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Der Klimawandel wird durch anthropogene Emissionen von Treibhausgasen aber auch komplexe natürliche Prozesse beeinflusst, die sich menschlicher Kontrolle weitestgehend entziehen. Die Berichte des IPCC erzeugen einen wissenschaftlich und politisch ausgehandelten Konsens, in dessen Folge die regierenden Eliten suggerieren, durch eine CO2 Steuer das Klima kontrollieren zu können. Diese und andere Maßnahmen basieren jedoch oft auf unsicheren Annahmen der Klimaforschung. Klimaprojektionen der Zukunft beruhen auf Modellen, deren Fehler zu groß sind und die interne Klimavariabilität unterschätzen. In mittleren Breiten können interne Klimatrends anthropogene Einflüsse sogar übertreffen. Wichtige Prozesse wie die geothermische Erwärmung der Ozeane werden zudem in allen Modellen vernachlässigt. Daher muss sich die menschliche Zivilisation auf unvorhersehbare Überraschungen vorbereiten, da interne Variabilität zu erheblicher Unsicherheit in den Klimaprojektionen führt und die Kontrolle des Klimawandels verhindert. Klimaänderungen haben komplexe ökonomische, ökologische, geopolitische sowie soziale Auswirkungen. [SS3] Die durch Medien und Politik dominierte Meinungsmaschinerie ignoriert die Unsicherheiten der Klimaprojektionen und benutzt diese für regionale Anpassungsmaßnahmen. In den wohlhabenden G7 Ländern und der EU wird eine unrealistisch schnelle Umstellung von fossilen Energieträgern auf erneuerbare Energien angestrebt. Die Diskussion um eine Dekarbonisierung der Industrie innerhalb von Jahrzehnten ist kontrovers, da eine Versorgungssicherheit mit regenerativen Energien in diesen Zeiträumen nicht erreichbar ist. Angesichts geopolitischer Spannungen steigt das Risiko eines Atomkriegs wieder an, was die Diskussionen um verstärkten Klimaschutz und militärische Aufrüstung widersprüchlich erscheinen lässt. Das Damoklesschwert einer gefahrenreichen Klimazukunft zwingt uns, politische und soziale Kurskorrekturen vorzunehmen und glaubwürdige Strategien zur nachhaltigen Nutzung unserer begrenzten Ressourcen zu entwickeln. Dieses Buch lädt Sie ein, die komplexen Zusammenhänge und die oft verschwiegenen Unsicherheiten der Klimaforschung zu erkunden. Über die Klimawissenschaften führt es zu einer tieferen Erkenntnis über unsere wirkliche Rolle in den globalen Klimaturbulenzen.

This book features all the women inducted in the first fifty years of the US National Inventors Hall of Fame. Each entry first provides a biography of the inductee and then goes on to describe one or more of their major inventions with descriptions that are accessible to those with little or no formal training in science. The evolution of the opportunities available to women in education and the professions becomes evident as the reader moves chronologically through biographies and inventions of the woman. Later inductees have received Nobel Prizes for their work and have become members of academies such as the National Academy of Engineering, the National Academy of Sciences, and the National Academy of Medicine. Others have received the National Medal of Science or the National Medal of Technology and Innovation. As an important part of the Women in Science and Engineering book series, the work highlights the contributions of women inventors, inspiring women and men, and girls and boys, in a variety of scientific fields.

