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Due to their open architecture, Internet of Things (IoT) devices have limited user access and are susceptible to various security vulnerabilities. When healthcare data is stored in the cloud, it often becomes vulnerable to side-channel attacks, Denial of Service (DoS) attacks, and eavesdropping. Consequently, there is a need for an efficient access control scheme to enhance the data-sharing processes of IoT devices. Different machine learning and rule-based decision support systems have been proposed to improve the security of cloud-based data storage. However, these models have exhibited increased false alarm rates, complex processing, and longer response times. To address this research gap, we propose a Fuzzy TOPSIS model based on Golden Search Optimization (GSO) to enhance the security of patient information at both IoT and cloud server levels. Additionally, we introduce a revolutionary Diagonal Kernel Convolution Neural Network with an adaptable kernel (DKCNN-AK) to enhance the accuracy of lung disease diagnosis. The GSO algorithm categorizes the security ranks determined by the fuzzy TOPSIS model into the best and worst security principles. We conducted simulations using the COVID-19 X-Ray detection dataset, the lung cancer dataset, and the data collected from IoT devices for analysis.The experiments were conducted to assess various aspects, including computational time, security level analysis, information leakage, privacy level, prediction accuracy, sensitivity, specificity, and confusion matrix. The improved prediction accuracy and security provided by our proposed approach demonstrate its efficiency • The IoT is now playing a vital role in the medical field's approach to providing people. • This paper presents DKCNN-AK architecture for disease prediction. • The DKCNN-AK architecture is used for both disease prediction and severity estimation. • The GSO optimized Fuzzy TOPSIS algorithm is used. [ABSTRACT FROM AUTHOR]