1. Role of m6A modifications in immune evasion and immunotherapy.
- Author
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Wu, Chunyu, Li, Lvyuan, Tang, Qiling, Liao, Qianjin, Chen, Pan, Guo, Can, Zeng, Zhaoyang, and Xiong, Wei
- Abstract
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N
6 -methyladenosine (m6 A) modification is the most prevalent RNA modification, which can affect the expression of RNA by methylating adenylate at the sixth N position to regulate the occurrence and development of tumors. Dysregulation of m6 A affects the activation of cancer-promoting pathways, destroys immune cell function, maintains immunosuppressive microenvironment, and promotes tumor cell growth. In this review, we delve into the latest insights into how abnormalities in m6 A modification in both tumor and immune cells orchestrate immune evasion through the activation of signaling pathways. Furthermore, we explore how dysregulated m6 A modification in tumor cells influences immune cells, thereby regulating tumor immune evasion via interactions within the tumor microenvironment (TME). Lastly, we highlight recent discoveries regarding specific inhibitors of m6 A modulators and the encapsulation of m6 A-targeting nanomaterials for cancer therapy, discussing their potential applications in immunotherapy. [ABSTRACT FROM AUTHOR]- Published
- 2024
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