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Objective: The aim of this study was to investigate the relationship between pancreatin-derived medications and the treatability of gastrointestinal complaints after cholecystectomy. Patients and Methods: The relationship between postoperative symptomatic status and the use of proton pump inhibitors (PPIs) and pancreatin-derivated medications in patients admitted to our hepatobiliary surgery service who underwent cholecystectomy was retrospectively analyzed. IBM SPSS Statistics 23 (IBM SPSS,Turkey) was used for statistical analysis. Descriptive statistical methods (mean, standard deviation, median, frequency, ratio, minimum, maximum) were used to evaluate the study data. Pearson Chi-Square Test and Fisher's Exact test were used to compare qualitative data. Significance was evaluated at the p<0.05 level. Results: Proton pump inhibitors and pancreatin-derivatives were prescribed to all patients in the postoperative period. Although, the rate of postoperative asymptomatic course was higher in all patients, the rate of postoperative symptoms was found to be higher in patients who received PPI and pancreatin therapy (p=0.001, p=0.022; p<0.01). Conclusions: Although, the high rate of asymptomatic postoperative course in all patients indicates that cholecystectomy alone is curative, some symptoms may persist in the postoperative period and it was found to be more frequent in patients who used PPI and pancreatin-derived medications in the postoperative period. [ABSTRACT FROM AUTHOR]