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A patent application has been filed by James A. Kaslik for a device that can transform toilet paper in real time to improve its effectiveness at cleaning residue off the skin and body hair. The device is pocket-sized and can be carried anywhere. It uses liquid, a mold, and pressure to transform the texture, density, and wetness of the paper. The transformed paper provides superior cleaning and decomposes in water without causing harm to sewage and septic systems. Various variations of the device are also described in the patent application. [Extracted from the article]

A patent application by Philip Morris USA Inc. has been made available online, detailing the invention of banded papers and smoking articles. The application explains that the invention aims to reduce the incidence of accidental fires caused by untended smoking articles. The invention focuses on reducing the Ignition Propensity (IP) value and increasing the Self-Extinction (SE) value of smoking articles. The application describes the testing methods for IP and SE values and discusses the use of an aqueous starch solution with an anti-wrinkling agent to achieve the desired results. The invention also includes patterns and characteristics for the add-on material used in the wrapper paper. [Extracted from the article]

A patent application has been filed for an apparatus that manufactures eco-friendly straws using wood as a raw material. The invention aims to prevent environmental pollution by creating straws that are easy to recycle and dispose of. The apparatus includes a supply unit, a processing unit, and a transfer unit to transport the raw material. It also features a polishing unit and a foreign matter removal device to improve hygiene by removing any foreign matter from the inside of the straw. The invention seeks to address the problem of single-use plastic straws and provide a cost-effective solution. [Extracted from the article]

Nestle Purina Petcare Company has filed a trademark application for the name "STOUFFER'S." The application includes a wide range of goods and services, such as rice, pasta, noodles, frozen entrees, sauces, preserved vegetables and fruit, meat and seafood, soups, and baking paper. The application was made public on January 31, 2024. The owner of the application is Andrea K. Cannon, and the company is located in St. Louis, MO. [Extracted from the article]

A patent has been issued for an image forming apparatus by Canon Kabushiki Kaisha. The patent describes a configuration that notifies the user of the position of a recording medium remaining in the apparatus. The invention includes a conveyance unit with sensors and light sources that determine the position of a paper jam and control the corresponding light source to turn on. The apparatus also includes a capacitor to reduce voltage fluctuation and a shut-off mechanism when the conveyance unit is pulled out. The invention aims to provide a less expensive configuration for notifying paper jams in an image forming apparatus. [Extracted from the article]

A report from KEDGE Business School in Talence, France discusses research on organization management and the impact of psychological contracts (PC) on employment relationships. The research was conducted by a group of PC and sustainability scholars from around the world. The paper explores how PC scholars can enhance the beneficial influence of PC knowledge on employment relationships through research, practice and society, and students. The research also contributes to the debate on sustainable PCs by integrating PCs with an 'ethics of care' perspective. The paper has been peer-reviewed and is available for further reading. [Extracted from the article]

General Mills Inc. has been issued a patent for a system and method for coating soft and sticky food cores. The patent describes a process for manufacturing food products with a coating on the core, specifically addressing the challenges of coating sticky and soft food materials. The system involves using conveyor belts and a carrier sheet to support the core material and maintain its shape during the coating process. The patent also mentions the use of parchment paper and a thin layer of coating material to prevent the core from sticking to the conveyor. The invention aims to provide an efficient and effective system for producing food products with soft and sticky cores in a commercial manufacturing setting. [Extracted from the article]

A new research perspective published in Oncoscience presents the rationale for adding five already approved and marketed generic drugs to the current standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC). The regimen, called IPIAD, includes an angiotensin receptor blocker, an antimicrobial drug, an antifungal drug, a broad-spectrum antibiotic, and an antibiotic. The researcher suggests that this augmentation regimen may slow the growth of PDAC and provide clinical benefit. The full paper provides more detailed information on the drugs and their potential impact on PDAC. [Extracted from the article]

A new editorial paper published in Oncotarget's Volume 15 discusses the challenges and setbacks in the process of drug discovery in academia. The researchers highlight the time-consuming and expensive nature of drug discovery, as many drug candidates fail to progress beyond the research bench. The lack of synergy between academia and industry, as well as the lack of streamlining the drug development process, contribute to this issue. The paper explores possible solutions to overcome these challenges. [Extracted from the article]

