1. A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis.
- Author
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Ding, Yuan-Lin, Yan, Rui-Chao, Chen, Hao-Kai, and Guo, Xu-Guang
- Subjects
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MEDICAL information storage & retrieval systems , *RECEIVER operating characteristic curves , *META-analysis , *DESCRIPTIVE statistics , *SYSTEMATIC reviews , *MEDLINE , *ODDS ratio , *MEDICAL databases , *ONLINE information services , *DATA analysis software , *QUALITY assurance , *CONFIDENCE intervals , *MYCOBACTERIUM tuberculosis , *RIFAMPIN , *DRUG resistance , *SENSITIVITY & specificity (Statistics) - Abstract
Objective A detection method with high efficiency and accuracy is urgently needed in clinical work. The purpose of our study was to determine the diagnostic accuracy of the Xpert MTB/RIF assay for intestinal tuberculosis (ITB). Methods We searched PubMed and 4 other databases from their establishment to July 19, 2022, for published essays of diagnostic performance in which Xpert MTB/RIF was used to test patients with clinically suspected ITB. An assessment of the quality of the selected literature was conducted using QUADAS-2. We built forest plots by MetaDiSc software. Results The pooled Xpert MTB/RIF sensitivity was 48%, and the specificity was 99%. Moreover, the positive likelihood ratio for ITB diagnosis was 21.61. The negative likelihood ratio was 0.54. There were substantial variations between the study estimates of sensitivity (I 2 = 87.6%) and specificity (I 2 = 82.4%). Conclusion Intestinal TB is detected with limited diagnostic sensitivity by Xpert MTB/RIF but with high specificity. An Xpert-positive result may facilitate the rapid identification of ITB cases. Nevertheless, a negative result has less certainty in excluding the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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