The book offers an exciting, non-technical intellectual journey around applying feedback control to emerging and managing local and global crises, thus keeping the world on a sustainable trajectory. There is a narrow border between destruction and prosperity: to ensure reasonable growth but avoid existential risk, we must find the fine-tuned balance between positive and negative feedback. This book addresses readers belonging to various generations, such as: young people growing up in a world where everything seems to be falling apart; people in their 30s and 40s who are thinking about how to live a fulfilling life; readers in their 50s and 60s thinking back on life; and Baby Boomers reflecting on their past successes and failures. Albert-László Barabási, Robert Gray Dodge Professor of Network Science, Northeastern University: “In a world where interconnectedness has fostered global prosperity, it has also introduced vulnerabilities that can escalate local failures into worldwide crises. “Feedback” by Peter Erdi explores this double-edged sword, offering a solution through the power of feedback mechanisms. These tools are designed to mitigate the negative impacts of connectedness, steering the complexity of modern life towards outcomes that enhance human welfare.” Patrick Grim, Philosopher in Residence Visiting Scholar Center for Complex Systems University of Michigan: “Érdi demonstrates that many of the critical problems we face—from climate crises to economic instability to the threat of terrorism—operate as runaway feedback loops. The first challenge is to understand them. The second is to introduce control mechanisms on the model of biological homeostasis—a different form of feedback—that will guide us toward a more sustainable social future. Érdi applies the analytic tools of complex systems to some of the most complex issues we face.” Ichiro Tsuda, Specially Appointed Professor at Sapporo City University, Sapporo, Japan, leaving Chubu University Academy of Emerging Sciences (Director and Professor), Chubu University, Japan: “This book is dangerous, because of making your own consideration on feedback impossible to stop by a continual feedback process of yourself. Nevertheless, you must be given a method of finding very narrow boundaries between prosperity and destruction, therefore this book is extremely valuable. We all must read.”

This book highlights microbial products and their applications in the health sector. The chapters introduce novel advancements and applications in different pharmaceutical and nutraceutical aspects of applied microbiology. Readers will obtain a detailed overview of the relevance of microbial metabolites to human health and nutrition. Besides knowing the products already developed, they will also get an idea of microbial products currently in the development pipeline and those that are likely to emerge as potential nutraceuticals. Readers will get an interesting and useful perspective on how supplementing food with microbes or their bioactive metabolites can realize the idea of'food as medicine'. This book introduces the biological activities of various microbial fermentation products, and how they are relevant to mitigating various disease conditions (e.g. neuropathy, diabetes, gut dysbiosis, malnutrition, etc.) in humans. One of the highlights of this volume is the exploration of microbial pigments as potential substitutes for synthetic colorants, offering safer and more sustainable alternatives for the food and healthcare industries. The book has equivalent contributions from experts in academia and industry to fill the communication gap between them. Through this book, readers will gain valuable insights into the historical perspectives, contemporary impacts, and future prospects of microbial applications in health and nutrition. From food preservation to biopharmaceutical production, the potential of microbial products to revolutionize our approach to health and wellness is undeniable.

The book analyzes socioeconomic through the lens of a lawyer. In the past decade the world has witnessed some severe financial and economic crises, espe­cially the financial crisis of 2007-2008 and the crisis caused by the COVID-19 pandemic. The author states that the socio-economic order has in the past four to five decades been thoroughly redesigned, generally favouring models that prio­ritize the free market over the public interest or even, more generally, government operation. He works out that during four to five decades, globalized, capitalist societies are facing a multiplicity of fundamental problems, such as: (1) increasing debt that severely burdens both the private and public sectors; (2) persistent poverty and an ever-increasing polarization between rich and poor, in addition to (3) intractable environmental problems that, fifty years after the Club of Rome's report entitled ‘Limits to growth'(1972), has dragged the world into what in recent years has been referred to as'climate change.'The book explains why all this is the direct result of value choices made from the late Middle Ages onwards, when in the Western world the societal models of that time were increasingly abandoned for a societal model that came to rely on the primacy of economic interests. The book not only subjects the ethical choices but also examines various problems it has caused and probes for possible ways out.This is an open access book.

This book examines the progress in the biotechnology sector in India towards knowledge and innovation driven Bioeconomy. The chapters of the book review different genome editing techniques and the GM crops focusing on the emerging potential in agricultural biotechnology. Chapters on Vaccines and AI in healthcare unfold huge opportunities in medical biotechnology. The book covers the advances in biotechnology towards delivering important benefits of healthcare, particularly through the pharmaceutical industry focusing on new healthcare interventions and delivering innovations. Further, it explores the major opportunities in industrial biotechnology related to bio-pharma, biorefinery, fermentation biotechnology, and growing synergies between industry-academia. Toward the end, the book also reviews the genetic regulation and the critical role of HRD. In summary, the book emphasizes on India as a strong bio-manufacturing hub for innovative, affordable and accessible products for the society and also for global markets while describing the sector wise strategies required.