Chundo Pharm Co. Ltd. has been issued a patent for a method of producing a test strip for detecting calcium levels in a biological fluid sample. The test strip is based on a colorimetric change and can be used to measure calcium concentrations in blood, urine, or saliva. Calcium plays a crucial role in various bodily functions, and abnormal calcium levels can indicate medical conditions such as cancer, muscle dysfunction, and bone diseases. The test strip provides an easy, inexpensive, and fast way to measure calcium levels, allowing for early detection and prevention of conditions like osteoporosis. [Extracted from the article]

A new editorial paper published in Oncotarget discusses acute myeloid leukemia (AML), a type of aggressive cancer. The paper highlights recent advancements in understanding AML biology and the potential for developing novel drug therapies. The researchers suggest exploring reductive carboxylation as a possible drug target to weaken tumor cell survival mechanisms and improve patient outcomes. The paper provides further information on this topic and can be accessed through the provided DOI link. [Extracted from the article]

A new editorial paper published in Aging explores the concept of clonal hematopoiesis (CH) and its impact on aging, cancer, and patient care. CH refers to the presence of hematologic malignancy-associated somatic mutations in blood cells without meeting the diagnostic criteria for hematologic disease. These mutations become more prevalent in the elderly population, reaching up to 18.4% in individuals aged 90 years or older. Aging itself is a significant factor associated with CH, particularly in individuals over 70 years old. The paper also discusses the potential role of CH in solid tumors, such as an increased risk of incident lung cancer. While initial studies associated CH mutations with worse survival outcomes, newer findings suggest that solid tumor patients with CH may experience longer survival, although the underlying mechanisms are not yet understood. [Extracted from the article]

A research paper titled "Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia" was recently published in Oncotarget's Volume 15. The paper investigates the potential of the growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 as a treatment for Doxorubicin-resistant acute myeloid leukemia (AML). The study found that MIA-602 significantly reduced cell viability in both wild-type AML cells and Doxorubicin-resistant clones. In an in vivo experiment using xenografted mice, MIA-602 treatment resulted in a reduction in tumor volume compared to the control group. The researchers suggest that GHRH antagonists like MIA-602 may offer an alternative treatment approach for AML and drug-resistant AML, potentially avoiding the side effects associated with standard chemotherapy. [Extracted from the article]

A research paper published in Aging suggests that chlorogenic acid, a major polyphenol found in Du-Zhong, a herb used in Traditional Chinese Medicine, may be a promising candidate for the treatment of osteoporosis. The study found that chlorogenic acid enhanced osteoblast functions and suppressed osteoclast formation, effectively preventing bone loss in ovariectomized rats. The researchers concluded that chlorogenic acid could potentially be developed into a novel anti-osteoporosis treatment. [Extracted from the article]

A research paper titled "Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort" explores the relationship between prenatal vitamins and metals and epigenetic aging biomarkers. The study found that essential and non-essential metals in the intrauterine environment can affect epigenetic aging biomarkers throughout a person's life. The researchers investigated the association between first-trimester folate, B12, essential metals, and non-essential metals in maternal circulation with epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration (EAA) in childhood. The study suggests that prenatal metals, including essential metals and arsenic, are associated with epigenetic aging in early life, which may have implications for future health. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 on February 22, 2024, titled "Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas," explores the potential of combining sacituzumab govitecan (SG) with platinum-based chemotherapeutics in treating triple-negative breast cancer (TNBC), urinary bladder carcinoma (UBC), and small-cell lung carcinoma (SCLC). The study found that combining SG with carboplatin or cisplatin produced additive growth-inhibitory effects in vitro and significant antitumor effects in mice bearing TNBC, UBC, and SCLC tumors. The researchers suggest that further clinical investigation is warranted to explore the benefits of this combination therapy. [Extracted from the article]

A patent has been issued for a mass spectrometry ionization-based assay that can detect enzyme activity and/or presence. The apparatus includes a spray material, a sample containing specific enzymes, a solvent to hydrate the sample and extract analytes of interest, an enzyme substrate, a power supply to create charged droplets of the analytes, and a mass spectrometer to identify the analytes and determine the presence of enzymes. The spray material can be porous or solid, and the solvent can be a single or multi-solvent. The method can be used with various samples such as blood, urine, and plasma. The patent was filed in October 2021 and published in February 2024. [Extracted from the article]

