of mussel adhesion protein, polydopamine-modified TiO2 (PDA-TiO2) was successfully prepared in this study. The effect of modified conditions on emulsifying capacity of Pickering emulsions stabilized by PDA-TiO2 were investigated, including pH, material ratio, reaction time, and temperature. The morphology and structure properties of modified TiO2 were characterized by SEM, TEM, FTIR, UV, TG, XPS, and XRD. The results suggested that PDA were successfully bonded to the TiO2 surface, which might improve the hydrophilicity of TiO2. PDA-TiO2 could stabilized Pickering emulsion with more uniform emulsified drops when m(TiO2)/m(DA) was 1/0.1, the reaction pH was 8.5, the reaction time was 3 h, and the reaction temperature was 50 °C. In addition, the introduction of polydopamine effectively improved the sun protection ability of TiO2. Compared to traditional sunscreen emulsion, Pickering emulsion stabilized by polydopamine-modified TiO2 could increase the sunscreen value by 55%, which broadened its application in cosmetic and other fields. [ABSTRACT FROM AUTHOR]