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To make recommendations on managing the surveillance of patients with stage I, II, III or resectable IV melanoma who are clinically free of disease following treatment with curative intent. This guideline was developed by Ontario Health's (Cancer Care Ontario's) Program in Evidence-Based Care and the Melanoma Disease Site Group (including seven medical oncologists, four surgical oncologists, three dermatologists, one radiation oncologist and one patient representative). The MEDLINE, EMBASE, Cochrane Library, PROSPERO databases and the main relevant guideline websites were searched. Internal and external reviews were conducted, with final approval by the Program in Evidence-Based Care and the Melanoma Disease Site Group. The Grading of Recommendations, Assessment, Development and Evaluation approach was followed, and the Modified Delphi method was used. Based on the current evidence (eight eligible original study papers and four relevant guidelines) and the clinical opinions of the authors of this guideline, the initial recommendations were made. To reach 75% agreement for each recommendation, the Melanoma Disease Site Group (16 members) voted twice and one recommendation was voted on three times. After a comprehensive internal and external review process (including national and international reviewers), 12 recommendations, three weak recommendations and six qualified statements were ultimately made. After a systematic review, a comprehensive internal and external review process and a consensus process, the current guideline has been created. The guideline authors believe that this guideline will help clinicians, patients and policymakers make well-informed healthcare decisions that will guide them in clinical melanoma surveillance and ultimately assist in improving patient outcomes. [ABSTRACT FROM AUTHOR]

This paper uses simple electricity market models to demonstrate the workings of, and problems with, Ontario's zonal price/two-schedule electricity market design. The roles played by zonal prices, Shadow LMP prices, and out-of-market congestion payments are explained. This market design is compared and contrasted to the much better-known single-schedule designs with LMP pricing used in neighboring U.S. markets. The ways in which congestion payments can, and have been, gamed is highlighted and shown to be special cases of counter-trading "inc-dec games". The bizarre outcomes for interjurisdictional trading arising from Ontario's use of congestion pricing on its interties combined with uniform pricing on the internal grid are demonstrated. Some gaming problems identified in other markets are reviewed compared to Ontario's situation. Finally, the paper recaps the system operator's efforts to remedy the various problems with the market while preparing a fundamental redesign. [ABSTRACT FROM AUTHOR]

• Lake processes are generally as sensitive to changes in wind speed as they are to changes in surface air temperature. • Changing climate resulted in a general increase in lake water temperature and the corresponding decrease in lake ice thickness and ice cover duration. • While lake water temperature is projected to increases at all depths, the shallow epilimnion layer is more sensitive to the changing climate than the deeper hypolimnion layer. • Projected climate resulted in seasonal changes in the biogeochemical cycling including projected change in the magnitude and timing of chlorophyll-a concentration over the depth of the lake. Regional climate plays an important role on in-lake physical and biogeochemical processes and determines the state of water quality and ecology of the lakes. This paper presents the result of a one-dimensional numerical modelling of lake ice cover, water temperature, as well as nutrient and phytoplankton dynamics in Lake 239 (Rawson Lake) located in the Experimental Lakes Area (ELA), Ontario, Canada. Using observed meteorological and inflow/outflow data, the Multi-year Lake simulation model (MyLake) was setup to replicate measured lake water temperature, ice-cover, dissolved organic carbon, particulate and dissolved phosphorus, and chlorophyll-a concentrations over the entire depth of the lake. The sensitivity of the lake to changes in climatic drivers, specifically to changes in surface air temperature and wind speed, was examined by incrementally changing the model input forcing for temperature and wind speed and mapping the resulting changes in the simulated outputs. The results show that lake processes are generally as sensitive to changes in wind speed as they are to changes in air temperature. Simulated changes in lake variables corresponding to projected changes in Global Climate Models (GCMs) under RCP4.5 and RCP8.5 emission scenarios reveal a general increase in lake water temperature and the corresponding decrease in lake ice thickness and ice cover duration under the changing climate. While lake water temperature increases at all depths, the shallow epilimnion layer is more sensitive to the changing climate than the deeper hypolimnion layer, reaching mean annual change value of +3.7 °C for RCP 8.5 and the 2090s as compared to the 1990s baseline period. While the simulated change in lake ice thickness reaches −20 cm by 2090s for the RCP 8.5 scenario, the corresponding change in ice-cover duration reaches -47 days. These changes are shown to result in seasonal changes in the biogeochemical cycling over the depth of the lake with projected increases in chlorophyll-a concentration during ice covered season of December to May reaching up to +0.15 mg/m3 for RCP 8.5 and the 2090s followed by a decrease during open water season of June to November reaching −0.15 mg/m3 compared to the 1990s baseline period. [ABSTRACT FROM AUTHOR]

