1. Nivalones C[sbnd]F, four new meroterpenoids from Rhododendron nivale.
- Author
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Wang, Lan, Zeng, Xi, Yuan, Tao, and Yao, Houzong
- Subjects
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INFLAMMATION prevention , *NONIONIZING radiation , *NUCLEAR magnetic resonance spectroscopy , *NITRIC oxide , *TERPENES , *PLANT stems , *ULTRAVIOLET radiation , *PLANT extracts , *NEUROLOGICAL disorders , *MEDICINAL plants , *MOLECULAR structure , *SPECTRUM analysis , *ELECTROSPRAY ionization mass spectrometry , *LIPOPOLYSACCHARIDES , *LEAVES - Abstract
Four new meroterpenoids, namely nivalones C F (1 – 4), along with a known meroterpenoid, cannabiorcicyclolic acid (5), were isolated from the branches and leaves of Rhododendron nivale. The chemical structures of compounds 1 – 4 were elucidated through comprehensive spectroscopic analyses, including NMR, UV–Vis, IR, ECD spectroscopy, as well as HR-ESI-MS. The isolated compounds were evaluated for their anti-inflammatory and neuroprotective properties. The inhibitory activity of compound 5 against lipopolysaccharide (LPS)-induced nitric oxide (NO) production was initially demonstrated, showcasing an IC 50 value of 21.1 μM. Additionally, both compounds 2 and 5 displayed a notable effect on the viability of H 2 O 2 -damaged SH-SY5Y cells, indicating their significant neuroprotection effects. Four new meroterpenoids 1 – 4 (nivalones C F) and a known meroterpenoid 5 with good anti-inflammatory and neuroprotective effects were isolated from Rhododendron nivale. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
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