1. The relationship between osmolality and electrolytes in rat gastric juice following histamine and insulin hypoglycaemia
- Author
-
Y.H. Lee and Jeremy H. Thompson
- Subjects
Gastric Fistula ,Male ,Osmosis ,medicine.medical_specialty ,Injections, Subcutaneous ,medicine.medical_treatment ,Sodium ,chemistry.chemical_element ,Stimulation ,Electrolyte ,Chloride ,Osmolar Concentration ,chemistry.chemical_compound ,Chlorides ,Internal medicine ,medicine ,Animals ,Insulin ,Pharmacology ,Gastric Juice ,digestive, oral, and skin physiology ,Hydrogen-Ion Concentration ,Rats ,Endocrinology ,chemistry ,Histamine ,medicine.drug - Abstract
In chronic gastric fistula rats hourly gastric juice collections were made before and after subcutaneous injections of histamine and insulin. Linear relationships were obtained between gastric juice osmolality and H + and Cl − ion concentrations. These relationships were independent of the type of the stimulant used. The osmotic effects of the individual gastric juice electrolytes were calculated. The contribution of the non-electrolyte component was greater than 50% of the total gastric juice osmolality. Apart from the first hour after stimulation, close correlation existed between the Na + and H + ion concentrations. Close correlation was apparent between the H + ion concentration and that of total and neutral chloride at all time periods.
- Published
- 1968