1. Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity.
- Author
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Salem, Sohair and Ashaat, Engy
- Subjects
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STATISTICAL correlation , *PEARSON correlation (Statistics) , *T-test (Statistics) , *RECEIVER operating characteristic curves , *DATA analysis , *STATISTICAL significance , *RESEARCH funding , *AUTISM , *LOGISTIC regression analysis , *DNA , *SEVERITY of illness index , *DESCRIPTIVE statistics , *DNA methylation , *STATISTICS , *ANALYSIS of variance , *TELOMERES , *DATA analysis software , *BIOMARKERS - Abstract
Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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