A research paper titled "The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut" explores the role of the vitamin D/vitamin D receptor (VitD/VDR) pathway in maintaining intestinal homeostasis and extending life expectancy. The study, conducted by researchers from Pusan National University and Korea Food Research Institute, used a Drosophila midgut model to investigate the protective role of VitD/VDR in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging. The findings suggest that vitamin D treatment reduces age- and oxidative stress-induced ISC proliferation and centrosome amplification, providing direct evidence of the anti-aging role of the VitD/VDR pathway. This study contributes valuable insights into the molecular mechanisms underlying healthy aging in Drosophila. [Extracted from the article]

A recent study on gene therapy has been published, focusing on the use of biotherapeutic modalities such as cell therapies, gene therapies, nucleic acids, and proteins for neurodegenerative disorders. The research, conducted by Sanofi, highlights the challenges and limited guidance in evaluating the biological consequences of these treatments. The study suggests expanding screening methods and neurohistological procedures to assess possible neural effects. This paper serves as a practical reference for preclinical safety testing and risk assessment of novel biologics. [Extracted from the article]

A recent editorial paper published in Oncoscience discusses the challenges of developing novel therapeutics for metastatic tumors. The author highlights that tumors that have spread to distant locations, such as the brain, are difficult to treat and cure. While immunotherapeutic approaches have shown success in some tumor types, there is evidence that they may cause hyper-progression in certain patients. The paper emphasizes the need for combination therapies targeting key signaling pathways to effectively control tumor growth and survival. [Extracted from the article]

Guardant Health, Inc., a precision oncology company, has reported its financial results for the fourth quarter and full year of 2023. In the fourth quarter, the company saw a 22% increase in revenue compared to the same period in 2022, with reported tests to clinical and biopharmaceutical customers increasing by 29% and 16% respectively. For the full year of 2023, revenue increased by 25% compared to 2022, with reported tests to clinical and biopharmaceutical customers increasing by 39% and 15% respectively. The company also improved its operating expenses and free cash flow compared to the previous year and ended the year with $1.2 billion in cash, cash equivalents, and marketable debt securities. Additionally, Guardant Health achieved improved average selling prices with its Guardant360 LDT CMS reimbursement and published a paper demonstrating improved adherence with blood-based colorectal cancer screening. The company also collaborated with the US Oncology Network and community oncology practices to increase the use of biomarker testing for identifying patients who would benefit from therapies. Terilyn Juarez Monroe was appointed as the chief people officer. [Extracted from the article]

A patent has been issued to Primera Technology Inc. for a food product platform that can be used with a food product printer. The platform is designed to securely support food products and has an attachment mechanism for connecting to a printer's receiving arm. The platform can be easily attached and detached from the arm without the need for tools. The system allows for printing on a variety of food products, such as cookies, frosting sheets, and rice paper, using edible ink. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 discusses the differential expression of the Mad2 gene in human esophageal cancer. The study focuses on the relationship between the consumption of raw areca nut and the development of esophageal squamous cell carcinoma (ESCC). The researchers found that Mad2 expression levels were both overexpressed and underexpressed in the samples, leading to premature anaphase and chromosome missegregation. The study suggests that Mad2 expression levels, along with chromosomal abnormalities, could serve as a clinical biomarker for esophageal cancer. Further research is needed to understand the role of the pRb-E2F1 circuit in Mad2 down-regulation. [Extracted from the article]

A research paper published in Genes & Cancer explores the use of blood-based biomarkers for early detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. The study focuses on the TGF-b signaling pathway, which plays a role in liver disease and cancer. Using machine learning methods, the researchers identified a pattern of proteomic markers that differentiate HCC from non-HCC in a cohort of 216 patients. They also found two other markers, Myostatin and Pyruvate Kinase M2, that were significantly associated with HCC. These findings have the potential to stratify the risk of HCC and improve early detection. [Extracted from the article]