This paper studies the challenges of designing and operating adiabatic compressed air energy storage (A-CAES) systems, identifies core causes for the reported discrepancies between round-trip efficiencies from current literature models versus experiments, and presents a near-adiabatic CAES (NA-CAES) system design that addresses these issues. The core causes are overly simplified heat management modeling, neglect of heat losses in the thermal energy reservoir, single-cycle modeling, replacing a diabatic CAES combustor with a TES without other major design changes, using a mirrored compression-expansion design, and/or efficiency definition limitations. To demonstrate an approach to designing an NA-CAES system that addresses the core causes of modeling vs. experiment efficiency discrepancies, a case study is presented for Ontario, Canada. This full system view approach yielded NA-CAES systems with maximum round-trip efficiencies of 60.5, 61.1, and 61.5% for a constant reservoir volume throttled system, a constant reservoir volume variable pressure system, and a constant pressure reservoir system, respectively. A sensitivity analysis was conducted to identify primary with a strong influence on efficiency (such as reservoir pressure limits and the expanders' pressure ratio), and secondary parameters that more strongly affect TES size (including TES charging and discharging mass flow rates, inlet temperatures to the expanders, and TES tank temperatures). Multi-objective hierarchical optimization was employed to improve efficiency while reducing TES capacity. In brief, the results reveal that through design configuration selection it should still be possible to achieve in practice high NA-CAES efficiencies in excess of 60%. • Core causes of efficiency disparities between models and experiments are identified. • A case study is presented to address the core causes of efficiency discrepancies. • Primary and secondary parameters affecting efficiency and TES size are determined. • A-CAES efficiency is enhanced through optimization techniques, considering TES capacity. • Possibility of achieving efficiencies above 60% through design selection is affirmed. [ABSTRACT FROM AUTHOR]

Increases in child welfare investigations involving children's exposure to intimate partner violence (IPV) in Ontario are likely the result of three factors: 1) changes to legislation, policy, and assessment instruments; 2) increased awareness of the risks of exposure to IPV for children, and 3) referrals from professionals (e.g., police). Using data from 6 cycles of the Ontario Incidence Study of Reported Child Abuse and Neglect (OIS) (1993, 1998, 2003, 2008, 2013, and 2018), this paper will examine the changes of the incidence rates of IPV exposure, providing important context for a type of investigation that is not well understood in Ontario. The incidence of investigations where the primary concern of the investigating worker is IPV was derived and compared across OIS cycles. Investigation were compared across cycles using incidence counts. After the nearly 2-fold increase of investigations for all maltreatment types in Ontario between 1998 and 2003, IPV investigations are the only type that continue to increase. There is a growing gap between these investigations and substantiating child maltreatment. Rates of placement have not changed over time, remaining low. Rates of transfers and referrals have increased but not significantly. The continued growth in the rate of child welfare investigations involving exposure to IPV as well as the overwhelming endorsement of substantiated exposure to IPV, while maintaining the same proportion of transfers to ongoing child welfare services and low placement rates, is a significant concern for Ontario. [ABSTRACT FROM AUTHOR]