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Your search keyword '"Susumu Ohshiro"' showing total 7 results
Start Over Author "Susumu Ohshiro" Publication Year Range More than 50 years ago
7 results on '"Susumu Ohshiro"'

1. Synthesis of DL-Menthol

Author

Kikuo Doi and Susumu Ohshiro

Subjects
Acetone, Pharmacology, Menthol, chemistry.chemical_compound, Chromatography, Gas, chemistry, Spectrum Analysis, Pharmaceutical Science, Organic chemistry, Ketones
Published
1968

2. Studies on the syntheses of hydrogenated quinolines and isoquinolines as analgesics—XVIII

Author

Susumu Ohshiro

Subjects
chemistry.chemical_compound, chemistry, Nitration, Organic Chemistry, Drug Discovery, Hydroxy group, Substituent, Organic chemistry, heterocyclic compounds, Biochemistry
Abstract

The introduction of a hydroxy group into N-methyl-8-aza-des-N-morphinan at the 3-position was achieved through nitration of the parent compound, followed by reduction and diazocization. The position of the substituent was determined by the spectral evidence from 3-methoxy-10-oxo-8-aza-des-N-morphinan which was derived from 3-hydroxy-8-aza-des-N-morphinan via the oxidation of 3-methoxy-derivative. A pharmacological study of the compound is also presented.

Published
1960

3. The Synthesis and Evaluation of the Local Anesthetic Activity of a Series of Aliphatic Amino Acid Anilides

Author

Masazumi Kawanishi, Michio Fujihara, T. Mizoguchi, Susumu Ohshiro, Yukio Sugihara, and Minoru Hirakura

Subjects
Pharmacology, chemistry.chemical_classification, Chemical Phenomena, Local anesthetic, medicine.drug_class, Stereochemistry, Pharmaceutical Science, Amino acid, Models, Structural, Chemistry, chemistry, medicine, Organic chemistry, Anilides, Anesthetics, Local
Published
1969

5. Studies on the syntheses of hydrogenated quinolines and isoquinolines as analgesics—XVII

Author

Susumu Ohshiro

Subjects
Steric effects, Morphinan, chemistry.chemical_compound, Stereochemistry, Chemistry, Potassium, Organic Chemistry, Drug Discovery, chemistry.chemical_element, Biochemistry
Abstract

The configuration of positions 13 and 14 in N-methyl-8-aza-des-N-morphinan has been investigated. Potassium t-but-oxide in t-butanol converts N-acetyl-10-oxo-8-aza-des-N-morphinan (XVI) into 10-hydroxy-8,10-(α-oxo-ethano)-8-aza-des-N-morphinan (XVII). Formation of these new lactams is possible only when rings B and C are cis . It follows, therefore, that 8-aza-des-N-morphinan synthesized in this investigation has B/C in cis and C/D in trans positions the same as the steric structure of morphinan (M).

Published
1960

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