A research paper published in Genes & Cancer titled "Roles of USP1 in Ewing sarcoma" explores the role of USP1 in Ewing sarcoma, a cancer that affects bone and soft tissue in children and young adults. The study reveals that Ewing sarcoma has two populations of cells, with the CD133high population displaying higher growth rate and the CD133low population displaying chemotherapy resistance. The researchers found that USP1, a deubiquitinating enzyme, is a transcriptional target of the EWS-FLI1 fusion oncoprotein and is expressed at high and low levels in the CD133high and CD133low populations, respectively. USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and stimulates Ewing sarcoma growth. The study also shows that a pharmacological inhibitor of USP1 can activate cdc42 and inhibit Ewing sarcoma growth. These findings uncover critical roles for USP1 in Ewing sarcoma, regulating growth and chemo-sensitivity through distinct mechanisms. [Extracted from the article]

A patent application by Daio Paper Corporation describes a disposable wearing article, such as a diaper, that aims to prevent skin irritation and rash. The article includes a top sheet with a two-layer structure and a glycerin-containing region. The method for manufacturing the article involves applying a body fluid pervious treatment agent and glycerin to the top sheet. The invention is intended to provide an effective solution for preventing diaper rash, particularly in infants with sensitive skin. [Extracted from the article]

A recent research paper published in Oncotarget's Volume 15 titled "BCAS1 defines a heterogeneous cell population in diffuse gliomas" explores the role of BCAS1 in diffuse gliomas. The study analyzes the expression of BCAS1 in different tumor samples from patients with diffuse gliomas and uncovers the molecular and ultrastructural features of BCAS1+ cells. The findings suggest that BCAS1 may serve as a diagnostic, prognostic, and therapeutic marker for the development of cutting-edge treatments for gliomas. Further investigation into the role of BCAS1 in tumor malignancy is warranted. [Extracted from the article]

Dr. Mikhail V. Blagosklonny, a researcher at Roswell Park Comprehensive Cancer Center, has published a brief report in Oncoscience discussing his battle with cancer. Diagnosed with metastatic lung cancer in his brain in January 2023, Dr. Blagosklonny felt a strong sense of purpose to find a cure for metastatic cancer. In the article, he argues that monotherapy with targeted drugs is not sufficient to cure metastatic cancer, but preemptive combinations of targeted drugs may hold promise. He also shares insights on rapamycin, an anti-aging drug that can delay cancer. The full paper can be accessed through the provided DOI. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 explores the use of the ATR inhibitor gartisertib in patient-derived glioblastoma cell lines. Glioblastoma cells can resist the DNA-damaging effects of chemotherapy and radiation therapy through the DNA damage response mechanism. The study shows that gartisertib alone reduces the viability of glioblastoma cell lines and enhances cell death when combined with chemotherapy and radiation therapy. The researchers also found that gartisertib induces an innate immune gene signature. This study suggests that ATR inhibition could enhance the effectiveness of standard glioblastoma treatment and warrants further investigation. [Extracted from the article]

A recent editorial paper published in Oncotarget discusses the challenge of PARP inhibitor resistance in ovarian cancer treatment. While PARP inhibitors have been effective in extending progression-free survival for patients with homologous recombination repair deficiency, resistance to these inhibitors remains a common issue. The researchers from Mayo Clinic School of Medicine and Science conducted a study on the drug Pixatimod (PG545), which showed promising results in inducing DNA damage and impeding the DNA repair pathway in ovarian cancer cells. This research highlights the need for innovative strategies to address PARP inhibitor resistance in ovarian cancer treatment. [Extracted from the article]

A recent editorial paper published in Oncotarget discusses the potential of using cancer stem cell-derived exosomes (CSC-Exos) in the diagnosis and treatment of cancer. Cancer stem cells (CSCs) are a small population of cancer cells that play a central role in tumor initiation, growth, metastasis, and recurrence. Exosomes, which are released by cells, contain various components that can influence the behavior of neighboring cells and contribute to cancer progression. Understanding the characteristics and functions of CSC-Exos could lead to the development of new diagnostic tools and therapies for cancer. [Extracted from the article]

A research paper titled "Evidence of a pan-tissue decline in stemness during human aging" has been published in the journal Aging. The study, conducted by researchers from the Universidade de Sao Paulo, University of Birmingham, and the University of Liverpool, used a machine learning method to analyze transcriptome data from healthy human tissues. The researchers found that approximately 60% of the tissues studied showed a negative correlation between age and stemness score, indicating a decline in stem cell function with aging. However, the uterus was an exception, showing increased stemness with age. The study suggests that stem cell deterioration may contribute to human aging. [Extracted from the article]

