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Your search keyword '"palmitoylethanolamide"' showing total 4 results
Start Over Descriptor "palmitoylethanolamide" Publication Year Range More than 50 years ago
4 results on '"palmitoylethanolamide"'

1. Lipid-Induced Changes of Pentobarbital Distribution and Metabolism

Author

J. Seifert, K. Mašek, I. Havlík, E. Buchar, and H. Obermajerová

Subjects
Male, Pentobarbital, Time Factors, Pharmacology, Mice, chemistry.chemical_compound, Naphthalenesulfonates, Amide, medicine, Animals, Distribution (pharmacology), Carbon Radioisotopes, Palmitoylethanolamide, Fatty Acids, Drug Synergism, General Medicine, Metabolism, Lipids, Spectrometry, Fluorescence, chemistry, Biochemistry, Microsomes, Liver, Sleep, medicine.drug
Abstract

The feeding of the naturally occurring lipid compound palmitoylethanol amide to mice for 12 days resulted in a marked prolongation of pentobarbital hypnosis. Analysis of 14C-pentobarbital l

Published
1973

2. Biochemical changes in mouse liver after palmitoylethanolamide (PEA) administration

Author

E. Buchar, H. Rašková, H. Obermajerová, and J. Seifert

Subjects
Male, Orotic acid, Phosphorylase Kinase, Mitochondria, Liver, Palmitic Acids, In Vitro Techniques, Biology, Toxicology, Ribosome, Uridine kinase, Mice, chemistry.chemical_compound, Ribonucleases, medicine, Animals, Ribonuclease, Uridine, Glucuronidase, Orotic Acid, chemistry.chemical_classification, Carbon Isotopes, Palmitoylethanolamide, Hydrolysis, Phosphorus Isotopes, RNA, DNA, General Medicine, Tryptophan Oxygenase, Amino acid, Liver, chemistry, Biochemistry, Ethanolamines, Microsomes, Liver, biology.protein, Microsome, Ribosomes, Thymidine, medicine.drug
Abstract

PEA (palmitoylethanolamide; N-(2-hydroxyethyl)palmitamide) daily and orally administered to male mice caused: (1) increased incorporation of labelled orotic acid into DNA and RNA, (2) an increase in the activity of uridine kinase and decrease of tryptophan pyrrolase, (3) decreased ribonuclease activity of isolated liver ribosomes, (4) raising of specific radioactivity after injection of labelled amino acids in both mitochondrial and microsomal fractions of liver homogenate, (5) increased incorporation of [14C]-palmitic acid and 32P into liver phospholipids.

Published
1973

3. Non-specific resistance induced by palmitoylethanolamide

Author

Karel Masek, O. Linèt, and H. Rašková

Subjects
Male, Time Factors, Shigella dysenteriae, Endogeny, Palmitic Acids, Pharmacology, Biology, Toxicology, medicine.disease_cause, Mice, chemistry.chemical_compound, Non specific, Corticosterone, Adrenal Glands, medicine, Animals, Mononuclear Phagocyte System, Toxins, Biological, Palmitoylethanolamide, Strain (chemistry), Toxin, Phosphorus Isotopes, Streptococcus, food and beverages, Adrenalectomy, biology.organism_classification, Shock, Septic, chemistry, Injections, Intravenous, Streptolysins, Immunology, Streptolysin
Abstract

The effectiveness of a naturally occurring lipid, palmitoylethanolamide (PEA) in enhancement of non-specific resistance was investigated in mice. The optimal oral dosage was 50 mg/kg, administered for 12 consecutive days. PEA treatment decreased markedly the mortality of animals injected either with Shigella dysenteriae toxin, Streptolysin O or with living A group Streptococcus strain. The clearance of P32 labelled streptococci from blood was more rapid in experimental animals. The mortality in PEA-pretreated mice caused by traumatic shock was also lower as compared with controls. The mechanism of PEA action was not due to endogenous corticosterone, but might be related to the activity of the RES system.

Published
1972

4. Structural and functional changes in liver mitochondria of mice fed palmitoylethanolamide (PEA)

Author

J. Seifert, Evžen Buchar, Hana Obermajerová, Karel Masek, and Ivan Havlík

Subjects
Male, Chromatography, Gas, Time Factors, Lipid composition, Staphylococcus, Mitochondria, Liver, Palmitic Acids, Biology, Mitochondrion, In Vitro Techniques, Biochemistry, Anilino Naphthalenesulfonates, Fluorescence, Phosphates, chemistry.chemical_compound, Mice, Staphylococcal toxin, medicine, Animals, Drug Interactions, Phospholipids, Toxins, Biological, Pharmacology, Palmitoylethanolamide, Membranes, Ethanol, Fatty Acids, food and beverages, Amides, Fluorescence ratio, Spectrometry, Fluorescence, chemistry, Ethanolamines, Fatty Acids, Unsaturated, lipids (amino acids, peptides, and proteins), Swelling, medicine.symptom, Mitochondrial Swelling
Abstract

Repeated administration of palmitoylethanolamide (PEA) to mice, at a dose of 50 mg/kg body wt, produced a characteristic change in lipid composition of liver mitochondria. The content of the saturated fatty acids, palmitic (16:0) and stearic (18:0), decreased in the fraction of neutral lipids while the content of the unsaturated acids, palmitoleic (16:1), and oleic (18:1) and of the higher saturated acid arachidonic (20:4) increased. In contrast the amount of palmitoleic (16:1) acid decreased and palmitic (16:0) acid increased in mitochondrial phospholipids. Concomitant with these changes in the lipid composition of mitochondria changes occurred in their biochemical properties. The swelling of liver mitochondria induced by orthophosphate and by crude staphylococcal toxin is delayed in PEA-treated mice. Structural changes in mitochondrial phospholipids were confirmed with the fluorescent hydrophobic probe. The mitochondria isolated from mice pretreated with PEA had a lower fluorescence ratio than mitochondria from control animals.

Published
1973

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