Since the publication of the Handbook of Experimental Pharmacology Vol. 197 in 2010 there have been important advances in drug development, drug delivery and – more recently – drug targeting. This is in particular relevant with the new generation of drugs acting on the immune system and tumors. These are quite often accompanied by major adverse reactions. Safe therapy is, therefore, an important area of research, in particular in chronic diseases and in persons of old age. In addition, the Covid-19 pandemic has brought renewed attention to vaccinations against viral infections, and mRNA vaccines have been tested for vaccination in tumor therapy, too. Vaccine delivery has stimulated important research on carriers which may pave the way for other applications and enhance a path to e.g. CRISPR-cas therapy.

This book offers a fresh perspective on how science and religion are connected, and how prayer aligns with the laws of nature. It explores a holistic worldview where science and religion complement each other, shedding light on life, society, and philosophical and societal concerns. We are born into a world full of mysteries that we only partially understand. We don't know where we are coming from, we don't know why we live, and we don't know where we will go. We don't know how everything started; we even don't know what “everything” really is. We are living in an era of rapid change marked by disruptive technologies, like artificial intelligence and computers. Combined with a perception that the old wisdom transferred to us by religion is outdated, traditional values and institutions that had worth and power over many centuries are now losing their appeal. Science has made remarkable progress but can't answer life's most profound questions about our origins, purpose, and destination – why do we live and what should we do? In this book, the author begins with an overview of science, our understanding of the universe, highlighting gaps in our knowledge, like what started the Big Bang, followed by examples of successful scientific achievements and insights into the limits of science. In the subsequent chapters, the author examines topics such as mind over matter and the coexistence of evolution, creation, natural laws, and miracles. An attempt to answer the theodicy question is also provided in this book, where the author connects new scientific discoveries with ancient religious wisdom. The book concludes with a chapter devoted to innovation and a call for building a better world. This book is a compelling read for scholars, professionals, and curious laymen alike, ready to expand their horizons.

As civilization rapidly evolves into a new radical post-pandemic era, organizations and leaders need to adapt, innovate, and reimagine the future. This guidebook offers insights and strategies for leaders to thrive in this new era, empowering them to embrace their roles as Neo-Innovators, Neo-managers, and Neo-futurists. It is a concise “how-to” guide for anyone who is (or wants to be) involved in the development of radical innovations that solve problems and exploit opportunities in the post-pandemic world. Featuring actionable advice and examples from generative AI and the influencer culture to humanoid robots, self-driving cars and age-slowing therapies, this book equips young and experienced innovators, innovation leaders, and practitioners with the essential tools and mindset to tackle challenges and explore opportunities in a dynamic innovative landscape.

This operations manual offers an accessible, step-by-step guide to launching, running, and achieving success with a life science and biotechnology business incubator. Written by the founder and President Emeritus of the Pennsylvania Biotechnology Center (PABC), one of the most successful biotech and drug discovery incubators in the United States, it is designed to introduce researchers and funders to the broad considerations and minute details of managing an incubation program.As of 2023, there are more than 1100 business incubators in the United States alone, and more than 5000 worldwide. One of the fastest-growing industries of the'new economy,'science business incubators are a tool for regional economic stimulation and commercial development for universities and research organizations. The PABC was founded in 2006 as a state-of-the-art research facility; its purpose and operation is unusual and its success has been remarkable. It was created by the nonprofit Hepatitis BFoundation and its research arm, the Baruch S. Blumberg Institute, to help their effort to find a cure for hepatitis B. But it has proved to be more than a source of funding for those nonprofits – it has become a major economic driver for its region and Pennsylvania, creating thousands of jobs and bringing in billions of dollars to the local economy. The PABC's model has drawn attention from economists, legislators, and the research community. The strategy of bringing nonprofit research organizations and biotech startups under one roof was a founding principle, and has created powerful, lasting collaborations between scientific innovators, entrepreneurs and investors. The partnerships forged at the PABC have led to the discovery, testing, and FDA approval of new drugs for cancer and gastrointestinal diseases and medical devices, as well as multiple multimillion-dollar IPOs, and thousands of jobs. There are currently more than 50 startups housed in the Center's offices, ranging in focusfrom pharmaceuticals and diagnostics, to medical wearables and nanomedicine research.Curing Disease from the Ground Up: How to Operate a Biotechnology Business Incubator tells both a personal story about the ups and downs of leveraging a business incubator to fund and find a cure for a deadly disease, as well as providing a practical guide to running a business incubator. It is a first-hand, expert perspective for running a science business incubator, and explains how the success of the PABC can be learned and replicated. Whether it is developing a mission-focused framework, the practicalities of managing a scalable, business-savvy research nonprofit, identifying ideal tenant partners, or planning for the infrastructure needs of a large research facility, this manual is the first and last stop for entrepreneurial thinkers in this field.