Cracker Barrel Old Country Store is offering free pancakes to dine-in guests to celebrate the solar eclipse on April 8. Guests can also purchase Solar Eclipse Paper Glasses at Cracker Barrel to safely view the eclipse. The total eclipse of the sun will be visible from Texas to Maine and will last up to 4 minutes and 27 seconds. Cracker Barrel provides a comfortable setting with rocking chairs on the front porch to witness the event. [Extracted from the article]

Stericycle, a leading provider of regulated medical waste management and secure information destruction solutions, has received a "B" rating on the 2023 CDP Climate Change Survey. This is the highest rating the company has received to date. CDP is a not-for-profit organization that manages the global disclosure system for environmental impacts. Stericycle's grade reflects their initiatives in treating medical waste, recycling paper, diverting plastic from landfills, and treating pharmaceutical waste. The company is committed to protecting the health and well-being of patients, staff, and the communities they serve. [Extracted from the article]

A patent has been issued to Koninklijke Philips N.V. for an indicator system for a milk container and a milk storage device. The system aims to address the need for a more robust approach to labeling stored breast milk, as current methods such as masking tape or adhesive labels are not ideal. The indicator system includes a time display element with different time scales for indicating the freshness of milk stored in different conditions, such as in the fridge or freezer. The system also features indicator elements to mark the beginning and end portions of the time scales. This invention provides a simple and efficient way to track the freshness of stored milk. [Extracted from the article]

A recent study conducted by researchers at Amrita Vishwa Vidyapeetham in India examined the use of machine learning techniques for the classification and recognition of sign language. The study found that sign language serves as an alternative communication mode for individuals with hearing and speaking impairments, and approximately 98% of the hearing impaired population in India use sign language as their primary mode of communication. The limited availability of human interpreters poses a challenge in recognizing and identifying diverse sign languages. The study reviewed 95 research papers focused on sign language categorization and identification using artificial intelligence-based techniques, and found that Support Vector Machine (SVM) exhibited higher performance measures among machine learning techniques, while Convolutional Neural Networks (CNN) exhibited higher performance among deep learning techniques. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 explores the synergistic cytotoxicity of ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, with the DNA alkylator thiotepa (Thio) in acute myeloid leukemia (AML) cells. The study demonstrates that the combination of ABT199/venetoclax and Thio enhances the cytotoxicity of fludarabine, cladribine, and busulfan in AML cell lines and leukemia patient-derived cell samples. The results suggest that this combination could be used in clinical trials as part of pre-transplant conditioning regimens for AML patients undergoing hematopoietic stem cell transplantation (HSCT). The study also indicates the potential clinical relevance of the combination in overcoming ABT199/venetoclax resistance and its activity against certain cell lines. [Extracted from the article]

A report from the Primary Health Care Corporation highlights the unique challenges faced by healthcare workers (HCWs) in Gaza due to the ongoing conflict. The research reveals that HCWs in Gaza experience extraordinary difficulties, including the targeting of medical facilities, shortages of medical supplies, and ethical dilemmas. These factors contribute to heightened stress, anxiety, and a sense of helplessness among HCWs. The lack of basic needs and support further compromises their ability to provide care effectively. The study emphasizes the need for targeted mental health interventions and support tailored to the specific challenges faced by HCWs in Gaza. [Extracted from the article]

A patent has been issued to Shanghai United Imaging Healthcare Co. Ltd. for a method and device for insulating a high-voltage generator tank. The patent addresses issues such as corona discharge, electrical leakage, and the aging of transformer oil, which can affect the stability and lifespan of the high-voltage tank. The patent describes various aspects of the transformer design, including the use of insulating paper layers, fixtures, and oil barriers to improve insulation and stability. The patent also mentions the inclusion of printed circuit boards and oil passages in the transformer design. [Extracted from the article]

A patent has been issued to R.J. Reynolds Tobacco Company for a biodegradable cigarette filter. The filter is made from a fibrous tow material coated with cellulose acetate and/or plasticized cellulose acetate. The filter is designed to degrade quickly in various disposal environments, such as landfills and composting sites, while still providing the desired smoke flavor. The patent includes various claims related to the composition and manufacturing of the filter material. [Extracted from the article]

