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Cyprus with its rich cultural heritage has been the showcase of ornamentation throughout history with a rich variety of materials, details, and narratives. Integrating ornamentation with its body architecture can be seen as one of the storytellers of these narratives through design elements. After the mid-1990s when casinos had been banned in Turkey, five-star casino hotels became one of the main investment areas in North Cyprus. Together with this new building type and new users' expectations with a new understanding of holidays, the 21st century brought the changing use of ornamentation in hotel interiors and, hence, decoration came to the fore more than before. Hotel lobbies welcoming the users to their second homes and introducing the hotels' identities have always been seen as the most important area of hotels by investors, designers, and hotel managers. Sometimes the reception areas were perceived as the living room of the hotel customers where they feel attached culturally, socially, or economically, and sometimes it could be a place where they can feel themselves as one of the characters of ancient history, a king or a queen for a while. Hence, hotel interiors, in general, and hotel lobbies, in particular, acted as a cultural representative, a social status symbol, and a political image of the story told. The aim of this paper is to examine five-star hotel lobbies within the framework of ornamentation through a reading model created with the concepts used by theoreticians. Together with the site visits and visual recordings, the analysis conducted in this paper is based on qualitative data incorporated by a rich theoretical background on ornamentation. The paper tries to highlight the representational value of ornamentation that can help to understand and interpret the spatial transformation of hotel interiors. [ABSTRACT FROM AUTHOR]

During the Bronze Age, the inhabitants of regions of Crete, mainland Greece, and Cyprus inscribed their languages using, among other scripts, a writing system called Linear A. These symbols, mainly characterized by combinations of lines, have, since their discovery, remained a mystery. Not only is the corpus very small, but it is challenging to link Minoan, the language behind Linear A, to any known language. Most decipherment attempts involve using the phonetic values of Linear B, a grammatological offspring of Linear A, to 'read' Linear A. However, this yields meaningless words. Recently, novel approaches to deciphering the script have emerged which involve a computational component. In this paper, two such approaches are combined to account for the biases involved in provisionally assigning Linear B phonetic values to Linear A and to shed more light on the possible connections of Linear A with other scripts and languages from the region. Additionally, the limitations inherent in such approaches are discussed. Firstly, a feature-based similarity measure is used to compare Linear A with the Carian Alphabet and the Cypriot Syllabary. A few Linear A symbols are matched with symbols from the Carian Alphabet and the Cypriot Syllabary. Finally, using the derived phonetic values, Linear A is compared with Ancient Egyptian, Luwian, Hittite, Proto-Celtic, and Uralic using a consonantal approach. Some possible word matches are identified from each language. [ABSTRACT FROM AUTHOR]

Many studies have shown that COVID-19 caused many problems in mental health. This paper presents the results of the Cyprus sample, part of the global initiative named "The Collaborative Outcomes Study on Health and Functioning during Infection Times" (COH-FIT). Methods: The study took place from April 2019 to January 2022, using the Greek version of the online standard COH-FIT questionnaire on 917 Cypriot adults. Weighted t-tests were applied to test the differences between pre-pandemic and intra-pandemic scores using the anesrake package. Results: Participant responses indicated a significant negative impact of the pandemic on measures of mental health (−7.55; 95% CI: −9.01 to −6.07), with worsening in the scores for anxiety (12.05; 95% CI: 9.33 to 14.77), well-being (−11.06; 95% CI: −12.69 to −9.45) and depression (4.60; 95% CI: 2.06 to 7.14). Similar negative effects were observed for feelings of anger (12.92; 95% CI: 10.54 to 15.29), helplessness (9.66; 95% CI: 7.25 to 12.07), fear (22.25; 95% CI: 19.25 to 25.26), and loneliness (12.52; 95% CI: 9.94 to15.11). Increased use of social media (0.89; 95% CI: 0.71 to 1.09), internet (0.86; 95% CI: 0.67 to 1.04), and substance consumption (0.06; 95% CI: 0.00 to 0.11) were reported, along with a significant decrease in physical health (−3.45; 95% CI: −4.59 to −2.32), self-care (−7.10; 95% CI: −9.00 to −5.20), and social function (−11.27; 95% CI: −13.19 to −9.35), including support (−0.72; 95% CI: −1.09 to −0.34) and family function (−7.97; 95% CI: −9.90 to −6.05). Conclusions: The COVID-19 pandemic significantly affected the daily life and emotional well-being of Cypriots. Identifying factors that influence vulnerability and resilience is essential to prioritize mental health support and address the long-term effects of the pandemic. [ABSTRACT FROM AUTHOR]

