Search

Objective: Non-cirrhotic porto-mesenteric vein thrombosis (NC-PMVT) is a rare but severe clinical condition. The study aims to assess the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) coupled with dual-access thrombolysis in patients with acute severe NC-PMVT., Methods: From January 2018 to February 2023, a total of 25 patients with acute severe NC-PMVT who were treated with TIPS in conjunction with mechanical thrombectomy and dual-access thrombolysis. The period of thrombolysis was determined by the improvement of clinical symptoms and vascular recanalization. The technical success, recanalization rate, clinical success, and procedure-related complications were analyzed., Results: The technical success rate was 100 %. The median duration for thrombolytic catheter removal was 5 (IQR 3.5 - 7) days. Full and partial recanalization were accomplished in 10 (40 %) and 15 (60 %) patients respectively before discharge. No significant procedure-related complications were reported. The clinical success rate was 88 %, with a mortality rate of 12 %. Over a median follow-up of 8 months, 3/22 (13.64 %) patients had a recurrence of thrombosis; 1/22 (4.54 %) patients underwent partial intestinal resection one and a half months post-discharge; the remaining patients did not experience any portal hypertensive complications., Conclusion: The combination of TIPS and dual-access thrombolysis appears to be safe and effective for patients with acute severe NC-PMVT., Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024. Published by Elsevier Ltd.)

The simultaneous balance of electrode materials and electrode structures can energize the development of innovative electrochemical sensors. In this work, a 3D nanocarbon layer of hybrid heteroatoms and metal atoms (CN/Fe) with excellent electrical properties and abundant active sites was self-constructed on the surface of a quartz-based nanofiber by high-temperature pyrolysis. Further, the nanofiber tip was selected as the sensing region to develop an electrochemical sensing platform with high sensitivity, miniaturization, and portability. A common broad-spectrum antibiotic (Doxycycline hyclate, DOX) was used as a model to evaluate the designed miniaturized sensing platform, and the stability, reproducibility, and applicability of the microsensor were verified in a variety of real samples, including algal solution, milk, human serum, and cell culture media. The results show that the proposed sensing platform has a detection limit as low as 82 nM in aqueous environments. Furthermore, it is further shown that coupling the design of electrode materials and electrode structures facilitates the development of electrochemical sensors with more practical applications. This concept will open up new avenues for the development of electrochemical sensors that meet many application scenarios., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)