A patent application has been published by Akyrian Systems LLC for an improved clinician-centered clinical trial verification system and method. This computerized system aims to enhance the process of verifying clinical trial data by minimizing human error. It allows medical professionals to capture and delineate specific areas of source capture images that contain answers to clinical trial questionnaires, rather than transcribing alphanumeric values. By doing so, this system has the potential to save time and reduce costs in the clinical trial process. Additionally, the patent application describes a system and method for improving the workflow and efficiency of clinical trials by reorienting questions in electronic case report forms (eCRFs) to match the order of information in electronic medical records (EMRs). It also incorporates robotic process automation (RPA) to automate tasks such as accessing EMRs, extracting data, redacting personal identifying information, and transmitting data to centralized servers. The overall goal of this system is to streamline the data capture and verification process in clinical trials, ultimately reducing errors and improving accuracy. [Extracted from the article]

Thermo Fisher Scientific has filed a trademark application for "QUALTRAK" for laboratory reagents, oligonucleotides, primers and probes, enzymes and enzyme mixes, nucleotide sets and nucleotide mixes, fluorescent dye, reaction buffers, and sample detection labels. These products are intended for scientific, research, or biopharmaceutical research use, specifically for nucleic acid genotyping, quantification, and amplification. The application was made by Kenya Williams and is currently pending. Thermo Fisher Scientific is a medical device company based in Carlsbad, CA. [Extracted from the article]

A research paper titled "Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma" explores the role of senescence in the tumor microenvironment and its impact on cancer prognosis and response to immunotherapy. The researchers identified two subtypes of head and neck squamous cell carcinoma based on the expression of senescence-related tumor microenvironment genes. They constructed a risk model consisting of senescence-related tumor microenvironment core genes and found that the high-risk group had poorer prognosis and reduced responsiveness to immunotherapy. This study contributes to a deeper understanding of the complex interplay between senescence and the tumor microenvironment, with potential implications for personalized treatment approaches in head and neck squamous cell carcinoma. [Extracted from the article]

A report from Lugano, Switzerland discusses research on thyroid nodules. The researchers aim to review different diagnostic tools available in clinical thyroidology and propose their integration. The paper discusses the pros and cons of various diagnostic methods, including ultrasound, scintigraphy, fine-needle aspiration cytology, molecular imaging, and artificial intelligence. The research concludes that molecular imaging and artificial intelligence can help spare patients from unnecessary surgeries, and further investigation is needed to determine the clinical value of AI in evaluating thyroid nodules. [Extracted from the article]

A report from Cairo University discusses the impact of public health expenditure on household poverty in Egypt. The research highlights that insufficient and inefficient spending on health services creates barriers for poor individuals and informal sector workers, leading to out-of-pocket payments for healthcare. The study focuses on the coverage of Reproductive, Maternal, and Child Health (RMNCH) services from 2005 to 2015 and evaluates the poverty impact of these payments. The findings reveal that OOP payments pushed around 30% of Egyptian households into poverty during the study period. [Extracted from the article]

A research paper titled "Effects of resveratrol on in vitro circadian clock gene expression in young and older human adipose-derived progenitor cells" was published in the journal Aging. The study aimed to investigate the association between age and the function of cell-autonomous circadian clocks in human tissue. The researchers cultured adipose progenitor cells from young and older female participants and compared the rhythmic gene expression profiles of core clock components. They found that some components showed increased levels in older cells, and resveratrol had effects on the rhythmicity of certain clock genes. The study suggests that resveratrol may have potential as a therapeutic agent for longevity by targeting the core clock. [Extracted from the article]

A case report published in Oncoscience discusses the use of pazopanib, a multi-kinase VEGF inhibitor, in the treatment of EWSR1-NFATC2 translocation-associated bone sarcoma. The report highlights the case of a patient who achieved exceptional tumor control for over 5 years with the use of pazopanib and surgery. While the report provides evidence of the activity of pazopanib in this type of sarcoma, further pre-clinical and clinical studies are needed to fully understand its effectiveness. The full paper can be accessed for more information. [Extracted from the article]