Author: "Wise KJ" / Publication Year Range: More than 50 years ago - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Wise KJ" Publication Year Range More than 50 years ago

Author: Yeary RA, Wise KJ, and Davis DR
Subjects: Animals, Genotype, Male, Microsomes, Liver enzymology, Nitrophenols metabolism, Polyethylene Glycols pharmacology, Rats, Stimulation, Chemical, Bilirubin metabolism, Glucuronosyltransferase metabolism, Hexosyltransferases metabolism, Jaundice enzymology, Light
Published: 1975
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Author: Yeary RA and Wise KJ
Subjects: Animals, Bile Ducts physiology, Bilirubin pharmacology, Female, Genotype, Indocyanine Green pharmacology, Jaundice blood, Kinetics, Male, Phenobarbital pharmacology, Rats, Time Factors, Hyperbilirubinemia blood, Indocyanine Green blood, Sulfobromophthalein blood
Abstract: Unconjugated hyperbilirubinemia as occurs in Gunn rats did not affect the plasma disappearance of sulfobromophthalein (BSP) or indocyanine green (ICG). The simultaneous injection of bilirubin and ICG decreased the plasma disappearance of ICG apparently by decreasing hepatic uptake. The data suggest that although bilirubin, ICG and BSP bind to the intracellular hepatic transport protein ligandin one cannot achieve conditions in intact rats to demonstrate effects of competitive interaction with ligandin that affect plasma kinetics of these substances.
Published: 1975

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