Linear Fresnel reflectors are a versatile solar concentration technology, suitable for a wide range of industrial processes and thermal conditioning applications. Such collectors entail a certain footprint, generating shading on the surface where they are installed. This effect is rarely quantified but may play an indirect role on the surface below. When installed on a roof, the solar radiation heats the building less. In places where the annual heating demand is higher than the cooling demand, this constitutes an asset. However, this becomes a disadvantage when the cooling demand is higher annually than the heating demand. Essentially, the reduced solar radiation allows for the growth of plants that would not grow without the shade provided by the collector. The present paper is a quantitative analysis of such shading based on the linear Fresnel reflector of the Cyprus Institute. The work was conducted using the Tonatiuh++ ray-tracing software to determine the annual radiation blocking. A total of four years of actual meteorological measurements were applied directly to the ray-tracing model. [ABSTRACT FROM AUTHOR]

The rational management of water, which is determined by the Framework Directive 2000/60/EC of the EU, is a contractual obligation of the Agricultural Sector of Cyprus, both towards the European Union and the next generations of Cypriot citizens. To make decisions about sustainable water use and improve water use, it is necessary to understand the water use of crops in different water-use areas. Especially in large water projects in Cyprus, there must be a good way to determine the water use of crops so that the correct use of crops can be ensured, thus eliminating problems such as a lack of new information about the crop area and agricultural evaporation, Demand, and water. In most projects, water is managed and supplied based on historical data, and current information is available to determine water demand and availability for large areas. This paper also adds, apart from the clear positive effect of remote sensing and new technologies in crop irrigation, to the emerging need for advisory services for the diffusion of innovation to Cypriot farmers since the estimation of crop water requirements is part of estimating the carbon footprint under the project CARBONICA (EU Funded) for carbon farming. [ABSTRACT FROM AUTHOR]

Cross-industry clusters are essential for the economic prosperity of a region. However, studies do not address competitive clusters among the airline and tourism industries. Thus, this paper considers the case of both industries in terms of the clusters and synergies formed. This research aim is to provide an understanding of both industries' protagonists' involvement in contributing to insights into the establishment of synergies or clusters among the two industries. Cyprus is highly dependent on tourism and airlines because they facilitate connectivity. The research comprises semi-structured interviews with the leading players and organizations of the airline and tourism industries (government bodies, airports, airlines, tour operators and hotels). The results indicate that in a small geographical context, the notion of clusters involves a synergetic relationship among tourism stakeholders. The airlines' role is essential and affects all stakeholders involved in tourism. Additionally, the research provides new insights into the role of Destination Management Organisations (DMOs) in providing applicable tourism policies that can positively impact effective cooperation among industry partners. [ABSTRACT FROM AUTHOR]

