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This book describes multiple effects of four stomach derived hormones (acylated and unacylated ghrelin, obestatin and nesfatin-1) collectively known as ghrelin family peptides (GFPs). The first part of the book focuses on known actions of GFPs under normal physiological conditions. Subsequent chapters describe the role of dysregulation in the production and action of these peptides in the complex network involved in numerous chronic diseases, musculoskeletal health, osteoporosis, falls and, consequently, osteoporotic fractures. The emerging data on the potential diagnostic and therapeutic benefits of GFPs in different disorders and implications on clinical practice is presented, and an extensive bibliography is provided.