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The excretion of estrogen and gonadotropin has been determined in 74 cases during pregnancy; 70 cases were studied during late pregnancy (thirty-five weeks) and 4 cases in early pregnancy. Of the 70 cases studied in late pregnancy, 57 cases were used for a statistical study of the relation of these hormones to the toxemias of pregnancy. Of these, 43 cases (11 normal, 14 hypertensive and renal disease, 13 pre-eclamptic, and 5 eclamptic patients) had parallel quantitative assays of both estrogens and gonadotropins and 14 estrogen only. The other 13 cases represented various other conditions complicating pregnancy.

A transplantable rat sarcoma arising in a colony of ovariectomized rats used for the assay of estrogens has been investigated. The tumor was transmitted by transfer of tissue fragments or by inoculation of a suspension of tissue. Bacteriologic examinations were negative and the tumor was not transmitted by filtrates of tumor tissue.

1.1. Control groups have been compiled to show (1) the effect of the number of the pregnancy upon the maternal weight changes during pregnancy and upon the weight of the newborn, (2) the effect of age and suckling upon the weight of the newborn, (3) the effect of the number per litter upon the mean weight of the newborn, and, (4) the effect of the method of breeding upon the mean weight of the newborn.2.2. Preparations of the growth hormone of the anterior lobe of the pituitary have been administered daily to pregnant rats for varying periods and in amounts which caused an average daily increase of 1 per cent in nonpregnant rats. Some preparations prolonged gestation, interfered with normal parturition and resulted in stillborn young as reported by other workers. Other preparations did not exhibit these effects. It has been concluded that the growth hormone itself is not responsible for these effects. The increases in the maternal weight changes during gestation were significant. The weight of the newborn young delivered at term was greater in the injected groups than in the control group. These differences, considered statistically, are significant.