The human immunodeficiency virus type 1 (HIV-1) epidemic has been a major public health threat on a global scale since the early 1980s. Despite the introduction of combination antiretroviral therapy (cART), the incidence of new HIV-1 infections continues to rise in some regions around the world. Thus, with the continuous transmission of HIV-1 and the lack of a cure, it is imperative for molecular epidemiological studies to be performed, to monitor the infection and ultimately be able to control the spread of this virus. This work provides a comprehensive molecular epidemiological analysis of the HIV-1 infection in Cyprus, through examining 305 HIV-1 sequences collected between 9 March 2017 and 14 October 2021. Employing advanced statistical and bioinformatic techniques, the research delved deeply into understanding the transmission dynamics of the HIV-1 epidemic in Cyprus, as well as the monitoring of HIV-1's genetic diversity and the surveillance of transmitted drug resistance. The characterization of Cyprus's HIV-1 epidemic revealed a diverse landscape, comprising 21 HIV-1 group M pure subtypes and circulating recombinant forms (CRFs), alongside numerous uncharacterized recombinant strains. Subtypes A1 and B emerged as the most prevalent strains, followed by CRF02_AG. The findings of this study also revealed high levels of transmitted drug resistance (TDR) patterns, raising concerns for the efficacy of cART. The demographic profiles of individuals involved in HIV-1 transmission underscored the disproportionate burden borne by young to middle-aged Cypriot males, particularly those in the MSM community, who reported contracting the virus in Cyprus. An assessment of the spatiotemporal evolutionary dynamics illustrated the global interconnectedness of HIV-1 transmission networks, implicating five continents in the dissemination of strains within Cyprus: Europe, Africa, Asia, North America, and Oceania. Overall, this study advances the comprehension of the HIV-1 epidemic in Cyprus and highlights the importance of understanding HIV-1's transmission dynamics through continuous surveillance efforts. Furthermore, this work emphasizes the critical role of state-of-the-art bioinformatics analyses in addressing the challenges posed by HIV-1 transmission globally, laying the groundwork for public health interventions aimed at curbing its spread and improving patient outcomes. [ABSTRACT FROM AUTHOR]

The alien Red Sea goatfish, Parupeneus forsskali (Fourmanoir & Guézé, 1976), is a Lessepsian migrant, entering the Mediterranean through the Suez Canal. This study explores its seasonal diet and biological traits in Cyprus, its non-native habitat. From August 2019 to July 2021, a total of 249 specimens were collected, ranging in total length (TL) from 5.8 to 27.7 cm, with a mean TL of 15.1 ± 4.54 cm (SD). These specimens were examined with respect to sex and season. Through various methods (F%, N%, W%, and IRI), the feeding habits of the species were analysed, revealing a diet dominated by Crustacea (mainly Decapoda) and Polychaeta, with the secondary consumption of Mollusca, Echinodermata, and others. Significant differences were found between males and juveniles and females and juveniles, with adults preferring Decapoda and juveniles Copepoda, while seasonal variations were mainly influenced by prey availability. The Red Sea goatfish exhibited ontogenetic niche shifts in its depth and habitat distribution, influenced by size and age. The trophic level (TROPH) of P. forsskali ranged from 3.22 to 3.46, corresponding to an omnivorous diet with a preference for animals. These findings suggest that P. forsskali is an opportunistic predator with a diverse diet, thriving in its new habitat and potentially impacting the local marine food webs by competing with economically important native species for resources. [ABSTRACT FROM AUTHOR]

Very little is known about the preservation and storage of fresh medicinal and aromatic plants (MAPs) and/or herbs. As with many leafy vegetables, i.e., lettuce, fresh spearmint is a very perishable product throughout the production line and requires special handling/processing. The current study aimed to examine the antibacterial activity of selected MAPs (Origanum dubium, Salvia fruticosa and Sideritis cypria) grown in Cyprus towards foodborne pathogens. Then, the most effective MAPs' essential oil (EO) and hydrosol (at different doses; combination of concentration and time of dipping submerge) were tested to preserve fresh spearmint quality and safety. The results showed that O. dubium EO and hydrosol presented great in vitro antibacterial activity against four foodborne pathogens and those products were further selected for application on fresh spearmint. During sensory evaluation, it was observed that higher O. dubium EO concentrations and longer time of application resulted into a less marketable product (less acceptable with less spearmint-like aroma), while hydrosol resulted in a more marketable product even at high doses. In general, EO and hydrosol applications increased spearmint's antioxidants (including polyphenols, flavonoids, and ascorbic acid), resulting in a product of increased nutritional value. The bacterial populations of Salmonella enterica and Listeria monocytogenes inoculated on fresh spearmint were decreased with the EO and hydrosol application doses applied, and their effects were evident even after six days of storage at 4 °C. From the findings of this study, it can be concluded that O. dubium EO and hydrosol could be a potential sanitation method for fresh spearmint preservation. [ABSTRACT FROM AUTHOR]