This book focuses on the individuals who invented specific forms of alternative medicine. Examples are Hahnemann (homeopathy), Still (osteopathy), Schulz (autogenic training). In total, about 40 such personalities are included in the book. They have all led unusual lives, and the book explores their journey towards their inventions. Certain characteristics seem to emerge: · They are all male! · Many originated from Europe · Most of them are white · Many gave their name to the therapy · Many inventions are relatively recent · Many inventors are not doctors · Most inventors claim to have found a panacea · Many adhere to vitalistic ideas · Almost all of the inventors are fully convinced of their invention · Inventions are often based on personal experience · The inventions tend to be implausible even by the standards of their time The book explores all these themes and, where appropriate, contrasts them with the corresponding situation in conventional medicine.

This book focuses primarily on the newly discovered theory and techniques of veterinary molecular immunology. It also covers application of modern immunological methods into the treatment and control of infectious diseases and cancer, and future research trends. In terms of new immunological theories, this book focuses on recently-discovered innate lymphocytes (ILCs), signal transduction triggered by engagement of pattern recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs), and signal communication between nerve and immune systems, antimicrobial peptides, immunoregulation and checkpoint, development and maturation of T and B lymphocytes, regulatory T cells, immune tolerance, and immunosuppression and evasion. In terms of new techniques and application, the book covers the categories and designs of preventive and therapeutic vaccines and the principle of developing vaccination program, occurrence, development and immune evasion of cancer cells, and the novel techniques for cancer therapy. In addition, comparison of avian and porcine cytokines with human and mouse ones is also provided in the appendices to illustrate the differences in cytokines between species. This book is valuable for the undergraduates, graduate students or professional researchers with requirement for advanced studies in veterinary immunology. It meets their requirements for improving and expanding knowledge of immunology.

This textbook for graduate veterinary students provides basic concepts of veterinary immunopathology with particular reference to immunopathogenesis. The initial chapters provide up-to-date knowledge on important aspects of immunology, immunodeficiency disorders, hypersensitivity reactions, and autoimmune disorders of various animal species. The book examines different natural and synthetic immunomodulatory products that can modulate the immune system of animals. It discusses the immunopathogenesis and immunopathology of multiple diseases and immunopathological disorders in diverse animal species, including cattle, buffalo, sheep, goat, swine, equine, and laboratory animals. The book also covers the immunopathology of various body systems, including lungs, reproductive system, enteric system, mammary gland, joints, kidneys, and skin. It provides clinical manifestations that are useful in diagnosing immunopathological conditions. The book presents a highly informative text with highquality gross and microscopic photographs, diagrammatic presentations of immunopathological disorders and techniques, making it useful in both classrooms and professional training courses for students, researchers, and professionals alike.

Nanotechnology is revolutionizing healthcare, by providing innovative solutions to some of the most challenging issues in medicine. This book provides an in-depth overview of nanoscale materials and devices that are advancing diagnostics, therapeutics, and personalized care in medical field. It focuses on nanomedicine's impact on vaccine efficacy as well as innovative diagnosis and therapy for various type of cancer while addressing concerns about safety and toxicity. It examines how nanotechnology is enhancing drug delivery by precisely targeting medicines to specific cells or tissues, thereby increasing treatment efficacy with reduced side effects. This book also explores how nanoparticles are advancing medical imaging for earlier and more accurate disease detection, and how nanosensors allow real-time biomarker monitoring for faster and more reliable diagnoses. Additionally, it explores nanomedicine's role in managing cardiovascular diseases, improving bone health through nano-extracellular vesicles, and regenerative medicine, including ongoing clinical trials and ethical considerations. This book is an essential resource for researchers, practitioners, and students, offering a comprehensive exploration of nanomedicine's role in shaping the future of health and medicine leading to a new era of precision medicine and improved patient care.