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Coal mining in the Loess Plateau can very easily generate ground cracks, and these cracks can immediately result in ventilation trouble under the mine shaft, runoff disturbance, and vegetation destruction. Advanced UAV (Unmanned Aerial Vehicle) high-resolution mapping and DL (Deep Learning) are introduced as the key methods to quickly delineate coal mining ground surface cracks for disaster prevention. Firstly, the dataset named the Ground Cracks of Coal Mining Area Unmanned Aerial Vehicle (GCCMA-UAV) is built, with a ground resolution of 3 cm, which is suitable to make a 1:500 thematic map of the ground crack. This GCCMA-UAV dataset includes 6280 images of ground cracks, and the size of the imagery is 256 × 256 pixels. Secondly, the DRA-UNet model is built effectively for coal mining ground surface crack delineation. This DRA-UNet model is an improved UNet DL model, which mainly includes the DAM (Dual Dttention Dechanism) module, the RN (residual network) module, and the ASPP (Atrous Spatial Pyramid Pooling) module. The DRA-UNet model shows the highest recall rate of 77.29% when the DRA-UNet was compared with other similar DL models, such as DeepLabV3+, SegNet, PSPNet, and so on. DRA-UNet also has other relatively reliable indicators; the precision rate is 84.92% and the F1 score is 78.87%. Finally, DRA-UNet is applied to delineate cracks on a DOM (Digital Orthophoto Map) of 3 km2 in the mining workface area, with a ground resolution of 3 cm. There were 4903 cracks that were delineated from the DOM in the Huojitu Coal Mine Shaft. This DRA-UNet model effectively improves the efficiency of crack delineation. [ABSTRACT FROM AUTHOR]

In this paper, berberine hydrochloride-loaded liposomes-in-gel were designed and developed to investigate their antioxidant properties and therapeutic effects on the eczema model of the mouse. Berberine hydrochloride-liposomes (BBH-L) as the nanoparticles were prepared by the thin-film hydration method and then dispersed BBH-L evenly in the gel matrix to prepare the berberine hydrochloride liposomes-gel (BBH-L-Gel) by the natural swelling method. Their antioxidant capacity was investigated by the free radical scavenging ability on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and H2O2 and the inhibition of lipid peroxides malondialdehyde (MDA). An eczema model was established, and the efficacy of the eczema treatment was preliminarily evaluated using ear swelling, the spleen index, and pathological sections as indicators. The results indicate that the entrapment efficiency of BBH-L prepared by the thin-film hydration method was 78.56% ± 0.7%, with a particle size of 155.4 ± 9.3 nm. For BBH-L-Gel, the viscosity and pH were 18.16 ± 6.34 m Pas and 7.32 ± 0.08, respectively. The cumulative release in the unit area of the in vitro transdermal study was 85.01 ± 4.53 μg/cm2. BBH-L-Gel had a good scavenging capacity on DPPH and H2O2, and it could effectively inhibit the production of hepatic lipid peroxides MDA in the concentration range of 0.4–2.0 mg/mL. The topical application of BBH-L-Gel could effectively alleviate eczema symptoms and reduce oxidative stress injury in mice. This study demonstrates that BBH-L-Gel has good skin permeability, excellent sustained release, and antioxidant capabilities. They can effectively alleviate the itching, inflammation, and allergic symptoms caused by eczema, providing a new strategy for clinical applications in eczema treatment. [ABSTRACT FROM AUTHOR]