In this article, we explore the ways language has been used in Cyprus during different historical periods as a means of a dividing power, with the use of Cypriot dialects as a form of resistance and reunification of the island. We situate these translanguaging themes within a context of affective biopolitics that impacts Cypriot generations in shaping their everyday life through borderscapes and nationalisms. More specifically, we first examine how the official languages of the island (Greek and Turkish) have been used in the dominant public sphere(s) of Cyprus to marginalise Cypriot dialects, which, in turn, have been used as an oral means of communication, but also to impose symbolic signifiers of the biopolitics of borders and nationalisms in dividing communities. Secondly, we explore ways in which Cypriot dialects have been used as forms of linguistic resistance to nationalism, offering an alternative collective identity for generations of both communities, even during periods when nationalism was dominant in both communities. The translanguaging exploration centres on a close discourse analysis of one particular radio programme—the 'Cypriot radio sketch'—that has been very popular among Cypriots since the appearance of radio in Cyprus in 1953. Finally, we analytically and discursively contextualise attempts of revival of the Cypriot dialects by younger generations as communicative forms of resistance to powers of partition, as well as translanguaging pathways to actualise their desire for the reunification of the island. We eclectically draw on a multi-method approach to combine datasets from interviews, media and social media while combining critical discourse analysis to theorise the affordances, borderscapes and affective biopolitics of generational language use within geographies of nationalism and resistance in the borderscapes of a divided Cyprus. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate alternative methods to control longhorn beetle (Oberea linearis) infestations in walnut orchards. Wild isolates of entomopathogenic fungi obtained from soil samples from Greece and Cyprus were tested for their efficacy against adults and larvae of O. linearis. Insect populations were acquired from a heavily infested walnut orchard and individuals were placed in Petri dishes provided with ground walnut wood for larvae and fresh leaves for adults. The tested insects were subjected to 16 different wild isolates from the genera Beauveria, Cordyceps, Metarhizium, and Purpureocillium, where 108 conidia/mL were applied by spraying, and insects were monitored daily for 16 days. The results showed that all the tested fungi resulted in a mortality rate of 66–100%, with Cordyceps fumosorosea exhibiting the highest virulence, causing complete mortality to both larvae and adults. These findings suggest that the management of O. linearis, which has traditionally relied on chemical applications, could transition to an organic approach by utilizing entomopathogenic fungi. [ABSTRACT FROM AUTHOR]

The article addresses the new normal for female researchers in the post-pandemic era by utilising information collected from the pandemic period, when disruption to 'business as usual' occurred. This information can inform a new normal that is as efficient, resilient, and ethical as possible. The research employs a case study methodology, with qualitative data collection and analysis approaches. To understand the circumstances faced by researchers in Cyprus during the pandemic, it was necessary to approach several scientists from different research areas and try to understand their experiences through conversations. The set of notes compiled from the completion of the informal conversations were analysed using thematic analysis. Three themes were identified: (a) misperceptions of flexibility in researchers' schedules and workload, (b) lack of flexibility in adjusting expected outcomes or timelines, and (c) inability to compartmentalise personal and professional life. To better contextualise these findings, the study additionally explored survey results published by the European Commission on relevant topics, enabling a critical juxtaposition of the European perspective to the Cyprus-based findings of these pandemic-induced challenges. The study highlights significant misconceptions and overlooked dynamics regarding research conducted in times of crisis and offers avenues for ensuring research quality in analogous future scenarios. [ABSTRACT FROM AUTHOR]

