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Objective: To explore the relationship between serum C-reactive protein (CRP), albumin, S100B protein and the severity of traumatic brain injury and its complication with acute traumatic coagulation disease. Methods: 80 patients with brain injury admitted to our hospital from March 2020 to March 2023 were selected as the research subjects. All patients were evaluated using the Glass Coma Score (GCS), and the severity of the brain injury was determined based on the score results. 25 patients with a GCS score of ≤ 8 were divided into a severe group, and 55 patients with a GCS score of>8 were divided into a non severe group. Compare the expression levels of serum CRP, albumin, and S100B protein between two groups of patients. Subsequently, 80 patients with traumatic brain injury were divided into an acute traumatic coagulation disease group (n=20) and a non acute traumatic coagulation disease group (n=60) based on whether they were complicated with acute traumatic coagulation disease. The general clinical situation of the two groups of patients was compared, and the predictive value of serum CRP, albumin, and S100B protein for the occurrence of acute traumatic coagulation disease in patients with traumatic brain injury was analyzed. Results: There was no difference in albumin levels among patients with different severity of brain injury(P>0.05), but there was a difference in CRP and S100B protein levels. The CRP level in the severe group was higher than that in the non severe group, while the S100B protein level was lower than that in the non severe group (P<0.05); The Spearman correlation analysis results showed that there was no significant correlation between albumin and the severity of brain injury (P>0.05), CRP was positively correlated with the severity of brain injury, and S100B protein was negatively correlated with the severity of brain injury (P<0.05); There was no significant difference in gender, age, BMI, and type of brain injury between the acute traumatic coagulation disease group and the non acute traumatic coagulation disease group(P>0.05). However, there was a significant difference in the range of brain contusion, treatment time, GCS score, shock index, CRP, albumin, and S100B protein levels between the acute traumatic coagulation disease group and the non acute traumatic coagulation disease group(P<0.05); The results of logistic regression analysis showed that GCS score, shock index, CRP, and albumin were independent influencing factors for acute traumatic coagulation disease after brain injury(P<0.05). Conclusion: The detection of CRP and S100B protein on admission can assist the severity of craniocerebral injury early, and when patients with high CRP level and low S100B protein and albumin level, they should be alert to the occurrence of acute traumatic coagulopathy, and take timely measures to intervene for patients. [ABSTRACT FROM AUTHOR]

To analyze the relationship between coagulation and fibrinolysis indicators and acute traumatic coagulopathy (ATC) after traumatic brain injury (TBI) and their predictive efficacy for cerebrocardiac syndrome ( CCS ). 80 patients withTBI admitted to our hospital from January 2020 to December 2022 were selected as the research objects. The levels of prothrombin time(PT), activated partial thromboplastin time (APTT), D-dimer (D-D), thrombin-antithrombin complex (TAT), plasminogen-α2 plasmino-gen inhibitor complex (PIC), international normalized ratio (INR) and TAT / PIC ratio were detected and calculated in non-ATC patientsand ATC patients, non-CCS patients and CCS patients, respectively. Bivariate Spearman correlation was used to test the correlation between coagulation and fibrinolysis indicators. Multivariate Logistic model was established to analyze the influencing factors of ATC andTBI combined with CCS after TBI, and the predictive efficacy of coagulation and fibrinolysis indicators on TBI combined with CCS wasanalyzed. The incidence of ATC in 80 TBI patients was 27. 50 %. Compared with the non-ATC group, the levels of PT, APTTand D-D in the ATC group were higher, and the TAT / PIC ratio was lower (P<0. 05). PT, APTT and D-D were positively correlated withATC after craniocerebral injury, and TAT / PIC was negatively correlated with ATC. Multivariate logistic analysis showed that TAT /PIC was an independent risk factor for ATC after craniocerebral injury (P<0. 05). The incidence of CCS in 80 TBI patients was 20. 00 %. Compared with the non-CCS group, the levels of PT, APTT and D-D in the CCS group were higher, and the TAT / PIC ratio was lower(P<0. 05). Multivariate logistic analysis showed that PT, APTT, D-D and TAT / PIC were independent risk factors for TBI combined with CCS (P<0. 05). In the prediction of TBI combined with CCS, the ACU of PT, APTT and D-D were all > 0. 70, and TAT / PIC > 0. 85. TAT / PIC is associated with ATC after TBI, and can also predict the occurrence of CCS, which has guiding significance in the prognosis prediction of TBI patients. [ABSTRACT FROM AUTHOR]