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The persistence of dissolved organic matter (DOM) plays a crucial role in the cycling and distribution of carbon and nutrients. Nonetheless, our understanding of how environmental alterations affect the persistence of sedimentary DOM remains incomplete. Excitation Emission Fluorescence Matrix-Parallel Factor Analysis (EEM-PARAFAC) was used to examine the fluorescence and compositional characteristics of hydrophilic and hydrophobic DOM (separated using XAD-8 resin) within sediments from twelve lakes and reservoirs. Fluorescence analysis indicated that DOM persistence is dependent on the proportions of the three components derived from PARAFAC. The Mantel test showed that climatic factors had the most significant impact on DOM persistence (Mantel's r = 0.46–0.54, Mantel's p = 0.001–0.007), while anthropogenic (Mantel's r = 0.24–0.32, Mantel's p = 0.03–0.05) and hydrological factors (Mantel's r = 0.03–0.22, Mantel's p = 0.06–0.40) had a somewhat lesser influence. Environmental changes resulted in a consistent decline in DOM persistence from Northeast to Southwest China, accompanied by an increase in gross primary productivity (GPP). Reduced DOM persistence due to climate, hydrological, and anthropogenic factors may lead to elevated concentrations of total phosphorus (TP), contributing to deteriorating water quality and events such as algal blooms. The decline in water quality due to reduced DOM persistence in lakes with high GPP can exacerbate the transition from carbon sinks to carbon sources. Consequently, the persistence of sedimentary DOM significantly influences nutrient and carbon cycling in lakes. Investigating DOM persistence in lakes across diverse geographic locations offers a new perspective on lake eutrophication and carbon emissions. Furthermore, it is crucial to develop targeted recommendations for lake restoration and management. [Display omitted] • The ratio of terrestrial humic-like/(microbial humic-like + protein-like) quantifies the persistence of the DOM. • Climate change is the primary cause of decreased DOM persistence. • Decreased DOM persistence exacerbates lake eutrophication. • Decreased DOM persistence promotes a shift in the lake towards becoming a carbon source. [ABSTRACT FROM AUTHOR]

3D hand pose estimation and shape reconstruction is to recover the hand joint points and hand mesh vertices coordinates from the image. However, existing methods usually only use the high-level semantic features extracted by the backbone network to represent the hand mesh vertex features, which leads to a single representation of the hand vertices features and cannot fully utilize the feature information extracted by the network. In this paper, we propose a method for real-time 3D reconstruction of hands from a single RGB image, which enriches the 3D semantic information of the mesh vertices through multi-feature fusion. Firstly, we regress the 2D features of mesh vertices through Integral Pose Regression (IPR) and regard them as prior information to 3D features. Then we design a Multi-Scale Sampling(MSS) module to extract multi-scale information. Finally we fuse 2D prior features, multi-scale features, and high-level semantic features extracted by backbone to represent 3D initial feature. Additionally, we propose a Multi-Root(MR) loss function to address the imbalance problem caused by a single root joint. The experimental results indicate that our network achieves competitive performance on the FreiHAND and HO-3D public datasets, achieving fast inference speed with fewer parameters. • We propose a Multi-Scale Sampling (MSS) module to extract multi-scale information. • We proposed a Multi-Root (MR) loss function to alleviate the imbalance issue of joints. • Our network achieves good performance in terms of model efficiency and accuracy. [ABSTRACT FROM AUTHOR]

• AEP-TrkB axis is upregulated in chronic stress-induced depressive-like behaviors. • TrkB cleavage by AEP links neuroinflammation and impaired neurotrophic signaling, mitochondrial dysfunction in depression. • AEP cleaves TrkB and disrupts BDNF/TrkB-mediated AMPARs membrane insertion. • TrkB 1–486 produced by AEP-mediated cleavage binds and suppresses PPAR-δ, leading to mitochondrial dysfunction. Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB is modified and mediates behavioral responses to chronic stress remains largely unknown. Here the effects and mechanisms of TrkB cleavage by asparagine endopeptidase (AEP) were examined on a preclinical murine model of chronic restraint stress (CRS)-induced depression. CRS activated IL-1β-C/EBPβ-AEP pathway in mice hippocampus, accompanied by elevated TrkB 1–486 fragment generated by AEP. Specifi.c overexpression or suppression of AEP-TrkB axis in hippocampal CaMKIIα-positive cells aggravated or relieved depressive-like behaviors, respectively. Mechanistically, in addition to facilitating AMPARs internalization, TrkB 1–486 interacted with peroxisome proliferator-activated receptor-δ (PPAR-δ) and sequestered it in cytoplasm, repressing PPAR-δ-mediated transactivation and mitochondrial function. Moreover, co-administration of 7,8-dihydroxyflavone and a peptide disrupting the binding of TrkB 1–486 with PPAR-δ attenuated depression-like symptoms not only in CRS animals, but also in Alzheimer's disease and aged mice. These findings reveal a novel role for TrkB cleavage in promoting depressive-like phenotype. [ABSTRACT FROM AUTHOR]