In this study, we present comprehensive climatologies of effective ultraviolet (UV) quantities and photosynthetically active radiation (PAR) over Cyprus for the period 2004 to 2023, leveraging the synergy of earth observation (EO) data and radiative transfer model simulations. The EO dataset, encompassing satellite and reanalysis data for aerosols, total ozone column, and water vapor, alongside cloud modification factors, captures the nuanced dynamics of Cyprus's atmospheric conditions. With a temporal resolution of 15 min and a spatial of 0.05° × 0.05°, these climatologies undergo rigorous validation against established satellite datasets and are further evaluated through comparisons with ground-based global horizontal irradiance measurements provided by the Meteorological Office of Cyprus. This dual-method validation approach not only underscores the models' accuracy but also highlights its proficiency in capturing intra-daily cloud coverage variations. Our analysis extends to investigating the long-term trends of these solar radiation quantities, examining their interplay with changes in cloud attenuation, aerosol optical depth (AOD), and total ozone column (TOC). Significant decreasing trends in the noon ultraviolet index (UVI), ranging from −2 to −4% per decade, have been found in autumn, especially marked in the island's northeastern part, mainly originating from the (significant) positive trends in TOC. The significant decreasing trends in TOC, of −2 to −3% per decade, which were found in spring, do not result in correspondingly significant positive trends in the noon UVI since variations in cloudiness and aerosols also have a strong impact on the UVI in this season. The seasonal trends in the day light integral (DLI) were generally not significant. These insights provide a valuable foundation for further studies aimed at developing public health strategies and enhancing agricultural productivity, highlighting the critical importance of accurate and high-resolution climatological data. [ABSTRACT FROM AUTHOR]

The Cyprus Continuously Operating Natural Hazards Monitoring and Prevention System, abbreviated CyCLOPS, is a national strategic research infrastructure devoted to systematically studying geohazards in Cyprus and the Eastern Mediterranean, Middle East, and North Africa (EMMENA) region. Amongst others, CyCLOPS comprises six permanent sites, each housing a Tier-1 GNSS reference station co-located with two calibration-grade corner reflectors (CRs). The latter are strategically positioned to account for both the ascending and descending tracks of SAR satellite missions, including the ESA's Sentinel-1. As of June 2021, CyCLOPS has reached full operational capacity and plays a crucial role in monitoring the geodynamic regime within the southeastern Mediterranean area. Additionally, it actively tracks landslides occurring in the western part of Cyprus. Although CyCLOPS primarily concentrates on geohazard monitoring, its infrastructure is also configured to facilitate the radiometric calibration and geometric validation of Synthetic Aperture Radar (SAR) imagery. Consequently, this study evaluates the performance of Sentinel-1A SAR by exploiting the CyCLOPS network to determine key parameters including spatial resolution, sidelobe levels, Radar Cross-Section (RCS), Signal-to-Clutter Ratio (SCR), phase stability, and localization accuracy, through Point Target Analysis (PTA). The findings reveal the effectiveness of the CyCLOPS infrastructure to maintain high-quality radiometric parameters in SAR imagery, with consistent spatial resolution, controlled sidelobe levels, and reliable RCS and SCR values that closely adhere to theoretical expectations. With over two years of operational data, these findings enhance the understanding of Sentinel-1 SAR product quality and affirm CyCLOPS infrastructure's reliability. [ABSTRACT FROM AUTHOR]

Addressing the urgent sustainability challenges in the wine industry, this study explores the efficacy of sustainability-oriented innovations (SOIs) and smart farming technologies (SFTs) across wine value chains in Cyprus and Italy. Utilising a mixed-methods approach that includes quantitative analysis through Key Performance Indicators (KPIs) and qualitative assessments to understand stakeholders' perspectives, this research delves into the environmental, economic, and social impacts of these technologies. In Cyprus, the integration of digital labelling and smart farming solutions led to a substantial reduction in pesticide usage by up to 75% and enhanced the perceived quality of wine by an average of 8%. A pilot study in Italy witnessed a 33.4% decrease in greenhouse gas emissions, with the additional benefit of a 5.3% improvement in intrinsic product quality. The pilot introduced a carbon credit system, potentially generating an average annual revenue of EUR 4140 per farm. These findings highlight the transformative potential of SOIs and SFTs in promoting sustainable practices within the wine industry, demonstrating significant advancements in reducing environmental impact, improving product quality, and enhancing economic viability. This study underscores the critical role of innovative technologies in achieving sustainability goals and provides a compelling case for their wider adoption within the agricultural sector. [ABSTRACT FROM AUTHOR]

Energy Performance Certification (EPC) systems are pivotal in addressing the global energy challenge, particularly in the building sector. This study evaluates the efficacy of the EPC offered by the Simplified Building Energy Model interface designed to indicate compliance with the Cypriot building regulations, widely known as iSBEM-Cy Version 3.4a, by examining a typical residential unit in Cyprus. Data on construction features and electromechanical systems were collected, and actual monthly electricity and oil bills were analyzed to determine the total primary energy consumption. Various factors were considered, including energy efficiency and operational parameters for heating, cooling, lighting, auxiliary systems, and domestic hot water. The building energy performance was simulated using iSBEM-Cy, allowing for comparison with real-world energy consumption. Notable discrepancies were observed, particularly in cooling, with deviations reaching 377.4%. Conversely, domestic hot water consumption exhibited minimal variance at 7%, while heating and lighting showed moderate discrepancies (24.3% and −113.9%, respectively). This study underscores the need for rigorous evaluations to shape effective EPC and provides insights into building energy performance in Mediterranean Cyprus. This research contributes to the broader discourse on sustainable construction practices by aligning simulation results with real-world energy consumption. [ABSTRACT FROM AUTHOR]

Inherited cardiomyopathies represent a highly heterogeneous group of cardiac diseases. DNA variants in genes expressed in cardiomyocytes cause a diverse spectrum of cardiomyopathies, ultimately leading to heart failure, arrythmias, and sudden cardiac death. We applied massive parallel DNA sequencing using a 72-gene panel for studying inherited cardiomyopathies. We report on variants in 25 families, where pathogenicity was predicted by different computational approaches, databases, and an in-house filtering analysis. All variants were validated using Sanger sequencing. Familial segregation was tested when possible. We identified 41 different variants in 26 genes. Analytically, we identified fifteen variants previously reported in the Human Gene Mutation Database: twelve mentioned as disease-causing mutations (DM) and three as probable disease-causing mutations (DM?). Additionally, we identified 26 novel variants. We classified the forty-one variants as follows: twenty-eight (68.3%) as variants of uncertain significance, eight (19.5%) as likely pathogenic, and five (12.2%) as pathogenic. We genetically characterized families with a cardiac phenotype. The genetic heterogeneity and the multiplicity of candidate variants are making a definite molecular diagnosis challenging, especially when there is a suspicion of incomplete penetrance or digenic-oligogenic inheritance. This is the first systematic study of inherited cardiac conditions in Cyprus, enabling us to develop a genetic baseline and precision cardiology. [ABSTRACT FROM AUTHOR]

The enshrinement of religious freedom in a State Constitution is determined by the system of relations between the State and Religions. A particular aspect of religious freedom is freedom of worship, which was reframed due to the COVID-19 pandemic with the adoption of measures for the protection of public health. The examples of Cyprus and Greece demonstrate that the self-regulation enjoyed by religious communities may be harmonized with the need to protect public health and is directly connected to the existing system of relations between the State and Religions. The case law on the State restrictive measures regarding worship in conjunction with the measures implemented by the religious communities themselves together give rise to the general principles of harmonization between religious freedom and the protection of public health, with respect for the principle of proportionality. [ABSTRACT FROM AUTHOR]

The +33 C>G variant [NM_000518.5(HBB):c.-18C>G] in the 5′ untranslated region (UTR) of the β-globin gene is described in the literature as both mild and silent, while it causes a phenotype of thalassemia intermedia in the presence of a severe β-thalassemia allele. Despite its potential clinical significance, the determination of its pathogenicity according to established standards requires a greater number of published cases and co-segregation evidence than what is currently available. The present study provides an extensive phenotypic characterization of +33 C>G using 26 heterozygous and 11 compound heterozygous novel cases detected in Cyprus and employs computational predictors (CADD, RegulomeDB) to better understand its impact on clinical severity. Genotype identification of globin gene variants, including α- and δ-thalassemia determinants, and rs7482144 (XmnI) was carried out using Sanger sequencing, gap-PCR, and restriction enzyme digestion methods. The heterozygous state of +33 C>G had a silent phenotype without apparent microcytosis or hypochromia, while compound heterozygosity with a β+ or β0 allele had a spectrum of clinical phenotypes. Awareness of the +33 C>G is required across Mediterranean populations where β-thalassemia is frequent, particularly in Cyprus, with significant relevance in population screening and fetal diagnostic applications. [ABSTRACT FROM AUTHOR]

Glass is considered a sustainable material with achievable recovery rates within the EU. However, there are limited data available for construction glass waste management. Furthermore, glass is a heavy material, and considering the geographical limitations of Cyprus, the transportation trading cost within the EU is extremely high. Therefore, another method for utilizing this by-product should be developed. The aim of this research is to investigate the production of a low-cost, lightweight and fireproof material able to retain its structural integrity, using the geopolymerization method with the incorporation of randomly collected construction glass waste. The glass waste was initially processed in a Los Angeles abrasion machine and then through a Micro-Deval apparatus in order to be converted to a fine powder. Mechanical (compressive and flexural strength), physical (setting time and water absorption) and thermal properties (thermal conductivity) were investigated. The fire-resistant materials presented densities averaging 450 kg/m3 with a range of compressive strengths of 0.5 to 3 MPa. Additionally, a techno-economic analysis was conducted to evaluate the viability of the adopted material. Based on the results, the final geopolymer product has the potential to be utilized as a fire resistance material, preventing yielding or spalling. [ABSTRACT FROM AUTHOR]

Molecular investigations of the HIV-1 pol region (2253–5250 in the HXB2 genome) were conducted on sequences obtained from 331 individuals infected with HIV-1 in Cyprus between 2017 and 2021. This study unveiled four distinct HIV-1 putative transmission clusters, encompassing 19 previously unidentified HIV-1 recombinants. These recombinants, each comprising eight, three, four, and four sequences, respectively, did not align with previously established Circulating Recombinant Forms (CRFs). To characterize these novel HIV-1 recombinants, near-full-length genome sequences were successfully obtained for 16 of the 19 recombinants (790–8795 in the HXB2 genome) using an in-house-developed RT-PCR assay. Phylogenetic analyses, employing MEGAX and Cluster-Picker, along with confirmatory neighbor-joining tree analyses of subregions, were conducted to identify distinct clusters and determine subtypes. The uniqueness of the HIV-1 recombinants was evident in their exclusive clustering within generated maximum likelihood trees. Recombination analyses highlighted the distinct chimeric nature of these recombinants, with consistent mosaic patterns observed across all sequences within each of the four putative transmission clusters. Conclusive genetic characterization identified four novel HIV-1 CRFs: CRF129_56G, CRF130_A1B, CRF131_A1B, and CRF138_cpx. CRF129_56G exhibited two recombination breakpoints and three fragments of subtypes CRF56_cpx and G. Both CRF130_A1B and CRF131_A1B featured seven recombination breakpoints and eight fragments of subtypes A1 and B. CRF138_cpx displayed five recombination breakpoints and six fragments of subtypes CRF22_01A1 and F2, along with an unclassified fragment. Additional BLAST analyses identified a Unique Recombinant Form (URF) of CRF138_cpx with three additional recombination sites, involving subtype F2, a fragment of unknown subtype origin, and CRF138_cpx. Post-identification, all putative transmission clusters remained active, with CRF130_A1B, CRF131_A1B, and CRF138_cpx clusters exhibiting further growth. Furthermore, international connections were identified through BLAST analyses, linking one sequence from the USA to the CRF130_A1B strain, and three sequences from Belgium and Cameroon to the CRF138_cpx strain. This study contributes valuable insights into the dynamic landscape of HIV-1 diversity and transmission patterns, emphasizing the need for ongoing molecular surveillance and global collaboration in tracking emerging viral variants. [ABSTRACT FROM AUTHOR]

Global Earth observation is becoming increasingly important in understanding and addressing critical aspects of life on our planet, including environmental issues, natural disasters, sustainable development, and others. Finding similarities in landscapes may provide useful information regarding applying contiguous policies, by making similar decisions or learning from best practices for events and occurrences that previously occurred in similar landscapes in the past. However, current applications of similar landscape retrieval are limited by a moderate performance and the need for time-consuming and costly annotations. We propose splitting the similar landscape retrieval task into a set of smaller tasks that aim to identify individual concepts inherent to satellite images. Our approach relies on several models trained using unsupervised representation learning on Google Earth images to identify these concepts. We show the efficacy of matching individual concepts for retrieving landscape(s) similar to a user-selected satellite image of the geographical territory of the Republic of Cyprus. Our results demonstrate the benefits of breaking up the landscape similarity task into individual concepts closely related to remote sensing, instead of applying a single model targeting all underlying concepts. [ABSTRACT FROM AUTHOR]

Simple Summary: Plant extracts and essential oils have been used for medicinal purposes since ancient times. Medicinal and aromatic plants (MAPs) are composed of various phytochemical and nutritive compounds with strong biological properties, including antioxidant, antimicrobial, and cytotoxic effects. These activities are often related to the synergistic effects of compounds other than the predominant molecule. Exploitation of endemic species such as Sideritis cypria may give a boost to the MAP sector, with high pharmacological interest in green medicine production using natural components. Medicinal and aromatic plants' properties, still an interesting research area, are attributed to the presence of various specialized products that possess important pharmacological activities. In the present study, six medicinal/aromatic plants (Sideritis cypria, Origanum dubium, Melissa officinalis, Mentha piperita, Thymus capitatus, and Salvia fruticosa) were evaluated for their phytochemical and nutritive composition, as well as their biological activities, including antioxidant, antimicrobial, and cytotoxic properties. The results obtained indicate that M. piperita was rich in proteins and minerals such as N and Mg, while S. cypria accumulated more K, Na, P, and Ca. The highest content of phenols and flavonoids was observed in M. piperita, followed by O. dubium and T. capitatus, which eventually influenced their high antioxidant capacity. NMR screening revealed the presence of (i) triterpenoids and hydroxycinnamic acid derivatives in M. officinalis; (ii) terpenoids, flavonoids, and phenolic acid derivatives in S. fruticosa; (iii) flavonoids and phenolic acid derivatives in M. piperita; (iv) phenolic monoterpenes in O. dubium and T. capitatus; and (v) terpenoids, flavones, and phenylethanoid glycosides in S. cypria. The results of the antimicrobial activity showed that the tested samples overall had quite good antimicrobial potential. High antibacterial activity was found in O. dubium and T. capitatus, while O. dubium and S. cypria exhibited great antifungal activities. The studied species also had an important effect on the viability of female-derived and colon cancer cells. In particular, in colon cancer cells, the extracts from T. capitatus, M. officinalis, M. piperita, and S. fruticosa exhibited a stronger effect on cell viability in the more metastatic cell line at significantly lower concentrations, indicating an important therapeutic potential in targeting highly metastatic tumors. This finding is worth further investigation. The present study unveiled interesting phytochemical profiles and biological properties of the six medicinal/aromatic plants, which should be further explored, contributing to green chemistry and the possible creation of natural health products for humans' health/nutrition and additives in cosmetics. [ABSTRACT FROM AUTHOR]